Folding project #15002, NOREPINEPHRINE-TRANSPORTER-FUNCTION research

Research section Research projects and references

Project #15002 overview

Project Summary AI Beta

The project relates to the norepinephrine transporter (NET), a protein that controls how much of a brain chemical called norepinephrine is available. NET affects things like attention, mood, and heart rate. Problems with NET are linked to conditions like depression and ADHD. Many medicines target NET to treat these issues.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Nathan Tvedt
Institution: University of Illinois at Urbana Champaign

Work unit

Atoms: 211,416
Core: 0x23
Status: Public

No related projects listed.

Source material

Official Project Description

The norepinephrine transporter (NET) regulates synaptic norepinephrine levels by reuptake into presynaptic neurons.

NET influences many functions of the nervous system including attention, arousal, stress responses, and cardiovascular regulation.

Dysregulation of NET has been implicated in psychiatric and neurological disorders such as depression, ADHD, anxiety, and Parkinson’s disease.

NET is also a major drug target for antidepressants, ADHD medication, and drugs of abuse.

Understanding NET mechanisms provides insight into many diseases and guides development of targeted therapies and treatments.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

norepinephrine transporter

A protein that transports norepinephrine back into presynaptic neurons.

Technical: BiotechnologyNeurobiology / Synaptic Transmission

The norepinephrine transporter (NET) is a vital protein that regulates the levels of norepinephrine in synapses. It does this by reabsorbing norepinephrine from the space between neurons back into the neuron that released it. This process is crucial for maintaining proper communication within the nervous system and influencing various functions like attention, mood, stress response, and heart rate. Disruptions in NET function are linked to several neurological and psychiatric disorders such as depression, ADHD, anxiety, and Parkinson's disease. Therefore, understanding how NET works is essential for developing effective treatments for these conditions.

NET

Norepinephrine Transporter

Acronym: BiotechnologyNeurobiology / Synaptic Transmission

NET stands for Norepinephrine Transporter. It's a protein found in nerve cells that plays a crucial role in regulating norepinephrine levels in the brain.

presynaptic neurons

Neurons that release neurotransmitters.

Technical: BiotechnologyNeurobiology / Synaptic Transmission

Presynaptic neurons are nerve cells that send signals to other nerve cells by releasing chemicals called neurotransmitters. These neurotransmitters cross a tiny gap (synapse) and bind to receptors on the receiving neuron (postsynaptic neuron), transmitting the signal.

neurotransmitters

Chemical messengers that transmit signals between neurons.

Technical: BiotechnologyNeurobiology / Synaptic Transmission

Neurotransmitters are specialized chemical messengers that allow nerve cells (neurons) to communicate with each other. They travel across a small gap called a synapse and bind to receptors on the receiving neuron, triggering various responses.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	38,042,902	118,480	321.09	0 ^hrs 4 ^mins
2	B200 GB100 [B200]	Nvidia	GB100	29,578,871	118,480	249.65	0 ^hrs 6 ^mins
3	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	23,451,018	402,687	58.24	0 ^hrs 25 ^mins
4	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	17,154,164	494,780	34.67	0 ^hrs 42 ^mins
5	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	16,125,009	279,739	57.64	0 ^hrs 25 ^mins
6	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	15,265,620	118,480	128.85	0 ^hrs 11 ^mins
7	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	12,526,411	157,237	79.67	0 ^hrs 18 ^mins
8	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	11,045,786	118,480	93.23	0 ^hrs 15 ^mins
9	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	11,006,238	545,012	20.19	1 ^hrs 11 ^mins
10	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	10,210,691	190,633	53.56	0 ^hrs 27 ^mins
11	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	10,177,791	881,315	11.55	2 ^hrs 5 ^mins
12	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,839,150	355,659	27.66	0 ^hrs 52 ^mins
13	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	8,760,807	118,480	73.94	0 ^hrs 19 ^mins
14	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	7,478,050	437,872	17.08	1 ^hrs 24 ^mins
15	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,353,115	169,174	37.55	0 ^hrs 38 ^mins
16	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	5,995,863	118,480	50.61	0 ^hrs 28 ^mins
17	Tesla V100 PCIe 16GB GV100GL [Tesla V100 PCIe 16GB] M 14028	Nvidia	GV100GL	5,710,731	118,480	48.20	0 ^hrs 30 ^mins
18	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,667,999	118,480	47.84	0 ^hrs 30 ^mins
19	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,612,984	489,072	11.48	2 ^hrs 5 ^mins

20	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,470,878	272,687	20.06	1 ^hrs 12 ^mins
21	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,066,826	118,480	42.77	0 ^hrs 34 ^mins
22	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,646,754	320,967	14.48	1 ^hrs 39 ^mins
23	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	4,577,757	118,480	38.64	0 ^hrs 37 ^mins
24	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,192,775	188,438	22.25	1 ^hrs 5 ^mins
25	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,517,697	118,480	29.69	0 ^hrs 49 ^mins
26	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	3,126,610	399,899	7.82	3 ^hrs 4 ^mins
27	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,083,834	397,155	7.76	3 ^hrs 5 ^mins
28	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,029,601	122,666	24.70	0 ^hrs 58 ^mins
29	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,904,997	392,371	7.40	3 ^hrs 14 ^mins
30	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,766,466	118,480	23.35	1 ^hrs 2 ^mins
31	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,612,245	207,641	12.58	1 ^hrs 54 ^mins
32	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,356,373	118,480	19.89	1 ^hrs 12 ^mins
33	Radeon RX 6600(XT/M) Navi 23 XT-XL [Radeon RX 6600(XT/M)]	AMD	Navi 23 XT-XL	2,313,813	118,480	19.53	1 ^hrs 14 ^mins
34	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,120,445	353,604	6.00	4 ^hrs 0 ^mins
35	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,035,314	348,389	5.84	4 ^hrs 6 ^mins
36	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,986,366	118,480	16.77	1 ^hrs 26 ^mins
37	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,693,632	118,480	14.29	1 ^hrs 41 ^mins
38	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,401,765	118,480	11.83	2 ^hrs 2 ^mins
39	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,390,899	118,480	11.74	2 ^hrs 3 ^mins

40	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,312,659	118,480	11.08	2 ^hrs 10 ^mins
41	P104-100 GP104 [P104-100]	Nvidia	GP104	1,310,227	118,480	11.06	2 ^hrs 10 ^mins
42	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,139,948	118,480	9.62	2 ^hrs 30 ^mins
43	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,089,635	283,786	3.84	6 ^hrs 15 ^mins
44	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,051,130	296,305	3.55	6 ^hrs 46 ^mins
45	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	610,527	118,480	5.15	4 ^hrs 39 ^mins
46	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	567,325	118,480	4.79	5 ^hrs 1 ^mins
47	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	291,755	118,480	2.46	9 ^hrs 45 ^mins

Research: NOREPINEPHRINE-TRANSPORTER-FUNCTION Folding Project #15002

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 15002

GPU PPD Averages

Research: NOREPINEPHRINE-TRANSPORTER-FUNCTION Folding Project #15002

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages