Folding project #17806, CANCER research

Research section Research projects and references

Project #17806 overview

Project Summary AI Beta

KRAS mutations cause lots of cancers, but it's hard to make drugs for them because KRAS is smooth and doesn't have binding pockets. This project tries to find unstable forms of KRAS that could be stabilized by a drug.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Dr. Stefan Ivanov
Institution: Redesign Science

Work unit

Atoms: 30,000
Core: OPENMM_22
Status: Public

No related projects listed.

Source material

Official Project Description

Mutations in the KRAS protein and its paralogs HRAS and NRAS are among the most frequent drivers of cancer, including three of the most lethal cancers – lung, colorectal, and pancreatic.

Thus, they represent extremely appealing drug targets in oncology research.

However, despite the immense therapeutic potential, targeting KRAS has proven extremely difficult because of its smooth molecular surface which presents little to no pockets capable of accommodating a drug-like ligand.

This project aims to ascertain whether KRAS exhibits certain druggable metastable states, even short-lived ones, which could then be stabilized by a suitable ligand.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Mutations

Permanent alterations in DNA sequence.

Scientific: BiotechnologyOncology / Cancer Research

Mutations are changes in the DNA code that can affect how genes work. In cancer, mutations can lead to uncontrolled cell growth and the spread of disease.

KRAS

Kirsten rat sarcoma viral oncogene homolog

Scientific: PharmaceuticalOncology / Cancer Genomics

KRAS is a gene that provides instructions for making a protein involved in cell growth and division. Mutations in the KRAS gene can lead to uncontrolled cell growth, contributing to the development of cancer.

HRAS

Harvey rat sarcoma viral oncogene homolog

Scientific: PharmaceuticalOncology / Cancer Genomics

HRAS is a gene related to KRAS, also involved in cell growth and division. Mutations in HRAS can contribute to cancer development.

NRAS

Neuroblastoma rat sarcoma viral oncogene homolog

Scientific: PharmaceuticalOncology / Cancer Genomics

NRAS is another gene related to KRAS and HRAS, playing a role in cell growth and division. Mutations in NRAS can contribute to cancer.

Drug Targets

Specific molecules or pathways involved in disease that can be targeted by drugs.

Technical: PharmaceuticalOncology / Drug Discovery

Drug targets are specific components of cells or pathways that are involved in the development and progression of diseases. By targeting these components with drugs, scientists aim to stop or slow down the disease process.

Oncology

The study and treatment of cancer.

Technical: Biotechnology, HealthcareMedicine / Cancer Research

Oncology is the branch of medicine that deals with the prevention, diagnosis, treatment, and management of cancer. Oncologists are physicians who specialize in treating cancer patients.

Cancer

A group of diseases characterized by abnormal cell growth and spread.

Medical: Biotechnology, HealthcareMedicine / Oncology

Cancer is a group of diseases caused by uncontrolled cell growth. Cancer cells can invade surrounding tissues and spread to other parts of the body.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	Tesla P100 16GB GP100GL [Tesla P100 16GB] 9340	Nvidia	GP100GL	2,182,756	139,779	15.62	1 ^hrs 32 ^mins
2	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,045,260	136,813	14.95	1 ^hrs 36 ^mins
3	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	1,794,717	130,856	13.72	1 ^hrs 45 ^mins
4	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,592,444	126,187	12.62	1 ^hrs 54 ^mins
5	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,553,354	125,186	12.41	1 ^hrs 56 ^mins
6	Tesla P40 GP102GL [Tesla P40] 11760	Nvidia	GP102GL	1,541,178	123,925	12.44	1 ^hrs 56 ^mins
7	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,449,001	121,913	11.89	2 ^hrs 1 ^mins
8	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,428,988	119,253	11.98	2 ^hrs 0 ^mins
9	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,375,637	116,801	11.78	2 ^hrs 2 ^mins
10	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,326,039	117,148	11.32	2 ^hrs 7 ^mins
11	Quadro P5000 GP104GL [Quadro P5000]	Nvidia	GP104GL	1,212,899	115,113	10.54	2 ^hrs 17 ^mins
12	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,166,526	113,865	10.24	2 ^hrs 21 ^mins
13	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] 4608	Nvidia	TU106M	1,132,263	112,623	10.05	2 ^hrs 23 ^mins
14	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,070,782	109,327	9.79	2 ^hrs 27 ^mins
15	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	998,606	105,883	9.43	2 ^hrs 33 ^mins
16	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	984,478	104,018	9.46	2 ^hrs 32 ^mins
17	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	980,328	106,209	9.23	2 ^hrs 36 ^mins
18	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	976,918	107,146	9.12	2 ^hrs 38 ^mins
19	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	951,634	105,839	8.99	2 ^hrs 40 ^mins

20	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	933,868	99,502	9.39	2 ^hrs 33 ^mins
21	Quadro P4000 GP104GL [Quadro P4000]	Nvidia	GP104GL	813,326	100,875	8.06	2 ^hrs 59 ^mins
22	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	813,166	100,203	8.12	2 ^hrs 57 ^mins
23	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	778,380	99,225	7.84	3 ^hrs 4 ^mins
24	RTX A2000 Mobile GA107GLM [RTX A2000 Mobile]	Nvidia	GA107GLM	762,784	99,175	7.69	3 ^hrs 7 ^mins
25	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	752,928	97,789	7.70	3 ^hrs 7 ^mins
26	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	669,757	94,202	7.11	3 ^hrs 23 ^mins
27	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	618,122	91,126	6.78	3 ^hrs 32 ^mins
28	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	612,606	91,698	6.68	3 ^hrs 36 ^mins
29	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	609,054	91,225	6.68	3 ^hrs 36 ^mins
30	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	596,414	90,813	6.57	3 ^hrs 39 ^mins
31	Quadro T1200 Mobile TU117GLM [Quadro T1200 Mobile]	Nvidia	TU117GLM	584,319	90,504	6.46	3 ^hrs 43 ^mins
32	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	580,790	89,308	6.50	3 ^hrs 41 ^mins
33	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	558,311	86,953	6.42	3 ^hrs 44 ^mins
34	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	547,234	88,197	6.20	3 ^hrs 52 ^mins
35	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	536,111	87,544	6.12	3 ^hrs 55 ^mins
36	GeForce GTX 1650 TU117 [GeForce GTX 1650] 3091	Nvidia	TU117	489,384	83,807	5.84	4 ^hrs 7 ^mins
37	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	485,406	83,059	5.84	4 ^hrs 6 ^mins
38	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	399,192	77,904	5.12	4 ^hrs 41 ^mins
39	GeForce GTX 980M GM204 [GeForce GTX 980M] 3189	Nvidia	GM204	391,302	78,818	4.96	4 ^hrs 50 ^mins

40	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	381,668	76,499	4.99	4 ^hrs 49 ^mins
41	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	376,036	71,004	5.30	4 ^hrs 32 ^mins
42	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	363,056	76,095	4.77	5 ^hrs 2 ^mins
43	Tesla K20C GK110 [Tesla K20C] 3524	Nvidia	GK110	357,509	76,496	4.67	5 ^hrs 8 ^mins
44	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	342,145	75,898	4.51	5 ^hrs 19 ^mins
45	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	296,880	71,916	4.13	5 ^hrs 49 ^mins
46	T600 TU117GL [T600]	Nvidia	TU117GL	281,393	65,384	4.30	5 ^hrs 35 ^mins
47	Tesla K20M GK110 [Tesla K20M] 3524	Nvidia	GK110	258,288	67,562	3.82	6 ^hrs 17 ^mins
48	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	257,814	68,748	3.75	6 ^hrs 24 ^mins
49	P106-090 GP106 [P106-090]	Nvidia	GP106	250,363	67,759	3.69	6 ^hrs 30 ^mins
50	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	249,865	67,343	3.71	6 ^hrs 28 ^mins
51	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	247,805	67,818	3.65	6 ^hrs 34 ^mins
52	P104-100 GP104 [P104-100]	Nvidia	GP104	235,188	66,761	3.52	6 ^hrs 49 ^mins
53	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	221,724	64,637	3.43	6 ^hrs 60 ^mins
54	GeForce GTX 670/GTX 760Ti OEM GK104 [GeForce GTX 670/GTX 760Ti OEM] 2634	Nvidia	GK104	195,655	62,990	3.11	7 ^hrs 44 ^mins
55	P106-100 GP106 [P106-100]	Nvidia	GP106	188,284	61,980	3.04	7 ^hrs 54 ^mins
56	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	180,518	60,460	2.99	8 ^hrs 2 ^mins
57	GeForce GTX 690 GK104 [GeForce GTX 690] 3130	Nvidia	GK104	174,950	57,705	3.03	7 ^hrs 55 ^mins
58	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	140,045	53,255	2.63	9 ^hrs 8 ^mins
59	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	130,806	54,045	2.42	9 ^hrs 55 ^mins

60	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	128,355	54,476	2.36	10 ^hrs 11 ^mins
61	Quadro M2000 GM206GL [Quadro M2000]	Nvidia	GM206GL	125,935	54,274	2.32	10 ^hrs 21 ^mins
62	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	124,481	53,972	2.31	10 ^hrs 24 ^mins
63	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	113,646	52,237	2.18	11 ^hrs 2 ^mins
64	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	113,202	49,099	2.31	10 ^hrs 25 ^mins
65	GRID M40 GM107GL [GRID M40]	Nvidia	GM107GL	110,258	51,883	2.13	11 ^hrs 18 ^mins
66	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	110,159	51,533	2.14	11 ^hrs 14 ^mins
67	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	106,495	50,979	2.09	11 ^hrs 29 ^mins
68	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	106,362	50,775	2.09	11 ^hrs 27 ^mins
69	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	100,724	49,189	2.05	11 ^hrs 43 ^mins
70	GeForce GTX 950M GM107 [GeForce GTX 950M] 1439	Nvidia	GM107	85,154	48,128	1.77	13 ^hrs 34 ^mins
71	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	82,530	46,953	1.76	13 ^hrs 39 ^mins
72	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	81,355	47,028	1.73	13 ^hrs 52 ^mins
73	GeForce GTX 570 HD GF110 [GeForce GTX 570 HD] 1405	Nvidia	GF110	70,832	44,269	1.60	14 ^hrs 60 ^mins
74	GeForce GT 840M GM108 [GeForce GT 840M]	Nvidia	GM108	67,784	34,115	1.99	12 ^hrs 5 ^mins
75	VGX K2 GK104GL [VGX K2]	Nvidia	GK104GL	57,922	41,811	1.39	17 ^hrs 19 ^mins
76	GeForce GTX 660 GK106 [GeForce GTX 660]	Nvidia	GK106	55,866	40,128	1.39	17 ^hrs 14 ^mins
77	GeForce 940MX GM107 [GeForce 940MX]	Nvidia	GM107	55,043	41,214	1.34	17 ^hrs 58 ^mins
78	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	52,146	37,583	1.39	17 ^hrs 18 ^mins
79	GeForce 940MX GM108M [GeForce 940MX]	Nvidia	GM108M	43,036	37,780	1.14	21 ^hrs 4 ^mins

80	GeForce MX130 GM108M [GeForce MX130]	Nvidia	GM108M	36,872	35,976	1.02	23 ^hrs 25 ^mins
81	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	36,288	34,793	1.04	23 ^hrs 1 ^mins
82	GeForce GTX 560 GF114 [GeForce GTX 560]	Nvidia	GF114	33,953	34,995	0.97	24 ^hrs 44 ^mins
83	GeForce GT 730 GK208B [GeForce GT 730] 692.7	Nvidia	GK208B	31,604	31,641	1.00	24 ^hrs 2 ^mins
84	GeForce 940M GM108 [GeForce 940M]	Nvidia	GM108	29,056	30,498	0.95	25 ^hrs 11 ^mins
85	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	25,410	29,827	0.85	28 ^hrs 10 ^mins
86	GeForce GTX 550 Ti GF116 [GeForce GTX 550 Ti] 691	Nvidia	GF116	21,151	29,205	0.72	33 ^hrs 8 ^mins
87	GeForce GTX 670M GF114 [GeForce GTX 670M]	Nvidia	GF114	20,858	29,307	0.71	33 ^hrs 43 ^mins
88	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	14,740	29,205	0.50	47 ^hrs 33 ^mins

Research: CANCER Folding Project #17806

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17806

GPU PPD Averages

Research: CANCER Folding Project #17806

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages