Folding project #16773, CANCER research

Research section Research projects and references

Project #16773 overview

Project Summary AI Beta

KRAS is a gene often messed up in cancers, making them grow out of control. It's hard to treat because it binds tightly to molecules. This project looks at how a protein called VHL interacts with KRAS, hoping to find new ways to 'glue' them together and turn off KRAS.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Xuhui Huang
Institution: University of Wisconsin-Madison

Work unit

Atoms: 134,547
Core: 0x27
Status: Public

Source material

Official Project Description

KRAS is one of the most frequently mutated oncogenes in human cancers, driving uncontrolled cell growth through persistent activation of the MAPK and PI3K signaling pathways.

Despite decades of effort, KRAS has long been considered “undruggable” due to its smooth surface and high affinity for GTP/GDP, which make traditional small-molecule inhibition extremely difficult.

The concept of molecular glues offers a transformative strategy by promoting or stabilizing interactions between KRAS and specific E3 ligases or regulatory partners, leading to selective degradation or allosteric modulation of KRAS.

These projects aim to discover the PPI between VHL and wild type and the G12 mutants.

Further, the novel PPI can aid the discovery of the novel molecular glue compunds that target KRAS.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

KRAS

Kirsten rat sarcoma viral oncogene homolog

Technical: BiotechnologyOncology / Cancer Research

KRAS is a gene that can become mutated and cause uncontrolled cell growth, leading to cancer. It's a common target for cancer research because of its role in driving tumor development.

oncogenes

Genes that have the potential to cause cancer when mutated or overexpressed.

Scientific: BiotechnologyOncology / Molecular Biology

Oncogenes are genes that can promote the development of cancer. When they become mutated or overactive, they can lead to uncontrolled cell growth and division.

MAPK

Mitogen-activated protein kinase

Technical: BiotechnologyMolecular Biology / Signaling Pathways

The MAPK pathway is a crucial signaling cascade involved in various cellular processes, including cell growth, differentiation, and survival. It's often dysregulated in cancer.

PI3K

Phosphoinositide 3-kinase

Technical: BiotechnologyMolecular Biology / Signaling Pathways

PI3K is another important signaling pathway involved in cell growth, proliferation, and survival. It's often activated in cancer cells, contributing to tumor development.

GTP/GDP

Guanosine triphosphate / Guanosine diphosphate

Technical: BiotechnologyMolecular Biology / Cellular Processes

GTP and GDP are molecules that play a vital role in cellular signaling and energy transfer. KRAS relies on these molecules to regulate its activity.

molecular glues

A class of drug that promotes interactions between proteins, leading to degradation or modulation of target proteins.

Technical: PharmaceuticalsDrug Discovery / Cancer Therapeutics

Molecular glues are a novel approach to drug development that aims to stabilize interactions between proteins. They can be used to degrade or modulate the activity of disease-causing proteins, such as KRAS.

E3 ligases

Enzymes that play a crucial role in protein degradation by marking proteins for destruction.

Scientific: BiotechnologyMolecular Biology / Protein Degradation

E3 ligases are enzymes that tag proteins with ubiquitin, a small protein that marks them for destruction. This process is essential for removing damaged or unwanted proteins from cells.

PPI

Protein-protein interaction

Technical: BiotechnologyBioinformatics / Protein-Protein Interactions

PPI refers to the interactions between different proteins. Understanding these interactions is crucial for comprehending cellular processes and developing new therapies.

VHL

Von Hippel-Lindau tumor suppressor gene

Technical: BiotechnologyOncology / Tumor Suppressor Genes

VHL is a tumor suppressor gene that plays a role in regulating cell growth and preventing cancer development. Mutations in VHL can lead to various cancers.

G12 mutants

KRAS mutations at the glycine-12 position.

Technical: BiotechnologyOncology / Cancer Genomics

G12 mutants are specific types of KRAS mutations that occur at the glycine-12 amino acid. These mutations are common in various cancers and contribute to uncontrolled cell growth.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	21,833,569	189,787	115.04	0 ^hrs 13 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	17,390,732	350,590	49.60	0 ^hrs 29 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	17,284,624	475,018	36.39	0 ^hrs 40 ^mins
4	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	13,861,683	283,369	48.92	0 ^hrs 29 ^mins
5	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	13,667,565	60,823	224.71	0 ^hrs 6 ^mins
6	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	11,870,060	205,103	57.87	0 ^hrs 25 ^mins
7	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	10,837,983	53,000	204.49	0 ^hrs 7 ^mins
8	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	9,475,332	53,000	178.78	0 ^hrs 8 ^mins
9	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,221,840	108,133	85.28	0 ^hrs 17 ^mins
10	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,947,216	184,860	48.40	0 ^hrs 30 ^mins
11	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	8,834,606	53,000	166.69	0 ^hrs 9 ^mins
12	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	8,510,982	159,422	53.39	0 ^hrs 27 ^mins
13	GeForce RTX 4090 Laptop GPU AD103M / GN21-X11 [GeForce RTX 4090 Laptop GPU]	Nvidia	AD103M / GN21-X11	8,186,150	53,000	154.46	0 ^hrs 9 ^mins
14	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	7,295,032	57,530	126.80	0 ^hrs 11 ^mins
15	Instinct MI300X Aqua Vanjaram [Instinct MI300X]	AMD	Aqua Vanjaram	7,252,806	53,000	136.85	0 ^hrs 11 ^mins
16	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,991,459	76,727	91.12	0 ^hrs 16 ^mins
17	GeForce RTX 4060 Ti AD104 [GeForce RTX 4060 Ti]	Nvidia	AD104	6,679,836	53,000	126.03	0 ^hrs 11 ^mins
18	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,530,614	244,302	26.73	0 ^hrs 54 ^mins
19	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	6,188,539	198,456	31.18	0 ^hrs 46 ^mins

20	GeForce RTX 5060 GB206 [GeForce RTX 5060]	Nvidia	GB206	5,982,703	53,000	112.88	0 ^hrs 13 ^mins
21	GeForce RTX 5070 Ti Mobile GB205M [GeForce RTX 5070 Ti Mobile]	Nvidia	GB205M	5,950,534	53,000	112.27	0 ^hrs 13 ^mins
22	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,760,278	53,000	108.68	0 ^hrs 13 ^mins
23	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,710,183	159,599	35.78	0 ^hrs 40 ^mins
24	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	5,593,120	360,230	15.53	1 ^hrs 33 ^mins
25	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,440,534	53,000	102.65	0 ^hrs 14 ^mins
26	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	5,354,275	137,183	39.03	0 ^hrs 37 ^mins
27	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	5,268,040	53,000	99.40	0 ^hrs 14 ^mins
28	RTX PRO 2000 Blackwell GB206GL [RTX PRO 2000 Blackwell]	Nvidia	GB206GL	5,118,447	53,000	96.57	0 ^hrs 15 ^mins
29	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	4,993,698	53,000	94.22	0 ^hrs 15 ^mins
30	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	4,717,052	53,000	89.00	0 ^hrs 16 ^mins
31	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	4,685,008	53,000	88.40	0 ^hrs 16 ^mins
32	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	4,601,368	112,011	41.08	0 ^hrs 35 ^mins
33	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	4,397,630	53,000	82.97	0 ^hrs 17 ^mins
34	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	4,001,775	53,000	75.51	0 ^hrs 19 ^mins
35	RTX 4000 SFF Ada Generation AD104GL [RTX 4000 SFF Ada Generation]	Nvidia	AD104GL	3,961,362	53,000	74.74	0 ^hrs 19 ^mins
36	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,851,857	53,000	72.68	0 ^hrs 20 ^mins
37	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,724,807	58,572	63.59	0 ^hrs 23 ^mins
38	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,670,931	55,551	66.08	0 ^hrs 22 ^mins
39	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,664,024	170,836	21.45	1 ^hrs 7 ^mins

40	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,571,349	157,447	22.68	1 ^hrs 3 ^mins
41	Intel Arc B580 Graphics Battlemage G21 [Intel Arc B580 Graphics]	Intel	Battlemage G21	3,346,900	53,000	63.15	0 ^hrs 23 ^mins
42	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,201,987	53,000	60.41	0 ^hrs 24 ^mins
43	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 Super]	Nvidia	TU106	2,804,194	128,645	21.80	1 ^hrs 6 ^mins
44	Radeon RX 9060(XT) Navi 44 [Radeon RX 9060(XT)]	AMD	Navi 44	2,771,476	53,000	52.29	0 ^hrs 28 ^mins
45	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,754,163	53,000	51.97	0 ^hrs 28 ^mins
46	P102-100 GP102 [P102-100]	Nvidia	GP102	2,629,240	53,000	49.61	0 ^hrs 29 ^mins
47	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,589,615	75,014	34.52	0 ^hrs 42 ^mins
48	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,588,219	53,000	48.83	0 ^hrs 29 ^mins
49	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	2,515,619	53,000	47.46	0 ^hrs 30 ^mins
50	Radeon 8050S/8060S Strix Halo [Radeon 8050S/8060S]	AMD	Strix Halo	2,507,656	53,000	47.31	0 ^hrs 30 ^mins
51	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,450,382	53,000	46.23	0 ^hrs 31 ^mins
52	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,432,429	53,000	45.89	0 ^hrs 31 ^mins
53	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,328,583	53,000	43.94	0 ^hrs 33 ^mins
54	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,167,637	283,562	7.64	3 ^hrs 8 ^mins
55	GeForce RTX 4050 Max-Q / Mobile AD107M [GeForce RTX 4050 Max-Q / Mobile]	Nvidia	AD107M	1,827,428	53,000	34.48	0 ^hrs 42 ^mins
56	Radeon RX 6650 XT Navi 23 [Radeon RX 6650 XT]	AMD	Navi 23	1,758,153	53,000	33.17	0 ^hrs 43 ^mins
57	Radeon 880M/890M Strix Point [Radeon 880M/890M]	AMD	Strix Point	1,665,151	53,000	31.42	0 ^hrs 46 ^mins
58	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,524,985	53,000	28.77	0 ^hrs 50 ^mins
59	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,431,705	53,000	27.01	0 ^hrs 53 ^mins

60	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,377,821	223,738	6.16	3 ^hrs 54 ^mins
61	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	1,363,876	53,000	25.73	0 ^hrs 56 ^mins
62	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,335,630	224,278	5.96	4 ^hrs 2 ^mins
63	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,303,524	53,000	24.59	0 ^hrs 59 ^mins
64	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,293,077	67,690	19.10	1 ^hrs 15 ^mins
65	RX 5600 OEM/5600XT/5700(XT) Navi 10 [RX 5600 OEM/5600XT/5700(XT)]	AMD	Navi 10	1,103,164	53,000	20.81	1 ^hrs 9 ^mins
66	P104-100 GP104 [P104-100]	Nvidia	GP104	1,082,594	53,000	20.43	1 ^hrs 10 ^mins
67	P106-100 GP106 [P106-100]	Nvidia	GP106	1,075,152	53,000	20.29	1 ^hrs 11 ^mins
68	CMP 30HX TU116 [CMP 30HX]	Nvidia	TU116	1,051,715	53,000	19.84	1 ^hrs 13 ^mins
69	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,035,043	53,000	19.53	1 ^hrs 14 ^mins
70	Radeon VII Vega 20 [Radeon VII]	AMD	Vega 20	922,262	53,000	17.40	1 ^hrs 23 ^mins
71	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	898,177	53,000	16.95	1 ^hrs 25 ^mins
72	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	886,937	78,945	11.23	2 ^hrs 8 ^mins
73	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	706,233	53,000	13.33	1 ^hrs 48 ^mins
74	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	641,385	53,000	12.10	1 ^hrs 59 ^mins
75	Radeon PRO W7500 Navi 33 [Radeon PRO W7500]	AMD	Navi 33	625,524	53,000	11.80	2 ^hrs 2 ^mins
76	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	601,485	53,000	11.35	2 ^hrs 7 ^mins
77	GeForce RTX 3050 6GB Laptop GPU GN20-P0-R-K2 [GeForce RTX 3050 6GB Laptop GPU]	Nvidia	GN20-P0-R-K2	579,010	53,000	10.92	2 ^hrs 12 ^mins
78	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	559,657	175,798	3.18	7 ^hrs 32 ^mins
79	GeForce RTX 3050 6GB GA107 [GeForce RTX 3050 6GB]	Nvidia	GA107	541,031	53,000	10.21	2 ^hrs 21 ^mins

80	RX 5500(M)/Pro 5500M Navi 14 [RX 5500(M)/Pro 5500M]	AMD	Navi 14	539,807	53,000	10.19	2 ^hrs 21 ^mins
81	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	448,553	53,000	8.46	2 ^hrs 50 ^mins
82	Radeon RX 580 2048SP Polaris 20 XL [Radeon RX 580 2048SP]	AMD	Polaris 20 XL	445,090	53,000	8.40	2 ^hrs 51 ^mins
83	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	428,536	53,000	8.09	2 ^hrs 58 ^mins
84	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	397,106	53,000	7.49	3 ^hrs 12 ^mins
85	Quadro M5000 GM204GL [Quadro M5000]	Nvidia	GM204GL	378,671	53,000	7.14	3 ^hrs 22 ^mins
86	R9 280X/HD 7900/8970 OEM Tahiti XT [R9 280X/HD 7900/8970 OEM]	AMD	Tahiti XT	361,378	53,000	6.82	3 ^hrs 31 ^mins
87	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	355,558	53,000	6.71	3 ^hrs 35 ^mins
88	Radeon PRO W6400 Navi 24 [Radeon PRO W6400]	AMD	Navi 24	338,378	53,000	6.38	3 ^hrs 46 ^mins
89	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	324,422	53,000	6.12	3 ^hrs 55 ^mins
90	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	317,859	99,973	3.18	7 ^hrs 33 ^mins
91	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	313,240	148,347	2.11	11 ^hrs 22 ^mins
92	GeForce GTX 1650 TU106 [GeForce GTX 1650]	Nvidia	TU106	286,845	53,000	5.41	4 ^hrs 26 ^mins
93	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	266,200	140,775	1.89	12 ^hrs 42 ^mins
94	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	218,352	53,000	4.12	5 ^hrs 50 ^mins
95	Quadro T400 Mobile TU117GLM [Quadro T400 Mobile]	Nvidia	TU117GLM	175,414	53,000	3.31	7 ^hrs 15 ^mins
96	Radeon 760M/780M Phoenix/Hawk Point [Radeon 760M/780M]	AMD	Phoenix/Hawk Point	163,145	53,000	3.08	7 ^hrs 48 ^mins
97	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	157,534	53,000	2.97	8 ^hrs 4 ^mins
98	Radeon 540(X)/550(X)/E9173 Lexa PRO [Radeon 540(X)/550(X)/E9173]	AMD	Lexa PRO	72,097	53,000	1.36	17 ^hrs 39 ^mins
99	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	69,308	53,000	1.31	18 ^hrs 21 ^mins

Research: CANCER Folding Project #16773

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 16773

GPU PPD Averages

Research: CANCER Folding Project #16773

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages