Folding project #12131, CANCER research

Research section Research projects and references

Project #12131 overview

Project Summary AI Beta

Proteins are like tiny machines that need to fold into specific shapes to work correctly. Sometimes mutations (changes) in the protein's instructions can mess up this folding, causing diseases like cancer and Alzheimer's. This project aims to study how these mutations affect protein folding so we can better understand and treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Hassan Nadeem
Institution: University of Illinois at Urbana-Champaign

Work unit

Atoms: 95,000
Core: 0x23
Status: Public

Source material

Official Project Description

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Protein

A large biomolecule consisting of chains of amino acids.

Scientific: BiotechnologyBiological Sciences / Biochemistry

Proteins are essential molecules found in all living organisms. They perform a wide range of functions, including catalyzing biochemical reactions, transporting molecules, and providing structural support. The sequence and folding of amino acids determine the specific function of each protein.

Peptide

A short chain of amino acids linked together by peptide bonds.

Scientific: PharmaceuticalBiological Sciences / Biochemistry

Peptides are smaller chains of amino acids. They often act as signaling molecules or precursors to larger proteins.

Misfolding

The process by which a protein fails to assume its correct three-dimensional shape.

Scientific: BiotechnologyBiological Sciences / Structural Biology

Misfolding occurs when a protein does not fold properly into its intended shape. This can lead to the protein losing its function and potentially causing disease.

Mutation

A permanent change in the DNA sequence.

Scientific: BiotechnologyBiological Sciences / Genetics

Mutations are alterations in the genetic code. They can be spontaneous or induced by environmental factors. Mutations can have various effects, including changes in protein structure and function.

Cancer

A group of diseases characterized by uncontrolled cell growth.

Medical: PharmaceuticalHealthcare / Oncology

Cancer is a group of diseases where abnormal cells grow and spread uncontrollably. This can lead to tumors and damage to various organs.

Alzheimer's

A progressive neurodegenerative disease that affects memory and cognitive function.

Medical: PharmaceuticalHealthcare / Neurology

Alzheimer's disease is a brain disorder that causes a gradual decline in memory, thinking, and behavior. It is the most common cause of dementia.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	20,633,573	173,492	118.93	0 ^hrs 12 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	13,502,119	294,097	45.91	0 ^hrs 31 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	13,357,875	115,006	116.15	0 ^hrs 12 ^mins
4	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	10,501,188	49,030	214.18	0 ^hrs 7 ^mins
5	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	10,448,753	88,223	118.44	0 ^hrs 12 ^mins
6	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	10,282,525	319,026	32.23	0 ^hrs 45 ^mins
7	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	10,229,308	269,880	37.90	0 ^hrs 38 ^mins
8	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,129,183	245,353	37.21	0 ^hrs 39 ^mins
9	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	7,316,386	46,485	157.39	0 ^hrs 9 ^mins
10	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,496,936	46,485	139.76	0 ^hrs 10 ^mins
11	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,824,201	46,485	125.29	0 ^hrs 11 ^mins
12	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,684,201	107,800	52.73	0 ^hrs 27 ^mins
13	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,530,262	46,485	118.97	0 ^hrs 12 ^mins
14	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,380,301	157,547	34.15	0 ^hrs 42 ^mins
15	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,216,135	51,505	101.27	0 ^hrs 14 ^mins
16	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,194,874	217,763	23.86	1 ^hrs 0 ^mins
17	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,132,781	54,153	94.78	0 ^hrs 15 ^mins
18	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	4,761,665	249,188	19.11	1 ^hrs 15 ^mins
19	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,714,794	244,058	19.32	1 ^hrs 15 ^mins

20	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,207,263	176,907	23.78	1 ^hrs 1 ^mins
21	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,057,450	101,853	39.84	0 ^hrs 36 ^mins
22	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,472,383	46,485	74.70	0 ^hrs 19 ^mins
23	Tesla V100 PCIe 16GB GV100GL [Tesla V100 PCIe 16GB] M 14028	Nvidia	GV100GL	3,382,641	46,485	72.77	0 ^hrs 20 ^mins
24	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	3,317,742	46,485	71.37	0 ^hrs 20 ^mins
25	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,311,419	219,293	15.10	1 ^hrs 35 ^mins
26	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,158,371	54,982	57.44	0 ^hrs 25 ^mins
27	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,157,775	216,109	14.61	1 ^hrs 39 ^mins
28	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	2,929,695	150,451	19.47	1 ^hrs 14 ^mins
29	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,853,168	210,944	13.53	1 ^hrs 46 ^mins
30	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,755,796	46,485	59.28	0 ^hrs 24 ^mins
31	Intel Arc B580 Graphics Battlemage G21 [Intel Arc B580 Graphics]	Intel	Battlemage G21	2,623,887	152,097	17.25	1 ^hrs 23 ^mins
32	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,487,086	46,485	53.50	0 ^hrs 27 ^mins
33	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,422,037	197,760	12.25	1 ^hrs 58 ^mins
34	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	2,413,154	185,126	13.04	1 ^hrs 50 ^mins
35	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,371,796	46,485	51.02	0 ^hrs 28 ^mins
36	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,307,671	85,828	26.89	0 ^hrs 54 ^mins
37	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,258,065	192,928	11.70	2 ^hrs 3 ^mins
38	Radeon RX 9060(XT) Navi 44 [Radeon RX 9060(XT)]	AMD	Navi 44	2,222,528	46,485	47.81	0 ^hrs 30 ^mins
39	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,210,340	46,485	47.55	0 ^hrs 30 ^mins

