PROJECT #18100 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Here we are testing what has long been the dream on F@h --- adaptive sampling algorithms guided by experimental data. The system used is caspase-7, one of a family of important mediators of apoptosis, and hence of interest for cancer drug design. We have collected experimental hydrogen-deuterium exchange (HDX) data (which informs on the extent of fluctuations of each region of the protein) in both apo (just protein) and holo (protein with another peptide bound) states, and are exploring adaptive sampling algorithms to reproduce the HDX data in each state separately, as well as the differences ('shielding') between them. All data is being made publicly available, and insight into the algorithmic methodology will be published.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ 

 

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 83,737

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,933,915 246,437 24.08 1 hrs 60 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,251,195 229,877 22.84 1 hrs 3 mins
3 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,375,912 223,639 19.57 1 hrs 14 mins
4 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,464,748 206,098 16.81 1 hrs 26 mins
5 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,379,257 203,244 16.63 1 hrs 27 mins
6 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 2,571,723 187,521 13.71 2 hrs 45 mins
7 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,523,104 186,032 13.56 2 hrs 46 mins
8 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,423,026 183,568 13.20 2 hrs 49 mins
9 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,352,074 181,630 12.95 2 hrs 51 mins
10 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,331,303 182,119 12.80 2 hrs 52 mins
11 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,233,888 178,565 12.51 2 hrs 55 mins
12 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,211,913 177,802 12.44 2 hrs 56 mins
13 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,106,828 174,950 12.04 2 hrs 60 mins
14 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,068,097 174,408 11.86 2 hrs 1 mins
15 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 1,876,007 167,896 11.17 2 hrs 9 mins
16 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,714,056 163,641 10.47 2 hrs 17 mins
17 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 1,535,302 148,177 10.36 2 hrs 19 mins
18 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 1,377,952 151,563 9.09 3 hrs 38 mins
19 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,342,213 150,846 8.90 3 hrs 42 mins
20 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,308,743 148,752 8.80 3 hrs 44 mins
21 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,267,496 147,577 8.59 3 hrs 48 mins
22 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,202,205 146,101 8.23 3 hrs 55 mins
23 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,130,692 142,520 7.93 3 hrs 2 mins
24 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,024,482 137,660 7.44 3 hrs 13 mins
25 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 901,797 129,821 6.95 3 hrs 27 mins
26 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 654,118 118,563 5.52 4 hrs 21 mins
27 P104-100
GP104 [P104-100]
Nvidia GP104 472,857 106,391 4.44 5 hrs 24 mins
28 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 431,665 103,782 4.16 6 hrs 46 mins
29 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 430,081 103,134 4.17 6 hrs 45 mins
30 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 397,021 91,089 4.36 6 hrs 30 mins
31 P106-100
GP106 [P106-100]
Nvidia GP106 334,466 94,751 3.53 7 hrs 48 mins
32 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 239,046 86,041 2.78 9 hrs 38 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make