Folding project #17922, MALARIA research

Research section Research projects and references

Project #17922 overview

Project Summary AI Beta

This project studies PfHT1, a sugar transporter in malaria parasites. By understanding how PfHT1 works, we hope to develop new ways to deliver anti-malarial drugs directly to the parasite.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Arnav Paul
Institution: University of Illinois

Work unit

Atoms: 103,824
Core: 0x22
Status: Public

No related projects listed.

Source material

Official Project Description

Malarial parasite transporter PfHT1 - Plasmodium falciparum hexose transporter is a sugar transporter found in the malarial parasite, which transports glucose and fructose across the membrane.

In this project we aim to understand the substrate specificity mechanism of the transporter and to obtain a possible pathway of targetted delivery of anti-malarial drugs.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Malarial parasite

A parasite that causes malaria.

Technical: HealthcareMedicine / Parasitology

Malarial parasites are single-celled organisms belonging to the Plasmodium genus. They infect red blood cells and cause the disease malaria, characterized by fever, chills, and other symptoms. Transmission occurs through the bite of infected mosquitoes.

transporter

A protein that moves substances across a cell membrane.

Scientific: HealthcareMedicine / Biochemistry

Transporters are essential proteins embedded in cell membranes. They facilitate the movement of molecules, such as nutrients, ions, and waste products, across the membrane. This process is crucial for various cellular functions, including nutrient uptake, waste removal, and signal transduction.

PfHT1

Plasmodium falciparum hexose transporter 1

Acronym: PharmaceuticalMedicine / Biotechnology

PfHT1 is a specific type of sugar transporter found in the malaria parasite Plasmodium falciparum. It plays a vital role in the parasite's ability to acquire glucose and fructose from its host's blood, providing essential energy for its survival and growth.

Plasmodium falciparum

The most dangerous species of malaria parasite.

Scientific: HealthcareMedicine / Parasitology

Plasmodium falciparum is a parasitic protozoan that causes the most severe form of malaria. It infects red blood cells and can lead to complications such as cerebral malaria, anemia, and organ failure. This species has developed resistance to many antimalarial drugs, making treatment challenging.

hexose transporter

A protein that transports hexoses (sugars like glucose and fructose).

Scientific: PharmaceuticalMedicine / Biochemistry

Hexose transporters are a class of membrane proteins responsible for transporting hexose sugars across cell membranes. These molecules play a crucial role in various metabolic processes, including energy production, biosynthesis, and nutrient uptake.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,931,543	204,194	43.74	0 ^hrs 33 ^mins
2	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	8,661,829	25,840	335.21	0 ^hrs 4 ^mins
3	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,616,980	201,995	42.66	0 ^hrs 34 ^mins
4	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,622,480	175,190	32.09	0 ^hrs 45 ^mins
5	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,559,025	170,287	32.65	0 ^hrs 44 ^mins
6	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,167,815	170,256	30.35	0 ^hrs 47 ^mins
7	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,132,579	170,861	30.04	0 ^hrs 48 ^mins
8	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,062,895	169,058	29.95	0 ^hrs 48 ^mins
9	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	4,332,578	161,140	26.89	0 ^hrs 54 ^mins
10	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,958,331	156,531	25.29	0 ^hrs 57 ^mins
11	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,653,025	152,350	23.98	1 ^hrs 0 ^mins
12	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,139,562	25,840	121.50	0 ^hrs 12 ^mins
13	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,892,815	140,583	20.58	1 ^hrs 10 ^mins
14	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,871,272	140,274	20.47	1 ^hrs 10 ^mins
15	GeForce RTX 4050 Max-Q / Mobile AD107M [GeForce RTX 4050 Max-Q / Mobile]	Nvidia	AD107M	2,693,699	138,605	19.43	1 ^hrs 14 ^mins
16	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,569,528	133,905	19.19	1 ^hrs 15 ^mins
17	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,560,451	127,424	20.09	1 ^hrs 12 ^mins
18	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,537,980	134,735	18.84	1 ^hrs 16 ^mins
19	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,501,246	133,460	18.74	1 ^hrs 17 ^mins

20	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,361,457	132,885	17.77	1 ^hrs 21 ^mins
21	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,142,750	127,472	16.81	1 ^hrs 26 ^mins
22	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,140,981	128,008	16.73	1 ^hrs 26 ^mins
23	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,044,964	119,116	17.17	1 ^hrs 24 ^mins
24	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	2,026,873	126,567	16.01	1 ^hrs 30 ^mins
25	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,998,729	124,976	15.99	1 ^hrs 30 ^mins
26	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	1,939,424	119,445	16.24	1 ^hrs 29 ^mins
27	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,934,050	119,377	16.20	1 ^hrs 29 ^mins
28	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,933,529	123,817	15.62	1 ^hrs 32 ^mins
29	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,914,232	123,122	15.55	1 ^hrs 33 ^mins
30	P102-100 GP102 [P102-100]	Nvidia	GP102	1,654,000	113,092	14.63	1 ^hrs 38 ^mins
31	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,531,273	114,170	13.41	1 ^hrs 47 ^mins
32	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,521,719	100,633	15.12	1 ^hrs 35 ^mins
33	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,397,049	108,374	12.89	1 ^hrs 52 ^mins
34	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	1,261,268	107,078	11.78	2 ^hrs 2 ^mins
35	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,202,771	105,832	11.36	2 ^hrs 7 ^mins
36	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,194,769	76,957	15.53	1 ^hrs 33 ^mins
37	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,189,520	81,056	14.68	1 ^hrs 38 ^mins
38	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,163,739	104,101	11.18	2 ^hrs 9 ^mins
39	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,156,926	103,376	11.19	2 ^hrs 9 ^mins

