PROJECT #18707 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

From https://www.tandfonline.com/doi/full/10.1080/1744666X.2022.2050596: "Dysregulation of JAK signaling is a feature of many diseases.

Targeting the JAK pathway started out as a therapeutic option in the field of myeloproliferative disorders.

The JAK2 Val617Phe mutation, which results in constitutive activation of the pathway, is found in over 50% of individuals with myelofibrosis and essential thrombocythaemia, and almost 100% of patients with polycythemia vera [5,6].

Ruxolitinib, a JAK1/JAK2 inhibitor, was the first JAK inhibitor approved for clinical use to treat myelofibrosis in 2011." Starting from an AlphaFold structure of the JAK2 mutant, In these projects were are generating data to aid virtual screening efforts for new (more selective) inhibitors, as well as conducting small molecule fragment screens to find potential starting points for design efforts (which are being shared with all of you in real time, and will be summarized regularly).

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 190,000

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 30 November 2022 06:13:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 13,045,142 835,033 15.62 2 hrs 32 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 7,163,803 688,440 10.41 2 hrs 18 mins
3 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,306,204 651,662 9.68 2 hrs 29 mins
4 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 6,087,007 634,448 9.59 3 hrs 30 mins
5 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,857,059 640,428 9.15 3 hrs 37 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,269,578 618,934 8.51 3 hrs 49 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,168,990 616,028 8.39 3 hrs 52 mins
8 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,294,578 579,962 7.40 3 hrs 14 mins
9 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,091,574 571,340 7.16 3 hrs 21 mins
10 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 3,637,084 533,448 6.82 4 hrs 31 mins
11 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,604,671 547,664 6.58 4 hrs 39 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,193,077 527,262 6.06 4 hrs 58 mins
13 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,136,957 520,673 6.02 4 hrs 59 mins
14 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,910,743 509,724 5.71 4 hrs 12 mins
15 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,626,049 492,744 5.33 5 hrs 30 mins
16 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 2,472,432 483,981 5.11 5 hrs 42 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,428,347 484,253 5.01 5 hrs 47 mins
18 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,231,754 478,642 4.66 5 hrs 9 mins
19 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,231,745 465,343 4.80 5 hrs 0 mins
20 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,169,663 440,552 4.92 5 hrs 52 mins
21 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 2,123,990 442,052 4.80 5 hrs 60 mins
22 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,091,123 457,409 4.57 5 hrs 15 mins
23 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 1,954,811 438,089 4.46 5 hrs 23 mins
24 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,843,438 445,726 4.14 6 hrs 48 mins
25 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,781,782 381,337 4.67 5 hrs 8 mins
26 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 1,729,766 417,250 4.15 6 hrs 47 mins
27 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,689,952 449,737 3.76 6 hrs 23 mins
28 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,676,852 424,007 3.95 6 hrs 4 mins
29 Radeon RX 6650 XT
Navi 23 [Radeon RX 6650 XT]
AMD Navi 23 1,662,963 416,807 3.99 6 hrs 1 mins
30 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,544,924 414,523 3.73 6 hrs 26 mins
31 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,439,235 407,537 3.53 7 hrs 48 mins
32 Radeon PRO W6600
Navi 23 WKS-XL [Radeon PRO W6600]
AMD Navi 23 WKS-XL 1,372,156 390,838 3.51 7 hrs 50 mins
33 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 1,250,291 373,406 3.35 7 hrs 10 mins
34 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,206,380 370,044 3.26 7 hrs 22 mins
35 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,183,192 344,644 3.43 7 hrs 59 mins
36 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,171,374 383,160 3.06 8 hrs 51 mins
37 Radeon RX 6700/6700 XT/6750 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT/6750 XT / 6800M]
AMD Navi 22 1,133,698 357,056 3.18 8 hrs 34 mins
38 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,118,046 361,120 3.10 8 hrs 45 mins
39 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 996,006 360,139 2.77 9 hrs 41 mins
40 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 986,386 359,172 2.75 9 hrs 44 mins
41 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 963,651 353,047 2.73 9 hrs 48 mins
42 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 941,407 350,028 2.69 9 hrs 55 mins
43 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 933,609 347,061 2.69 9 hrs 55 mins
44 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 887,307 363,656 2.44 10 hrs 50 mins
45 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 876,231 380,865 2.30 10 hrs 26 mins
46 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 860,732 359,833 2.39 10 hrs 2 mins
47 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 852,203 364,233 2.34 10 hrs 15 mins
48 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 842,436 344,014 2.45 10 hrs 48 mins
49 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 832,850 340,978 2.44 10 hrs 50 mins
50 Radeon Instinct MI25
Vega 10 [Radeon Instinct MI25]
AMD Vega 10 762,537 326,761 2.33 10 hrs 17 mins
51 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 683,355 313,611 2.18 11 hrs 1 mins
52 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 656,996 310,864 2.11 11 hrs 21 mins
53 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 644,274 309,167 2.08 12 hrs 31 mins
54 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 607,889 309,389 1.96 12 hrs 13 mins
55 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 597,710 299,984 1.99 12 hrs 3 mins
56 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 548,431 288,651 1.90 13 hrs 38 mins
57 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 502,659 270,886 1.86 13 hrs 56 mins
58 P106-100
GP106 [P106-100]
Nvidia GP106 490,968 296,543 1.66 14 hrs 30 mins
59 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 445,719 285,255 1.56 15 hrs 22 mins
60 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 389,369 266,854 1.46 16 hrs 27 mins
61 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 377,439 264,057 1.43 17 hrs 47 mins
62 Radeon Pro WX 7100 Graphics
[Radeon Pro WX 7100 Graphics] 4150
AMD 348,207 276,699 1.26 19 hrs 4 mins
63 P106-090
GP106 [P106-090]
Nvidia GP106 338,458 249,035 1.36 18 hrs 40 mins
64 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 331,212 252,550 1.31 18 hrs 18 mins
65 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 325,153 246,016 1.32 18 hrs 10 mins
66 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 256,178 225,539 1.14 21 hrs 8 mins
67 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 241,321 222,957 1.08 22 hrs 10 mins
68 FirePro Series
Tonga PRO GL [FirePro Series]
AMD Tonga PRO GL 224,523 231,460 0.97 25 hrs 44 mins
69 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 218,607 213,070 1.03 23 hrs 24 mins
70 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 192,441 192,444 1.00 24 hrs 0 mins
71 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 132,125 175,000 0.76 32 hrs 47 mins
72 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 129,025 179,273 0.72 33 hrs 21 mins
73 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 118,727 175,000 0.68 35 hrs 23 mins
74 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 101,278 175,000 0.58 41 hrs 28 mins
75 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 97,356 175,000 0.56 43 hrs 8 mins
76 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 94,667 175,000 0.54 44 hrs 22 mins
77 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 83,820 175,000 0.48 50 hrs 6 mins
78 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 69,490 175,869 0.40 61 hrs 44 mins
79 Quadro P400
GP107GL [Quadro P400]
Nvidia GP107GL 65,038 175,000 0.37 65 hrs 35 mins
80 Radeon WX 3100
[Radeon WX 3100]
AMD 62,729 175,000 0.36 67 hrs 57 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 30 November 2022 06:13:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make