Folding project #17948, CRISPR-GUIDE-RNA-MODIFICATION research

Research section Research projects and references

Project #17948 overview

Project Summary AI Beta

This project explores how changing the guide RNA (gRNA) in CRISPR-Cas12 affects its ability to cut DNA. By tweaking the gRNA, scientists hope to improve CRISPR's precision and understand how it works better. This could lead to more effective gene editing tools for treating diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Arnav Paul
Institution: University of Illinois

Work unit

Atoms: 170,000
Core: 0x23
Status: Public

Source material

Official Project Description

These projects simualte the CRISPR-Cas12 systems involving the CRISPR protein, DNA and guide RNA.

The aim of this project is to understand the effects of modification of gRNA and develop better guide RNAs.

This will provide us with a better molecular understanding of the Crispr mechanism.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

CRISPR

Clustered Regularly Interspaced Short Palindromic Repeats

Scientific: Pharmaceutical ResearchBiotechnology / Gene Editing

CRISPR is a revolutionary gene editing technology derived from a natural bacterial defense mechanism. It allows scientists to precisely target and modify DNA sequences, opening up possibilities for treating genetic diseases, developing new therapies, and advancing our understanding of biology.

Cas12

CRISPR-associated protein 12

Scientific: Pharmaceutical ResearchBiotechnology / Gene Editing

Cas12 is a type of enzyme that acts as the cutting tool in CRISPR gene editing systems. It binds to a specific DNA sequence guided by a short RNA molecule (gRNA) and makes precise cuts within the DNA, allowing for modifications or deletions.

guide RNA

A short RNA molecule that guides the Cas enzyme to a specific DNA target.

Scientific: Pharmaceutical ResearchBiotechnology / Gene Editing

Guide RNA (gRNA) is a crucial component of CRISPR gene editing. It acts as a GPS, directing the Cas enzyme to the precise location on the DNA where modifications are desired. The sequence of gRNA is designed to match the target DNA region.

DNA

Deoxyribonucleic acid - the molecule carrying genetic information.

Scientific: Pharmaceutical ResearchBiotechnology / Molecular Biology

DNA is the blueprint of life. It's a long, complex molecule that contains the instructions for building and maintaining an organism. DNA is made up of four chemical bases (adenine, guanine, cytosine, and thymine) arranged in a specific order, forming genes that code for proteins.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	26,496,647	40,100	660.76	0 ^hrs 2 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	20,112,260	246,711	81.52	0 ^hrs 18 ^mins
3	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	16,222,037	40,100	404.54	0 ^hrs 4 ^mins
4	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	14,570,788	161,532	90.20	0 ^hrs 16 ^mins
5	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	13,775,019	68,910	199.90	0 ^hrs 7 ^mins
6	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	12,717,008	309,580	41.08	0 ^hrs 35 ^mins
7	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	10,847,030	150,732	71.96	0 ^hrs 20 ^mins
8	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	10,623,303	40,100	264.92	0 ^hrs 5 ^mins
9	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	9,652,455	40,100	240.71	0 ^hrs 6 ^mins
10	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,891,913	246,262	36.11	0 ^hrs 40 ^mins
11	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	8,260,289	165,844	49.81	0 ^hrs 29 ^mins
12	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,195,044	129,965	63.06	0 ^hrs 23 ^mins
13	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	7,589,280	262,300	28.93	0 ^hrs 50 ^mins
14	GeForce RTX 4090 Laptop GPU AD103M / GN21-X11 [GeForce RTX 4090 Laptop GPU]	Nvidia	AD103M / GN21-X11	6,968,744	40,100	173.78	0 ^hrs 8 ^mins
15	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,955,672	54,834	126.85	0 ^hrs 11 ^mins
16	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,773,776	222,609	30.43	0 ^hrs 47 ^mins
17	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	6,629,505	40,100	165.32	0 ^hrs 9 ^mins
18	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	6,342,408	40,100	158.16	0 ^hrs 9 ^mins
19	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,247,886	40,100	155.81	0 ^hrs 9 ^mins

20	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,878,224	157,634	37.29	0 ^hrs 39 ^mins
21	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,615,559	73,955	75.93	0 ^hrs 19 ^mins
22	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,378,110	40,100	134.12	0 ^hrs 11 ^mins
23	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,943,529	225,580	21.91	1 ^hrs 6 ^mins
24	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,741,559	143,512	33.04	0 ^hrs 44 ^mins
25	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,288,473	126,557	33.89	0 ^hrs 42 ^mins
26	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	4,006,531	40,100	99.91	0 ^hrs 14 ^mins
27	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	3,964,162	74,143	53.47	0 ^hrs 27 ^mins
28	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	3,884,080	115,465	33.64	0 ^hrs 43 ^mins
29	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	3,720,869	40,100	92.79	0 ^hrs 16 ^mins
30	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,334,900	47,501	70.21	0 ^hrs 21 ^mins
31	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,323,078	40,100	82.87	0 ^hrs 17 ^mins
32	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	3,271,751	113,293	28.88	0 ^hrs 50 ^mins
33	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,258,758	40,100	81.27	0 ^hrs 18 ^mins
34	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,218,751	70,191	45.86	0 ^hrs 31 ^mins
35	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	3,040,560	191,758	15.86	1 ^hrs 31 ^mins
36	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,973,874	192,244	15.47	1 ^hrs 33 ^mins
37	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,527,928	181,010	13.97	1 ^hrs 43 ^mins
38	Intel Arc B580 Graphics Battlemage G21 [Intel Arc B580 Graphics]	Intel	Battlemage G21	2,485,966	40,100	61.99	0 ^hrs 23 ^mins
39	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,381,341	98,995	24.06	0 ^hrs 60 ^mins

40	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,975,642	40,100	49.27	0 ^hrs 29 ^mins
41	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,780,044	98,238	18.12	1 ^hrs 19 ^mins
42	Radeon RX 9060(XT) Navi 44 [Radeon RX 9060(XT)]	AMD	Navi 44	1,767,012	40,100	44.07	0 ^hrs 33 ^mins
43	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,475,108	40,100	36.79	0 ^hrs 39 ^mins
44	Radeon VII Vega 20 [Radeon VII]	AMD	Vega 20	1,450,266	40,100	36.17	0 ^hrs 40 ^mins
45	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,446,329	40,100	36.07	0 ^hrs 40 ^mins
46	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,172,646	40,100	29.24	0 ^hrs 49 ^mins
47	Radeon RX 6600(XT/M) Navi 23 XT-XL [Radeon RX 6600(XT/M)]	AMD	Navi 23 XT-XL	1,135,524	85,564	13.27	1 ^hrs 49 ^mins
48	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	1,106,872	40,100	27.60	0 ^hrs 52 ^mins
49	P106-100 GP106 [P106-100]	Nvidia	GP106	856,502	126,847	6.75	3 ^hrs 33 ^mins
50	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	833,896	40,100	20.80	1 ^hrs 9 ^mins
51	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	678,467	40,100	16.92	1 ^hrs 25 ^mins
52	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	577,317	40,100	14.40	1 ^hrs 40 ^mins
53	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	288,756	40,100	7.20	3 ^hrs 20 ^mins
54	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	287,226	40,100	7.16	3 ^hrs 21 ^mins
55	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	209,885	81,306	2.58	9 ^hrs 18 ^mins
56	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	191,054	76,594	2.49	9 ^hrs 37 ^mins
57	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	167,075	42,996	3.89	6 ^hrs 11 ^mins
58	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	109,875	40,100	2.74	8 ^hrs 46 ^mins
59	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	94,822	40,100	2.36	10 ^hrs 9 ^mins

60	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	13,241	40,100	0.33	72 ^hrs 41 ^mins

Research: CRISPR-GUIDE-RNA-MODIFICATION Folding Project #17948

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17948

GPU PPD Averages

Research: CRISPR-GUIDE-RNA-MODIFICATION Folding Project #17948

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages