Folding project #12002, CANCER research

Research section Research projects and references

Project #12002 overview

Project Summary AI Beta

Class A GPCRs are important proteins that control many things in our bodies. They act like cellular communication systems, transmitting signals from outside to inside cells. This project aims to understand how they work so we can develop new drugs for diseases like cancer, diabetes, and mental health conditions.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 78,776
Core: 0x22
Status: Public

Source material

Official Project Description

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPCRs

G Protein-Coupled Receptors

Scientific: BiotechnologyPharmacology / Drug Targets

GPCRs are a large family of cell surface receptors that play a crucial role in signal transduction. They bind to various ligands, such as hormones and neurotransmitters, and activate intracellular signaling pathways that regulate diverse physiological processes.

FDA

Food and Drug Administration

Acronym: MedicinePharmacology / Drug Approval

The FDA is a US federal agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

Cancer

A group of diseases characterized by abnormal cell growth with the potential to invade or spread to other parts of the body.

Pathology: HealthcareMedicine / Disease

Cancer is a broad term for diseases where cells grow uncontrollably and can damage surrounding tissues. These abnormal cells can form tumors and spread to other areas through the bloodstream or lymphatic system.

Diabetes

A group of metabolic disorders characterized by high blood sugar levels due to defects in insulin production or action.

Pathology: HealthcareMedicine / Metabolic Disorder

Diabetes is a chronic condition where the body struggles to regulate blood sugar (glucose) levels. This can result from insufficient insulin production or the body's inability to use insulin effectively. Common symptoms include excessive thirst, frequent urination, and increased hunger.

Depression

A mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities.

Mental Health: HealthcareMedicine / Psychiatric Disorder

Depression is a common mental health condition that affects how you feel, think, and behave. It can cause intense sadness, hopelessness, loss of energy, changes in appetite and sleep patterns, difficulty concentrating, and thoughts of death or suicide.

Anxiety

A feeling of worry, nervousness, or unease.

Mental Health: HealthcareMedicine / Psychiatric Disorder

Anxiety is a normal human emotion, but when it becomes excessive and persistent, it can be a sign of an anxiety disorder. People with anxiety may experience symptoms such as rapid heartbeat, sweating, trembling, shortness of breath, dizziness, and difficulty concentrating.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,711,173	76,284	22.43	1 ^hrs 4 ^mins
2	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,279,822	63,576	20.13	1 ^hrs 12 ^mins
3	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	788,432	53,691	14.68	1 ^hrs 38 ^mins
4	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	714,355	52,062	13.72	1 ^hrs 45 ^mins
5	Quadro P4000 GP104GL [Quadro P4000]	Nvidia	GP104GL	706,221	51,763	13.64	1 ^hrs 46 ^mins
6	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	550,174	47,160	11.67	2 ^hrs 3 ^mins
7	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	305,051	39,573	7.71	3 ^hrs 7 ^mins
8	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	212,677	35,178	6.05	3 ^hrs 58 ^mins
9	Quadro M2000 GM206GL [Quadro M2000]	Nvidia	GM206GL	195,388	34,281	5.70	4 ^hrs 13 ^mins
10	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	123,044	29,116	4.23	5 ^hrs 41 ^mins
11	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	85,892	25,641	3.35	7 ^hrs 10 ^mins

Research: CANCER Folding Project #12002

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12002

GPU PPD Averages

Research: CANCER Folding Project #12002

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages