Folding project #17924, PFHT1-SUBSTRATE-SPECIFICITY research

Research section Research projects and references

Project #17924 overview

Project Summary AI Beta

The project relates to understanding how PfHT1, a sugar transporter in malaria parasites, works. Scientists want to learn which sugars it moves and use this knowledge to deliver anti-malarial drugs more effectively.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Arnav Paul
Institution: University of Illinois

Work unit

Atoms: 109,125
Core: 0x22
Status: Public

No related projects listed.

Source material

Official Project Description

Malarial parasite transporter PfHT1 - Plasmodium falciparum hexose transporter is a sugar transporter found in the malarial parasite, which transports glucose and fructose across the membrane.

In this project we aim to understand the substrate specificity mechanism of the transporter and to obtain a possible pathway of targetted delivery of anti-malarial drugs.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Malarial parasite

A parasitic organism that causes malaria.

Clinical: Biotechnology, MedicineParasitology / Infectious Disease

A malarial parasite is a type of single-celled organism that infects humans and causes the disease malaria. These parasites are spread through the bite of infected mosquitoes and can lead to severe illness if not treated promptly.

transporter

A protein that moves substances across a cell membrane.

Scientific: Biotechnology, MedicineMolecular Biology / Biochemistry

Transporters are essential proteins found in cell membranes. They act like tiny gates, allowing specific molecules to move into or out of the cell. This process is crucial for various cellular functions, including nutrient uptake, waste removal, and signal transduction.

PfHT1

Plasmodium falciparum hexose transporter 1

Acronym: PharmaceuticalBiotechnology / Drug Discovery

PfHT1 is a specific sugar transporter protein found in the malaria parasite, Plasmodium falciparum. It plays a vital role in transporting glucose and fructose into the parasite, which are essential for its survival and growth.

Plasmodium falciparum

The species of malaria parasite that causes the most severe form of malaria.

Pathogen: Medicine, ResearchParasitology / Infectious Disease

Plasmodium falciparum is a single-celled parasitic organism responsible for causing the deadliest type of malaria. This parasite infects red blood cells and can lead to life-threatening complications such as cerebral malaria, organ failure, and anemia.

hexose transporter

A protein that transports hexose sugars across a cell membrane.

Scientific: Biotechnology, MedicineBiochemistry / Cellular Transport

Hexose transporters are specialized proteins embedded in cell membranes. Their primary function is to facilitate the movement of hexose sugars, such as glucose and fructose, into or out of cells. This process is crucial for various metabolic processes, including energy production and nutrient utilization.

anti-malarial drugs

Medicines used to treat malaria.

Pharmaceutical: PharmaceuticalDrug Discovery / Infectious Disease

Anti-malarial drugs are medications specifically designed to kill or inhibit the growth of malaria parasites. They work by interfering with various stages of the parasite's life cycle, preventing its replication and spread within the body.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	17,910,197	176,970	101.20	0 ^hrs 14 ^mins
2	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	17,745,698	26,270	675.51	0 ^hrs 2 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	13,419,356	26,270	510.82	0 ^hrs 3 ^mins
4	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,569,906	160,348	78.39	0 ^hrs 18 ^mins
5	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,588,378	212,285	45.17	0 ^hrs 32 ^mins
6	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	8,859,077	207,513	42.69	0 ^hrs 34 ^mins
7	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	8,809,882	89,588	98.34	0 ^hrs 15 ^mins
8	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,446,847	169,431	49.85	0 ^hrs 29 ^mins
9	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,365,011	168,893	49.53	0 ^hrs 29 ^mins
10	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	8,282,702	26,270	315.29	0 ^hrs 5 ^mins
11	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,942,756	189,106	36.71	0 ^hrs 39 ^mins
12	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,146,453	183,288	33.53	0 ^hrs 43 ^mins
13	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,823,394	180,877	32.20	0 ^hrs 45 ^mins
14	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,062,777	139,120	36.39	0 ^hrs 40 ^mins
15	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,993,331	152,820	32.67	0 ^hrs 44 ^mins
16	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,703,908	167,802	28.03	0 ^hrs 51 ^mins
17	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	4,587,488	167,370	27.41	0 ^hrs 53 ^mins
18	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	4,126,821	132,343	31.18	0 ^hrs 46 ^mins
19	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,767,135	155,728	24.19	0 ^hrs 60 ^mins

20	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	3,757,265	133,458	28.15	0 ^hrs 51 ^mins
21	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,311,794	120,272	27.54	0 ^hrs 52 ^mins
22	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,239,931	148,323	21.84	1 ^hrs 6 ^mins
23	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,182,218	147,420	21.59	1 ^hrs 7 ^mins
24	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	3,141,040	147,326	21.32	1 ^hrs 8 ^mins
25	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,911,703	53,333	54.59	0 ^hrs 26 ^mins
26	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,825,235	140,951	20.04	1 ^hrs 12 ^mins
27	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,753,967	141,479	19.47	1 ^hrs 14 ^mins
28	GeForce RTX 4050 Max-Q / Mobile AD107M [GeForce RTX 4050 Max-Q / Mobile]	Nvidia	AD107M	2,607,951	139,023	18.76	1 ^hrs 17 ^mins
29	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,606,202	138,277	18.85	1 ^hrs 16 ^mins
30	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	2,595,009	137,381	18.89	1 ^hrs 16 ^mins
31	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,422,883	133,495	18.15	1 ^hrs 19 ^mins
32	GeForce RTX 2060 12GB TU106 [GeForce RTX 2060 12GB]	Nvidia	TU106	2,381,322	134,001	17.77	1 ^hrs 21 ^mins
33	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,322,122	129,978	17.87	1 ^hrs 21 ^mins
34	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,305,027	133,068	17.32	1 ^hrs 23 ^mins
35	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,194,039	130,498	16.81	1 ^hrs 26 ^mins
36	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,189,790	131,435	16.66	1 ^hrs 26 ^mins
37	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,139,585	128,550	16.64	1 ^hrs 27 ^mins
38	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,138,318	116,845	18.30	1 ^hrs 19 ^mins
39	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,925,531	107,392	17.93	1 ^hrs 20 ^mins

40	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	1,918,089	125,168	15.32	1 ^hrs 34 ^mins
41	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,914,366	124,651	15.36	1 ^hrs 34 ^mins
42	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	1,898,667	122,861	15.45	1 ^hrs 33 ^mins
43	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,847,025	119,799	15.42	1 ^hrs 33 ^mins
44	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,816,408	106,828	17.00	1 ^hrs 25 ^mins
45	Quadro RTX 5000 Mobile / Max-Q TU104GLM [Quadro RTX 5000 Mobile / Max-Q]	Nvidia	TU104GLM	1,699,906	105,401	16.13	1 ^hrs 29 ^mins
46	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,582,713	117,543	13.46	1 ^hrs 47 ^mins
47	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,443,100	116,385	12.40	1 ^hrs 56 ^mins
48	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,386,363	112,362	12.34	1 ^hrs 57 ^mins
49	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,363,111	110,192	12.37	1 ^hrs 56 ^mins
50	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,342,102	110,503	12.15	1 ^hrs 59 ^mins
51	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,261,758	86,983	14.51	1 ^hrs 39 ^mins
52	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,194,631	26,270	45.48	0 ^hrs 32 ^mins
53	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,124,688	102,582	10.96	2 ^hrs 11 ^mins
54	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,095,034	103,008	10.63	2 ^hrs 15 ^mins
55	GeForce RTX 3050 6GB Laptop GPU GN20-P0-R-K2 [GeForce RTX 3050 6GB Laptop GPU]	Nvidia	GN20-P0-R-K2	1,074,568	103,616	10.37	2 ^hrs 19 ^mins
56	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,050,904	98,996	10.62	2 ^hrs 16 ^mins
57	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	1,042,073	101,939	10.22	2 ^hrs 21 ^mins
58	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,025,454	101,237	10.13	2 ^hrs 22 ^mins
59	P104-100 GP104 [P104-100]	Nvidia	GP104	1,021,506	101,225	10.09	2 ^hrs 23 ^mins

60	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	993,600	26,270	37.82	0 ^hrs 38 ^mins
61	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	957,377	96,835	9.89	2 ^hrs 26 ^mins
62	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	950,443	97,924	9.71	2 ^hrs 28 ^mins
63	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	934,728	95,131	9.83	2 ^hrs 27 ^mins
64	Radeon Vega FE Vega 10 XTX [Radeon Vega FE]	AMD	Vega 10 XTX	929,703	96,184	9.67	2 ^hrs 29 ^mins
65	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	849,729	94,520	8.99	2 ^hrs 40 ^mins
66	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	835,026	91,322	9.14	2 ^hrs 37 ^mins
67	Radeon PRO W6600 Navi 23 XL [Radeon PRO W6600]	AMD	Navi 23 XL	792,840	93,211	8.51	2 ^hrs 49 ^mins
68	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	776,282	89,768	8.65	2 ^hrs 47 ^mins
69	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	768,725	92,187	8.34	2 ^hrs 53 ^mins
70	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	738,688	92,358	8.00	3 ^hrs 0 ^mins
71	Quadro P4000 GP104GL [Quadro P4000]	Nvidia	GP104GL	723,768	90,286	8.02	2 ^hrs 60 ^mins
72	GeForce GTX 1060 6GB GP104 [GeForce GTX 1060 6GB]	Nvidia	GP104	717,779	90,229	7.96	3 ^hrs 1 ^mins
73	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	708,141	26,270	26.96	0 ^hrs 53 ^mins
74	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	677,442	87,584	7.73	3 ^hrs 6 ^mins
75	P106-100 GP106 [P106-100]	Nvidia	GP106	663,858	87,701	7.57	3 ^hrs 10 ^mins
76	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	615,031	85,532	7.19	3 ^hrs 20 ^mins
77	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	606,584	85,113	7.13	3 ^hrs 22 ^mins
78	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	584,515	81,789	7.15	3 ^hrs 21 ^mins
79	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	542,659	61,780	8.78	2 ^hrs 44 ^mins

80	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	523,891	79,649	6.58	3 ^hrs 39 ^mins
81	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	478,053	78,796	6.07	3 ^hrs 57 ^mins
82	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	473,105	76,895	6.15	3 ^hrs 54 ^mins
83	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	426,928	72,785	5.87	4 ^hrs 5 ^mins
84	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	321,603	66,357	4.85	4 ^hrs 57 ^mins
85	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	292,350	67,319	4.34	5 ^hrs 32 ^mins
86	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	284,647	69,254	4.11	5 ^hrs 50 ^mins
87	GeForce GTX 1050 3 GB Max-Q GP107M [GeForce GTX 1050 3 GB Max-Q]	Nvidia	GP107M	279,782	66,424	4.21	5 ^hrs 42 ^mins
88	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	260,853	64,216	4.06	5 ^hrs 54 ^mins
89	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	239,877	62,507	3.84	6 ^hrs 15 ^mins
90	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	238,129	62,645	3.80	6 ^hrs 19 ^mins
91	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	226,774	26,270	8.63	2 ^hrs 47 ^mins
92	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	212,647	63,152	3.37	7 ^hrs 8 ^mins
93	Quadro M2000 GM206GL [Quadro M2000]	Nvidia	GM206GL	207,372	57,406	3.61	6 ^hrs 39 ^mins
94	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	189,798	57,965	3.27	7 ^hrs 20 ^mins
95	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	137,652	26,270	5.24	4 ^hrs 35 ^mins
96	R9 280X/HD 7900/8970 OEM Tahiti XT [R9 280X/HD 7900/8970 OEM]	AMD	Tahiti XT	126,740	54,140	2.34	10 ^hrs 15 ^mins
97	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	101,172	51,227	1.97	12 ^hrs 9 ^mins
98	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	93,646	51,376	1.82	13 ^hrs 10 ^mins
99	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	71,755	42,463	1.69	14 ^hrs 12 ^mins

100	Quadro P600 GP107GL [Quadro P600]	Nvidia	GP107GL	70,241	48,450	1.45	16 ^hrs 33 ^mins
101	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	51,096	37,611	1.36	17 ^hrs 40 ^mins

Research: PFHT1-SUBSTRATE-SPECIFICITY Folding Project #17924

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17924

GPU PPD Averages

Research: PFHT1-SUBSTRATE-SPECIFICITY Folding Project #17924

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages