Folding.LAR.Systems Folding.LAR.Systems Folding.LAR.Systems Folding.LAR.Systems
Research section Research projects and references
  1. Projects
  2. Research Project Folding Profile

Research: Β-LACTMASES Folding Project #14520

Project #14520 overview

Project Summary AI Beta

This project relates to understanding how TEM-1 beta-lactamase breaks down penicillin and related antibiotics, making bacteria resistant. Researchers are studying the protein's structure to find areas that could be blocked by drugs, potentially leading to new treatments for drug-resistant infections.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Neha Vithani
Institution
Washington University in St. Louis

Work unit

Atoms
34,514
Core
GRO_A7
Status
Public
Source material

Official Project Description

Beta lactamases are proteins which degrade penicillin and related antibiotics, enabling pathogenic bacteria to resist their effects.

We are modeling the dynamics of TEM-1 beta-lactamase to look for pockets in the protein which could bind small molecules and prevent it from functioning.

Drugs which could target these pockets could therefore help to treat drug resistant infections.

Performance data

Hardware Performance for Project 14520

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:06:39

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 3950X 16-CORE 32 22,171 709,472 AMD
2 RYZEN 9 5950X 16-CORE 32 20,353 651,296 AMD
3 RYZEN 9 3900X 12-CORE 24 16,778 402,672 AMD
4 CORE I9-9900K CPU @ 3.60GHZ 16 17,614 281,824 Intel
5 RYZEN 7 5800X 8-CORE 16 13,475 215,600 AMD
6 RYZEN 7 3700X 8-CORE 16 11,424 182,784 AMD
7 RYZEN 7 3800X 8-CORE 16 11,269 180,304 AMD
8 RYZEN 5 3600 6-CORE 12 13,238 158,856 AMD
9 RYZEN 5 1600X SIX-CORE 12 11,905 142,860 AMD
10 RYZEN 7 2700X EIGHT-CORE 16 5,546 88,736 AMD
11 RYZEN 7 1700 EIGHT-CORE 16 3,853 61,648 AMD
12 CORE I7-4790K CPU @ 4.00GHZ 8 7,312 58,496 Intel
13 CORE I7-8705G CPU @ 3.10GHZ 8 7,129 57,032 Intel
14 RYZEN 5 2600 SIX-CORE 12 4,099 49,188 AMD
15 CORE I5-7600 CPU @ 3.50GHZ 4 10,855 43,420 Intel
16 XEON CPU E5-2650 0 @ 2.00GHZ 16 2,588 41,408 Intel
17 CORE I5-6500 CPU @ 3.20GHZ 4 9,898 39,592 Intel
18 PHENOM II X4 965 4 3,777 15,108 AMD
19 CORE I3-6006U CPU @ 2.00GHZ 4 2,317 9,268 Intel
20 CELERON(R) CPU G550 @ 2.60GHZ 2 1,854 3,708 Intel
21 A8-6410 APU 4 651 2,604 AMD