Folding project #18500, PARKINSONS research

Research section Research projects and references

Project #18500 overview

Project Summary AI Beta

Project 18500 studies TMEM175, a protein that controls potassium flow in cells. It's found in lysosomes, which break down waste. While its exact role isn't clear, messed up TMEM175 is linked to Parkinson's disease. Researchers hope understanding TMEM175 can lead to new treatments for Parkinson's.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Viktor Belay
Institution: Memorial Sloan Kettering Cancer Center
Website: Open project site

Work unit

Atoms: 151,920
Core: 0x22
Status: Public

No related projects listed.

Source material

Official Project Description

Project 18500 is running wild-type Transmembrane Protein 175 (TMEM175).

Transmembrane Protein 175 (TMEM175) is a protein in the lysosomal membrane that functions as a "channel" for potassium ions to move between the open space in the cell (the cytoplasm) and the space within the lysosome (the lysosomal lumen).

TMEM175 is thought to play an important role in autophagy as a lysosomal protein, but its exact function in this process is not yet clear.

Nevertheless, dysfunction of TMEM175 is implicated in the development of Parkinson’s.

We know this because several mutational variants of TMEM175 have been identified in Parkinson’s patients, and experiments have shown that mice with these variants have some of the molecular and behavioral hallmarks of Parkinson’s.

An understanding of the fundamental mechanisms of TMEM175 will lead to new ways to discover drugs or therapeutic interventions to treat, prevent, or potentially even reverse Parkinson’s Disease.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Transmembrane Protein 175

A protein located in cell membranes that transports potassium ions.

Scientific: Pharmaceutical ResearchBiotechnology / Molecular Biology

Transmembrane Protein 175 (TMEM175) is a protein found within the membranes of cells. Its primary role is to act as a channel, allowing potassium ions to move between the cell's interior and the lysosome, an organelle responsible for breaking down waste materials. This protein is believed to be important for autophagy, the process by which cells recycle their components. Research suggests that malfunctions in TMEM175 can contribute to the development of Parkinson's disease.

Lysosomal Membrane

The membrane that encloses the lysosome, an organelle involved in waste degradation.

Scientific: Pharmaceutical ResearchBiotechnology / Cellular Biology

The lysosomal membrane is a barrier that surrounds the lysosome, a cellular compartment responsible for breaking down waste products and cellular debris. This membrane plays a crucial role in regulating the transport of molecules into and out of the lysosome, ensuring proper functioning of this essential organelle.

Potassium Ions

Positively charged atoms of the element potassium.

Scientific: Pharmaceutical ResearchBiotechnology / Physiology

Potassium ions (K+) are electrically charged particles of the element potassium. They play a vital role in various bodily functions, including nerve impulse transmission, muscle contractions, and maintaining fluid balance within cells.

Autophagy

The process of cellular self-eating, where damaged organelles or proteins are broken down and recycled.

Scientific: Pharmaceutical ResearchBiotechnology / Cellular Biology

Autophagy is a natural process within cells where they break down and recycle their own components. Think of it as cellular housekeeping. Damaged organelles or proteins are engulfed by a membrane and transported to a compartment called the lysosome, where they are degraded and reused. This process is essential for maintaining cellular health and removing harmful waste products.

Parkinson's Disease

A neurodegenerative disorder characterized by tremors, rigidity, and slow movements.

