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Research: CANCER Folding Project #19421

Project #19421 overview

Project Summary AI Beta

Breast cancer is a serious health threat with many causes. This project looks at how changes in the BRCA1 gene increase breast cancer risk. Researchers are studying a specific change, C61G, to see how it affects the protein's structure and function. The goal is to develop a drug that can fix this problem and prevent cancer.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Ayan Bhattacharjee
Institution
University of Pennsylvania

Work unit

Atoms
75,500
Core
0xa8
Status
Public

No related projects listed.

Source material

Official Project Description

Breast cancer is a leading cause for cancer-related deaths in women around the world.

The disease can result from many different genetic mutations and exhibits a high degree of variability.

Furthermore, breast cancer is prone to metastasizing (spreading to other parts of the body) and therapeutic resistance.

Mutations in a protein known as BRCA1 are one of the hereditary risk factors for developing breast cancer.

Determining how these mutations disrupt common structural features is a key step in developing therapeutics to combat breast cancer.

Many single amino-acid substitutions in BRCA1 lead to increased risk of cancer, but it is unknown how these variants lead to loss of function.

The p194XX series of projects is dedicated to understanding how mutations in the N-terminal RING domain of BRCA1 lead to deleterious effects.

In p19421, we are simulating the mutant C61G BRCA1, which is a major hereditary risk factor and significantly alters the dynamics of the protein.

We hope that this knowledge can lead to a key strategy for developing a small molecule drug capable of “structure correcting” mutant BRCA1.

Performance data

Hardware Performance for Project 19421

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:48:29

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 EPYC 7B12 64-CORE 64 20,933 1,339,712 AMD
2 12TH GEN CORE I9-12900K 24 49,646 1,191,504 Intel
3 APPLE M2 ULTRA 24 38,931 934,344 Apple
4 RYZEN 9 7950X 16-CORE 32 23,761 760,352 AMD
5 RYZEN 9 5950X 16-CORE 32 22,463 718,816 AMD
6 RYZEN 9 7900 12-CORE 24 28,150 675,600 AMD
7 RYZEN 9 7900X3D 12-CORE 24 26,148 627,552 AMD
8 RYZEN 7 5700X 8-CORE 16 32,711 523,376 AMD
9 XEON CPU E5-2696 V4 @ 2.20GHZ 44 11,612 510,928 Intel
10 RYZEN 7 7700X 8-CORE 16 30,876 494,016 AMD
11 RYZEN 7 5700G 16 30,513 488,208 AMD
12 12TH GEN CORE I7-12700K 20 22,490 449,800 Intel
13 RYZEN 7 5800X3D 8-CORE 16 26,970 431,520 AMD
14 RYZEN 9 5900X 12-CORE 24 17,879 429,096 AMD
15 RYZEN 9 3900X 12-CORE 24 17,269 414,456 AMD
16 RYZEN 9 3950X 16-CORE 32 12,710 406,720 AMD
17 11TH GEN CORE I7-11700K @ 3.60GHZ 16 24,153 386,448 Intel
18 RYZEN 9 6900HS CREATOR EDITION 16 23,314 373,024 AMD
19 13TH GEN CORE I5-13500 20 18,583 371,660 Intel
20 RYZEN 7 5800X 8-CORE 16 22,599 361,584 AMD
21 12TH GEN CORE I7-12700F 20 17,807 356,140 Intel
22 RYZEN 5 7600X 6-CORE 12 29,055 348,660 AMD
23 CORE I5-10600K CPU @ 4.10GHZ 12 21,886 262,632 Intel
24 RYZEN 5 5600X 6-CORE 12 20,723 248,676 AMD
25 RYZEN 5 5600 6-CORE 12 20,415 244,980 AMD
26 RYZEN 5 3600 6-CORE 12 19,892 238,704 AMD
27 CORE I7-10700K CPU @ 3.80GHZ 16 14,780 236,480 Intel
28 XEON CPU E5-2680 V2 @ 2.80GHZ 40 5,551 222,040 Intel
29 RYZEN 7 3700X 8-CORE 16 11,037 176,592 AMD
30 CORE I7-7700K CPU @ 4.20GHZ 8 20,613 164,904 Intel
31 11TH GEN CORE I7-11700F @ 2.50GHZ 16 10,167 162,672 Intel
32 11TH GEN CORE I9-11900K @ 3.50GHZ 16 10,007 160,112 Intel
33 EPYC 7262 8-CORE 16 9,395 150,320 AMD
34 CORE I7-5930K CPU @ 3.50GHZ 12 12,181 146,172 Intel
35 CORE I7-5820K CPU @ 3.30GHZ 12 11,808 141,696 Intel
36 13TH GEN CORE I7-13700 24 5,743 137,832 Intel
37 CORE I7-8700K CPU @ 3.70GHZ 12 11,348 136,176 Intel
38 CORE I5-9500T CPU @ 2.20GHZ 6 21,536 129,216 Intel
39 XEON SILVER 4114 CPU @ 2.20GHZ 40 3,107 124,280 Intel
40 CORE I7-9750H CPU @ 2.60GHZ 12 9,958 119,496 Intel
41 XEON CPU E5-2660 V3 @ 2.60GHZ 20 5,518 110,360 Intel
42 13TH GEN CORE I7-13700K 24 4,403 105,672 Intel
43 CORE I7-8705G CPU @ 3.10GHZ 8 12,986 103,888 Intel
44 XEON CPU E3-1270 V5 @ 3.60GHZ 8 12,435 99,480 Intel
45 CORE I3-10100F CPU @ 3.60GHZ 8 12,184 97,472 Intel
46 12TH GEN CORE I7-12700H 20 4,567 91,340 Intel
47 CORE I9-8950HK CPU @ 2.90GHZ 12 7,429 89,148 Intel
48 CORE I7-4790K CPU @ 4.00GHZ 8 10,461 83,688 Intel
49 CORE I7-10700T CPU @ 2.00GHZ 16 5,053 80,848 Intel
50 CORE I7-6700K CPU @ 4.00GHZ 8 9,734 77,872 Intel
51 XEON CPU E5-2697 V2 @ 2.70GHZ 24 2,880 69,120 Intel
52 CORE I5-6500 CPU @ 3.20GHZ 4 16,853 67,412 Intel
53 CORE I5-7400 CPU @ 3.00GHZ 4 16,713 66,852 Intel
54 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,138 66,208 Intel
55 CORE I5-6600 CPU @ 3.30GHZ 4 16,433 65,732 Intel
56 XEON CPU E3-1245 V3 @ 3.40GHZ 8 7,705 61,640 Intel
57 CORE I7-4770 CPU @ 3.40GHZ 8 7,702 61,616 Intel
58 CORE I5-6600K CPU @ 3.50GHZ 4 14,436 57,744 Intel
59 CORE I5-4690 CPU @ 3.50GHZ 4 14,112 56,448 Intel
60 XEON CPU X5680 @ 3.33GHZ 12 4,665 55,980 Intel
61 CORE I5-6400 CPU @ 2.70GHZ 4 13,876 55,504 Intel
62 CORE I7-3770K CPU @ 3.50GHZ 8 6,923 55,384 Intel
63 CORE I7-3720QM CPU @ 2.60GHZ 8 6,664 53,312 Intel
64 CORE I5-4590 CPU @ 3.30GHZ 4 13,238 52,952 Intel
65 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,418 51,344 Intel
66 XEON CPU E5-1620 V2 @ 3.70GHZ 8 6,311 50,488 Intel
67 CORE I7-3770 CPU @ 3.40GHZ 8 5,739 45,912 Intel
68 APPLE M1 8 5,548 44,384 Apple
69 XEON CPU E5-1620 0 @ 3.60GHZ 8 5,542 44,336 Intel
70 XEON CPU E5-1630 V3 @ 3.70GHZ 8 5,392 43,136 Intel
71 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,258 42,064 Intel
72 CORE I5-4670 CPU @ 3.40GHZ 4 10,381 41,524 Intel
73 12TH GEN CORE I7-12700 20 1,974 39,480 Intel
74 CORE I3-1005G1 CPU @ 1.20GHZ 4 8,354 33,416 Intel
75 CORE I5-3570K CPU @ 3.40GHZ 4 7,714 30,856 Intel
76 11TH GEN CORE I5-11400F @ 2.60GHZ 12 1,771 21,252 Intel
77 XEON CPU E5-2689 0 @ 2.60GHZ 16 891 14,256 Intel
78 CORE I3-6006U CPU @ 2.00GHZ 4 3,331 13,324 Intel
79 CORE I5-8400 CPU @ 2.80GHZ 6 1,912 11,472 Intel
80 CORE I5-3210M CPU @ 2.50GHZ 4 2,765 11,060 Intel
81 CORE I5-10210U CPU @ 1.60GHZ 7 1,448 10,136 Intel
82 CORE I3-5005U CPU @ 2.00GHZ 4 2,317 9,268 Intel
83 A10-7870K RADEON R7, 12 COMPUTE CORES 4C+8G 4 1,450 5,800 AMD
84 A10-8700P RADEON R6, 10 COMPUTE CORES 4C+6G 4 1,065 4,260 AMD
85 CORE I3-2310M CPU @ 2.10GHZ 4 1,013 4,052 Intel
86 CORE2 DUO CPU T8300 @ 2.40GHZ 2 1,243 2,486 Intel
87 CORE I7-6500U CPU @ 2.50GHZ 4 374 1,496 Intel
88 CORE2 DUO CPU E6550 @ 2.33GHZ 2 705 1,410 Intel