PROJECT #18101 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Here we are testing what has long been the dream on F@h --- adaptive sampling algorithms guided by experimental data. The system used is caspase-7, one of a family of important mediators of apoptosis, and hence of interest for cancer drug design. We have collected experimental hydrogen-deuterium exchange (HDX) data (which informs on the extent of fluctuations of each region of the protein) in both apo (just protein) and holo (protein with another peptide bound) states, and are exploring adaptive sampling algorithms to reproduce the HDX data in each state separately, as well as the differences ('shielding') between them. All data is being made publicly available, and insight into the algorithmic methodology will be published.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ 

 

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 86,257

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 26 October 2021 06:56:06

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,576,460 246,593 22.61 1 hrs 4 mins
2 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,117,875 239,850 21.34 1 hrs 7 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,055,450 235,033 21.51 1 hrs 7 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,188,122 226,114 18.52 1 hrs 18 mins
5 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,739,888 216,887 17.24 1 hrs 24 mins
6 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 3,316,080 208,367 15.91 2 hrs 30 mins
7 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,662,577 194,575 13.68 2 hrs 45 mins
8 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,502,382 190,130 13.16 2 hrs 49 mins
9 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,244,794 183,681 12.22 2 hrs 58 mins
10 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,213,008 182,840 12.10 2 hrs 59 mins
11 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,043,657 178,322 11.46 2 hrs 6 mins
12 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,027,567 177,608 11.42 2 hrs 6 mins
13 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,005,637 177,033 11.33 2 hrs 7 mins
14 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 1,984,592 173,298 11.45 2 hrs 6 mins
15 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 1,860,163 172,283 10.80 2 hrs 13 mins
16 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,820,097 171,480 10.61 2 hrs 16 mins
17 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,735,093 168,689 10.29 2 hrs 20 mins
18 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 1,700,629 166,488 10.21 2 hrs 21 mins
19 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,638,722 164,616 9.95 2 hrs 25 mins
20 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,576,508 164,209 9.60 2 hrs 30 mins
21 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 1,534,511 162,680 9.43 3 hrs 33 mins
22 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 1,356,615 133,944 10.13 2 hrs 22 mins
23 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,299,667 153,004 8.49 3 hrs 50 mins
24 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,128,179 146,341 7.71 3 hrs 7 mins
25 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,105,946 145,152 7.62 3 hrs 9 mins
26 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,039,020 141,616 7.34 3 hrs 16 mins
27 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 961,355 134,378 7.15 3 hrs 21 mins
28 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 687,411 123,716 5.56 4 hrs 19 mins
29 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 678,037 123,378 5.50 4 hrs 22 mins
30 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 598,053 118,436 5.05 5 hrs 45 mins
31 P104-100
GP104 [P104-100]
Nvidia GP104 473,118 109,567 4.32 6 hrs 33 mins
32 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 469,345 108,887 4.31 6 hrs 34 mins
33 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 401,869 103,643 3.88 6 hrs 11 mins
34 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 147,548 43,264 3.41 7 hrs 2 mins
35 Ryzen vega 8 mobile
Raven [Ryzen vega 8 mobile]
AMD Raven 69,255 57,558 1.20 20 hrs 57 mins
36 Radeon R7 250X/HD 7700/8760
R575A [Radeon R7 250X/HD 7700/8760]
AMD R575A 49,774 43,264 1.15 21 hrs 52 mins
37 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 38,547 44,702 0.86 28 hrs 50 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Tuesday, 26 October 2021 06:56:06

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make