PROJECT #18101 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Here we are testing what has long been the dream on F@h --- adaptive sampling algorithms guided by experimental data.

The system used is caspase-7, one of a family of important mediators of apoptosis, and hence of interest for cancer drug design.

We have collected experimental hydrogen-deuterium exchange (HDX) data (which informs on the extent of fluctuations of each region of the protein) in both apo (just protein) and holo (protein with another peptide bound) states, and are exploring adaptive sampling algorithms to reproduce the HDX data in each state separately, as well as the differences ('shielding') between them.

All data is being made publicly available, and insight into the algorithmic methodology will be published. This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 86,257

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 27 May 2022 17:25:50

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	5,576,460	246,593	22.61	1 ^hrs 4 ^mins
2	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,117,875	239,850	21.34	1 ^hrs 7 ^mins
3	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	5,055,450	235,033	21.51	1 ^hrs 7 ^mins
4	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	4,188,122	226,114	18.52	1 ^hrs 18 ^mins
5	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	3,739,888	216,887	17.24	1 ^hrs 24 ^mins
6	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,316,080	208,367	15.91	2 ^hrs 30 ^mins
7	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	2,662,577	194,575	13.68	2 ^hrs 45 ^mins
8	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,502,382	190,130	13.16	2 ^hrs 49 ^mins
9	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,244,794	183,681	12.22	2 ^hrs 58 ^mins
10	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,213,008	182,840	12.10	2 ^hrs 59 ^mins
11	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,043,657	178,322	11.46	2 ^hrs 6 ^mins
12	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,027,567	177,608	11.42	2 ^hrs 6 ^mins
13	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,005,637	177,033	11.33	2 ^hrs 7 ^mins
14	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	1,984,592	173,298	11.45	2 ^hrs 6 ^mins
15	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	1,860,163	172,283	10.80	2 ^hrs 13 ^mins
16	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,820,097	171,480	10.61	2 ^hrs 16 ^mins
17	GeForce RTX 3070 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	1,735,093	168,689	10.29	2 ^hrs 20 ^mins
18	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	1,700,629	166,488	10.21	2 ^hrs 21 ^mins
19	Tesla P40 GP102GL [Tesla P40] 11760	Nvidia	GP102GL	1,638,722	164,616	9.95	2 ^hrs 25 ^mins
20	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,576,508	164,209	9.60	2 ^hrs 30 ^mins
21	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,534,511	162,680	9.43	3 ^hrs 33 ^mins
22	Radeon RX 6700/6700 XT / 6800M Navi 22 [Radeon RX 6700/6700 XT / 6800M]	AMD	Navi 22	1,356,615	133,944	10.13	2 ^hrs 22 ^mins
23	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	1,299,667	153,004	8.49	3 ^hrs 50 ^mins
24	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,128,179	146,341	7.71	3 ^hrs 7 ^mins
25	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,105,946	145,152	7.62	3 ^hrs 9 ^mins
26	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,039,020	141,616	7.34	3 ^hrs 16 ^mins
27	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	961,355	134,378	7.15	3 ^hrs 21 ^mins
28	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	687,411	123,716	5.56	4 ^hrs 19 ^mins
29	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	678,037	123,378	5.50	4 ^hrs 22 ^mins
30	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	598,053	118,436	5.05	5 ^hrs 45 ^mins
31	P104-100 GP104 [P104-100]	Nvidia	GP104	473,118	109,567	4.32	6 ^hrs 33 ^mins
32	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	469,345	108,887	4.31	6 ^hrs 34 ^mins
33	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	401,869	103,643	3.88	6 ^hrs 11 ^mins
34	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	147,548	43,264	3.41	7 ^hrs 2 ^mins
35	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	69,255	57,558	1.20	20 ^hrs 57 ^mins
36	Radeon R7 250X/HD 7700/8760 R575A [Radeon R7 250X/HD 7700/8760]	AMD	R575A	49,774	43,264	1.15	21 ^hrs 52 ^mins
37	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	38,547	44,702	0.86	28 ^hrs 50 ^mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 27 May 2022 17:25:50

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make

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