Official Project Description
Protein Brush Polymers Short peptides are considered ideal therapeutics because of their small size and bioactivity, however they are prone to enzyme degradation.
Protein Brush Polymers allow peptides to bind to a hydrophobic backbone in a polymeric scheme which enhances the penetration of these peptides in cell/targets. In this project we simulate Trpzip2, which is a beta-hairpin peptide, for investigation of beta-sheet secondary structure effect on the polymer conformation. We have two broad aims in this study.
To simulate the peptide monomer as well as simulate a 15-mer polymer system with different configurations to investigate beta-sheet content.