PROJECT #18707 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

From https://www.tandfonline.com/doi/full/10.1080/1744666X.2022.2050596: "Dysregulation of JAK signaling is a feature of many diseases.

Targeting the JAK pathway started out as a therapeutic option in the field of myeloproliferative disorders.

The JAK2 Val617Phe mutation, which results in constitutive activation of the pathway, is found in over 50% of individuals with myelofibrosis and essential thrombocythaemia, and almost 100% of patients with polycythemia vera [5,6].

Ruxolitinib, a JAK1/JAK2 inhibitor, was the first JAK inhibitor approved for clinical use to treat myelofibrosis in 2011." Starting from an AlphaFold structure of the JAK2 mutant, In these projects were are generating data to aid virtual screening efforts for new (more selective) inhibitors, as well as conducting small molecule fragment screens to find potential starting points for design efforts (which are being shared with all of you in real time, and will be summarized regularly).

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 190,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 16 August 2022 22:52:18

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 6,914,385 681,588 10.14 2 hrs 22 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,485,863 661,230 9.81 2 hrs 27 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,349,301 652,112 9.74 2 hrs 28 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,553,803 632,524 8.78 3 hrs 44 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,099,372 613,773 8.31 3 hrs 53 mins
6 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,313,886 581,413 7.42 3 hrs 14 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,237,793 578,059 7.33 3 hrs 16 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,547,307 544,484 6.51 4 hrs 41 mins
9 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,193,160 524,243 6.09 4 hrs 56 mins
10 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,137,661 524,148 5.99 4 hrs 1 mins
11 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,092,363 520,988 5.94 4 hrs 3 mins
12 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 3,024,845 496,419 6.09 4 hrs 56 mins
13 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,639,605 494,687 5.34 4 hrs 30 mins
14 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,527,643 487,781 5.18 5 hrs 38 mins
15 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,091,123 457,409 4.57 5 hrs 15 mins
16 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,043,323 463,473 4.41 5 hrs 27 mins
17 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,781,782 381,337 4.67 5 hrs 8 mins
18 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,751,417 440,958 3.97 6 hrs 3 mins
19 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,730,081 428,642 4.04 6 hrs 57 mins
20 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,686,237 436,534 3.86 6 hrs 13 mins
21 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,475,235 396,653 3.72 6 hrs 27 mins
22 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,415,911 400,957 3.53 7 hrs 48 mins
23 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 951,638 351,097 2.71 9 hrs 51 mins
24 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 944,486 319,665 2.95 8 hrs 7 mins
25 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 916,969 373,185 2.46 10 hrs 46 mins
26 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 897,102 342,875 2.62 9 hrs 10 mins
27 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 860,298 341,331 2.52 10 hrs 31 mins
28 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 853,515 364,128 2.34 10 hrs 14 mins
29 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 851,715 338,256 2.52 10 hrs 32 mins
30 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 807,517 335,563 2.41 10 hrs 58 mins
31 Radeon Instinct MI25
Vega 10 [Radeon Instinct MI25]
AMD Vega 10 762,537 326,761 2.33 10 hrs 17 mins
32 Radeon RX 6700/6700 XT/6750 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT/6750 XT / 6800M]
AMD Navi 22 719,824 320,626 2.25 11 hrs 41 mins
33 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 660,129 311,024 2.12 11 hrs 18 mins
34 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 644,274 309,167 2.08 12 hrs 31 mins
35 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 635,746 307,708 2.07 12 hrs 37 mins
36 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 596,075 300,693 1.98 12 hrs 6 mins
37 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 418,477 262,121 1.60 15 hrs 2 mins
38 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 409,375 265,657 1.54 16 hrs 34 mins
39 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 403,959 267,299 1.51 16 hrs 53 mins
40 P106-090
GP106 [P106-090]
Nvidia GP106 379,186 258,223 1.47 16 hrs 21 mins
41 Radeon Pro WX 7100 Graphics
[Radeon Pro WX 7100 Graphics] 4150
AMD 348,207 276,699 1.26 19 hrs 4 mins
42 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 324,653 245,802 1.32 18 hrs 10 mins
43 FirePro Series
Tonga PRO GL [FirePro Series]
Tonga PRO GL 224,523 231,460 0.97 25 hrs 44 mins
44 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 129,025 179,273 0.72 33 hrs 21 mins
45 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 97,141 176,778 0.55 44 hrs 41 mins
46 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 94,667 175,000 0.54 44 hrs 22 mins
47 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 85,010 175,000 0.49 49 hrs 24 mins
48 Quadro P400
GP107GL [Quadro P400]
Nvidia GP107GL 65,038 175,000 0.37 65 hrs 35 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Tuesday, 16 August 2022 22:52:18

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make