PROJECT #18500 RESEARCH FOR PARKINSONS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Project 18500 is running wild-type Transmembrane Protein 175 (TMEM175).

Transmembrane Protein 175 (TMEM175) is a protein in the lysosomal membrane that functions as a "channel" for potassium ions to move between the open space in the cell (the cytoplasm) and the space within the lysosome (the lysosomal lumen).

TMEM175 is thought to play an important role in autophagy as a lysosomal protein, but its exact function in this process is not yet clear.

Nevertheless, dysfunction of TMEM175 is implicated in the development of Parkinson’s.

We know this because several mutational variants of TMEM175 have been identified in Parkinson’s patients, and experiments have shown that mice with these variants have some of the molecular and behavioral hallmarks of Parkinson’s.

An understanding of the fundamental mechanisms of TMEM175 will lead to new ways to discover drugs or therapeutic interventions to treat, prevent, or potentially even reverse Parkinson’s Disease..

PROJECT INFO

Manager(s): Viktor Belay

Institution: Memorial Sloan Kettering Cancer Center

Project URL: viktor.belay@choderalab.org

PROJECT WORK UNIT SUMMARY

Atoms: 151,920

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 June 2022 11:45:17

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	9,990,835	606,533	16.47	1 ^hrs 27 ^mins
2	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,084,115	583,628	15.56	2 ^hrs 33 ^mins
3	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	8,233,191	567,745	14.50	2 ^hrs 39 ^mins
4	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	7,895,687	556,069	14.20	2 ^hrs 41 ^mins
5	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,700,229	520,685	12.87	2 ^hrs 52 ^mins
6	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,399,124	493,067	10.95	2 ^hrs 12 ^mins
7	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,756,371	468,972	10.14	2 ^hrs 22 ^mins
8	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,715,654	468,707	10.06	2 ^hrs 23 ^mins
9	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,275,927	451,039	9.48	3 ^hrs 32 ^mins
10	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,946,777	371,162	10.63	2 ^hrs 15 ^mins
11	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,893,984	442,418	8.80	3 ^hrs 44 ^mins
12	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	3,514,758	429,618	8.18	3 ^hrs 56 ^mins
13	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,488,929	428,084	8.15	3 ^hrs 57 ^mins
14	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,456,045	424,804	8.14	3 ^hrs 57 ^mins
15	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,613,134	394,658	6.62	4 ^hrs 37 ^mins
16	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,472,520	380,878	6.49	4 ^hrs 42 ^mins
17	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,356,053	376,991	6.25	4 ^hrs 50 ^mins
18	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,287,946	367,263	6.23	4 ^hrs 51 ^mins
19	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,072,027	359,411	5.77	4 ^hrs 10 ^mins
20	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,967,765	366,430	5.37	4 ^hrs 28 ^mins
21	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	1,739,808	329,111	5.29	5 ^hrs 32 ^mins
22	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,578,178	330,971	4.77	5 ^hrs 2 ^mins
23	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,509,202	331,221	4.56	5 ^hrs 16 ^mins
24	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,446,275	319,392	4.53	5 ^hrs 18 ^mins
25	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,385,645	325,839	4.25	6 ^hrs 39 ^mins
26	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q]	Nvidia	TU106M	1,307,843	308,472	4.24	6 ^hrs 40 ^mins
27	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,272,299	311,693	4.08	6 ^hrs 53 ^mins
28	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,212,645	305,345	3.97	6 ^hrs 3 ^mins
29	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	1,126,831	293,070	3.84	6 ^hrs 15 ^mins
30	P104-100 GP104 [P104-100]	Nvidia	GP104	1,076,818	290,046	3.71	6 ^hrs 28 ^mins
31	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	820,154	265,546	3.09	8 ^hrs 46 ^mins
32	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	599,866	238,272	2.52	10 ^hrs 32 ^mins
33	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	536,274	257,254	2.08	12 ^hrs 31 ^mins
34	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	472,959	222,651	2.12	11 ^hrs 18 ^mins
35	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	347,483	166,768	2.08	12 ^hrs 31 ^mins
36	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	259,538	137,227	1.89	13 ^hrs 41 ^mins
37	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	258,612	179,847	1.44	17 ^hrs 41 ^mins
38	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	236,964	169,054	1.40	17 ^hrs 7 ^mins
39	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	142,755	147,616	0.97	25 ^hrs 49 ^mins
40	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	75,150	138,448	0.54	44 ^hrs 13 ^mins
41	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	39,845	105,852	0.38	64 ^hrs 45 ^mins
42	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	7,126	77,795	0.09	262 ^hrs 1 ^mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 June 2022 11:45:17

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make

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