Folding project #14955, PARKINSONS research

Research section Research projects and references

Project #14955 overview

Project Summary AI Beta

This project looks at special proteins called Class C receptors found in the brain. These receptors play a big role in how we feel and react to things, like pain and happiness. By studying how these receptors work, scientists hope to understand diseases like Parkinson's and addiction, and develop better medicines.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 299,845
Core: 0x22
Status: Public

Source material

Official Project Description

Class C Receptors Class C Receptors consist of human proteins that are involved in the control of neuronal signaling in the brain.

Overactivation/Inactivation of these receptors has been linked to Parkinsons, Anxiety, Depression, Pain Relief.

This receptor also shows significant importance when it comes to treating opioid addiction.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease, and design more effective anti-opioid drugs.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class C Receptors

A group of G protein-coupled receptors involved in neuronal signaling.

Scientific: BiotechnologyNeuroscience / Neuropharmacology

Class C receptors are a type of protein found on the surface of nerve cells. They play a role in transmitting signals between neurons and are involved in various brain functions, including mood regulation, pain perception, and addiction. Overactivation or underactivation of these receptors has been linked to neurological and psychiatric disorders such as Parkinson's disease, anxiety, depression, and opioid addiction.

Parkinsons

A progressive neurodegenerative disorder characterized by tremors, rigidity, and slow movements.

Pathology: HealthcareNeurology / Movement Disorders

Parkinson's disease is a brain disorder that causes shaking, stiffness, and difficulty with movement. It is caused by the loss of dopamine-producing cells in the brain, leading to impaired communication between nerve cells. Symptoms typically develop gradually and worsen over time.

Anxiety

A feeling of worry, nervousness, or unease.

Mental Health: HealthcarePsychiatry / Neurological Disorders

Anxiety is a common mental health condition characterized by excessive worry, fear, and apprehension. It can manifest in physical symptoms such as rapid heartbeat, sweating, and shortness of breath. Anxiety disorders can significantly impact daily life and well-being.

Depression

A mood disorder characterized by persistent sadness, loss of interest, and feelings of hopelessness.

Mental Health: HealthcarePsychiatry / Neurological Disorders

Depression is a serious mental illness that causes persistent feelings of sadness, emptiness, and hopelessness. It can affect thoughts, behavior, and physical health. Symptoms include changes in appetite, sleep patterns, energy levels, and difficulty concentrating.

Pain Relief

The reduction or elimination of pain.

Therapeutic: PharmaceuticalsMedicine / Anesthesiology

Pain relief refers to the management and treatment of pain. It can involve various methods such as medication, physical therapy, or alternative therapies. The goal is to alleviate pain and improve quality of life.

Opioid Addiction

A dependence on opioid drugs that leads to compulsive drug seeking and use.

Medical Condition: HealthcareMedicine / Addiction Medicine

Opioid addiction is a serious medical condition characterized by an overwhelming craving for opioids despite harmful consequences. It involves changes in the brain's reward pathways and can lead to physical dependence, withdrawal symptoms, and overdose.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	34,230,039	100,000	342.30	0 ^hrs 4 ^mins
2	B200 GB100 [B200]	Nvidia	GB100	25,424,780	100,000	254.25	0 ^hrs 6 ^mins
3	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	23,868,019	403,172	59.20	0 ^hrs 24 ^mins
4	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	18,635,973	100,000	186.36	0 ^hrs 8 ^mins
5	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	16,993,713	529,935	32.07	0 ^hrs 45 ^mins
6	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	16,606,854	244,688	67.87	0 ^hrs 21 ^mins
7	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	15,189,576	137,465	110.50	0 ^hrs 13 ^mins
8	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	12,650,171	163,391	77.42	0 ^hrs 19 ^mins
9	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	11,402,705	416,316	27.39	0 ^hrs 53 ^mins
10	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	11,004,512	542,590	20.28	1 ^hrs 11 ^mins
11	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	10,683,389	224,055	47.68	0 ^hrs 30 ^mins
12	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,975,587	471,279	21.17	1 ^hrs 8 ^mins
13	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	9,455,558	100,000	94.56	0 ^hrs 15 ^mins
14	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,001,924	487,178	18.48	1 ^hrs 18 ^mins
15	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	8,731,699	503,672	17.34	1 ^hrs 23 ^mins
16	RTX PRO 4000 Blackwell GB203GL [RTX PRO 4000 Blackwell]	Unknown	GB203GL	8,437,689	100,000	84.38	0 ^hrs 17 ^mins
17	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	8,402,106	495,610	16.95	1 ^hrs 25 ^mins
18	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	7,693,281	440,528	17.46	1 ^hrs 22 ^mins
19	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,746,353	409,653	16.47	1 ^hrs 27 ^mins

20	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,467,385	377,477	17.13	1 ^hrs 24 ^mins
21	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,936,258	441,108	13.46	1 ^hrs 47 ^mins
22	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,630,615	431,367	13.05	1 ^hrs 50 ^mins
23	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,444,770	142,616	38.18	0 ^hrs 38 ^mins
24	RTX A4500 GA102GL [RTX A4500]	Nvidia	GA102GL	5,174,542	423,351	12.22	1 ^hrs 58 ^mins
25	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,101,804	312,796	16.31	1 ^hrs 28 ^mins
26	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,872,705	410,929	11.86	2 ^hrs 1 ^mins
27	GeForce RTX 5060 GB206 [GeForce RTX 5060]	Nvidia	GB206	4,862,294	100,000	48.62	0 ^hrs 30 ^mins
28	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	4,751,123	100,000	47.51	0 ^hrs 30 ^mins
29	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,621,885	346,381	13.34	1 ^hrs 48 ^mins
30	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	4,472,960	227,716	19.64	1 ^hrs 13 ^mins
31	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	4,322,904	377,652	11.45	2 ^hrs 6 ^mins
32	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,313,703	396,887	10.87	2 ^hrs 12 ^mins
33	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	4,236,472	100,000	42.36	0 ^hrs 34 ^mins
34	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,775,221	359,083	10.51	2 ^hrs 17 ^mins
35	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,654,914	377,580	9.68	2 ^hrs 29 ^mins
36	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,654,471	376,281	9.71	2 ^hrs 28 ^mins
37	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,632,581	244,722	14.84	1 ^hrs 37 ^mins
38	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	3,608,098	373,210	9.67	2 ^hrs 29 ^mins
39	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,444,848	362,036	9.52	2 ^hrs 31 ^mins

40	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,393,492	304,235	11.15	2 ^hrs 9 ^mins
41	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,193,802	290,550	10.99	2 ^hrs 11 ^mins
42	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	2,935,536	344,101	8.53	2 ^hrs 49 ^mins
43	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,890,639	347,293	8.32	2 ^hrs 53 ^mins
44	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,784,000	100,000	27.84	0 ^hrs 52 ^mins
45	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,711,802	208,067	13.03	1 ^hrs 50 ^mins
46	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,659,397	314,451	8.46	2 ^hrs 50 ^mins
47	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,612,404	325,525	8.03	2 ^hrs 59 ^mins
48	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,535,564	334,252	7.59	3 ^hrs 10 ^mins
49	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,414,841	305,324	7.91	3 ^hrs 2 ^mins
50	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,403,933	326,796	7.36	3 ^hrs 16 ^mins
51	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,401,178	271,418	8.85	2 ^hrs 43 ^mins
52	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	2,339,280	326,884	7.16	3 ^hrs 21 ^mins
53	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,243,903	100,000	22.44	1 ^hrs 4 ^mins
54	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,156,697	322,769	6.68	3 ^hrs 36 ^mins
55	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,088,185	317,928	6.57	3 ^hrs 39 ^mins
56	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,027,620	262,990	7.71	3 ^hrs 7 ^mins
57	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,893,465	303,495	6.24	3 ^hrs 51 ^mins
58	GeForce RTX 4050 Max-Q / Mobile AD107M [GeForce RTX 4050 Max-Q / Mobile]	Nvidia	AD107M	1,846,664	100,000	18.47	1 ^hrs 18 ^mins
59	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	1,838,724	293,252	6.27	3 ^hrs 50 ^mins

60	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,625,546	295,607	5.50	4 ^hrs 22 ^mins
61	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,580,048	287,242	5.50	4 ^hrs 22 ^mins
62	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,528,473	173,800	8.79	2 ^hrs 44 ^mins
63	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,454,555	247,218	5.88	4 ^hrs 5 ^mins
64	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,394,672	230,662	6.05	3 ^hrs 58 ^mins
65	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,355,270	267,483	5.07	4 ^hrs 44 ^mins
66	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,320,401	240,292	5.49	4 ^hrs 22 ^mins
67	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,190,298	260,252	4.57	5 ^hrs 15 ^mins
68	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,156,589	268,268	4.31	5 ^hrs 34 ^mins
69	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	1,139,289	252,260	4.52	5 ^hrs 19 ^mins
70	P104-100 GP104 [P104-100]	Nvidia	GP104	1,134,996	256,443	4.43	5 ^hrs 25 ^mins
71	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	1,133,544	250,548	4.52	5 ^hrs 18 ^mins
72	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	1,133,320	100,000	11.33	2 ^hrs 7 ^mins
73	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,130,441	100,000	11.30	2 ^hrs 7 ^mins
74	Radeon PRO WX 9100 Vega 10 XT [Radeon PRO WX 9100]	AMD	Vega 10 XT	1,112,355	254,985	4.36	5 ^hrs 30 ^mins
75	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,097,938	250,013	4.39	5 ^hrs 28 ^mins
76	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	943,217	241,502	3.91	6 ^hrs 9 ^mins
77	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	680,960	215,046	3.17	7 ^hrs 35 ^mins
78	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	630,367	209,148	3.01	7 ^hrs 58 ^mins
79	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	561,915	209,168	2.69	8 ^hrs 56 ^mins

80	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	477,174	201,554	2.37	10 ^hrs 8 ^mins
81	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	470,774	191,706	2.46	9 ^hrs 46 ^mins
82	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	323,780	100,000	3.24	7 ^hrs 25 ^mins
83	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	208,075	146,011	1.43	16 ^hrs 50 ^mins
84	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	81,928	100,000	0.82	29 ^hrs 18 ^mins
85	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	73,568	100,000	0.74	32 ^hrs 37 ^mins
86	GeForce MX350 GP107M [GeForce MX350]	Nvidia	GP107M	56,232	100,000	0.56	42 ^hrs 41 ^mins
87	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	21,144	100,000	0.21	113 ^hrs 30 ^mins

Research: PARKINSONS Folding Project #14955

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14955

GPU PPD Averages

Research: PARKINSONS Folding Project #14955

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages