Folding project #12706, CANNABINOID research

Research section Research projects and references

Project #12706 overview

Project Summary AI Beta

This project relates to how cannabinoid receptors in our brains affect things like pain, hunger, learning, and addiction. By using computer simulations with different chemicals, scientists can learn more about these receptors and how drugs might work on them.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Michael Chen
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 82,526
Core: 0x27
Status: Public

Source material

Official Project Description

Cannabinoid G Protein Coupled Receptors Improper signaling through Cannabinoid receptors is linked to drug addiction, pain perception, appetite regulation and learning.

Simulation of these proteins with different small molecules helps us to understand their function and the selectivity/efficacy of these potential drugs to the nervous system.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Cannabinoid

A class of lipid compounds with psychoactive effects.

Scientific: Biotechnology, MedicinePharmacology / Neuropharmacology

Cannabinoids are a group of chemicals found in the cannabis plant. They interact with specific receptors in the brain and body, affecting various functions like mood, pain sensation, appetite, and memory. Understanding how cannabinoids work is crucial for developing new medications for conditions like chronic pain, anxiety, and epilepsy.

G Protein Coupled Receptors

Cell surface receptors that activate intracellular signaling pathways.

Scientific: Biotechnology, MedicinePharmacology / Molecular Pharmacology

G protein-coupled receptors (GPCRs) are a large family of membrane proteins that play a vital role in cellular communication. When a molecule binds to a GPCR, it triggers a cascade of events inside the cell, leading to various responses like changes in gene expression, metabolism, or even cell movement. They are involved in many physiological processes and are targets for numerous drugs.

Drug Addiction

A chronic, relapsing disorder characterized by compulsive drug seeking and use.

Clinical: HealthcareMedicine / Addiction Psychiatry

Drug addiction is a serious medical condition marked by an uncontrollable urge to seek and use drugs despite harmful consequences. It affects the brain's reward system, leading to cravings and withdrawal symptoms when drug use stops. Addiction can have devastating impacts on individuals, families, and communities.

Pain Perception

The ability to sense and process pain signals.

Clinical: HealthcareMedicine / Pain Management

Pain perception is a complex process involving the detection of noxious stimuli by sensory neurons, transmission of pain signals to the brain, and interpretation of these signals as painful. Various factors influence pain perception, including genetics, experience, and psychological state.

Appetite Regulation

The control of food intake and satiety.

Clinical: HealthcareMedicine / Endocrinology

Appetite regulation is a complex process involving hormones, neurotransmitters, and environmental cues that influence our desire to eat. It ensures we consume enough calories to meet our body's needs while avoiding overeating.

Learning

The process of acquiring new knowledge or skills.

Scientific: Biotechnology, AcademiaNeuroscience / Cognitive Science

Learning is a fundamental ability that allows us to acquire information and adapt to our environment. It involves changes in the brain's structure and function, enabling us to store memories, solve problems, and make decisions.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	28,106,397	44,350	633.74	0 ^hrs 2 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	21,243,833	213,320	99.59	0 ^hrs 14 ^mins
3	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	15,659,494	134,215	116.67	0 ^hrs 12 ^mins
4	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	15,308,403	96,215	159.11	0 ^hrs 9 ^mins
5	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	14,488,143	44,350	326.68	0 ^hrs 4 ^mins
6	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	14,034,995	147,171	95.37	0 ^hrs 15 ^mins
7	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	11,617,715	297,703	39.02	0 ^hrs 37 ^mins
8	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	11,488,138	161,252	71.24	0 ^hrs 20 ^mins
9	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	10,579,231	44,350	238.54	0 ^hrs 6 ^mins
10	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	9,966,326	44,350	224.72	0 ^hrs 6 ^mins
11	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	9,644,189	44,350	217.46	0 ^hrs 7 ^mins
12	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,377,382	227,492	36.82	0 ^hrs 39 ^mins
13	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,082,345	44,350	182.24	0 ^hrs 8 ^mins
14	GeForce RTX 4060 Ti AD104 [GeForce RTX 4060 Ti]	Nvidia	AD104	7,406,738	44,350	167.01	0 ^hrs 9 ^mins
15	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	7,060,847	44,350	159.21	0 ^hrs 9 ^mins
16	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	6,808,404	51,156	133.09	0 ^hrs 11 ^mins
17	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,580,612	44,350	148.38	0 ^hrs 10 ^mins
18	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,545,624	137,987	47.44	0 ^hrs 30 ^mins
19	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	6,314,415	44,350	142.38	0 ^hrs 10 ^mins

20	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	6,132,384	199,976	30.67	0 ^hrs 47 ^mins
21	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	6,020,751	44,350	135.76	0 ^hrs 11 ^mins
22	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,718,944	44,350	128.95	0 ^hrs 11 ^mins
23	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,716,760	176,646	32.36	0 ^hrs 44 ^mins
24	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	5,350,243	108,004	49.54	0 ^hrs 29 ^mins
25	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	5,119,487	44,350	115.43	0 ^hrs 12 ^mins
26	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,517,296	89,842	50.28	0 ^hrs 29 ^mins
27	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,347,449	200,058	21.73	1 ^hrs 6 ^mins
28	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	4,261,830	44,350	96.10	0 ^hrs 15 ^mins
29	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	3,993,045	111,470	35.82	0 ^hrs 40 ^mins
30	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	3,968,975	44,350	89.49	0 ^hrs 16 ^mins
31	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,801,534	44,350	85.72	0 ^hrs 17 ^mins
32	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,545,393	58,201	60.92	0 ^hrs 24 ^mins
33	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,508,849	157,228	22.32	1 ^hrs 5 ^mins
34	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,198,346	53,764	59.49	0 ^hrs 24 ^mins
35	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	3,019,863	246,258	12.26	1 ^hrs 57 ^mins
36	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,875,993	125,474	22.92	1 ^hrs 3 ^mins
37	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,671,605	168,488	15.86	1 ^hrs 31 ^mins
38	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,646,237	44,350	59.67	0 ^hrs 24 ^mins
39	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,616,138	195,657	13.37	1 ^hrs 48 ^mins

40	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,523,773	44,350	56.91	0 ^hrs 25 ^mins
41	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,449,985	135,290	18.11	1 ^hrs 20 ^mins
42	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,444,879	193,190	12.66	1 ^hrs 54 ^mins
43	RTX PRO 6000 Blackwell Max-Q Workstation Edition GB202GL [RTX PRO 6000 Blackwell Max-Q Workstation Edition]	Nvidia	GB202GL	1,923,019	44,350	43.36	0 ^hrs 33 ^mins
44	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,870,751	44,350	42.18	0 ^hrs 34 ^mins
45	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,852,525	44,350	41.77	0 ^hrs 34 ^mins
46	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,737,579	44,350	39.18	0 ^hrs 37 ^mins
47	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q]	Nvidia	TU106M	1,684,049	44,350	37.97	0 ^hrs 38 ^mins
48	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,643,724	163,458	10.06	2 ^hrs 23 ^mins
49	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,564,548	166,325	9.41	2 ^hrs 33 ^mins
50	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,481,610	44,350	33.41	0 ^hrs 43 ^mins
51	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,454,279	161,707	8.99	2 ^hrs 40 ^mins
52	Radeon RX 9060(XT) Navi 44 [Radeon RX 9060(XT)]	AMD	Navi 44	1,434,694	161,776	8.87	2 ^hrs 42 ^mins
53	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,397,986	159,446	8.77	2 ^hrs 44 ^mins
54	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	1,265,533	44,350	28.54	0 ^hrs 50 ^mins
55	Radeon RX 6600(XT/M) Navi 23 XT-XL [Radeon RX 6600(XT/M)]	AMD	Navi 23 XT-XL	1,217,973	129,016	9.44	2 ^hrs 33 ^mins
56	RTX A1000 GA107GL [RTX A1000]	Nvidia	GA107GL	1,198,295	44,350	27.02	0 ^hrs 53 ^mins
57	P104-100 GP104 [P104-100]	Nvidia	GP104	1,193,275	44,350	26.91	0 ^hrs 54 ^mins
58	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,059,404	44,350	23.89	1 ^hrs 0 ^mins
59	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	618,622	44,350	13.95	1 ^hrs 43 ^mins

60	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	513,285	44,350	11.57	2 ^hrs 4 ^mins
61	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	410,349	44,350	9.25	2 ^hrs 36 ^mins
62	GeForce GTX 1650 TU106 [GeForce GTX 1650]	Nvidia	TU106	246,112	44,350	5.55	4 ^hrs 19 ^mins
63	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	230,493	87,369	2.64	9 ^hrs 6 ^mins
64	RX 5500(M)/Pro 5500M Navi 14 [RX 5500(M)/Pro 5500M]	AMD	Navi 14	161,968	44,350	3.65	6 ^hrs 34 ^mins

Research: CANNABINOID Folding Project #12706

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12706

GPU PPD Averages

Research: CANNABINOID Folding Project #12706

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages