Folding project #12126, CANCER research

Research section Research projects and references

Project #12126 overview

Project Summary AI Beta

Proteins need to fold into specific shapes to work right. Sometimes changes in a protein's code can mess up this folding, causing diseases like cancer and Alzheimer's. This project is trying to figure out how these changes affect how proteins fold so we can better understand and treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Hassan Nadeem
Institution: University of Illinois at Urbana-Champaign

Work unit

Atoms: 95,000
Core: 0x23
Status: Public

Source material

Official Project Description

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Protein

Large biomolecules essential for various cellular functions.

Scientific: PharmaceuticalBiotechnology / Molecular Biology

Proteins are complex molecules found in all living things. They perform many vital roles, such as building and repairing tissues, transporting substances, and catalyzing chemical reactions.

Misfolding

An incorrect three-dimensional shape adopted by a protein.

Scientific: PharmaceuticalBiotechnology / Structural Biology

Protein misfolding happens when a protein doesn't fold into its correct shape. This can lead to problems with the protein's function and cause diseases.

Mutation

A permanent change in the DNA sequence.

Scientific: PharmaceuticalBiotechnology / Genetics

Mutations are changes in the genetic code. They can be caused by errors during DNA replication or exposure to mutagens like radiation. Mutations can have various effects on organisms, including no effect, beneficial effects, or harmful effects.

Alzheimer's

A progressive neurodegenerative disease.

Pathology: HealthcareMedicine / Neurology

Alzheimer's disease is a brain disorder that causes memory loss, thinking problems, and behavioral changes. It is the most common cause of dementia.

Cancer

Uncontrolled cell growth and spread.

Pathology: HealthcareMedicine / Oncology

Cancer is a group of diseases characterized by the abnormal growth and spread of cells. It can affect any part of the body.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	9,837,123	209,349	46.99	0 ^hrs 31 ^mins
2	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,691,043	204,411	47.41	0 ^hrs 30 ^mins
3	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,658,672	163,273	53.03	0 ^hrs 27 ^mins
4	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,693,473	256,935	26.05	0 ^hrs 55 ^mins
5	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,213,753	183,962	33.78	0 ^hrs 43 ^mins
6	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,938,925	41,638	142.63	0 ^hrs 10 ^mins
7	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,679,145	229,148	24.78	0 ^hrs 58 ^mins
8	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,667,519	92,696	61.14	0 ^hrs 24 ^mins
9	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,878,941	215,019	22.69	1 ^hrs 3 ^mins
10	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,756,465	116,550	40.81	0 ^hrs 35 ^mins
11	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,917,430	216,649	18.08	1 ^hrs 20 ^mins
12	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,645,223	144,202	25.28	0 ^hrs 57 ^mins
13	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,451,889	41,638	82.90	0 ^hrs 17 ^mins
14	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,062,233	161,632	18.95	1 ^hrs 16 ^mins
15	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,814,568	198,080	14.21	1 ^hrs 41 ^mins
16	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,619,953	158,991	16.48	1 ^hrs 27 ^mins
17	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,329,249	50,000	46.58	0 ^hrs 31 ^mins
18	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,250,999	177,450	12.69	1 ^hrs 54 ^mins
19	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,221,703	41,638	53.36	0 ^hrs 27 ^mins

20	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,147,792	124,061	17.31	1 ^hrs 23 ^mins
21	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,118,459	175,677	12.06	1 ^hrs 59 ^mins
22	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,084,496	138,563	15.04	1 ^hrs 36 ^mins
23	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,032,104	56,871	35.73	0 ^hrs 40 ^mins
24	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,023,829	172,275	11.75	2 ^hrs 3 ^mins
25	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,852,200	171,535	10.80	2 ^hrs 13 ^mins
26	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,601,576	159,777	10.02	2 ^hrs 24 ^mins
27	Radeon VII Vega 20 [Radeon VII]	AMD	Vega 20	1,581,946	41,638	37.99	0 ^hrs 38 ^mins
28	Radeon 740M/760M/780M Phoenix [Radeon 740M/760M/780M]	AMD	Phoenix	1,341,778	125,837	10.66	2 ^hrs 15 ^mins
29	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,336,652	151,046	8.85	2 ^hrs 43 ^mins
30	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,194,968	41,638	28.70	0 ^hrs 50 ^mins
31	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,148,430	142,913	8.04	2 ^hrs 59 ^mins
32	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,141,468	41,638	27.41	0 ^hrs 53 ^mins
33	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,073,132	118,188	9.08	2 ^hrs 39 ^mins
34	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,068,135	75,759	14.10	1 ^hrs 42 ^mins
35	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,019,976	41,638	24.50	0 ^hrs 59 ^mins
36	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	723,945	122,548	5.91	4 ^hrs 4 ^mins
37	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	723,177	122,610	5.90	4 ^hrs 4 ^mins
38	P106-100 GP106 [P106-100]	Nvidia	GP106	702,851	121,804	5.77	4 ^hrs 10 ^mins
39	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	692,155	41,638	16.62	1 ^hrs 27 ^mins

40	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	642,246	41,638	15.42	1 ^hrs 33 ^mins
41	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	596,300	41,638	14.32	1 ^hrs 41 ^mins
42	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	573,229	41,638	13.77	1 ^hrs 45 ^mins
43	Quadro P4000 GP104GL [Quadro P4000]	Nvidia	GP104GL	573,098	41,638	13.76	1 ^hrs 45 ^mins
44	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	555,551	41,638	13.34	1 ^hrs 48 ^mins
45	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	495,472	52,960	9.36	2 ^hrs 34 ^mins
46	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	488,524	104,706	4.67	5 ^hrs 9 ^mins
47	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	480,781	41,638	11.55	2 ^hrs 5 ^mins
48	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	415,522	96,498	4.31	5 ^hrs 34 ^mins
49	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	260,931	49,849	5.23	4 ^hrs 35 ^mins
50	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	215,251	41,638	5.17	4 ^hrs 39 ^mins
51	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	198,206	80,209	2.47	9 ^hrs 43 ^mins
52	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	157,919	41,638	3.79	6 ^hrs 20 ^mins
53	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	143,430	71,777	2.00	12 ^hrs 1 ^mins
54	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	100,432	41,638	2.41	9 ^hrs 57 ^mins
55	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	82,235	59,394	1.38	17 ^hrs 20 ^mins
56	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	74,909	41,638	1.80	13 ^hrs 20 ^mins

Research: CANCER Folding Project #12126

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12126

GPU PPD Averages

Research: CANCER Folding Project #12126

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages