PROJECT #18500 RESEARCH FOR PARKINSONS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Project 18500 is running wild-type Transmembrane Protein 175 (TMEM175).

Transmembrane Protein 175 (TMEM175) is a protein in the lysosomal membrane that functions as a "channel" for potassium ions to move between the open space in the cell (the cytoplasm) and the space within the lysosome (the lysosomal lumen).

TMEM175 is thought to play an important role in autophagy as a lysosomal protein, but its exact function in this process is not yet clear.

Nevertheless, dysfunction of TMEM175 is implicated in the development of Parkinson’s.

We know this because several mutational variants of TMEM175 have been identified in Parkinson’s patients, and experiments have shown that mice with these variants have some of the molecular and behavioral hallmarks of Parkinson’s.

An understanding of the fundamental mechanisms of TMEM175 will lead to new ways to discover drugs or therapeutic interventions to treat, prevent, or potentially even reverse Parkinson’s Disease..

PROJECT INFO

Manager(s): Viktor Belay

Institution: Memorial Sloan Kettering Cancer Center

Project URL: viktor.belay@choderalab.org

PROJECT WORK UNIT SUMMARY

Atoms: 151,920

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 June 2022 11:45:17

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,990,835 606,533 16.47 1 hrs 27 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 9,084,115 583,628 15.56 2 hrs 33 mins
3 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 8,233,191 567,745 14.50 2 hrs 39 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,895,687 556,069 14.20 2 hrs 41 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,700,229 520,685 12.87 2 hrs 52 mins
6 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,399,124 493,067 10.95 2 hrs 12 mins
7 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,756,371 468,972 10.14 2 hrs 22 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,715,654 468,707 10.06 2 hrs 23 mins
9 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,275,927 451,039 9.48 3 hrs 32 mins
10 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,946,777 371,162 10.63 2 hrs 15 mins
11 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,893,984 442,418 8.80 3 hrs 44 mins
12 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,514,758 429,618 8.18 3 hrs 56 mins
13 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,488,929 428,084 8.15 3 hrs 57 mins
14 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,456,045 424,804 8.14 3 hrs 57 mins
15 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,613,134 394,658 6.62 4 hrs 37 mins
16 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,472,520 380,878 6.49 4 hrs 42 mins
17 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,356,053 376,991 6.25 4 hrs 50 mins
18 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,287,946 367,263 6.23 4 hrs 51 mins
19 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 2,072,027 359,411 5.77 4 hrs 10 mins
20 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,967,765 366,430 5.37 4 hrs 28 mins
21 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,739,808 329,111 5.29 5 hrs 32 mins
22 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,578,178 330,971 4.77 5 hrs 2 mins
23 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,509,202 331,221 4.56 5 hrs 16 mins
24 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,446,275 319,392 4.53 5 hrs 18 mins
25 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,385,645 325,839 4.25 6 hrs 39 mins
26 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,307,843 308,472 4.24 6 hrs 40 mins
27 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,272,299 311,693 4.08 6 hrs 53 mins
28 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,212,645 305,345 3.97 6 hrs 3 mins
29 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,126,831 293,070 3.84 6 hrs 15 mins
30 P104-100
GP104 [P104-100]
Nvidia GP104 1,076,818 290,046 3.71 6 hrs 28 mins
31 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 820,154 265,546 3.09 8 hrs 46 mins
32 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 599,866 238,272 2.52 10 hrs 32 mins
33 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 536,274 257,254 2.08 12 hrs 31 mins
34 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 472,959 222,651 2.12 11 hrs 18 mins
35 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 347,483 166,768 2.08 12 hrs 31 mins
36 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 259,538 137,227 1.89 13 hrs 41 mins
37 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 258,612 179,847 1.44 17 hrs 41 mins
38 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 236,964 169,054 1.40 17 hrs 7 mins
39 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 142,755 147,616 0.97 25 hrs 49 mins
40 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 75,150 138,448 0.54 44 hrs 13 mins
41 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 39,845 105,852 0.38 64 hrs 45 mins
42 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 7,126 77,795 0.09 262 hrs 1 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 June 2022 11:45:17

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make