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Research: CANCER Folding Project #15203

Project #15203 overview

Project Summary AI Beta

This project looks at how PTCH1, a protein in our cells, moves cholesterol around to control cancer growth. When PTCH1 doesn't work right, it can lead to cancers like medulloblastoma and basal cell carcinoma. Understanding this process could help us develop new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
363,896
Core
0x24
Status
Public
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15203

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Friday, 14 August 2026 15:39:20

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 35,302,671 120,000 294.19 0 hrs 5 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 24,032,888 617,892 38.89 0 hrs 37 mins
3 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 19,990,841 120,000 166.59 0 hrs 9 mins
4 GeForce RTX 5080
GB203 [GeForce RTX 5080]		 Nvidia GB203 18,039,520 253,259 71.23 0 hrs 20 mins
5 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 16,634,115 137,919 120.61 0 hrs 12 mins
6 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 13,465,807 410,164 32.83 0 hrs 44 mins
7 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 11,825,400 849,606 13.92 1 hrs 43 mins
8 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 11,153,724 276,166 40.39 0 hrs 36 mins
9 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 10,640,402 207,521 51.27 0 hrs 28 mins
10 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]		 Nvidia GA102 9,530,610 523,169 18.22 1 hrs 19 mins
11 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 8,807,075 772,994 11.39 2 hrs 6 mins
12 Radeon RX 7900XT/XTX/GRE
Navi 31 [Radeon RX 7900XT/XTX/GRE]		 AMD Navi 31 7,176,497 120,000 59.80 0 hrs 24 mins
13 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 6,962,577 410,820 16.95 1 hrs 25 mins
14 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 6,790,991 710,727 9.55 2 hrs 31 mins
15 GeForce RTX 4060 Ti
AD106 [GeForce RTX 4060 Ti]		 Nvidia AD106 6,634,365 996,240 6.66 3 hrs 36 mins
16 GeForce RTX 4070 Max-Q / Mobile
AD106M [GeForce RTX 4070 Max-Q / Mobile]		 Nvidia AD106M 6,173,645 120,000 51.45 0 hrs 28 mins
17 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448		 Nvidia TU102 5,662,896 680,627 8.32 2 hrs 53 mins
18 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]		 Nvidia GA104 5,589,192 665,810 8.39 2 hrs 52 mins
19 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]		 Nvidia GA104 3,888,337 279,045 13.93 1 hrs 43 mins
20 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]		 AMD Navi 21 3,838,941 382,239 10.04 2 hrs 23 mins
21 TITAN RTX
TU102 [TITAN RTX] 16310		 Nvidia TU102 3,268,794 120,000 27.24 0 hrs 53 mins
22 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]		 Nvidia GA106 3,201,634 555,287 5.77 4 hrs 10 mins
23 GeForce RTX 2070
TU106 [GeForce RTX 2070]		 Nvidia TU106 2,969,617 541,133 5.49 4 hrs 22 mins
24 Radeon RX 6600(XT/M)
Navi 23 XT-XL [Radeon RX 6600(XT/M)]		 AMD Navi 23 XT-XL 1,163,993 386,879 3.01 7 hrs 59 mins