PROJECT #17806 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Mutations in the KRAS protein and its paralogs HRAS and NRAS are among the most frequent drivers of cancer, including three of the most lethal cancers – lung, colorectal, and pancreatic. Thus, they represent extremely appealing drug targets in oncology research. However, despite the immense therapeutic potential, targeting KRAS has proven extremely difficult because of its smooth molecular surface which presents little to no pockets capable of accommodating a drug-like ligand. This project aims to ascertain whether KRAS exhibits certain druggable metastable states, even short-lived ones, which could then be stabilized by a suitable ligand.

PROJECT INFO

Manager(s): Dr. Stefan Ivanov

Institution: Redesign Science

PROJECT WORK UNIT SUMMARY

Atoms: 30,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 30 July 2021 03:40:22

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 1,784,195 130,949 13.63 2 hrs 46 mins
2 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,550,021 124,451 12.45 2 hrs 56 mins
3 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,371,067 117,141 11.70 2 hrs 3 mins
4 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,312,827 110,415 11.89 2 hrs 1 mins
5 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,235,583 115,301 10.72 2 hrs 14 mins
6 Quadro P5000
GP104GL [Quadro P5000]
Nvidia GP104GL 1,212,899 115,113 10.54 2 hrs 17 mins
7 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,195,192 111,880 10.68 2 hrs 15 mins
8 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,019,428 107,948 9.44 3 hrs 32 mins
9 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 850,459 101,026 8.42 3 hrs 51 mins
10 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 843,844 102,550 8.23 3 hrs 55 mins
11 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 832,114 101,615 8.19 3 hrs 56 mins
12 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 770,025 92,085 8.36 3 hrs 52 mins
13 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 614,428 67,076 9.16 3 hrs 37 mins
14 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 550,903 88,431 6.23 4 hrs 51 mins
15 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 540,388 87,320 6.19 4 hrs 53 mins
16 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 506,105 85,490 5.92 4 hrs 3 mins
17 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 501,613 84,067 5.97 4 hrs 1 mins
18 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 483,854 82,696 5.85 4 hrs 6 mins
19 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 406,187 78,830 5.15 5 hrs 39 mins
20 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 376,322 70,240 5.36 4 hrs 29 mins
21 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 350,678 74,572 4.70 5 hrs 6 mins
22 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 337,933 73,938 4.57 5 hrs 15 mins
23 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 334,330 73,904 4.52 5 hrs 18 mins
24 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 294,276 71,683 4.11 6 hrs 51 mins
25 Tesla K20M
GK110 [Tesla K20M] 3524
Nvidia GK110 258,288 67,562 3.82 6 hrs 17 mins
26 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 249,865 67,343 3.71 6 hrs 28 mins
27 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 248,671 67,919 3.66 7 hrs 33 mins
28 P104-100
GP104 [P104-100]
Nvidia GP104 227,342 66,018 3.44 7 hrs 58 mins
29 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 217,104 63,989 3.39 7 hrs 4 mins
30 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 197,162 58,671 3.36 7 hrs 9 mins
31 P106-100
GP106 [P106-100]
Nvidia GP106 186,860 61,802 3.02 8 hrs 56 mins
32 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 172,176 58,757 2.93 8 hrs 11 mins
33 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 123,680 53,916 2.29 10 hrs 28 mins
34 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 121,988 53,638 2.27 11 hrs 33 mins
35 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 118,695 52,549 2.26 11 hrs 38 mins
36 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 115,069 52,656 2.19 11 hrs 59 mins
37 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 111,730 52,137 2.14 11 hrs 12 mins
38 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 110,319 48,267 2.29 11 hrs 30 mins
39 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 96,197 49,019 1.96 12 hrs 14 mins
40 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 88,445 48,184 1.84 13 hrs 4 mins
41 GeForce GT 840M
GM108 [GeForce GT 840M]
Nvidia GM108 67,784 34,115 1.99 12 hrs 5 mins
42 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 52,146 37,583 1.39 17 hrs 18 mins
43 GeForce GTX 560
GF114 [GeForce GTX 560]
Nvidia GF114 33,599 34,941 0.96 25 hrs 58 mins
44 GeForce 920M
GK208 [GeForce 920M]
Nvidia GK208 23,890 30,597 0.78 31 hrs 44 mins
45 GeForce GTX 670M
GF114 [GeForce GTX 670M]
Nvidia GF114 20,831 29,363 0.71 34 hrs 50 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 30 July 2021 03:40:22

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make