Folding project #12007, CANCER research

Research section Research projects and references

Project #12007 overview

Project Summary AI Beta

Class A GPCRs are super important proteins that control almost everything in our bodies! They act like cell phones, sending signals within. This project will help us understand how they work so we can design new drugs to treat diseases like cancer, diabetes, and depression.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 129,797
Core: 0x22
Status: Public

Source material

Official Project Description

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPCRs

G Protein-Coupled Receptors

Technical: BiotechnologyPharmacology / Drug Targets

GPCRs are a large family of cell surface receptors that play crucial roles in transmitting signals within the body. They are involved in various physiological processes and are important targets for drug development.

FDA

Food and Drug Administration

Acronym: HealthcareMedicine / Drug Regulation

The FDA is a US government agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

Cancer

A group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

Disease: HealthcareMedicine / Oncology

Cancer is a broad term for diseases characterized by uncontrolled cell growth. These cells can invade surrounding tissues and spread to other parts of the body (metastasis). Cancer arises from genetic mutations that disrupt normal cellular processes.

Diabetes

A metabolic disorder characterized by high blood sugar levels due to problems with insulin production or action.

Disease: HealthcareMedicine / Endocrinology

Diabetes is a chronic condition affecting how the body regulates blood sugar. It occurs when the pancreas doesn't produce enough insulin (Type 1) or when cells become resistant to insulin's effects (Type 2). This leads to high blood sugar levels, which can damage organs over time.

Depression

A mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest.

Mental Health Disorder: HealthcareMedicine / Psychiatry

Depression is a common mental health condition that affects how people feel, think, and behave. Symptoms include persistent sadness, loss of interest in activities, changes in appetite and sleep, fatigue, and difficulty concentrating.

Anxiety

A feeling of worry, nervousness, or unease, often about an imminent event or something with an uncertain outcome.

Mental Health Disorder: HealthcareMedicine / Psychiatry

Anxiety is a common human emotion characterized by feelings of worry, fear, and apprehension. It can manifest as physical symptoms like increased heart rate, sweating, and difficulty breathing. When anxiety becomes persistent and interferes with daily life, it may be a sign of an anxiety disorder.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,408,953	148,289	22.99	1 ^hrs 3 ^mins
2	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,807,908	139,336	20.15	1 ^hrs 11 ^mins
3	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	2,455,829	130,969	18.75	1 ^hrs 17 ^mins
4	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,432,647	132,362	18.38	1 ^hrs 18 ^mins
5	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,104,432	126,550	16.63	1 ^hrs 27 ^mins
6	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,054,734	124,822	16.46	1 ^hrs 27 ^mins
7	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,266,777	106,285	11.92	2 ^hrs 1 ^mins
8	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,153,851	93,355	12.36	1 ^hrs 57 ^mins
9	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	827,838	92,925	8.91	2 ^hrs 42 ^mins
10	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	787,259	91,023	8.65	2 ^hrs 46 ^mins
11	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	632,354	82,147	7.70	3 ^hrs 7 ^mins
12	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	582,579	83,642	6.97	3 ^hrs 27 ^mins
13	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	390,694	71,817	5.44	4 ^hrs 25 ^mins
14	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	351,358	68,045	5.16	4 ^hrs 39 ^mins
15	P106-090 GP106 [P106-090]	Nvidia	GP106	350,012	69,577	5.03	4 ^hrs 46 ^mins
16	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	42,456	40,076	1.06	22 ^hrs 39 ^mins

Research: CANCER Folding Project #12007

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12007

GPU PPD Averages

Research: CANCER Folding Project #12007

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages