PROJECT #18912 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Lasso peptides are a class of RiPPs that are found in bacteria and characterized by a specific knotted structure, called lasso fold.

They have a macrolactam ring formed between the N-terminus and a glutamate or aspartate at position 8 or 9.

The C-terminal tail is trapped within the macrocycle.

This knotted structure confers lasso peptide remarkable thermal and proteolytic stability.

Furthermore, the specific shape and volume enable these peptides to bind important receptors, which cannot be easily targeted by traditional antibodies and small molecule drugs.

Lasso peptides have been promosing drug candidates for treating human diseases such as cancer and autoimmune disorders.

Elucidating the folding process of lasso peptide and finding the key features regulating the formation of the lasso topology will allow us to enhance their stability and facilate its formation by lasso synthetases.

However, how lasso peptides fold into this lariat knot structure is still unclear.

In this study, we would like to run atomic-level MD simulation for each of 20 lasso peptides with known structures..

PROJECT INFO

Manager(s): Xuenan Mi

Institution: University of Illinois Urbana-Champaign

Project URL: shuklagroup.org

PROJECT WORK UNIT SUMMARY

Atoms: 34,715

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Saturday, 28 January 2023 00:14:35

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 9,709,190 229,211 42.36 0 hrs 34 mins
2 GeForce RTX 4080
AD103 [GeForce RTX 4080]
Nvidia AD103 9,460,439 231,472 40.87 0 hrs 35 mins
3 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]
Nvidia AD104 9,080,910 210,700 43.10 0 hrs 33 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,593,206 204,535 32.24 0 hrs 45 mins
5 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,367,501 200,350 31.78 0 hrs 45 mins
6 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,171,236 197,935 31.18 0 hrs 46 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,934,881 187,607 26.30 0 hrs 55 mins
8 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 4,420,178 178,919 24.70 0 hrs 58 mins
9 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,251,165 178,369 23.83 1 hrs 0 mins
10 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 4,027,126 171,488 23.48 1 hrs 1 mins
11 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,813,755 171,625 22.22 1 hrs 5 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,780,314 170,241 22.21 1 hrs 5 mins
13 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,679,898 168,247 21.87 1 hrs 6 mins
14 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 3,485,384 166,360 20.95 1 hrs 9 mins
15 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,396,660 162,595 20.89 1 hrs 9 mins
16 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,990,774 157,185 19.03 1 hrs 16 mins
17 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 2,767,518 149,788 18.48 1 hrs 18 mins
18 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,699,721 150,335 17.96 1 hrs 20 mins
19 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,591,044 150,349 17.23 1 hrs 24 mins
20 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,579,714 149,731 17.23 1 hrs 24 mins
21 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,405,752 146,912 16.38 1 hrs 28 mins
22 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,325,241 145,082 16.03 1 hrs 30 mins
23 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,211,463 138,344 15.99 2 hrs 30 mins
24 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,013,953 135,141 14.90 2 hrs 37 mins
25 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,925,645 133,202 14.46 2 hrs 40 mins
26 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,753,517 129,080 13.58 2 hrs 46 mins
27 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,567,523 123,299 12.71 2 hrs 53 mins
28 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,538,381 120,836 12.73 2 hrs 53 mins
29 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,507,521 127,593 11.82 2 hrs 2 mins
30 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,445,969 111,543 12.96 2 hrs 51 mins
31 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,423,360 122,783 11.59 2 hrs 4 mins
32 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,379,964 118,911 11.61 2 hrs 4 mins
33 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,267,854 108,515 11.68 2 hrs 3 mins
34 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,253,575 108,795 11.52 2 hrs 5 mins
35 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 1,237,342 118,277 10.46 2 hrs 18 mins
36 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,164,497 113,459 10.26 2 hrs 20 mins
37 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 1,020,130 108,903 9.37 3 hrs 34 mins
38 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 899,285 99,625 9.03 3 hrs 40 mins
39 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 892,751 100,602 8.87 3 hrs 42 mins
40 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 746,663 99,618 7.50 3 hrs 12 mins
41 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 527,697 80,267 6.57 4 hrs 39 mins
42 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 527,135 85,759 6.15 4 hrs 54 mins
43 RX 5500/5500M/Pro 5500M
Navi 14 [RX 5500/5500M/Pro 5500M]
Navi 14 440,422 70,341 6.26 4 hrs 50 mins
44 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 425,126 82,633 5.14 5 hrs 40 mins
45 P106-090
GP106 [P106-090]
Nvidia GP106 401,383 81,063 4.95 5 hrs 51 mins
46 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 281,971 72,515 3.89 6 hrs 10 mins
47 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 278,980 68,431 4.08 6 hrs 53 mins
48 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 247,138 66,756 3.70 6 hrs 29 mins
49 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 161,559 59,737 2.70 9 hrs 52 mins
50 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 159,165 57,910 2.75 9 hrs 44 mins
51 GeForce MX450
TU117M [GeForce MX450]
Nvidia TU117M 102,754 43,887 2.34 10 hrs 15 mins
52 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 90,240 48,597 1.86 13 hrs 55 mins
53 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 73,847 44,085 1.68 14 hrs 20 mins
54 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 54,744 38,496 1.42 17 hrs 53 mins
55 Radeon 540/540X/550/550X/RX 540X/550/550X
Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]
AMD Lexa PRO 42,707 31,724 1.35 18 hrs 50 mins
56 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 42,225 36,383 1.16 21 hrs 41 mins
57 Vega Mobile APU
Lucienne [Vega Mobile APU]
Lucienne 7,422 29,900 0.25 97 hrs 41 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Saturday, 28 January 2023 00:14:35

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make