PROJECT #18911 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Lasso peptides are a class of RiPPs that are found in bacteria and characterized by a specific knotted structure, called lasso fold.

They have a macrolactam ring formed between the N-terminus and a glutamate or aspartate at position 8 or 9.

The C-terminal tail is trapped within the macrocycle.

This knotted structure confers lasso peptide remarkable thermal and proteolytic stability.

Furthermore, the specific shape and volume enable these peptides to bind important receptors, which cannot be easily targeted by traditional antibodies and small molecule drugs.

Lasso peptides have been promosing drug candidates for treating human diseases such as cancer and autoimmune disorders.

Elucidating the folding process of lasso peptide and finding the key features regulating the formation of the lasso topology will allow us to enhance their stability and facilate its formation by lasso synthetases.

However, how lasso peptides fold into this lariat knot structure is still unclear.

In this study, we would like to run atomic-level MD simulation for each of 20 lasso peptides with known structures..

PROJECT INFO

Manager(s): Xuenan Mi

Institution: University of Illinois Urbana-Champaign

Project URL: shuklagroup.org

PROJECT WORK UNIT SUMMARY

Atoms: 34,712

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Saturday, 28 January 2023 00:14:35

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 10,719,950 235,556 45.51 0 hrs 32 mins
2 GeForce RTX 4080
AD103 [GeForce RTX 4080]
Nvidia AD103 10,712,690 240,835 44.48 0 hrs 32 mins
3 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,545,667 231,342 41.26 0 hrs 35 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,448,107 189,751 33.98 0 hrs 42 mins
5 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,970,257 199,162 29.98 0 hrs 48 mins
6 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,841,710 190,376 30.69 0 hrs 47 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,752,558 191,539 30.03 0 hrs 48 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,653,732 196,257 28.81 0 hrs 50 mins
9 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,259,739 185,573 28.34 0 hrs 51 mins
10 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 4,605,126 169,793 27.12 0 hrs 53 mins
11 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,601,215 182,232 25.25 0 hrs 57 mins
12 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,144,666 175,787 23.58 1 hrs 1 mins
13 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,945,435 170,627 23.12 1 hrs 2 mins
14 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,389,920 164,417 20.62 1 hrs 10 mins
15 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,386,529 158,461 21.37 1 hrs 7 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,344,688 161,632 20.69 1 hrs 10 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,246,929 162,979 19.92 1 hrs 12 mins
18 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,724,354 151,040 18.04 1 hrs 20 mins
19 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,665,927 151,667 17.58 1 hrs 22 mins
20 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,376,555 145,931 16.29 1 hrs 28 mins
21 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,272,533 142,687 15.93 2 hrs 30 mins
22 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,196,135 140,236 15.66 2 hrs 32 mins
23 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,081,345 138,709 15.01 2 hrs 36 mins
24 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,050,709 128,998 15.90 2 hrs 31 mins
25 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,673,405 129,897 12.88 2 hrs 52 mins
26 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,572,555 124,137 12.67 2 hrs 54 mins
27 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,464,597 124,799 11.74 2 hrs 3 mins
28 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,456,239 122,596 11.88 2 hrs 1 mins
29 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,438,087 112,340 12.80 2 hrs 52 mins
30 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 1,413,557 118,928 11.89 2 hrs 1 mins
31 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,207,362 115,897 10.42 2 hrs 18 mins
32 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 996,219 109,266 9.12 3 hrs 38 mins
33 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 983,439 108,702 9.05 3 hrs 39 mins
34 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 745,376 99,476 7.49 3 hrs 12 mins
35 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 641,565 94,156 6.81 4 hrs 31 mins
36 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 598,291 92,365 6.48 4 hrs 42 mins
37 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 544,539 86,145 6.32 4 hrs 48 mins
38 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 512,633 87,307 5.87 4 hrs 5 mins
39 P106-090
GP106 [P106-090]
Nvidia GP106 416,713 81,771 5.10 5 hrs 43 mins
40 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 297,182 73,049 4.07 6 hrs 54 mins
41 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 245,446 69,207 3.55 7 hrs 46 mins
42 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 221,539 63,958 3.46 7 hrs 56 mins
43 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 145,212 49,233 2.95 8 hrs 8 mins
44 Radeon RX 460/560D
Baffin [Radeon RX 460/560D]
AMD Baffin 124,331 54,838 2.27 11 hrs 35 mins
45 GeForce MX450
TU117M [GeForce MX450]
Nvidia TU117M 122,896 52,369 2.35 10 hrs 14 mins
46 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 116,789 60,700 1.92 12 hrs 28 mins
47 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 78,650 47,071 1.67 14 hrs 22 mins
48 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 74,716 46,292 1.61 15 hrs 52 mins
49 Radeon 540/540X/550/550X/RX 540X/550/550X
Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]
AMD Lexa PRO 54,269 39,580 1.37 18 hrs 30 mins
50 Radeon PRO WX3100
Lexa XT [Radeon PRO WX3100]
AMD Lexa XT 44,238 37,845 1.17 21 hrs 32 mins
51 RX Vega 10 Mobile
Picasso APU [RX Vega 10 Mobile]
Picasso APU 27,611 29,900 0.92 26 hrs 59 mins
52 GeForce 940MX
GM108M [GeForce 940MX]
Nvidia GM108M 16,515 29,900 0.55 43 hrs 27 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Saturday, 28 January 2023 00:14:35

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make