Medical: Pharmaceutical ResearchBiotechnology / Neuroscience

Parkinson's disease is a progressive brain disorder that affects movement. It occurs when nerve cells in the part of the brain responsible for controlling movement are damaged and die. This damage leads to characteristic symptoms such as tremors (shaking), stiffness, slow movements, and difficulty with balance. There is no cure for Parkinson's, but treatments can help manage the symptoms.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	20,290,671	757,520	26.79	0 ^hrs 54 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	15,159,759	697,547	21.73	1 ^hrs 6 ^mins
3	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	10,530,701	617,042	17.07	1 ^hrs 24 ^mins
4	A40 GA102GL [A40]	Nvidia	GA102GL	8,518,880	575,202	14.81	1 ^hrs 37 ^mins
5	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,478,034	566,924	14.95	1 ^hrs 36 ^mins
6	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,236,259	563,336	14.62	1 ^hrs 38 ^mins
7	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	8,175,500	567,589	14.40	1 ^hrs 40 ^mins
8	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	8,001,891	562,337	14.23	1 ^hrs 41 ^mins
9	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	7,299,611	543,349	13.43	1 ^hrs 47 ^mins
10	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,836,591	528,569	12.93	1 ^hrs 51 ^mins
11	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,434,529	492,754	11.03	2 ^hrs 11 ^mins
12	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,266,650	482,948	10.91	2 ^hrs 12 ^mins
13	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,134,173	484,816	10.59	2 ^hrs 16 ^mins
14	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,574,261	462,064	9.90	2 ^hrs 25 ^mins
15	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,453,667	460,792	9.67	2 ^hrs 29 ^mins
16	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	4,034,736	447,654	9.01	2 ^hrs 40 ^mins
17	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	3,564,841	429,141	8.31	2 ^hrs 53 ^mins
18	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	3,514,758	429,618	8.18	2 ^hrs 56 ^mins
19	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,396,733	422,253	8.04	2 ^hrs 59 ^mins

20	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,347,102	420,841	7.95	3 ^hrs 1 ^mins
21	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	3,300,114	418,577	7.88	3 ^hrs 3 ^mins
22	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,089,125	412,657	7.49	3 ^hrs 12 ^mins
23	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	3,054,794	409,377	7.46	3 ^hrs 13 ^mins
24	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,722,745	384,733	7.08	3 ^hrs 23 ^mins
25	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,712,772	393,741	6.89	3 ^hrs 29 ^mins
26	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,467,459	381,805	6.46	3 ^hrs 43 ^mins
27	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,450,876	380,488	6.44	3 ^hrs 44 ^mins
28	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,433,698	369,783	6.58	3 ^hrs 39 ^mins
29	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,386,762	367,164	6.50	3 ^hrs 42 ^mins
30	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,325,490	365,192	6.37	3 ^hrs 46 ^mins
31	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,235,770	366,237	6.10	3 ^hrs 56 ^mins
32	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,132,948	353,949	6.03	3 ^hrs 59 ^mins
33	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,061,004	344,963	5.97	4 ^hrs 1 ^mins
34	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,952,782	349,955	5.58	4 ^hrs 18 ^mins
35	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,950,209	346,632	5.63	4 ^hrs 16 ^mins
36	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,540,041	326,025	4.72	5 ^hrs 5 ^mins
37	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,408,447	323,284	4.36	5 ^hrs 31 ^mins
38	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,402,340	318,538	4.40	5 ^hrs 27 ^mins
39	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,382,782	318,140	4.35	5 ^hrs 31 ^mins

40	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,360,700	305,387	4.46	5 ^hrs 23 ^mins
41	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	1,335,090	323,119	4.13	5 ^hrs 49 ^mins
42	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q]	Nvidia	TU106M	1,316,418	308,952	4.26	5 ^hrs 38 ^mins
43	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,278,684	308,531	4.14	5 ^hrs 47 ^mins
44	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,273,529	312,099	4.08	5 ^hrs 53 ^mins
45	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,160,298	320,244	3.62	6 ^hrs 37 ^mins
46	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,154,761	299,091	3.86	6 ^hrs 13 ^mins
47	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	1,138,613	294,755	3.86	6 ^hrs 13 ^mins
48	Quadro P4000 GP104GL [Quadro P4000]	Nvidia	GP104GL	1,074,439	284,912	3.77	6 ^hrs 22 ^mins
49	P104-100 GP104 [P104-100]	Nvidia	GP104	1,060,140	290,028	3.66	6 ^hrs 34 ^mins
50	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	983,902	286,073	3.44	6 ^hrs 59 ^mins
51	Radeon RX 6600/6600 XT/6600M Navi 23 [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23	855,286	268,318	3.19	7 ^hrs 32 ^mins
52	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	847,354	265,360	3.19	7 ^hrs 31 ^mins
53	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	794,676	266,961	2.98	8 ^hrs 4 ^mins
54	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	769,628	262,842	2.93	8 ^hrs 12 ^mins
55	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	722,610	253,996	2.84	8 ^hrs 26 ^mins
56	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	687,299	215,634	3.19	7 ^hrs 32 ^mins
57	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	588,694	250,516	2.35	10 ^hrs 13 ^mins
58	P106-100 GP106 [P106-100]	Nvidia	GP106	534,713	257,731	2.07	11 ^hrs 34 ^mins
59	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	529,316	216,203	2.45	9 ^hrs 48 ^mins

60	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	524,768	226,784	2.31	10 ^hrs 22 ^mins
61	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	484,378	176,685	2.74	8 ^hrs 45 ^mins
62	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	374,621	216,231	1.73	13 ^hrs 51 ^mins
63	GeForce GTX 980M GM204 [GeForce GTX 980M] 3189	Nvidia	GM204	363,940	195,903	1.86	12 ^hrs 55 ^mins
64	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	347,215	194,381	1.79	13 ^hrs 26 ^mins
65	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	345,036	206,725	1.67	14 ^hrs 23 ^mins
66	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	339,361	204,879	1.66	14 ^hrs 29 ^mins
67	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	326,937	194,632	1.68	14 ^hrs 17 ^mins
68	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	319,687	191,470	1.67	14 ^hrs 22 ^mins
69	P106-090 GP106 [P106-090]	Nvidia	GP106	316,975	197,088	1.61	14 ^hrs 55 ^mins
70	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	293,218	193,976	1.51	15 ^hrs 53 ^mins
71	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	259,538	137,227	1.89	12 ^hrs 41 ^mins
72	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	257,105	179,213	1.43	16 ^hrs 44 ^mins
73	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	240,270	185,078	1.30	18 ^hrs 29 ^mins
74	Radeon Pro WX 7100 Graphics [Radeon Pro WX 7100 Graphics] 4150	AMD		227,867	190,778	1.19	20 ^hrs 6 ^mins
75	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	217,110	190,407	1.14	21 ^hrs 3 ^mins
76	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	212,427	165,226	1.29	18 ^hrs 40 ^mins
77	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	158,777	151,518	1.05	22 ^hrs 54 ^mins
78	GeForce MX450 TU117M [GeForce MX450]	Nvidia	TU117M	157,096	152,283	1.03	23 ^hrs 16 ^mins
79	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	153,657	151,471	1.01	23 ^hrs 40 ^mins

80	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	142,755	147,616	0.97	24 ^hrs 49 ^mins
81	Quadro M2000 GM206GL [Quadro M2000]	Nvidia	GM206GL	115,959	158,415	0.73	32 ^hrs 47 ^mins
82	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	111,193	134,738	0.83	29 ^hrs 5 ^mins
83	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	77,024	132,449	0.58	41 ^hrs 16 ^mins
84	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	76,222	119,059	0.64	37 ^hrs 29 ^mins
85	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	55,749	107,997	0.52	46 ^hrs 30 ^mins
86	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	35,246	105,514	0.33	71 ^hrs 51 ^mins
87	Radeon R9 200 Series Hawaii [Radeon R9 200 Series]	AMD	Hawaii	24,194	88,769	0.27	88 ^hrs 3 ^mins
88	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	7,126	77,795	0.09	262 ^hrs 1 ^mins

Research: PARKINSONS Folding Project #18500

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 18500

GPU PPD Averages

Research: PARKINSONS Folding Project #18500

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages