PROJECT #18109 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Here we are testing what has long been the dream on F@h --- adaptive sampling algorithms guided by experimental data.

The system used is caspase-7, one of a family of important mediators of apoptosis, and hence of interest for cancer drug design.

We have collected experimental hydrogen-deuterium exchange (HDX) data (which informs on the extent of fluctuations of each region of the protein) in both apo (just protein) and holo (protein with another peptide bound) states, and are exploring adaptive sampling algorithms to reproduce the HDX data in each state separately, as well as the differences ('shielding') between them.

All data is being made publicly available at https://console.cloud.google.com/storage/browser/stxfah-bucket, and insight into the algorithmic methodology will be published. This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 86,257

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 01 December 2022 06:13:25

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,248,477 536,979 11.64 2 hrs 4 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,847,755 523,591 11.17 2 hrs 9 mins
3 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 4,998,793 493,170 10.14 2 hrs 22 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,917,096 497,557 9.88 2 hrs 26 mins
5 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,653,897 488,536 9.53 3 hrs 31 mins
6 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,966,229 461,980 8.59 3 hrs 48 mins
7 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,907,029 461,067 8.47 3 hrs 50 mins
8 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,069,490 422,400 7.27 3 hrs 18 mins
9 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,990,636 427,146 7.00 3 hrs 26 mins
10 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 2,917,808 415,472 7.02 3 hrs 25 mins
11 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,482,111 384,195 6.46 4 hrs 43 mins
12 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,469,633 395,624 6.24 4 hrs 51 mins
13 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,433,857 394,035 6.18 4 hrs 53 mins
14 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,427,985 382,240 6.35 4 hrs 47 mins
15 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,261,053 384,684 5.88 4 hrs 5 mins
16 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 2,045,988 371,742 5.50 4 hrs 22 mins
17 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 1,986,506 367,560 5.40 4 hrs 26 mins
18 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,957,058 366,222 5.34 4 hrs 29 mins
19 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,824,020 357,289 5.11 5 hrs 42 mins
20 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,811,256 357,076 5.07 5 hrs 44 mins
21 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,773,366 354,686 5.00 5 hrs 48 mins
22 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,757,467 353,330 4.97 5 hrs 50 mins
23 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 1,745,547 351,061 4.97 5 hrs 50 mins
24 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,728,516 350,164 4.94 5 hrs 52 mins
25 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,708,788 308,988 5.53 4 hrs 20 mins
26 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,464,323 331,611 4.42 5 hrs 26 mins
27 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,248,629 315,701 3.96 6 hrs 4 mins
28 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,202,708 311,266 3.86 6 hrs 13 mins
29 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,141,897 299,822 3.81 6 hrs 18 mins
30 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,130,039 302,142 3.74 6 hrs 25 mins
31 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 902,236 283,149 3.19 8 hrs 32 mins
32 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 775,595 269,028 2.88 8 hrs 19 mins
33 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 722,052 265,230 2.72 9 hrs 49 mins
34 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 656,263 254,714 2.58 9 hrs 19 mins
35 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 627,097 251,489 2.49 10 hrs 37 mins
36 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 476,592 226,607 2.10 11 hrs 25 mins
37 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 472,721 226,986 2.08 12 hrs 31 mins
38 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 317,205 201,624 1.57 15 hrs 15 mins
39 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 214,728 175,140 1.23 20 hrs 35 mins
40 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 118,077 130,000 0.91 26 hrs 25 mins
41 Radeon WX 3100
[Radeon WX 3100]
AMD 89,956 130,000 0.69 35 hrs 41 mins
42 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 48,622 130,000 0.37 64 hrs 10 mins
43 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 18,395 130,000 0.14 170 hrs 37 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 01 December 2022 06:13:25

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make