PROJECT #18501 RESEARCH FOR PARKINSONS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Project 18500 is running wild-type Transmembrane Protein 175 (TMEM175).

Transmembrane Protein 175 (TMEM175) is a protein in the lysosomal membrane that functions as a "channel" for potassium ions to move between the open space in the cell (the cytoplasm) and the space within the lysosome (the lysosomal lumen).

TMEM175 is thought to play an important role in autophagy as a lysosomal protein, but its exact function in this process is not yet clear.

Nevertheless, dysfunction of TMEM175 is implicated in the development of Parkinson’s.

We know this because several mutational variants of TMEM175 have been identified in Parkinson’s patients, and experiments have shown that mice with these variants have some of the molecular and behavioral hallmarks of Parkinson’s.

An understanding of the fundamental mechanisms of TMEM175 will lead to new ways to discover drugs or therapeutic interventions to treat, prevent, or potentially even reverse Parkinson’s Disease. Project 18501 is the same as 18500 except that a histidine in the pore is modelled as neutral instead of positively charged (i.e.

it has one less proton).

We are testing to see if we need this as a way to bridge the open and closed states of the channel.

PROJECT INFO

Manager(s): Viktor Belay

Institution: Memorial Sloan Kettering Cancer Center

Project URL: viktor.belay@choderalab.org

PROJECT WORK UNIT SUMMARY

Atoms: 151,920

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 June 2022 11:45:17

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,413,252 570,884 14.74 2 hrs 38 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 8,329,379 562,839 14.80 2 hrs 37 mins
3 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 6,545,253 524,880 12.47 2 hrs 55 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,690,092 500,240 11.37 2 hrs 7 mins
5 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,164,657 485,421 10.64 2 hrs 15 mins
6 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,488,710 460,281 9.75 2 hrs 28 mins
7 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,396,629 461,204 9.53 3 hrs 31 mins
8 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 4,110,151 452,372 9.09 3 hrs 38 mins
9 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,407,255 378,458 6.36 4 hrs 46 mins
10 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 351,645 198,661 1.77 14 hrs 34 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 June 2022 11:45:17

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make