PROJECT #18019 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

In this system we are simulating an E3 ligase (specifically, culling-ring-VHL) in presence of another protein called NEDD8.

Culling ring is normally in inactive form, but NEDD8 can activate it.

Using these simulations we are trying to understand how protein-protein interactions help induce conformational changes that enable activation of cullin ring.

Understanding this process help us better understand how cullin-ring based E3 ligases transfer ubiquitin to proteins which results in their subsequent degradation by the proteasome system. This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 498,112

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 30 June 2022 00:49:56

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,675,385 794,999 10.91 2 hrs 12 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,840,698 757,766 10.35 2 hrs 19 mins
3 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,818,385 735,160 9.27 3 hrs 35 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,649,956 729,414 9.12 3 hrs 38 mins
5 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,266,434 677,588 7.77 3 hrs 5 mins
6 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,062,167 668,876 7.57 3 hrs 10 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,805,870 655,215 7.33 3 hrs 16 mins
8 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,990,832 619,051 6.45 4 hrs 43 mins
9 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 3,288,757 578,961 5.68 4 hrs 14 mins
10 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,206,923 574,557 5.58 4 hrs 18 mins
11 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 3,061,266 566,276 5.41 4 hrs 26 mins
12 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,044,617 564,538 5.39 4 hrs 27 mins
13 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,723,151 539,713 5.05 5 hrs 45 mins
14 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,713,814 544,298 4.99 5 hrs 49 mins
15 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,458,188 523,657 4.69 5 hrs 7 mins
16 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,428,905 522,728 4.65 5 hrs 10 mins
17 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 2,381,193 455,384 5.23 5 hrs 35 mins
18 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,345,630 517,417 4.53 5 hrs 18 mins
19 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,320,107 515,615 4.50 5 hrs 20 mins
20 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,196,861 507,377 4.33 6 hrs 33 mins
21 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,835,008 478,627 3.83 6 hrs 16 mins
22 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,830,669 469,395 3.90 6 hrs 9 mins
23 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,815,081 475,111 3.82 6 hrs 17 mins
24 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,789,184 473,593 3.78 6 hrs 21 mins
25 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,643,538 460,263 3.57 7 hrs 43 mins
26 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,578,554 454,920 3.47 7 hrs 55 mins
27 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,493,255 446,371 3.35 7 hrs 10 mins
28 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,459,626 442,304 3.30 7 hrs 16 mins
29 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,440,759 441,026 3.27 7 hrs 21 mins
30 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,371,560 430,373 3.19 8 hrs 32 mins
31 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 1,293,753 425,420 3.04 8 hrs 54 mins
32 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,259,969 421,500 2.99 8 hrs 2 mins
33 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,235,649 402,192 3.07 8 hrs 49 mins
34 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,233,446 413,095 2.99 8 hrs 2 mins
35 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 955,402 383,450 2.49 10 hrs 38 mins
36 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 793,949 358,975 2.21 11 hrs 51 mins
37 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 750,901 354,044 2.12 11 hrs 19 mins
38 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 674,530 342,474 1.97 12 hrs 11 mins
39 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 646,427 338,177 1.91 13 hrs 33 mins
40 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 519,572 314,367 1.65 15 hrs 31 mins
41 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 499,769 303,672 1.65 15 hrs 35 mins
42 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 355,615 276,904 1.28 19 hrs 41 mins
43 P106-090
GP106 [P106-090]
Nvidia GP106 352,895 276,036 1.28 19 hrs 46 mins
44 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 352,813 276,313 1.28 19 hrs 48 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 30 June 2022 00:49:56

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make