PROJECT #18100 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Here we are testing what has long been the dream on F@h --- adaptive sampling algorithms guided by experimental data. The system used is caspase-7, one of a family of important mediators of apoptosis, and hence of interest for cancer drug design. We have collected experimental hydrogen-deuterium exchange (HDX) data (which informs on the extent of fluctuations of each region of the protein) in both apo (just protein) and holo (protein with another peptide bound) states, and are exploring adaptive sampling algorithms to reproduce the HDX data in each state separately, as well as the differences ('shielding') between them. All data is being made publicly available, and insight into the algorithmic methodology will be published.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 83,737

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	5,933,915	246,437	24.08	1 ^hrs 60 ^mins
2	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	5,251,195	229,877	22.84	1 ^hrs 3 ^mins
3	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	4,375,912	223,639	19.57	1 ^hrs 14 ^mins
4	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	3,464,748	206,098	16.81	1 ^hrs 26 ^mins
5	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	3,379,257	203,244	16.63	1 ^hrs 27 ^mins
6	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	2,571,723	187,521	13.71	2 ^hrs 45 ^mins
7	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	2,523,104	186,032	13.56	2 ^hrs 46 ^mins
8	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,423,026	183,568	13.20	2 ^hrs 49 ^mins
9	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,352,074	181,630	12.95	2 ^hrs 51 ^mins
10	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,331,303	182,119	12.80	2 ^hrs 52 ^mins
11	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,233,888	178,565	12.51	2 ^hrs 55 ^mins
12	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,211,913	177,802	12.44	2 ^hrs 56 ^mins
13	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,106,828	174,950	12.04	2 ^hrs 60 ^mins
14	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,068,097	174,408	11.86	2 ^hrs 1 ^mins
15	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	1,876,007	167,896	11.17	2 ^hrs 9 ^mins
16	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,714,056	163,641	10.47	2 ^hrs 17 ^mins
17	Radeon RX 6700/6700 XT / 6800M Navi 22 [Radeon RX 6700/6700 XT / 6800M]	AMD	Navi 22	1,535,302	148,177	10.36	2 ^hrs 19 ^mins
18	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,377,952	151,563	9.09	3 ^hrs 38 ^mins
19	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	1,342,213	150,846	8.90	3 ^hrs 42 ^mins
20	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,308,743	148,752	8.80	3 ^hrs 44 ^mins
21	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,267,496	147,577	8.59	3 ^hrs 48 ^mins
22	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,202,205	146,101	8.23	3 ^hrs 55 ^mins
23	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,130,692	142,520	7.93	3 ^hrs 2 ^mins
24	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,024,482	137,660	7.44	3 ^hrs 13 ^mins
25	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	901,797	129,821	6.95	3 ^hrs 27 ^mins
26	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	654,118	118,563	5.52	4 ^hrs 21 ^mins
27	P104-100 GP104 [P104-100]	Nvidia	GP104	472,857	106,391	4.44	5 ^hrs 24 ^mins
28	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	431,665	103,782	4.16	6 ^hrs 46 ^mins
29	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	430,081	103,134	4.17	6 ^hrs 45 ^mins
30	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	397,021	91,089	4.36	6 ^hrs 30 ^mins
31	P106-100 GP106 [P106-100]	Nvidia	GP106	334,466	94,751	3.53	7 ^hrs 48 ^mins
32	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	239,046	86,041	2.78	9 ^hrs 38 ^mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make

Legal Information: This sites use is for entertainment purposes only and comes with no guarantees or warranties in its use or related to any data displayed, collected or calcuated. This site is not affilated with folding@home or any folding team or GPU / CPU company in any official capacity and is an enthusiast creation in support of folding@home and the users / teams folding data for the greater good.

Please Note: By using this site, and / or our chrome extension you understand that you may be periodically providing information such as your IP, stats regarding use of our site, and folding@home GPU / CPU model, Work Unit ID and PPD estimate data when using our Chrome extention to the site developer for site optimization and PPD related data displayed on the site.

IF YOU DO NOT WISH TO CONTRIBUTE DATA TO THE PPD DATABASE PLEASE UNINSTALL OUR PLUGIN/TOOLS AND DISCONTINUE USE OF THIS SITE IMMEDIATELY.