PROJECT #18109 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Here we are testing what has long been the dream on F@h --- adaptive sampling algorithms guided by experimental data. The system used is caspase-7, one of a family of important mediators of apoptosis, and hence of interest for cancer drug design. We have collected experimental hydrogen-deuterium exchange (HDX) data (which informs on the extent of fluctuations of each region of the protein) in both apo (just protein) and holo (protein with another peptide bound) states, and are exploring adaptive sampling algorithms to reproduce the HDX data in each state separately, as well as the differences ('shielding') between them. All data is being made publicly available at https://console.cloud.google.com/storage/browser/stxfah-bucket, and insight into the algorithmic methodology will be published.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ 

All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 86,257

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 September 2021 17:59:03

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,245,229 537,139 11.63 2 hrs 4 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,901,334 525,684 11.23 2 hrs 8 mins
3 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,041,841 493,966 10.21 2 hrs 21 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,898,025 497,129 9.85 2 hrs 26 mins
5 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,043,341 465,083 8.69 3 hrs 46 mins
6 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,876,567 459,826 8.43 3 hrs 51 mins
7 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 3,325,413 434,421 7.65 3 hrs 8 mins
8 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,018,650 419,542 7.20 3 hrs 20 mins
9 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,986,055 426,938 6.99 3 hrs 26 mins
10 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,594,924 403,116 6.44 4 hrs 44 mins
11 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,421,796 393,427 6.16 4 hrs 54 mins
12 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,334,081 388,573 6.01 4 hrs 60 mins
13 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,279,464 385,345 5.92 4 hrs 3 mins
14 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,269,671 385,167 5.89 4 hrs 4 mins
15 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 2,045,988 371,742 5.50 4 hrs 22 mins
16 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 1,986,506 367,560 5.40 4 hrs 26 mins
17 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,957,058 366,222 5.34 4 hrs 29 mins
18 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,826,594 357,423 5.11 5 hrs 42 mins
19 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,811,256 357,076 5.07 5 hrs 44 mins
20 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,773,366 354,686 5.00 5 hrs 48 mins
21 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 1,745,547 351,061 4.97 5 hrs 50 mins
22 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,728,516 350,164 4.94 5 hrs 52 mins
23 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,728,223 351,150 4.92 5 hrs 53 mins
24 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,708,788 308,988 5.53 4 hrs 20 mins
25 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,462,052 331,386 4.41 5 hrs 26 mins
26 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,248,629 315,701 3.96 6 hrs 4 mins
27 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,207,877 311,170 3.88 6 hrs 11 mins
28 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,136,387 302,488 3.76 6 hrs 23 mins
29 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,130,231 298,140 3.79 6 hrs 20 mins
30 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 902,236 283,149 3.19 8 hrs 32 mins
31 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 775,595 269,028 2.88 8 hrs 19 mins
32 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 656,263 254,714 2.58 9 hrs 19 mins
33 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 627,097 251,489 2.49 10 hrs 37 mins
34 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 476,592 226,607 2.10 11 hrs 25 mins
35 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 475,074 227,919 2.08 12 hrs 31 mins
36 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 320,938 201,952 1.59 15 hrs 6 mins
37 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 206,215 173,402 1.19 20 hrs 11 mins
38 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 118,077 130,000 0.91 26 hrs 25 mins
39 Radeon WX 3100
[Radeon WX 3100]
AMD 89,956 130,000 0.69 35 hrs 41 mins
40 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 48,622 130,000 0.37 64 hrs 10 mins
41 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 18,395 130,000 0.14 170 hrs 37 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 September 2021 17:59:03

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make