40	P104-100 GP104 [P104-100]	Nvidia	GP104	1,049,038	101,479	10.34	2 ^hrs 19 ^mins
41	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	989,253	99,570	9.94	2 ^hrs 25 ^mins
42	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	890,035	95,605	9.31	2 ^hrs 35 ^mins
43	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	881,196	94,850	9.29	2 ^hrs 35 ^mins
44	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	873,412	94,326	9.26	2 ^hrs 36 ^mins
45	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	756,116	91,219	8.29	2 ^hrs 54 ^mins
46	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	731,975	89,750	8.16	2 ^hrs 57 ^mins
47	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	720,347	73,959	9.74	2 ^hrs 28 ^mins
48	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	675,152	86,156	7.84	3 ^hrs 4 ^mins
49	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	627,809	83,966	7.48	3 ^hrs 13 ^mins
50	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	619,551	81,677	7.59	3 ^hrs 10 ^mins
51	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	616,723	84,255	7.32	3 ^hrs 17 ^mins
52	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	597,158	84,040	7.11	3 ^hrs 23 ^mins
53	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	504,498	79,751	6.33	3 ^hrs 48 ^mins
54	GeForce GTX Titan Z GK110 [GeForce GTX Titan Z] 8122	Nvidia	GK110	499,788	80,074	6.24	3 ^hrs 51 ^mins
55	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	494,688	76,855	6.44	3 ^hrs 44 ^mins
56	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	494,535	78,844	6.27	3 ^hrs 50 ^mins
57	P106-090 GP106 [P106-090]	Nvidia	GP106	337,822	69,289	4.88	4 ^hrs 55 ^mins
58	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	331,840	70,112	4.73	5 ^hrs 4 ^mins
59	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	324,004	69,063	4.69	5 ^hrs 7 ^mins

60	GeForce GTX 1050 3 GB Max-Q GP107M [GeForce GTX 1050 3 GB Max-Q]	Nvidia	GP107M	304,217	67,166	4.53	5 ^hrs 18 ^mins
61	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	259,200	25,840	10.03	2 ^hrs 24 ^mins
62	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	253,400	63,015	4.02	5 ^hrs 58 ^mins
63	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	192,835	58,031	3.32	7 ^hrs 13 ^mins
64	Quadro M2000 GM206GL [Quadro M2000]	Nvidia	GM206GL	190,661	57,634	3.31	7 ^hrs 15 ^mins
65	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	152,579	53,210	2.87	8 ^hrs 22 ^mins
66	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	150,842	53,915	2.80	8 ^hrs 35 ^mins
67	Ryzen 7000 Series iGPU Raphael [Ryzen 7000 Series iGPU]	AMD	Raphael	127,677	35,251	3.62	6 ^hrs 38 ^mins
68	R9 280X/HD 7900/8970 OEM Tahiti XT [R9 280X/HD 7900/8970 OEM]	AMD	Tahiti XT	110,272	53,161	2.07	11 ^hrs 34 ^mins
69	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	105,683	51,488	2.05	11 ^hrs 42 ^mins
70	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	93,984	45,394	2.07	11 ^hrs 36 ^mins
71	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	90,628	44,832	2.02	11 ^hrs 52 ^mins
72	Radeon 660M-680M Rembrandt [Radeon 660M-680M]	AMD	Rembrandt	81,936	29,412	2.79	8 ^hrs 37 ^mins
73	Quadro P600 GP107GL [Quadro P600]	Nvidia	GP107GL	79,358	48,715	1.63	14 ^hrs 44 ^mins
74	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	57,572	38,488	1.50	16 ^hrs 3 ^mins
75	HD 7850/R7 265/R9 270 1024SP Pitcairn PRO [HD 7850/R7 265/R9 270 1024SP]	AMD	Pitcairn PRO	52,324	33,919	1.54	15 ^hrs 33 ^mins
76	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	47,949	32,205	1.49	16 ^hrs 7 ^mins
77	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	34,469	38,279	0.90	26 ^hrs 39 ^mins
78	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	16,218	25,840	0.63	38 ^hrs 14 ^mins
79	R7 240/340/520/HD8570 Hawaii [R7 240/340/520/HD8570]	AMD	Hawaii	8,675	25,840	0.34	71 ^hrs 29 ^mins

80	Radeon R7/R6/R5 Series Carrizo [Radeon R7/R6/R5 Series]	AMD	Carrizo	7,794	25,840	0.30	79 ^hrs 34 ^mins

Research: MALARIA Folding Project #17922

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17922

GPU PPD Averages

Research: MALARIA Folding Project #17922

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages