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Research: CANCER Folding Project #15201

Project #15201 overview

Project Summary AI Beta

This project studies how PTCH1, a protein that controls cell growth, moves cholesterol around. When PTCH1 doesn't work right, it can lead to cancers like medulloblastoma and basal cell carcinoma. Understanding how PTCH1 works could help develop new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
366,069
Core
0x24
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15201

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Friday, 14 August 2026 15:39:22

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 36,468,043 120,000 303.90 0 hrs 5 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 24,338,050 663,673 36.67 0 hrs 39 mins
3 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 20,123,316 125,044 160.93 0 hrs 9 mins
4 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 17,790,748 265,554 66.99 0 hrs 21 mins
5 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 16,582,211 146,628 113.09 0 hrs 13 mins
6 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 13,438,108 357,082 37.63 0 hrs 38 mins
7 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 12,213,255 863,567 14.14 1 hrs 42 mins
8 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 10,926,444 835,392 13.08 1 hrs 50 mins
9 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 10,805,756 161,778 66.79 0 hrs 22 mins
10 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 10,117,943 120,000 84.32 0 hrs 17 mins
11 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]		 Nvidia GA102 10,040,362 637,175 15.76 1 hrs 31 mins
12 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 8,159,060 351,078 23.24 1 hrs 2 mins
13 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 6,829,582 713,456 9.57 2 hrs 30 mins
14 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]		 Nvidia GA104 6,757,722 120,000 56.31 0 hrs 26 mins
15 GeForce RTX 4060 Ti
AD106 [GeForce RTX 4060 Ti]		 Nvidia AD106 6,613,075 995,484 6.64 3 hrs 37 mins
16 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 6,173,596 120,000 51.45 0 hrs 28 mins
17 GeForce RTX 4080 Max-Q / Mobile
AD104M [GeForce RTX 4080 Max-Q / Mobile]		 Nvidia AD104M 5,442,035 685,947 7.93 3 hrs 2 mins
18 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 3,466,385 355,611 9.75 2 hrs 28 mins
19 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]		 Nvidia GA104 3,434,157 120,000 28.62 0 hrs 50 mins
20 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218		 Nvidia TU104 1,703,551 120,000 14.20 1 hrs 41 mins