40	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,104,282	156,762	13.42	1 ^hrs 47 ^mins
41	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,538,421	46,485	33.09	0 ^hrs 44 ^mins
42	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,520,966	160,213	9.49	2 ^hrs 32 ^mins
43	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,492,942	165,334	9.03	2 ^hrs 39 ^mins
44	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,489,990	46,485	32.05	0 ^hrs 45 ^mins
45	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,353,342	163,264	8.29	2 ^hrs 54 ^mins
46	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,328,260	46,485	28.57	0 ^hrs 50 ^mins
47	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,296,573	160,610	8.07	2 ^hrs 58 ^mins
48	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,261,742	116,122	10.87	2 ^hrs 13 ^mins
49	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,251,278	46,485	26.92	0 ^hrs 53 ^mins
50	P104-100 GP104 [P104-100]	Nvidia	GP104	1,242,053	46,485	26.72	0 ^hrs 54 ^mins
51	RTX A2000 Mobile GA107GLM [RTX A2000 Mobile]	Nvidia	GA107GLM	1,140,923	46,485	24.54	0 ^hrs 59 ^mins
52	RTX A1000 GA107GL [RTX A1000]	Nvidia	GA107GL	1,122,019	46,485	24.14	0 ^hrs 60 ^mins
53	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	907,048	141,558	6.41	3 ^hrs 45 ^mins
54	P106-100 GP106 [P106-100]	Nvidia	GP106	761,334	46,485	16.38	1 ^hrs 28 ^mins
55	GeForce RTX 3050 6GB Laptop GPU GN20-P0-R-K2 [GeForce RTX 3050 6GB Laptop GPU]	Nvidia	GN20-P0-R-K2	716,964	46,485	15.42	1 ^hrs 33 ^mins
56	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	713,895	130,782	5.46	4 ^hrs 24 ^mins
57	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	711,392	46,485	15.30	1 ^hrs 34 ^mins
58	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	650,362	46,485	13.99	1 ^hrs 43 ^mins
59	Radeon 880M/890M Strix Point [Radeon 880M/890M]	AMD	Strix Point	644,775	46,485	13.87	1 ^hrs 44 ^mins

60	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	556,436	46,485	11.97	2 ^hrs 0 ^mins
61	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	521,864	73,842	7.07	3 ^hrs 24 ^mins
62	GeForce GTX 1650 TU106 [GeForce GTX 1650]	Nvidia	TU106	517,642	46,485	11.14	2 ^hrs 9 ^mins
63	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	487,790	46,485	10.49	2 ^hrs 17 ^mins
64	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	475,713	122,677	3.88	6 ^hrs 11 ^mins
65	Quadro P2000 GP106GL [Quadro P2000] [MED-XN71] 3935	Nvidia	GP106GL	425,330	46,485	9.15	2 ^hrs 37 ^mins
66	RX 5500(M)/Pro 5500M Navi 14 [RX 5500(M)/Pro 5500M]	AMD	Navi 14	420,971	46,485	9.06	2 ^hrs 39 ^mins
67	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	339,842	102,639	3.31	7 ^hrs 15 ^mins
68	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	328,966	48,904	6.73	3 ^hrs 34 ^mins
69	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	266,757	46,485	5.74	4 ^hrs 11 ^mins
70	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	195,053	46,485	4.20	5 ^hrs 43 ^mins
71	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	151,072	78,593	1.92	12 ^hrs 29 ^mins
72	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	142,627	46,485	3.07	7 ^hrs 49 ^mins
73	Quadro M1000M GM107GLM [Quadro M1000M]	Nvidia	GM107GLM	101,725	68,224	1.49	16 ^hrs 6 ^mins
74	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	98,322	56,053	1.75	13 ^hrs 41 ^mins
75	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	85,438	64,879	1.32	18 ^hrs 13 ^mins
76	GeForce MX250 GP108M [GeForce MX250]	Nvidia	GP108M	63,700	68,956	0.92	25 ^hrs 59 ^mins
77	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	60,057	46,485	1.29	18 ^hrs 35 ^mins
78	GeForce MX350 GP107M [GeForce MX350]	Nvidia	GP107M	37,032	46,485	0.80	30 ^hrs 8 ^mins
79	Quadro K420 GK107 [Quadro K420]	Nvidia	GK107	10,572	46,485	0.23	105 ^hrs 32 ^mins

Research: CANCER Folding Project #12131

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12131

GPU PPD Averages

Research: CANCER Folding Project #12131

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages