PROJECT #17806 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Mutations in the KRAS protein and its paralogs HRAS and NRAS are among the most frequent drivers of cancer, including three of the most lethal cancers – lung, colorectal, and pancreatic. Thus, they represent extremely appealing drug targets in oncology research. However, despite the immense therapeutic potential, targeting KRAS has proven extremely difficult because of its smooth molecular surface which presents little to no pockets capable of accommodating a drug-like ligand. This project aims to ascertain whether KRAS exhibits certain druggable metastable states, even short-lived ones, which could then be stabilized by a suitable ligand.

PROJECT INFO

Manager(s): Dr. Stefan Ivanov

Institution: Redesign Science

PROJECT WORK UNIT SUMMARY

Atoms: 30,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	Tesla P100 16GB GP100GL [Tesla P100 16GB] 9340	Nvidia	GP100GL	2,182,756	139,779	15.62	2 ^hrs 32 ^mins
2	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,983,478	134,664	14.73	2 ^hrs 38 ^mins
3	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	1,764,211	130,438	13.53	2 ^hrs 46 ^mins
4	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,550,103	125,105	12.39	2 ^hrs 56 ^mins
5	Tesla P40 GP102GL [Tesla P40] 11760	Nvidia	GP102GL	1,541,178	123,925	12.44	2 ^hrs 56 ^mins
6	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,470,355	122,617	11.99	2 ^hrs 0 ^mins
7	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,442,957	121,742	11.85	2 ^hrs 1 ^mins
8	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,371,724	117,056	11.72	2 ^hrs 3 ^mins
9	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,362,000	119,130	11.43	2 ^hrs 6 ^mins
10	Quadro P5000 GP104GL [Quadro P5000]	Nvidia	GP104GL	1,212,899	115,113	10.54	2 ^hrs 17 ^mins
11	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,186,972	113,121	10.49	2 ^hrs 17 ^mins
12	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,178,017	113,921	10.34	2 ^hrs 19 ^mins
13	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] 4608	Nvidia	TU106M	1,152,307	113,466	10.16	2 ^hrs 22 ^mins
14	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,098,304	109,979	9.99	2 ^hrs 24 ^mins
15	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	987,077	106,956	9.23	3 ^hrs 36 ^mins
16	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	973,813	107,020	9.10	3 ^hrs 38 ^mins
17	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	964,628	102,886	9.38	3 ^hrs 34 ^mins
18	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	957,258	103,861	9.22	3 ^hrs 36 ^mins
19	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	922,932	99,895	9.24	3 ^hrs 36 ^mins
20	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	901,514	103,508	8.71	3 ^hrs 45 ^mins
21	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	892,972	100,204	8.91	3 ^hrs 42 ^mins
22	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	778,380	99,225	7.84	3 ^hrs 4 ^mins
23	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	765,351	98,374	7.78	3 ^hrs 5 ^mins
24	RTX A2000 Mobile GA107GLM [RTX A2000 Mobile]		GA107GLM	762,784	99,175	7.69	3 ^hrs 7 ^mins
25	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	698,195	95,542	7.31	3 ^hrs 17 ^mins
26	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	669,757	94,202	7.11	3 ^hrs 23 ^mins
27	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	609,054	91,225	6.68	4 ^hrs 36 ^mins
28	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	607,225	91,379	6.65	4 ^hrs 37 ^mins
29	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	592,714	90,621	6.54	4 ^hrs 40 ^mins
30	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	591,335	90,036	6.57	4 ^hrs 39 ^mins
31	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	587,688	89,453	6.57	4 ^hrs 39 ^mins
32	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	536,813	87,585	6.13	4 ^hrs 55 ^mins
33	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	532,067	87,368	6.09	4 ^hrs 56 ^mins
34	GeForce GTX 1650 TU117 [GeForce GTX 1650] 3091	Nvidia	TU117	481,862	83,278	5.79	4 ^hrs 9 ^mins
35	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	464,736	80,102	5.80	4 ^hrs 8 ^mins
36	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	399,192	77,904	5.12	5 ^hrs 41 ^mins
37	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	376,036	71,004	5.30	5 ^hrs 32 ^mins
38	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	375,482	76,379	4.92	5 ^hrs 53 ^mins
39	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	350,448	75,166	4.66	5 ^hrs 9 ^mins
40	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	342,145	75,898	4.51	5 ^hrs 19 ^mins
41	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	292,503	71,565	4.09	6 ^hrs 52 ^mins
42	P106-090 GP106 [P106-090]	Nvidia	GP106	260,890	68,986	3.78	6 ^hrs 21 ^mins
43	Tesla K20C GK110 [Tesla K20C] 3524	Nvidia	GK110	259,473	66,463	3.90	6 ^hrs 9 ^mins
44	Tesla K20M GK110 [Tesla K20M] 3524	Nvidia	GK110	258,288	67,562	3.82	6 ^hrs 17 ^mins
45	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	250,727	68,126	3.68	7 ^hrs 31 ^mins
46	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	249,865	67,343	3.71	6 ^hrs 28 ^mins
47	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	248,671	67,919	3.66	7 ^hrs 33 ^mins
48	P104-100 GP104 [P104-100]	Nvidia	GP104	228,694	66,162	3.46	7 ^hrs 57 ^mins
49	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	219,621	64,449	3.41	7 ^hrs 3 ^mins
50	GeForce GTX 670/GTX 760Ti OEM GK104 [GeForce GTX 670/GTX 760Ti OEM] 2634	Nvidia	GK104	195,655	62,990	3.11	8 ^hrs 44 ^mins
51	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	195,422	60,837	3.21	7 ^hrs 28 ^mins
52	GeForce GTX 690 GK104 [GeForce GTX 690] 3130	Nvidia	GK104	195,040	60,007	3.25	7 ^hrs 23 ^mins
53	P106-100 GP106 [P106-100]	Nvidia	GP106	187,379	61,880	3.03	8 ^hrs 56 ^mins
54	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	185,199	59,167	3.13	8 ^hrs 40 ^mins
55	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	179,379	60,327	2.97	8 ^hrs 4 ^mins
56	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	167,684	58,519	2.87	8 ^hrs 23 ^mins
57	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	132,370	54,250	2.44	10 ^hrs 50 ^mins
58	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	125,105	54,114	2.31	10 ^hrs 23 ^mins
59	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	124,278	53,951	2.30	10 ^hrs 25 ^mins
60	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	114,541	52,397	2.19	11 ^hrs 59 ^mins
61	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	113,202	49,099	2.31	10 ^hrs 25 ^mins
62	GRID M40 GM107GL [GRID M40]	Nvidia	GM107GL	110,258	51,883	2.13	11 ^hrs 18 ^mins
63	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	110,159	51,533	2.14	11 ^hrs 14 ^mins
64	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	98,966	48,733	2.03	12 ^hrs 49 ^mins
65	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	87,635	47,956	1.83	13 ^hrs 8 ^mins
66	GeForce GTX 950M GM107 [GeForce GTX 950M] 1439	Nvidia	GM107	85,154	48,128	1.77	14 ^hrs 34 ^mins
67	GeForce GTX 570 HD GF110 [GeForce GTX 570 HD] 1405	Nvidia	GF110	70,832	44,269	1.60	15 ^hrs 60 ^mins
68	GeForce GT 840M GM108 [GeForce GT 840M]	Nvidia	GM108	67,784	34,115	1.99	12 ^hrs 5 ^mins
69	VGX K2 GK104GL [VGX K2]		GK104GL	57,922	41,811	1.39	17 ^hrs 19 ^mins
70	GeForce 940MX GM107 [GeForce 940MX]	Nvidia	GM107	54,850	41,195	1.33	18 ^hrs 2 ^mins
71	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	52,146	37,583	1.39	17 ^hrs 18 ^mins
72	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	36,288	34,793	1.04	23 ^hrs 1 ^mins
73	GeForce GTX 560 GF114 [GeForce GTX 560]	Nvidia	GF114	33,953	34,995	0.97	25 ^hrs 44 ^mins
74	GeForce 940M GM108 [GeForce 940M]	Nvidia	GM108	29,597	30,718	0.96	25 ^hrs 55 ^mins
75	GeForce GT 730 GK208B [GeForce GT 730] 692.7	Nvidia	GK208B	29,581	30,422	0.97	25 ^hrs 41 ^mins
76	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	25,410	29,827	0.85	28 ^hrs 10 ^mins
77	GeForce GTX 550 Ti GF116 [GeForce GTX 550 Ti] 691	Nvidia	GF116	21,151	29,205	0.72	33 ^hrs 8 ^mins
78	GeForce GTX 670M GF114 [GeForce GTX 670M]	Nvidia	GF114	20,858	29,307	0.71	34 ^hrs 43 ^mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make

Legal Information: This sites use is for entertainment purposes only and comes with no guarantees or warranties in its use or related to any data displayed, collected or calcuated. This site is not affilated with folding@home or any folding team or GPU / CPU company in any official capacity and is an enthusiast creation in support of folding@home and the users / teams folding data for the greater good.

Please Note: By using this site, and / or our chrome extension you understand that you may be periodically providing information such as your IP, stats regarding use of our site, and folding@home GPU / CPU model, Work Unit ID and PPD estimate data when using our Chrome extention to the site developer for site optimization and PPD related data displayed on the site.

IF YOU DO NOT WISH TO CONTRIBUTE DATA TO THE PPD DATABASE PLEASE UNINSTALL OUR PLUGIN/TOOLS AND DISCONTINUE USE OF THIS SITE IMMEDIATELY.