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Research: LOGP Folding Project #18465

Project #18465 overview

Project Summary AI Beta

Scientists are using computer simulations to predict how well drugs dissolve in water and fat. This is important because the way a drug dissolves affects how well it works in the body. The project relates to predicting how likely a drug molecule is to be found in water versus oil, which helps determine its ability to move through different parts of the body.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Vincent Voelz
Institution
Temple University

Work unit

Atoms
21,086
Core
0xa8
Status
Public
Source material

Official Project Description

A key challenge in computational drug discovery is developing and testing methods to predict experimental partition coefficients for the relative solubility of organic molecules in aquoeus vs/ non-polar media.

The logarithm of the partition coeffient, logP, is an important predictor of lipophilicity, which dictates the bioavailability of drugs.

These CPU projects are expanded-ensemble (EE) simulations designed to predict water/toluene partition coefficients of small-molecule drugs as part of the recent SAMPL9 logP challenge.

Performance data

Hardware Performance for Project 18465

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:51:13

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 7900X 12-CORE 24 39,561 949,464 AMD
2 13TH GEN CORE I9-13900KS 32 29,084 930,688 Intel
3 RYZEN 9 7900 12-CORE 24 26,831 643,944 AMD
4 RYZEN 7 7700X 8-CORE 16 38,466 615,456 AMD
5 RYZEN 9 5950X 16-CORE 32 14,216 454,912 AMD
6 RYZEN 7 5700X 8-CORE 16 26,392 422,272 AMD
7 CORE I9-10900K CPU @ 3.70GHZ 20 19,873 397,460 Intel
8 11TH GEN CORE I7-11700K @ 3.60GHZ 16 23,959 383,344 Intel
9 RYZEN 7 5700G 16 23,439 375,024 AMD
10 RYZEN 7 5800X3D 8-CORE 16 23,366 373,856 AMD
11 RYZEN 9 5900X 12-CORE 24 13,952 334,848 AMD
12 RYZEN 7 5800X 8-CORE 16 19,583 313,328 AMD
13 RYZEN 7 3800X 8-CORE 16 19,562 312,992 AMD
14 12TH GEN CORE I5-12600K 16 18,959 303,344 Intel
15 CORE I7-10700K CPU @ 3.80GHZ 16 18,302 292,832 Intel
16 RYZEN 9 3900X 12-CORE 24 11,571 277,704 AMD
17 RYZEN THREADRIPPER 2950X 16-CORE 32 8,631 276,192 AMD
18 GENUINE 0000 @ 1.80GHZ 16 17,238 275,808 Intel
19 12TH GEN CORE I7-12700 20 12,909 258,180 Intel
20 RYZEN 5 5600X 6-CORE 12 19,850 238,200 AMD
21 RYZEN 7 3700X 8-CORE 16 14,533 232,528 AMD
22 CORE I7-9700K CPU @ 3.60GHZ 8 27,288 218,304 Intel
23 11TH GEN CORE I9-11900K @ 3.50GHZ 16 13,642 218,272 Intel
24 CORE I9-9900K CPU @ 3.60GHZ 16 11,828 189,248 Intel
25 RYZEN 7 PRO 4750G 16 11,601 185,616 AMD
26 RYZEN 5 3600 6-CORE 12 15,256 183,072 AMD
27 CORE I7-6950X CPU @ 3.00GHZ 20 9,097 181,940 Intel
28 CORE I9-7940X CPU @ 3.10GHZ 28 6,410 179,480 Intel
29 RYZEN 5 3500 6-CORE 6 29,076 174,456 AMD
30 CORE I7-5930K CPU @ 3.50GHZ 12 10,680 128,160 Intel
31 RYZEN 5 1600 SIX-CORE 12 10,398 124,776 AMD
32 CORE I7-7700K CPU @ 4.20GHZ 8 15,361 122,888 Intel
33 12TH GEN CORE I9-12900H 20 6,107 122,140 Intel
34 CORE I7-5820K CPU @ 3.30GHZ 12 9,433 113,196 Intel
35 RYZEN 7 1700 EIGHT-CORE 16 6,563 105,008 AMD
36 12TH GEN CORE I7-12700H 20 5,125 102,500 Intel
37 CORE I7-10700T CPU @ 2.00GHZ 16 6,360 101,760 Intel
38 11TH GEN CORE I7-11800H @ 2.30GHZ 16 5,746 91,936 Intel
39 CORE I9-8950HK CPU @ 2.90GHZ 12 7,622 91,464 Intel
40 CORE I7-8705G CPU @ 3.10GHZ 8 10,900 87,200 Intel
41 CORE I7-6700T CPU @ 2.80GHZ 8 10,389 83,112 Intel
42 CORE I3-10100F CPU @ 3.60GHZ 8 10,137 81,096 Intel
43 CORE I7-8700 CPU @ 3.20GHZ 12 6,117 73,404 Intel
44 APPLE M1 8 8,373 66,984 Apple
45 CORE I7-6700K CPU @ 4.00GHZ 8 8,206 65,648 Intel
46 CORE I7-4770HQ CPU @ 2.20GHZ 8 8,136 65,088 Intel
47 CORE I7-4770 CPU @ 3.40GHZ 8 7,837 62,696 Intel
48 CORE I7-3770K CPU @ 3.50GHZ 8 7,510 60,080 Intel
49 RYZEN 5 2400G 8 7,187 57,496 AMD
50 CORE I5-4590 CPU @ 3.30GHZ 4 11,135 44,540 Intel
51 RYZEN 5 5500U 12 3,684 44,208 AMD
52 APPLE M1 PRO 10 4,103 41,030 Apple
53 11TH GEN CORE I7-11375H @ 3.30GHZ 8 3,884 31,072 Intel
54 XEON CPU E5-2697 V2 @ 2.70GHZ 24 1,270 30,480 Intel
55 CORE I5-10210U CPU @ 1.60GHZ 7 3,283 22,981 Intel
56 CORE I7-7700HQ CPU @ 2.80GHZ 8 2,503 20,024 Intel
57 CORE I3-3220 CPU @ 3.30GHZ 4 4,759 19,036 Intel
58 CORE I5-3210M CPU @ 2.50GHZ 4 4,353 17,412 Intel
59 CORE I3-3110M CPU @ 2.40GHZ 4 3,103 12,412 Intel
60 CORE I3-6006U CPU @ 2.00GHZ 4 3,077 12,308 Intel
61 FX-4300 QUAD-CORE 4 739 2,956 AMD