PROJECT #18500 RESEARCH FOR PARKINSONS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Project 18500 is running wild-type Transmembrane Protein 175 (TMEM175).

Transmembrane Protein 175 (TMEM175) is a protein in the lysosomal membrane that functions as a "channel" for potassium ions to move between the open space in the cell (the cytoplasm) and the space within the lysosome (the lysosomal lumen).

TMEM175 is thought to play an important role in autophagy as a lysosomal protein, but its exact function in this process is not yet clear.

Nevertheless, dysfunction of TMEM175 is implicated in the development of Parkinson’s.

We know this because several mutational variants of TMEM175 have been identified in Parkinson’s patients, and experiments have shown that mice with these variants have some of the molecular and behavioral hallmarks of Parkinson’s.

An understanding of the fundamental mechanisms of TMEM175 will lead to new ways to discover drugs or therapeutic interventions to treat, prevent, or potentially even reverse Parkinson’s Disease..

PROJECT INFO

Manager(s): Viktor Belay

Institution: Memorial Sloan Kettering Cancer Center

Project URL: viktor.belay@choderalab.org

PROJECT WORK UNIT SUMMARY

Atoms: 151,920

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 04 December 2022 18:13:19

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 20,405,501 757,310 26.94 0 hrs 53 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,427,051 614,590 16.97 1 hrs 25 mins
3 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,366,288 561,942 14.89 2 hrs 37 mins
4 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 8,212,556 567,885 14.46 2 hrs 40 mins
5 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 8,191,928 564,028 14.52 2 hrs 39 mins
6 RTX A6000
GA102GL [RTX A6000]
Nvidia GA102GL 8,001,891 562,337 14.23 2 hrs 41 mins
7 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,216,919 539,944 13.37 2 hrs 48 mins
8 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,542,018 519,632 12.59 2 hrs 54 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,392,811 491,439 10.97 2 hrs 11 mins
10 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,215,731 480,243 10.86 2 hrs 13 mins
11 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,154,298 485,156 10.62 2 hrs 16 mins
12 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,627,047 462,243 10.01 2 hrs 24 mins
13 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,518,760 460,917 9.80 2 hrs 27 mins
14 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 4,296,947 457,603 9.39 3 hrs 33 mins
15 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,659,247 433,911 8.43 3 hrs 51 mins
16 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,514,758 429,618 8.18 3 hrs 56 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,461,538 425,139 8.14 3 hrs 57 mins
18 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,418,522 424,599 8.05 3 hrs 59 mins
19 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 3,300,114 418,577 7.88 3 hrs 3 mins
20 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 3,170,516 415,776 7.63 3 hrs 9 mins
21 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,071,935 407,320 7.54 3 hrs 11 mins
22 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,025,554 410,459 7.37 3 hrs 15 mins
23 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,712,772 393,741 6.89 3 hrs 29 mins
24 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,456,822 382,301 6.43 4 hrs 44 mins
25 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,433,698 369,783 6.58 4 hrs 39 mins
26 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,403,675 377,838 6.36 4 hrs 46 mins
27 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,336,282 362,950 6.44 4 hrs 44 mins
28 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,325,490 365,192 6.37 4 hrs 46 mins
29 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,235,770 366,237 6.10 4 hrs 56 mins
30 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,085,930 349,458 5.97 4 hrs 1 mins
31 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,009,527 344,346 5.84 4 hrs 7 mins
32 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,952,782 349,955 5.58 4 hrs 18 mins
33 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,950,209 346,632 5.63 4 hrs 16 mins
34 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,513,840 324,126 4.67 5 hrs 8 mins
35 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,449,132 326,865 4.43 5 hrs 25 mins
36 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,443,864 320,951 4.50 5 hrs 20 mins
37 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,385,428 317,576 4.36 6 hrs 30 mins
38 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,360,700 305,387 4.46 5 hrs 23 mins
39 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 1,360,497 322,952 4.21 6 hrs 42 mins
40 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,316,418 308,952 4.26 6 hrs 38 mins
41 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,295,474 314,560 4.12 6 hrs 50 mins
42 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,268,228 306,888 4.13 6 hrs 48 mins
43 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,160,298 320,244 3.62 7 hrs 37 mins
44 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,139,595 298,189 3.82 6 hrs 17 mins
45 Quadro P4000
GP104GL [Quadro P4000]
Nvidia GP104GL 1,074,439 284,912 3.77 6 hrs 22 mins
46 P104-100
GP104 [P104-100]
Nvidia GP104 1,060,140 290,028 3.66 7 hrs 34 mins
47 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 992,592 286,178 3.47 7 hrs 55 mins
48 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 855,286 268,318 3.19 8 hrs 32 mins
49 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 847,354 265,360 3.19 8 hrs 31 mins
50 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 794,676 266,961 2.98 8 hrs 4 mins
51 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 755,621 262,341 2.88 8 hrs 20 mins
52 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 710,396 252,639 2.81 9 hrs 32 mins
53 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 616,585 198,045 3.11 8 hrs 43 mins
54 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 588,694 250,516 2.35 10 hrs 13 mins
55 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 566,123 199,679 2.84 8 hrs 28 mins
56 P106-100
GP106 [P106-100]
Nvidia GP106 534,713 257,731 2.07 12 hrs 34 mins
57 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 529,316 216,203 2.45 10 hrs 48 mins
58 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 521,931 226,478 2.30 10 hrs 25 mins
59 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 374,621 216,231 1.73 14 hrs 51 mins
60 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 363,940 195,903 1.86 13 hrs 55 mins
61 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 347,215 194,381 1.79 13 hrs 26 mins
62 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 345,481 207,039 1.67 14 hrs 23 mins
63 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 339,361 204,879 1.66 14 hrs 29 mins
64 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 326,937 194,632 1.68 14 hrs 17 mins
65 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 319,687 191,470 1.67 14 hrs 22 mins
66 P106-090
GP106 [P106-090]
Nvidia GP106 312,004 197,100 1.58 15 hrs 10 mins
67 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 279,384 193,878 1.44 17 hrs 39 mins
68 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 276,190 205,195 1.35 18 hrs 50 mins
69 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 259,538 137,227 1.89 13 hrs 41 mins
70 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 257,082 189,561 1.36 18 hrs 42 mins
71 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 257,061 179,145 1.43 17 hrs 44 mins
72 Radeon Pro WX 7100 Graphics
[Radeon Pro WX 7100 Graphics] 4150
AMD 227,867 190,778 1.19 20 hrs 6 mins
73 RX 5600 OEM/5600XT/5700/5700XT
Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]
Navi 10 210,331 167,687 1.25 19 hrs 8 mins
74 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 158,777 151,518 1.05 23 hrs 54 mins
75 GeForce MX450
TU117M [GeForce MX450]
Nvidia TU117M 157,096 152,283 1.03 23 hrs 16 mins
76 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 153,657 151,471 1.01 24 hrs 40 mins
77 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 142,755 147,616 0.97 25 hrs 49 mins
78 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 115,959 158,415 0.73 33 hrs 47 mins
79 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 111,193 134,738 0.83 29 hrs 5 mins
80 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 77,024 132,449 0.58 41 hrs 16 mins
81 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 76,222 119,059 0.64 37 hrs 29 mins
82 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 35,246 105,514 0.33 72 hrs 51 mins
83 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 24,194 88,769 0.27 88 hrs 3 mins
84 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 7,126 77,795 0.09 262 hrs 1 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 04 December 2022 18:13:19

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make