Folding project #15102, PARKINSONS research

Research section Research projects and references

Project #15102 overview

Project Summary AI Beta

This project uses computer simulations to study how the noradrenaline transporter (NET) works. NET is a protein that helps regulate brain signals and is a target for many antidepressants and pain medications. Understanding how NET works could lead to better drugs.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Ning Wang
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 155,671
Core: 0x23
Status: Public

Source material

Official Project Description

These projects involve simulations of the noradrenaline transporter (NET), a key protein responsible for terminating noradrenergic signaling by using sodium and chloride gradients to drive the reuptake of noradrenaline into presynaptic neurons.

NET is a crucial pharmacological target for numerous antidepressants and analgesics.

The aim of these simulations is to unravel the molecular mechanisms underlying noradrenaline transport, providing insights that could facilitate the design of more effective drugs.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

noradrenaline transporter

A protein responsible for reuptaking noradrenaline into presynaptic neurons.

Technical: BiotechnologyPharmacology / Neurotransmission

The noradrenaline transporter (NET) is a crucial protein that helps control the levels of noradrenaline in the brain. It works by moving noradrenaline back into nerve cells after it has been released, effectively stopping its effects. This process is important for regulating mood, attention, and pain perception. Because of its role in these functions, NET is a target for many medications, including antidepressants and painkillers.

NET

Noradrenaline transporter

Acronym: BiotechnologyPharmacology / Neurotransmission

NET stands for Noradrenaline Transporter. It's a protein found in nerve cells that helps regulate the levels of noradrenaline in the brain.

noradrenergic signaling

The process of communication in the nervous system involving noradrenaline.

Technical: BiotechnologyPharmacology / Neurotransmission

Noradrenergic signaling is how nerve cells communicate using the neurotransmitter called noradrenaline. This type of signaling plays a vital role in regulating many bodily functions, including mood, attention, and stress response.

antidepressants

Medications used to treat depression.

Medical Term: MedicinePharmacology / Mental Health

Antidepressants are a class of medications prescribed to help manage symptoms of depression. They work by affecting the balance of certain chemicals in the brain, such as serotonin and norepinephrine.

analgesics

Medications used to relieve pain.

Medical Term: MedicinePharmacology / Pain Management

Analgesics are medications designed to reduce or eliminate pain. They can work in various ways, such as blocking pain signals in the nerves or reducing inflammation.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	11,005,731	313,478	35.11	0 ^hrs 41 ^mins
2	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	10,763,809	178,556	60.28	0 ^hrs 24 ^mins
3	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	7,797,243	276,495	28.20	0 ^hrs 51 ^mins
4	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	7,752,219	276,274	28.06	0 ^hrs 51 ^mins
5	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	7,505,049	271,947	27.60	0 ^hrs 52 ^mins
6	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,755,067	252,426	22.80	1 ^hrs 3 ^mins
7	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,833,662	236,103	20.47	1 ^hrs 10 ^mins
8	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	4,383,526	43,428	100.94	0 ^hrs 14 ^mins
9	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,510,347	125,260	28.02	0 ^hrs 51 ^mins
10	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	3,307,977	210,029	15.75	1 ^hrs 31 ^mins
11	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,254,150	133,370	24.40	0 ^hrs 59 ^mins
12	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	3,031,449	202,137	15.00	1 ^hrs 36 ^mins
13	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,845,233	197,038	14.44	1 ^hrs 40 ^mins
14	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,266,550	184,995	12.25	1 ^hrs 58 ^mins
15	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	2,190,380	43,428	50.44	0 ^hrs 29 ^mins
16	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	1,475,970	43,428	33.99	0 ^hrs 42 ^mins

Research: PARKINSONS Folding Project #15102

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 15102

GPU PPD Averages

Research: PARKINSONS Folding Project #15102

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages