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Research: PROTEIN-VITRIFICATION-CRYOEM Folding Project #18820

Project #18820 overview

Project Summary AI Beta

Cryogenic electron microscopy helps us see tiny protein structures, which is important for making new medicines. This project uses computer simulations to figure out how the freezing process affects these proteins, so we can use this technique even better to develop drugs faster.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Dr. Sonya Hanson
Institution
Flatiron Institute

Work unit

Atoms
13,625
Core
0xa9
Status
Public

No related projects listed.

Source material

Official Project Description

Cryogenic electron microscopy has revolutionized the field of molecular biology.

It has revealed the structures of thousands of previously uncharacterised proteins, enabling the development of new therapeutics for every kind of human disease.

A crucial step in the preparation of proteins for study in this method involves the rapid cooling and vitrification of dissolved protein in liquid ethane.

Despite the ubiquity of this technique, its effects on molecular structure are not well understood, leaving important implications for the field of molecular biophysics.

In this project we will explicitly simulate the vitrification process to understand how it perturbs molecular structures-teaching us what kinds of structures are preserved during cooling and which ones are lost.

This will enable the transformation of cryogenic electron microscopy into a quantitative biophysical tool, letting us develop drugs more quickly and accurately for all diseases.

Performance data

Hardware Performance for Project 18820

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:50:13

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 9950X 16-CORE 32 41,563 1,330,016 AMD
2 RYZEN 9 9900X 12-CORE 24 54,728 1,313,472 AMD
3 RYZEN 9 7950X 16-CORE 32 35,523 1,136,736 AMD
4 XEON GOLD 5218R CPU @ 2.10GHZ 80 12,902 1,032,160 Intel
5 CORE I9-10920X CPU @ 3.50GHZ 24 42,359 1,016,616 Intel
6 CORE ULTRA 7 265K 20 45,930 918,600 Intel
7 RYZEN 9 7950X3D 16-CORE 32 24,409 781,088 AMD
8 RYZEN 7 7700X 8-CORE 16 48,671 778,736 AMD
9 RYZEN 9 5950X 16-CORE 32 22,431 717,792 AMD
10 RYZEN 9 5900X 12-CORE 24 29,108 698,592 AMD
11 XEON CPU E5-2697 V4 @ 2.30GHZ 72 9,190 661,680 Intel
12 CORE I9-10850K CPU @ 3.60GHZ 20 33,016 660,320 Intel
13 RYZEN 7 7800X3D 8-CORE 16 40,899 654,384 AMD
14 RYZEN 9 7900 12-CORE 24 27,185 652,440 AMD
15 RYZEN 7 5800X3D 8-CORE 16 37,786 604,576 AMD
16 CORE I9-14900K 32 17,785 569,120 Intel
17 RYZEN 7 5700G 16 33,488 535,808 AMD
18 XEON PHI(TM) CPU 7210 @ 1.30GHZ 256 2,025 518,400 Intel
19 XEON W-3245 CPU @ 3.20GHZ 32 15,779 504,928 Intel
20 RYZEN 5 7600 6-CORE 12 42,023 504,276 AMD
21 12TH GEN CORE I7-12700 20 23,421 468,420 Intel
22 RYZEN 7 5800X 8-CORE 16 27,463 439,408 AMD
23 RYZEN 7 5700X 8-CORE 16 26,209 419,344 AMD
24 11TH GEN CORE I9-11900K @ 3.50GHZ 16 25,893 414,288 Intel
25 RYZEN 9 3900X 12-CORE 24 16,570 397,680 AMD
26 RYZEN 7 5700X3D 8-CORE 16 24,140 386,240 AMD
27 12TH GEN CORE I9-12900K 24 15,915 381,960 Intel
28 13TH GEN CORE I9-13900KF 32 11,545 369,440 Intel
29 12TH GEN CORE I7-12700F 20 18,452 369,040 Intel
30 CORE I9-10900 CPU @ 2.80GHZ 20 16,867 337,340 Intel
31 12TH GEN CORE I7-12700K 20 16,630 332,600 Intel
32 RYZEN 5 7600X 6-CORE 12 27,405 328,860 AMD
33 CORE I9-14900KF 24 13,587 326,088 Intel
