Folding project #19022, PARKINSONS research

Research section Research projects and references

Project #19022 overview

Project Summary AI Beta

This project simulates how a protein called the glycine transporter moves glycine in the brain. Glycine helps control nerve signals, and problems with this transporter can lead to diseases like schizophrenia. By understanding how it works, scientists can design better drugs to treat these conditions.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Nicole Chiang
Institution: University of Illinois

Work unit

Atoms: 105,419
Core: 0x22
Status: Public

Source material

Official Project Description

These projects contains simulations of the glycine transporter, the protein responsible for terminating neurotransmission in neurons.

Glycine is a major inhibitory neurontramitter of the spinal cord and brain stem.

Malfunctions in the glycine transporter have been assoicated with neurological diseases including schizophrenia and hyperekplexia.

Our goal in performing these simulations is to understand how the ions are coupled with substrate transport, which will enable better design of drugs targetting the glycine transporter.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

glycine transporter

Protein responsible for terminating neurotransmission of glycine.

Technical: BiotechnologyNeuroscience / Neurotransmission

The glycine transporter is a protein found in neurons that helps regulate the level of glycine, an inhibitory neurotransmitter. It moves glycine from the synapse (the space between neurons) back into the neuron, effectively stopping its action. Dysfunction in this transporter can contribute to neurological disorders like schizophrenia and hyperekplexia.

neurotransmission

The process of nerve impulse transmission.

Scientific: BiotechnologyNeuroscience / Synaptic Function

Neurotransmission is the complex process by which nerve cells (neurons) communicate with each other. It involves the release of chemical messengers called neurotransmitters from one neuron across a tiny gap (synapse) to another neuron. These neurotransmitters bind to receptors on the receiving neuron, triggering a signal that can either excite or inhibit the neuron.

schizophrenia

A chronic mental disorder characterized by hallucinations, delusions, and disorganized thinking.

Medical: HealthcarePsychiatry / Neurological Disorders

Schizophrenia is a serious mental illness that affects how a person thinks, feels, and behaves. It can cause hallucinations (seeing or hearing things that aren't there), delusions (false beliefs), and disorganized thinking. People with schizophrenia may also have difficulty with social interactions, work, and daily tasks.

hyperekplexia

A rare genetic disorder characterized by exaggerated startle reflex.

Medical: HealthcareNeurology / Movement Disorders

Hyperekplexia is a rare neurological disorder that causes an overly sensitive startle reflex. Even minor stimuli, like touching or sudden noise, can trigger a strong and prolonged muscle spasm, often leading to falls. It's usually caused by mutations in genes involved in regulating nerve signals.

drugs

Substances used for medical treatment or recreational purposes.

Medical: PharmaceuticalPharmacology / Drug Development

Drugs are chemical substances that can alter bodily functions. They are used to treat a wide range of conditions, from infections and pain to mental health disorders. The development and testing of new drugs is a complex process involving extensive research and clinical trials.

targetting

The process of designing drugs to interact with specific biological molecules.

Technical: PharmaceuticalDrug Development / Pharmacodynamics

Targeting in drug development involves identifying specific proteins or enzymes that are involved in a disease pathway. Drugs are then designed to bind to these targets and modulate their activity. This can either block harmful processes or enhance beneficial ones.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,833,803	200,972	19.08	1 ^hrs 15 ^mins
2	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	3,137,262	186,413	16.83	1 ^hrs 26 ^mins
3	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,903,301	185,493	15.65	1 ^hrs 32 ^mins
4	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,764,405	181,161	15.26	1 ^hrs 34 ^mins
5	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,365,648	173,571	13.63	1 ^hrs 46 ^mins
6	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,099,671	166,856	12.58	1 ^hrs 54 ^mins
7	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,822,689	153,382	11.88	2 ^hrs 1 ^mins
8	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,782,773	157,583	11.31	2 ^hrs 7 ^mins
9	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,532,703	151,026	10.15	2 ^hrs 22 ^mins
10	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,117,572	135,115	8.27	2 ^hrs 54 ^mins
11	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,047,977	133,617	7.84	3 ^hrs 4 ^mins
12	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	1,027,088	131,501	7.81	3 ^hrs 4 ^mins
13	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,003,765	129,121	7.77	3 ^hrs 5 ^mins
14	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	962,747	115,039	8.37	2 ^hrs 52 ^mins
15	P104-100 GP104 [P104-100]	Nvidia	GP104	891,415	116,473	7.65	3 ^hrs 8 ^mins
16	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	798,280	119,670	6.67	3 ^hrs 36 ^mins
17	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	721,517	116,695	6.18	3 ^hrs 53 ^mins
18	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	701,961	113,037	6.21	3 ^hrs 52 ^mins
19	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	654,412	112,230	5.83	4 ^hrs 7 ^mins

20	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	583,624	109,035	5.35	4 ^hrs 29 ^mins
21	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	515,497	104,443	4.94	4 ^hrs 52 ^mins
22	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	493,355	95,156	5.18	4 ^hrs 38 ^mins
23	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	392,768	99,457	3.95	6 ^hrs 5 ^mins
24	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	312,651	88,385	3.54	6 ^hrs 47 ^mins
25	P106-090 GP106 [P106-090]	Nvidia	GP106	308,335	88,146	3.50	6 ^hrs 52 ^mins
26	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	213,047	78,120	2.73	8 ^hrs 48 ^mins
27	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	209,484	79,433	2.64	9 ^hrs 6 ^mins
28	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	184,323	74,617	2.47	9 ^hrs 43 ^mins
29	GeForce MX450 TU117M [GeForce MX450]	Nvidia	TU117M	141,725	66,057	2.15	11 ^hrs 11 ^mins
30	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	100,127	68,460	1.46	16 ^hrs 25 ^mins
31	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	33,346	48,787	0.68	35 ^hrs 7 ^mins
32	GeForce GTX 745 GM107 [GeForce GTX 745] 793	Nvidia	GM107	26,861	38,657	0.69	34 ^hrs 32 ^mins

Research: PARKINSONS Folding Project #19022

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 19022

GPU PPD Averages

Research: PARKINSONS Folding Project #19022

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages