PROJECT #17806 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Mutations in the KRAS protein and its paralogs HRAS and NRAS are among the most frequent drivers of cancer, including three of the most lethal cancers – lung, colorectal, and pancreatic. Thus, they represent extremely appealing drug targets in oncology research. However, despite the immense therapeutic potential, targeting KRAS has proven extremely difficult because of its smooth molecular surface which presents little to no pockets capable of accommodating a drug-like ligand. This project aims to ascertain whether KRAS exhibits certain druggable metastable states, even short-lived ones, which could then be stabilized by a suitable ligand.

PROJECT INFO

Manager(s): Dr. Stefan Ivanov

Institution: Redesign Science

PROJECT WORK UNIT SUMMARY

Atoms: 30,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,182,756 139,779 15.62 2 hrs 32 mins
2 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,983,478 134,664 14.73 2 hrs 38 mins
3 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 1,764,211 130,438 13.53 2 hrs 46 mins
4 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,550,103 125,105 12.39 2 hrs 56 mins
5 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,541,178 123,925 12.44 2 hrs 56 mins
6 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,470,355 122,617 11.99 2 hrs 0 mins
7 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,442,957 121,742 11.85 2 hrs 1 mins
8 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,371,724 117,056 11.72 2 hrs 3 mins
9 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,362,000 119,130 11.43 2 hrs 6 mins
10 Quadro P5000
GP104GL [Quadro P5000]
Nvidia GP104GL 1,212,899 115,113 10.54 2 hrs 17 mins
11 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,186,972 113,121 10.49 2 hrs 17 mins
12 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,178,017 113,921 10.34 2 hrs 19 mins
13 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile] 4608
Nvidia TU106M 1,152,307 113,466 10.16 2 hrs 22 mins
14 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,098,304 109,979 9.99 2 hrs 24 mins
15 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 987,077 106,956 9.23 3 hrs 36 mins
16 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 973,813 107,020 9.10 3 hrs 38 mins
17 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 964,628 102,886 9.38 3 hrs 34 mins
18 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 957,258 103,861 9.22 3 hrs 36 mins
19 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 922,932 99,895 9.24 3 hrs 36 mins
20 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 901,514 103,508 8.71 3 hrs 45 mins
21 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 892,972 100,204 8.91 3 hrs 42 mins
22 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 778,380 99,225 7.84 3 hrs 4 mins
23 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 765,351 98,374 7.78 3 hrs 5 mins
24 RTX A2000 Mobile
GA107GLM [RTX A2000 Mobile]
GA107GLM 762,784 99,175 7.69 3 hrs 7 mins
25 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 698,195 95,542 7.31 3 hrs 17 mins
26 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 669,757 94,202 7.11 3 hrs 23 mins
27 GeForce GTX 1070 Mobile
GP104BM [GeForce GTX 1070 Mobile] 6463
Nvidia GP104BM 609,054 91,225 6.68 4 hrs 36 mins
28 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 607,225 91,379 6.65 4 hrs 37 mins
29 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 592,714 90,621 6.54 4 hrs 40 mins
30 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 591,335 90,036 6.57 4 hrs 39 mins
31 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 587,688 89,453 6.57 4 hrs 39 mins
32 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 536,813 87,585 6.13 4 hrs 55 mins
33 GeForce GTX 1650 Ti Mobile
TU117M [GeForce GTX 1650 Ti Mobile]
Nvidia TU117M 532,067 87,368 6.09 4 hrs 56 mins
34 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 481,862 83,278 5.79 4 hrs 9 mins
35 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 464,736 80,102 5.80 4 hrs 8 mins
36 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 399,192 77,904 5.12 5 hrs 41 mins
37 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 376,036 71,004 5.30 5 hrs 32 mins
38 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 375,482 76,379 4.92 5 hrs 53 mins
39 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 350,448 75,166 4.66 5 hrs 9 mins
40 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]
Nvidia TU117GLM 342,145 75,898 4.51 5 hrs 19 mins
41 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 292,503 71,565 4.09 6 hrs 52 mins
42 P106-090
GP106 [P106-090]
Nvidia GP106 260,890 68,986 3.78 6 hrs 21 mins
43 Tesla K20C
GK110 [Tesla K20C] 3524
Nvidia GK110 259,473 66,463 3.90 6 hrs 9 mins
44 Tesla K20M
GK110 [Tesla K20M] 3524
Nvidia GK110 258,288 67,562 3.82 6 hrs 17 mins
45 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 250,727 68,126 3.68 7 hrs 31 mins
46 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 249,865 67,343 3.71 6 hrs 28 mins
47 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 248,671 67,919 3.66 7 hrs 33 mins
48 P104-100
GP104 [P104-100]
Nvidia GP104 228,694 66,162 3.46 7 hrs 57 mins
49 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 219,621 64,449 3.41 7 hrs 3 mins
50 GeForce GTX 670/GTX 760Ti OEM
GK104 [GeForce GTX 670/GTX 760Ti OEM] 2634
Nvidia GK104 195,655 62,990 3.11 8 hrs 44 mins
51 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 195,422 60,837 3.21 7 hrs 28 mins
52 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 195,040 60,007 3.25 7 hrs 23 mins
53 P106-100
GP106 [P106-100]
Nvidia GP106 187,379 61,880 3.03 8 hrs 56 mins
54 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 185,199 59,167 3.13 8 hrs 40 mins
55 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 179,379 60,327 2.97 8 hrs 4 mins
56 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 167,684 58,519 2.87 8 hrs 23 mins
57 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 132,370 54,250 2.44 10 hrs 50 mins
58 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 125,105 54,114 2.31 10 hrs 23 mins
59 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 124,278 53,951 2.30 10 hrs 25 mins
60 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 114,541 52,397 2.19 11 hrs 59 mins
61 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 113,202 49,099 2.31 10 hrs 25 mins
62 GRID M40
GM107GL [GRID M40]
Nvidia GM107GL 110,258 51,883 2.13 11 hrs 18 mins
63 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 110,159 51,533 2.14 11 hrs 14 mins
64 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 98,966 48,733 2.03 12 hrs 49 mins
65 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 87,635 47,956 1.83 13 hrs 8 mins
66 GeForce GTX 950M
GM107 [GeForce GTX 950M] 1439
Nvidia GM107 85,154 48,128 1.77 14 hrs 34 mins
67 GeForce GTX 570 HD
GF110 [GeForce GTX 570 HD] 1405
Nvidia GF110 70,832 44,269 1.60 15 hrs 60 mins
68 GeForce GT 840M
GM108 [GeForce GT 840M]
Nvidia GM108 67,784 34,115 1.99 12 hrs 5 mins
69 VGX K2
GK104GL [VGX K2]
GK104GL 57,922 41,811 1.39 17 hrs 19 mins
70 GeForce 940MX
GM107 [GeForce 940MX]
Nvidia GM107 54,850 41,195 1.33 18 hrs 2 mins
71 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 52,146 37,583 1.39 17 hrs 18 mins
72 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 36,288 34,793 1.04 23 hrs 1 mins
73 GeForce GTX 560
GF114 [GeForce GTX 560]
Nvidia GF114 33,953 34,995 0.97 25 hrs 44 mins
74 GeForce 940M
GM108 [GeForce 940M]
Nvidia GM108 29,597 30,718 0.96 25 hrs 55 mins
75 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 29,581 30,422 0.97 25 hrs 41 mins
76 GeForce 920M
GK208 [GeForce 920M]
Nvidia GK208 25,410 29,827 0.85 28 hrs 10 mins
77 GeForce GTX 550 Ti
GF116 [GeForce GTX 550 Ti] 691
Nvidia GF116 21,151 29,205 0.72 33 hrs 8 mins
78 GeForce GTX 670M
GF114 [GeForce GTX 670M]
Nvidia GF114 20,858 29,307 0.71 34 hrs 43 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make