34 RYZEN 9 3950X 16-CORE 32 10,048 321,536 AMD
35 CORE I9-14900KS 16 19,747 315,952 Intel
36 CORE I7-10700K CPU @ 3.80GHZ 16 19,504 312,064 Intel
37 RYZEN 5 5600X 6-CORE 12 25,303 303,636 AMD
38 XEON W-2145 CPU @ 3.70GHZ 16 18,927 302,832 Intel
39 CORE I5-10400F CPU @ 2.90GHZ 12 24,908 298,896 Intel
40 XEON CPU E5-2683 V4 @ 2.10GHZ 32 8,239 263,648 Intel
41 RYZEN 5 5500 12 21,772 261,264 AMD
42 CORE I7-10700KF CPU @ 3.80GHZ 16 16,161 258,576 Intel
43 RYZEN 5 5600 6-CORE 12 20,188 242,256 AMD
44 CORE I7-9700F CPU @ 3.00GHZ 8 30,240 241,920 Intel
45 CORE I7-9700 CPU @ 3.00GHZ 8 27,955 223,640 Intel
46 RYZEN 5 3600 6-CORE 12 17,929 215,148 AMD
47 RYZEN 7 5800H 16 13,327 213,232 AMD
48 13TH GEN CORE I7-13700 24 8,525 204,600 Intel
49 13TH GEN CORE I5-13600K 14 14,000 196,000 Intel
50 CORE I7-8700 CPU @ 3.20GHZ 12 15,791 189,492 Intel
51 XEON CPU E5-2666 V3 @ 2.90GHZ 20 9,379 187,580 Intel
52 11TH GEN CORE I7-11800H @ 2.30GHZ 16 10,915 174,640 Intel
53 XEON CPU E5-1680 V4 @ 3.40GHZ 16 10,878 174,048 Intel
54 13TH GEN CORE I5-1345U 12 13,472 161,664 Intel
55 CORE I7-5820K CPU @ 3.30GHZ 12 13,337 160,044 Intel
56 CORE I5-10500T CPU @ 2.30GHZ 12 13,254 159,048 Intel
57 RYZEN 9 3900XT 12-CORE 24 6,374 152,976 AMD
58 12TH GEN CORE I5-12400F 12 12,579 150,948 Intel
59 XEON E-2144G CPU @ 3.60GHZ 8 18,617 148,936 Intel
60 CORE I5-8600K CPU @ 3.60GHZ 6 24,815 148,890 Intel
61 CORE I5-8600 CPU @ 3.10GHZ 6 24,215 145,290 Intel
62 CORE I5-9400F CPU @ 2.90GHZ 6 24,091 144,546 Intel
63 11TH GEN CORE I7-11700F @ 2.50GHZ 16 8,741 139,856 Intel
64 XEON CPU E3-1240 V5 @ 3.50GHZ 8 17,416 139,328 Intel
65 CORE I7-7700K CPU @ 4.20GHZ 8 15,971 127,768 Intel
66 XEON GOLD 5412U 48 2,623 125,904 Intel
67 CORE I7-6700K CPU @ 4.00GHZ 8 15,719 125,752 Intel
68 RYZEN 5 3600X 6-CORE 12 10,374 124,488 AMD
69 CORE I9-8950HK CPU @ 2.90GHZ 12 10,208 122,496 Intel
70 CORE I7-8705G CPU @ 3.10GHZ 8 15,206 121,648 Intel
71 CORE I5-9600T CPU @ 2.30GHZ 6 20,187 121,122 Intel
72 CORE I7-10750H CPU @ 2.60GHZ 12 8,794 105,528 Intel
73 XEON CPU E3-1270 V5 @ 3.60GHZ 8 13,019 104,152 Intel
74 CORE I7-4790K CPU @ 4.00GHZ 8 12,354 98,832 Intel
75 12TH GEN CORE I5-1235U 12 7,678 92,136 Intel
76 XEON CPU E5-2699 V3 @ 2.30GHZ 36 2,477 89,172 Intel
77 CORE I5-6500 CPU @ 3.20GHZ 4 22,049 88,196 Intel
78 XEON CPU E3-1231 V3 @ 3.40GHZ 8 10,966 87,728 Intel
79 CORE I7-8700K CPU @ 3.70GHZ 12 7,068 84,816 Intel
80 CORE I3-8100T CPU @ 3.10GHZ 4 19,841 79,364 Intel
81 CORE I5-14500 20 3,805 76,100 Intel
82 CORE I7-4790 CPU @ 3.60GHZ 8 9,456 75,648 Intel
83 CORE I5-6500T CPU @ 2.50GHZ 4 18,066 72,264 Intel
84 CORE I7-4870HQ CPU @ 2.50GHZ 8 8,928 71,424 Intel
85 12TH GEN CORE I5-1245U 12 5,076 60,912 Intel
86 CORE I5-4590 CPU @ 3.30GHZ 4 14,220 56,880 Intel
87 CORE I5-8600T CPU @ 2.30GHZ 6 8,539 51,234 Intel
88 RYZEN 7 3700X 8-CORE 16 3,152 50,432 AMD
89 CORE I5-8350U CPU @ 1.70GHZ 8 6,295 50,360 Intel
90 CORE I5-4570 CPU @ 3.20GHZ 4 12,377 49,508 Intel
91 CORE I7-7700HQ CPU @ 2.80GHZ 8 5,321 42,568 Intel
92 RYZEN 7 4800U 16 2,413 38,608 AMD
93 CORE I7-1065G7 CPU @ 1.30GHZ 8 4,170 33,360 Intel
94 CORE I7-4770HQ CPU @ 2.20GHZ 8 3,981 31,848 Intel
95 CORE I7-7500U CPU @ 2.70GHZ 4 7,432 29,728 Intel
96 CORE I7-7600U CPU @ 2.80GHZ 4 7,265 29,060 Intel
97 CORE I5-6300U CPU @ 2.40GHZ 4 6,766 27,064 Intel
98 CORE I5-14500T 20 1,059 21,180 Intel
99 CORE I7-4770S CPU @ 3.10GHZ 8 490 3,920 Intel
100 CORE I7-6560U CPU @ 2.20GHZ 4 895 3,580 Intel