Folding project #15506, PEPTIDOMIMETIC-CD40L-BINDING research

Research section Research projects and references

Project #15506 overview

Project Summary AI Beta

This project is studying how special molecules called peptidomimetics attach to the CD40L receptor. This receptor is a potential target for treating autoimmune diseases. Researchers from Temple University are collaborating on this work.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Vincent Voelz
Institution: Temple University

Work unit

Atoms: 96,809
Core: 0x28
Status: Beta

Source material

Official Project Description

This project simulates binding of peptidomimetic ligands to the CD40L receptor, a promising therapeutic target for autoimmune diseases.

This work is a collaboration with Christian Schafmeister's group at Temple University.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

peptidomimetic

Molecules that mimic the structure and function of peptides.

scientific: pharmaceuticalsbiotechnology / drug discovery

Peptidomimetics are synthetic compounds designed to resemble the actions of naturally occurring peptides. They are valuable in drug development because they can possess similar biological activity as peptides but with improved stability and pharmacokinetic properties. Peptidomimetics have applications in treating various diseases, including autoimmune disorders.

ligands

Molecules that bind to a specific receptor or site on another molecule.

scientific: pharmaceuticalsbiotechnology / pharmacology

Ligands are molecules that attach themselves to other molecules, often called receptors. This binding can trigger various cellular responses, such as activating a signaling pathway or changing the shape of a protein. Ligands play crucial roles in many biological processes, including cell communication, metabolism, and immune responses.

CD40L receptor

Cluster of Differentiation 40 Ligand

scientific: pharmaceuticalsimmunology / autoimmune diseases

CD40L receptor is a protein found on the surface of certain immune cells. It plays a vital role in activating immune responses by interacting with CD40 on other immune cells. Dysregulation of this pathway can contribute to autoimmune diseases, where the immune system mistakenly attacks healthy tissues.

autoimmune diseases

Diseases caused by the immune system attacking the body's own tissues.

medical: pharmaceuticalsimmunology / pathology

Autoimmune diseases occur when the immune system, which normally protects the body from infections, mistakenly attacks healthy cells and tissues. This can lead to inflammation and damage in various parts of the body. Examples of autoimmune diseases include rheumatoid arthritis, lupus, and type 1 diabetes.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	12,920,016	42,602	303.27	0 ^hrs 5 ^mins
2	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	9,929,946	42,602	233.09	0 ^hrs 6 ^mins
3	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,712,696	42,602	87.15	0 ^hrs 17 ^mins
4	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	164,751	42,602	3.87	6 ^hrs 12 ^mins

Research: PEPTIDOMIMETIC-CD40L-BINDING Folding Project #15506

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 15506

GPU PPD Averages

Research: PEPTIDOMIMETIC-CD40L-BINDING Folding Project #15506

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages