Folding project #12005, CANCER research

Research section Research projects and references

Project #12005 overview

Project Summary AI Beta

This project looks at how Class A GPCRs work in our bodies. These proteins act like messengers, sending signals that control many important processes. Understanding them better could lead to new drugs for diseases like cancer, diabetes, and depression.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 109,489
Core: 0x22
Status: Public

Source material

Official Project Description

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPCRs

G Protein-Coupled Receptors

Scientific: BiotechnologyPharmacology / Drug Discovery

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play crucial roles in transmitting signals from outside the cell to inside. They are involved in various physiological processes, making them important drug targets for treating diseases like cancer, diabetes, and depression.

Drug Targets

Molecules or biological pathways that are the focus of drug action.

Technical: MedicinePharmacology / Drug Development

Drug targets are specific molecules or processes within the body that medications aim to interact with. Identifying and understanding these targets is essential for developing effective drugs. Examples include proteins like GPCRs that play roles in cell signaling.

FDA

Food and Drug Administration

Acronym: HealthcareMedicine / Regulatory Bodies

The FDA is a US government agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

Cancer

Uncontrolled growth and spread of abnormal cells.

Medical Condition: HealthcarePathology / Oncology

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. These cells can invade surrounding tissues and spread to other parts of the body.

Diabetes

A metabolic disorder affecting blood sugar regulation.

Medical Condition: HealthcarePathology / Endocrinology

Diabetes is a chronic condition where the body either doesn't produce enough insulin or can't effectively use the insulin it produces. This leads to high blood sugar levels and can cause various complications.

Depression

A mood disorder characterized by persistent sadness and loss of interest.

Mental Health Condition: HealthcarePsychiatry / Mental Disorders

Depression is a common mental health disorder that involves persistent feelings of sadness, hopelessness, and loss of interest in activities. It can affect thoughts, behavior, sleep, appetite, and energy levels.

Anxiety

Excessive worry and fear.

Mental Health Condition: HealthcarePsychiatry / Mental Disorders

Anxiety is a feeling of unease, nervousness, or apprehension. It can be mild or severe, and it often involves physical symptoms like rapid heartbeat, sweating, and shortness of breath.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,409,640	125,136	27.25	0 ^hrs 53 ^mins
2	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	3,108,820	121,794	25.53	0 ^hrs 56 ^mins
3	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,660,055	115,391	23.05	1 ^hrs 2 ^mins
4	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,539,242	112,913	22.49	1 ^hrs 4 ^mins
5	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	2,505,116	112,463	22.28	1 ^hrs 5 ^mins
6	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,434,269	99,178	24.54	0 ^hrs 59 ^mins
7	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,417,791	111,282	21.73	1 ^hrs 6 ^mins
8	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,138,161	107,071	19.97	1 ^hrs 12 ^mins
9	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,098,210	105,788	19.83	1 ^hrs 13 ^mins
10	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,437,805	92,271	15.58	1 ^hrs 32 ^mins
11	P102-100 GP102 [P102-100]	Nvidia	GP102	1,419,812	84,486	16.81	1 ^hrs 26 ^mins
12	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,345,597	92,072	14.61	1 ^hrs 39 ^mins
13	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,322,028	87,056	15.19	1 ^hrs 35 ^mins
14	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,303,433	90,898	14.34	1 ^hrs 40 ^mins
15	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,216,458	89,386	13.61	1 ^hrs 46 ^mins
16	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,142,871	85,586	13.35	1 ^hrs 48 ^mins
17	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	1,084,688	84,685	12.81	1 ^hrs 52 ^mins
18	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,060,906	85,225	12.45	1 ^hrs 56 ^mins
19	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	978,352	79,469	12.31	1 ^hrs 57 ^mins

20	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	747,173	75,731	9.87	2 ^hrs 26 ^mins
21	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	616,589	70,756	8.71	2 ^hrs 45 ^mins
22	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	231,555	34,707	6.67	3 ^hrs 36 ^mins
23	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	127,894	41,754	3.06	7 ^hrs 50 ^mins
24	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	116,566	40,820	2.86	8 ^hrs 24 ^mins

Research: CANCER Folding Project #12005

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12005

GPU PPD Averages

Research: CANCER Folding Project #12005

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages