PROJECT #18501 RESEARCH FOR PARKINSONS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Project 18500 is running wild-type Transmembrane Protein 175 (TMEM175).

Transmembrane Protein 175 (TMEM175) is a protein in the lysosomal membrane that functions as a "channel" for potassium ions to move between the open space in the cell (the cytoplasm) and the space within the lysosome (the lysosomal lumen).

TMEM175 is thought to play an important role in autophagy as a lysosomal protein, but its exact function in this process is not yet clear.

Nevertheless, dysfunction of TMEM175 is implicated in the development of Parkinson’s.

We know this because several mutational variants of TMEM175 have been identified in Parkinson’s patients, and experiments have shown that mice with these variants have some of the molecular and behavioral hallmarks of Parkinson’s.

An understanding of the fundamental mechanisms of TMEM175 will lead to new ways to discover drugs or therapeutic interventions to treat, prevent, or potentially even reverse Parkinson’s Disease. Project 18501 is the same as 18500 except that a histidine in the pore is modelled as neutral instead of positively charged (i.e.

it has one less proton).

We are testing to see if we need this as a way to bridge the open and closed states of the channel.

PROJECT INFO

Manager(s): Viktor Belay

Institution: Memorial Sloan Kettering Cancer Center

Project URL: viktor.belay@choderalab.org

PROJECT WORK UNIT SUMMARY

Atoms: 151,920

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 04 December 2022 18:13:19

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 20,146,817 765,733 26.31 0 hrs 55 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,875,189 625,238 17.39 1 hrs 23 mins
3 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,410,713 570,523 14.74 2 hrs 38 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,845,128 551,008 14.24 2 hrs 41 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,866,795 527,629 13.01 2 hrs 51 mins
6 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,625,917 501,900 11.21 2 hrs 8 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,371,098 492,755 10.90 2 hrs 12 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,249,166 490,375 10.70 2 hrs 15 mins
9 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,954,040 478,294 10.36 2 hrs 19 mins
10 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,564,133 463,662 9.84 2 hrs 26 mins
11 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,456,059 463,052 9.62 2 hrs 30 mins
12 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,805,392 440,016 8.65 3 hrs 47 mins
13 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,635,396 433,743 8.38 3 hrs 52 mins
14 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,284,445 419,624 7.83 3 hrs 4 mins
15 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,247,951 418,411 7.76 3 hrs 6 mins
16 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,105,170 410,712 7.56 3 hrs 10 mins
17 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,376,564 378,070 6.29 4 hrs 49 mins
18 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,179,032 365,569 5.96 4 hrs 2 mins
19 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,962,987 352,594 5.57 4 hrs 19 mins
20 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,676,159 314,441 5.33 5 hrs 30 mins
21 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,472,218 320,365 4.60 5 hrs 13 mins
22 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,463,678 324,006 4.52 5 hrs 19 mins
23 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,447,279 318,730 4.54 5 hrs 17 mins
24 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,393,445 313,793 4.44 5 hrs 24 mins
25 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,281,731 305,218 4.20 6 hrs 43 mins
26 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,071,428 299,086 3.58 7 hrs 42 mins
27 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,016,992 286,766 3.55 7 hrs 46 mins
28 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 874,190 270,033 3.24 7 hrs 25 mins
29 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 870,333 270,392 3.22 7 hrs 27 mins
30 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 638,860 180,964 3.53 7 hrs 48 mins
31 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 555,986 231,947 2.40 10 hrs 1 mins
32 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 351,645 198,661 1.77 14 hrs 34 mins
33 P106-090
GP106 [P106-090]
Nvidia GP106 345,443 198,537 1.74 14 hrs 48 mins
34 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 319,685 222,536 1.44 17 hrs 42 mins
35 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 258,004 191,265 1.35 18 hrs 48 mins
36 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 227,791 172,358 1.32 18 hrs 10 mins
37 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 227,475 198,026 1.15 21 hrs 54 mins
38 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 108,891 134,834 0.81 30 hrs 43 mins
39 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 93,716 128,885 0.73 33 hrs 0 mins
40 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 93,314 137,672 0.68 35 hrs 25 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 04 December 2022 18:13:19

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make