Folding project #15505, PEPTIDOMIMETIC-CD40L-BINDING research

Research section Research projects and references

Project #15505 overview

Project Summary AI Beta

This project looks at how special drug-like molecules (peptidomimetics) attach to the CD40L receptor. Scientists hope this could help treat autoimmune diseases like lupus and rheumatoid arthritis.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Vincent Voelz
Institution: Temple University

Work unit

Atoms: 94,105
Core: 0x28
Status: Beta

Source material

Official Project Description

This project simulates binding of peptidomimetic ligands to the CD40L receptor, a promising therapeutic target for autoimmune diseases.

This work is a collaboration with Christian Schafmeister's group at Temple University.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

peptidomimetic

A molecule that mimics the action of a peptide.

Technical: BiotechnologyMedicine / Immunology

Peptidomimetics are synthetic compounds designed to resemble peptides, which are short chains of amino acids. They can bind to specific receptors and proteins in the body, similar to natural peptides. In drug development, peptidomimetics offer advantages over traditional peptides, such as improved stability, oral bioavailability, and resistance to enzymatic degradation.

ligands

Molecules that bind to receptors or other biomolecules.

Scientific: BiotechnologyMedicine / Pharmacology

Ligands are molecules that have a specific affinity for binding to other molecules called receptors. This binding interaction often triggers a biological response within the cell. Ligands can be naturally occurring substances like hormones or neurotransmitters, or they can be synthetic compounds developed as drugs.

CD40L receptor

Cluster of Differentiation 40 Ligand Receptor

Technical: BiotechnologyMedicine / Immunology

The CD40L receptor is a protein found on the surface of immune cells. It plays a crucial role in activating B cells, which are responsible for producing antibodies. Stimulating the CD40L receptor can enhance immune responses and is being investigated as a therapeutic strategy for autoimmune diseases.

autoimmune diseases

Diseases caused by the immune system attacking the body's own tissues.

Scientific: PharmacologyMedicine / Immunology

Autoimmune diseases occur when the immune system, which normally defends the body against foreign invaders, mistakenly attacks healthy cells and tissues. This can lead to a wide range of symptoms and complications depending on the specific disease.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	12,946,103	37,886	341.71	0 ^hrs 4 ^mins
2	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	7,289,189	37,886	192.40	0 ^hrs 7 ^mins
3	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,505,176	37,886	92.52	0 ^hrs 16 ^mins
4	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	98,370	37,886	2.60	9 ^hrs 15 ^mins

Research: PEPTIDOMIMETIC-CD40L-BINDING Folding Project #15505

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 15505

GPU PPD Averages

Research: PEPTIDOMIMETIC-CD40L-BINDING Folding Project #15505

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages