PROJECT #17806 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Mutations in the KRAS protein and its paralogs HRAS and NRAS are among the most frequent drivers of cancer, including three of the most lethal cancers – lung, colorectal, and pancreatic. Thus, they represent extremely appealing drug targets in oncology research. However, despite the immense therapeutic potential, targeting KRAS has proven extremely difficult because of its smooth molecular surface which presents little to no pockets capable of accommodating a drug-like ligand. This project aims to ascertain whether KRAS exhibits certain druggable metastable states, even short-lived ones, which could then be stabilized by a suitable ligand.

PROJECT INFO

Manager(s): Dr. Stefan Ivanov

Institution: Redesign Science

PROJECT WORK UNIT SUMMARY

Atoms: 30,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 30 July 2021 03:40:22

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	1,784,195	130,949	13.63	2 ^hrs 46 ^mins
2	Tesla P40 GP102GL [Tesla P40] 11760	Nvidia	GP102GL	1,550,021	124,451	12.45	2 ^hrs 56 ^mins
3	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,371,067	117,141	11.70	2 ^hrs 3 ^mins
4	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,312,827	110,415	11.89	2 ^hrs 1 ^mins
5	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,235,583	115,301	10.72	2 ^hrs 14 ^mins
6	Quadro P5000 GP104GL [Quadro P5000]	Nvidia	GP104GL	1,212,899	115,113	10.54	2 ^hrs 17 ^mins
7	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,195,192	111,880	10.68	2 ^hrs 15 ^mins
8	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,019,428	107,948	9.44	3 ^hrs 32 ^mins
9	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	850,459	101,026	8.42	3 ^hrs 51 ^mins
10	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	843,844	102,550	8.23	3 ^hrs 55 ^mins
11	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	832,114	101,615	8.19	3 ^hrs 56 ^mins
12	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	770,025	92,085	8.36	3 ^hrs 52 ^mins
13	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	614,428	67,076	9.16	3 ^hrs 37 ^mins
14	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	550,903	88,431	6.23	4 ^hrs 51 ^mins
15	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	540,388	87,320	6.19	4 ^hrs 53 ^mins
16	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	506,105	85,490	5.92	4 ^hrs 3 ^mins
17	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	501,613	84,067	5.97	4 ^hrs 1 ^mins
18	GeForce GTX 1650 TU117 [GeForce GTX 1650] 3091	Nvidia	TU117	483,854	82,696	5.85	4 ^hrs 6 ^mins
19	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	406,187	78,830	5.15	5 ^hrs 39 ^mins
20	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	376,322	70,240	5.36	4 ^hrs 29 ^mins
21	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	350,678	74,572	4.70	5 ^hrs 6 ^mins
22	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	337,933	73,938	4.57	5 ^hrs 15 ^mins
23	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	334,330	73,904	4.52	5 ^hrs 18 ^mins
24	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	294,276	71,683	4.11	6 ^hrs 51 ^mins
25	Tesla K20M GK110 [Tesla K20M] 3524	Nvidia	GK110	258,288	67,562	3.82	6 ^hrs 17 ^mins
26	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	249,865	67,343	3.71	6 ^hrs 28 ^mins
27	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	248,671	67,919	3.66	7 ^hrs 33 ^mins
28	P104-100 GP104 [P104-100]	Nvidia	GP104	227,342	66,018	3.44	7 ^hrs 58 ^mins
29	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	217,104	63,989	3.39	7 ^hrs 4 ^mins
30	GeForce GTX 690 GK104 [GeForce GTX 690] 3130	Nvidia	GK104	197,162	58,671	3.36	7 ^hrs 9 ^mins
31	P106-100 GP106 [P106-100]	Nvidia	GP106	186,860	61,802	3.02	8 ^hrs 56 ^mins
32	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	172,176	58,757	2.93	8 ^hrs 11 ^mins
33	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	123,680	53,916	2.29	10 ^hrs 28 ^mins
34	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	121,988	53,638	2.27	11 ^hrs 33 ^mins
35	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	118,695	52,549	2.26	11 ^hrs 38 ^mins
36	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	115,069	52,656	2.19	11 ^hrs 59 ^mins
37	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	111,730	52,137	2.14	11 ^hrs 12 ^mins
38	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	110,319	48,267	2.29	11 ^hrs 30 ^mins
39	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	96,197	49,019	1.96	12 ^hrs 14 ^mins
40	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	88,445	48,184	1.84	13 ^hrs 4 ^mins
41	GeForce GT 840M GM108 [GeForce GT 840M]	Nvidia	GM108	67,784	34,115	1.99	12 ^hrs 5 ^mins
42	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	52,146	37,583	1.39	17 ^hrs 18 ^mins
43	GeForce GTX 560 GF114 [GeForce GTX 560]	Nvidia	GF114	33,599	34,941	0.96	25 ^hrs 58 ^mins
44	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	23,890	30,597	0.78	31 ^hrs 44 ^mins
45	GeForce GTX 670M GF114 [GeForce GTX 670M]	Nvidia	GF114	20,831	29,363	0.71	34 ^hrs 50 ^mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 30 July 2021 03:40:22

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make

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