Folding project #19020, PARKINSONS research

Research section Research projects and references

Project #19020 overview

Project Summary AI Beta

This project uses computer simulations to study the glycine transporter, a protein that controls brain activity. Glycine helps calm nerves, and problems with this transporter can cause diseases like schizophrenia. Understanding how it works will help scientists develop better drugs.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Nicole Chiang
Institution: University of Illinois

Work unit

Atoms: 104,950
Core: 0x22
Status: Public

No related projects listed.

Source material

Official Project Description

These projects contains simulations of the glycine transporter, the protein responsible for terminating neurotransmission in neurons.

Glycine is a major inhibitory neurontramitter of the spinal cord and brain stem.

Malfunctions in the glycine transporter have been assoicated with neurological diseases including schizophrenia and hyperekplexia.

Our goal in performing these simulations is to understand how the ions are coupled with substrate transport, which will enable better design of drugs targetting the glycine transporter.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

glycine transporter

A protein responsible for transporting glycine across cell membranes.

Technical: Biotechnology, PharmaceuticalsNeuroscience / Neurotransmission

The glycine transporter is a crucial protein found in neurons that helps regulate the levels of glycine, an inhibitory neurotransmitter. It works by moving glycine across the cell membrane, effectively terminating its signaling and allowing for precise control of neuronal activity. Dysfunctions in this transporter have been linked to various neurological disorders, highlighting its importance in maintaining brain health.

neurotransmission

The process of transmitting signals between neurons.

Scientific: Biotechnology, PharmaceuticalsNeuroscience / Signal Transduction

Neurotransmission is the fundamental mechanism by which our nervous system communicates. It involves the release of chemical messengers called neurotransmitters from one neuron and their reception by another neuron across a tiny gap called the synapse. This process allows for the transmission of information throughout the brain and body, enabling us to think, feel, and act.

neurons

Specialized cells that transmit information throughout the body.

Scientific: Biotechnology, PharmaceuticalsNeuroscience / Cellular Biology

Neurons are the fundamental units of our nervous system. These highly specialized cells receive, process, and transmit information through electrical and chemical signals. They form complex networks within the brain and throughout the body, allowing us to perceive our surroundings, think, learn, and control our movements.

schizophrenia

A chronic mental disorder characterized by disturbances in thought, perception, emotion, and behavior.

Medical: HealthcarePsychiatry / Mental Disorders

Schizophrenia is a complex brain disorder that affects a person's ability to think, feel, and behave clearly. People with schizophrenia may experience hallucinations, delusions, disorganized thinking, and difficulty with social interactions. It is a chronic condition that requires ongoing treatment and support.

hyperekplexia

A rare neurological disorder characterized by exaggerated startle reflexes.

Medical: HealthcareNeurology / Movement Disorders

Hyperekplexia is a genetic disorder that causes individuals to have unusually strong and involuntary muscle contractions in response to sudden stimuli. These startle reactions can be severe and potentially dangerous, leading to falls or injuries.

drugs

Substances that have a physiological effect on the body.

Technical: PharmaceuticalsPharmacology / Drug Development

Drugs are chemical substances that can alter the way our bodies function. They work by interacting with specific receptors and molecules in the body, triggering various effects. Drugs can be used for therapeutic purposes to treat diseases or manage symptoms, but they can also be misused or abused.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	18,223,586	39,000	467.27	0 ^hrs 3 ^mins
2	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	13,333,066	96,608	138.01	0 ^hrs 10 ^mins
3	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	12,789,046	302,706	42.25	0 ^hrs 34 ^mins
4	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	11,138,988	249,031	44.73	0 ^hrs 32 ^mins
5	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	8,901,408	39,000	228.24	0 ^hrs 6 ^mins
6	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	8,203,935	264,797	30.98	0 ^hrs 46 ^mins
7	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	7,746,870	218,791	35.41	0 ^hrs 41 ^mins
8	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,662,680	250,161	30.63	0 ^hrs 47 ^mins
9	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	7,400,516	253,360	29.21	0 ^hrs 49 ^mins
10	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	7,174,645	252,134	28.46	0 ^hrs 51 ^mins
11	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	7,029,752	253,928	27.68	0 ^hrs 52 ^mins
12	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,036,395	238,181	25.34	0 ^hrs 57 ^mins
13	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,377,921	192,653	27.92	0 ^hrs 52 ^mins
14	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,277,575	105,277	50.13	0 ^hrs 29 ^mins
15	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,205,459	103,522	50.28	0 ^hrs 29 ^mins
16	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	4,869,514	197,396	24.67	0 ^hrs 58 ^mins
17	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,572,647	83,618	54.68	0 ^hrs 26 ^mins
18	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	4,475,421	208,202	21.50	1 ^hrs 7 ^mins
19	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,400,052	176,311	24.96	0 ^hrs 58 ^mins

20	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,231,696	178,314	23.73	1 ^hrs 1 ^mins
21	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,200,061	90,825	46.24	0 ^hrs 31 ^mins
22	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,148,387	209,271	19.82	1 ^hrs 13 ^mins
23	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	4,073,020	56,018	72.71	0 ^hrs 20 ^mins
24	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,767,849	203,568	18.51	1 ^hrs 18 ^mins
25	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	3,346,094	195,801	17.09	1 ^hrs 24 ^mins
26	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,274,050	193,283	16.94	1 ^hrs 25 ^mins
27	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,217,729	162,961	19.75	1 ^hrs 13 ^mins
28	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	3,015,922	156,635	19.25	1 ^hrs 15 ^mins
29	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,917,810	187,171	15.59	1 ^hrs 32 ^mins
30	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,873,202	186,474	15.41	1 ^hrs 33 ^mins
31	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	2,832,893	130,833	21.65	1 ^hrs 7 ^mins
32	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,659,183	189,924	14.00	1 ^hrs 43 ^mins
33	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,590,740	84,180	30.78	0 ^hrs 47 ^mins
34	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	2,581,403	135,987	18.98	1 ^hrs 16 ^mins
35	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,552,432	175,757	14.52	1 ^hrs 39 ^mins
36	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,405,808	72,422	33.22	0 ^hrs 43 ^mins
37	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,276,439	151,132	15.06	1 ^hrs 36 ^mins
38	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	2,229,640	153,512	14.52	1 ^hrs 39 ^mins
39	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,227,283	56,018	39.76	0 ^hrs 36 ^mins

40	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 Super]	Nvidia	TU106	2,218,147	160,435	13.83	1 ^hrs 44 ^mins
41	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,087,367	92,750	22.51	1 ^hrs 4 ^mins
42	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	1,981,267	163,795	12.10	1 ^hrs 59 ^mins
43	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,975,674	106,133	18.62	1 ^hrs 17 ^mins
44	GeForce RTX 2060 12GB TU106 [GeForce RTX 2060 12GB]	Nvidia	TU106	1,889,338	148,817	12.70	1 ^hrs 53 ^mins
45	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,863,408	79,455	23.45	1 ^hrs 1 ^mins
46	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,834,754	120,374	15.24	1 ^hrs 34 ^mins
47	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,809,142	56,018	32.30	0 ^hrs 45 ^mins
48	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	1,796,010	56,018	32.06	0 ^hrs 45 ^mins
49	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	1,734,504	56,018	30.96	0 ^hrs 47 ^mins
50	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,729,891	147,234	11.75	2 ^hrs 3 ^mins
51	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,685,415	56,018	30.09	0 ^hrs 48 ^mins
52	GeForce RTX 4050 Max-Q / Mobile AD107M [GeForce RTX 4050 Max-Q / Mobile]	Nvidia	AD107M	1,558,957	83,683	18.63	1 ^hrs 17 ^mins
53	Radeon 8050S/8060S Strix Halo [Radeon 8050S/8060S]	AMD	Strix Halo	1,521,380	56,018	27.16	0 ^hrs 53 ^mins
54	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,490,134	136,320	10.93	2 ^hrs 12 ^mins
55	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,436,073	146,549	9.80	2 ^hrs 27 ^mins
56	Radeon RX 9060(XT) Navi 44 [Radeon RX 9060(XT)]	AMD	Navi 44	1,434,618	49,010	29.27	0 ^hrs 49 ^mins
57	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,407,621	137,999	10.20	2 ^hrs 21 ^mins
58	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,377,370	131,736	10.46	2 ^hrs 18 ^mins
59	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	1,363,423	143,165	9.52	2 ^hrs 31 ^mins

60	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,211,334	101,487	11.94	2 ^hrs 1 ^mins
61	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,185,586	139,003	8.53	2 ^hrs 49 ^mins
62	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,177,034	138,662	8.49	2 ^hrs 50 ^mins
63	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,170,937	58,133	20.14	1 ^hrs 11 ^mins
64	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,162,850	152,300	7.64	3 ^hrs 9 ^mins
65	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,137,847	136,730	8.32	2 ^hrs 53 ^mins
66	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	1,124,327	135,687	8.29	2 ^hrs 54 ^mins
67	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,108,364	142,696	7.77	3 ^hrs 5 ^mins
68	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	1,055,367	132,389	7.97	3 ^hrs 1 ^mins
69	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	971,990	62,706	15.50	1 ^hrs 33 ^mins
70	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	969,813	130,048	7.46	3 ^hrs 13 ^mins
71	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	908,190	166,509	5.45	4 ^hrs 24 ^mins
72	P104-100 GP104 [P104-100]	Nvidia	GP104	880,408	56,018	15.72	1 ^hrs 32 ^mins
73	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	872,455	94,972	9.19	2 ^hrs 37 ^mins
74	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	791,526	118,125	6.70	3 ^hrs 35 ^mins
75	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	758,334	113,070	6.71	3 ^hrs 35 ^mins
76	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	728,106	50,699	14.36	1 ^hrs 40 ^mins
77	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	698,399	117,112	5.96	4 ^hrs 1 ^mins
78	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	473,163	100,942	4.69	5 ^hrs 7 ^mins
79	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	460,430	101,152	4.55	5 ^hrs 16 ^mins

80	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	425,850	128,232	3.32	7 ^hrs 14 ^mins
81	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	404,679	97,614	4.15	5 ^hrs 47 ^mins
82	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	376,398	82,802	4.55	5 ^hrs 17 ^mins
83	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	322,947	89,358	3.61	6 ^hrs 38 ^mins
84	P106-090 GP106 [P106-090]	Nvidia	GP106	299,017	87,626	3.41	7 ^hrs 2 ^mins
85	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	216,215	78,859	2.74	8 ^hrs 45 ^mins
86	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	189,986	53,583	3.55	6 ^hrs 46 ^mins
87	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	179,382	79,128	2.27	10 ^hrs 35 ^mins
88	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	155,545	70,849	2.20	10 ^hrs 56 ^mins
89	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	140,738	56,018	2.51	9 ^hrs 33 ^mins
90	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	133,854	67,479	1.98	12 ^hrs 6 ^mins
91	Radeon 660M-680M Rembrandt [Radeon 660M-680M]	AMD	Rembrandt	89,066	39,000	2.28	10 ^hrs 31 ^mins
92	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	86,400	39,000	2.22	10 ^hrs 50 ^mins
93	R9 280X/HD 7900/8970 OEM Tahiti XT [R9 280X/HD 7900/8970 OEM]	AMD	Tahiti XT	85,822	57,787	1.49	16 ^hrs 10 ^mins
94	HD 7850/R7 265/R9 270 1024SP Pitcairn PRO [HD 7850/R7 265/R9 270 1024SP]	AMD	Pitcairn PRO	60,326	58,322	1.03	23 ^hrs 12 ^mins
95	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	48,071	49,664	0.97	24 ^hrs 48 ^mins
96	Radeon PRO WX3100 Lexa XT [Radeon PRO WX3100]	AMD	Lexa XT	39,594	49,991	0.79	30 ^hrs 18 ^mins
97	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	31,661	40,311	0.79	30 ^hrs 33 ^mins
98	RX Vega 10 Mobile Picasso APU [RX Vega 10 Mobile]	AMD	Picasso APU	20,450	39,000	0.52	45 ^hrs 46 ^mins
99	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	18,962	39,000	0.49	49 ^hrs 22 ^mins

100	Vega Mobile APU Lucienne [Vega Mobile APU]	AMD	Lucienne	6,895	39,000	0.18	135 ^hrs 45 ^mins

Research: PARKINSONS Folding Project #19020

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 19020

GPU PPD Averages

Research: PARKINSONS Folding Project #19020

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages