PROJECT #18019 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
In this system we are simulating an E3 ligase (specifically, culling-ring-VHL) in presence of another protein called NEDD8.
Culling ring is normally in inactive form, but NEDD8 can activate it.
Using these simulations we are trying to understand how protein-protein interactions help induce conformational changes that enable activation of cullin ring.
Understanding this process help us better understand how cullin-ring based E3 ligases transfer ubiquitin to proteins which results in their subsequent degradation by the proteasome system. This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.
PROJECT INFO
Manager(s): Rafal Wiewiora
Institution: Roivant Sciences (Silicon Therapeutics)
Project URL: roivant.com
PROJECT WORK UNIT SUMMARY
Atoms: 498,112
Core: OPENMM_22
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Saturday, 01 April 2023 12:14:47
|
Rank Project |
Model Name Folding@Home Identifier |
Make Brand |
GPU Model |
PPD Average |
Points WU Average |
WUs Day Average |
WU Time Average |
|---|---|---|---|---|---|---|---|
| 1 | GeForce RTX 3090 GA102 [GeForce RTX 3090] |
Nvidia | GA102 | 8,675,385 | 794,999 | 10.91 | 2 hrs 12 mins |
| 2 | GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti] |
Nvidia | GA102 | 7,840,698 | 757,766 | 10.35 | 2 hrs 19 mins |
| 3 | GeForce RTX 3080 GA102 [GeForce RTX 3080] |
Nvidia | GA102 | 6,818,385 | 735,160 | 9.27 | 3 hrs 35 mins |
| 4 | GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate] |
Nvidia | GA102 | 6,649,956 | 729,414 | 9.12 | 3 hrs 38 mins |
| 5 | GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti] |
Nvidia | GA104 | 5,266,434 | 677,588 | 7.77 | 3 hrs 5 mins |
| 6 | GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448 |
Nvidia | TU102 | 5,062,167 | 668,876 | 7.57 | 3 hrs 10 mins |
| 7 | GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 |
Nvidia | TU102 | 4,805,870 | 655,215 | 7.33 | 3 hrs 16 mins |
| 8 | GeForce RTX 3070 GA104 [GeForce RTX 3070] |
Nvidia | GA104 | 3,990,832 | 619,051 | 6.45 | 4 hrs 43 mins |
| 9 | Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT] |
AMD | Navi 21 | 3,288,757 | 578,961 | 5.68 | 4 hrs 14 mins |
| 10 | GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068 |
Nvidia | TU104 | 3,206,923 | 574,557 | 5.58 | 4 hrs 18 mins |
| 11 | TITAN Xp GP102 [TITAN Xp] 12150 |
Nvidia | GP102 | 3,061,266 | 566,276 | 5.41 | 4 hrs 26 mins |
| 12 | GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER] |
Nvidia | TU104 | 3,044,617 | 564,538 | 5.39 | 4 hrs 27 mins |
| 13 | GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218 |
Nvidia | TU104 | 2,723,151 | 539,713 | 5.05 | 5 hrs 45 mins |
| 14 | GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465 |
Nvidia | TU106 | 2,713,814 | 544,298 | 4.99 | 5 hrs 49 mins |
| 15 | GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380 |
Nvidia | GP102 | 2,458,188 | 523,657 | 4.69 | 5 hrs 7 mins |
| 16 | GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER] |
Nvidia | TU106 | 2,428,905 | 522,728 | 4.65 | 5 hrs 10 mins |
| 17 | Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT] |
AMD | Navi 21 | 2,381,193 | 455,384 | 5.23 | 5 hrs 35 mins |
| 18 | GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate] |
Nvidia | GA106 | 2,345,630 | 517,417 | 4.53 | 5 hrs 18 mins |
| 19 | TITAN X GP102 [TITAN X] 6144 |
Nvidia | GP102 | 2,320,107 | 515,615 | 4.50 | 5 hrs 20 mins |
| 20 | GeForce RTX 3070 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB] |
Nvidia | GA104M | 2,196,861 | 507,377 | 4.33 | 6 hrs 33 mins |
| 21 | GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q] |
Nvidia | GA106M | 1,835,008 | 478,627 | 3.83 | 6 hrs 16 mins |
| 22 | GeForce RTX 2060 TU106 [Geforce RTX 2060] |
Nvidia | TU106 | 1,830,669 | 469,395 | 3.90 | 6 hrs 9 mins |
| 23 | GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497 |
Nvidia | TU106 | 1,815,081 | 475,111 | 3.82 | 6 hrs 17 mins |
| 24 | Tesla P40 GP102GL [Tesla P40] 11760 |
Nvidia | GP102GL | 1,789,184 | 473,593 | 3.78 | 6 hrs 21 mins |
| 25 | GeForce RTX 2060 TU104 [GeForce RTX 2060] |
Nvidia | TU104 | 1,643,538 | 460,263 | 3.57 | 7 hrs 43 mins |
| 26 | GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632 |
Nvidia | GM200 | 1,578,554 | 454,920 | 3.47 | 7 hrs 55 mins |
| 27 | GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186 |
Nvidia | GP104 | 1,493,255 | 446,371 | 3.35 | 7 hrs 10 mins |
| 28 | Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT] |
AMD | Navi 10 | 1,459,626 | 442,304 | 3.30 | 7 hrs 16 mins |
| 29 | GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463 |
Nvidia | GP104 | 1,440,759 | 441,026 | 3.27 | 7 hrs 21 mins |
| 30 | GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873 |
Nvidia | GP104 | 1,371,560 | 430,373 | 3.19 | 8 hrs 32 mins |
| 31 | GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550 |
Nvidia | TU106M | 1,293,753 | 425,420 | 3.04 | 8 hrs 54 mins |
| 32 | GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti] |
Nvidia | TU116 | 1,259,969 | 421,500 | 2.99 | 8 hrs 2 mins |
| 33 | GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] |
Nvidia | TU106M | 1,235,649 | 402,192 | 3.07 | 8 hrs 49 mins |
| 34 | GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER] |
Nvidia | TU116 | 1,233,446 | 413,095 | 2.99 | 8 hrs 2 mins |
| 35 | GeForce GTX 1660 TU116 [GeForce GTX 1660] |
Nvidia | TU116 | 955,402 | 383,450 | 2.49 | 10 hrs 38 mins |
| 36 | GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935 |
Nvidia | GP106 | 793,949 | 358,975 | 2.21 | 11 hrs 51 mins |
| 37 | GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372 |
Nvidia | GP106 | 750,901 | 354,044 | 2.12 | 11 hrs 19 mins |
| 38 | GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER] |
Nvidia | TU116 | 674,530 | 342,474 | 1.97 | 12 hrs 11 mins |
| 39 | GeForce GTX 1650 TU117 [GeForce GTX 1650] 3091 |
Nvidia | TU117 | 646,427 | 338,177 | 1.91 | 13 hrs 33 mins |
| 40 | Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q] |
Nvidia | TU117GLM | 519,572 | 314,367 | 1.65 | 15 hrs 31 mins |
| 41 | GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984 |
Nvidia | TU116 | 499,769 | 303,672 | 1.65 | 15 hrs 35 mins |
| 42 | GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q] |
Nvidia | TU117M | 355,615 | 276,904 | 1.28 | 19 hrs 41 mins |
| 43 | P106-090 GP106 [P106-090] |
Nvidia | GP106 | 352,895 | 276,036 | 1.28 | 19 hrs 46 mins |
| 44 | GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862 |
Nvidia | GP107 | 352,813 | 276,313 | 1.28 | 19 hrs 48 mins |
PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Saturday, 01 April 2023 12:14:47
|
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
|---|