Folding project #17741, CANCER research

Research section Research projects and references

Project #17741 overview

Project Summary AI Beta

This project studies how proteins use ion gradients to move molecules across cell membranes. These proteins are important for many bodily functions and are often drug targets for diseases like cancer and diabetes. By simulating these proteins, we can learn how they work and develop better treatments.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Matthew Chan
Institution: University of Illinois at Urbana-Champaign

Work unit

Atoms: 116,298
Core: OPENMM_22
Status: Public

Source material

Official Project Description

Projects 17711-17724 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat disease like cancer, diabetes, and neurological disorders.

These simulations will allow us to understand a universal role of ion-coupling across different families of proteins.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Secondary active transporters

Proteins that use ion gradients to transport molecules across cell membranes.

Scientific: BiotechnologyMembrane Transport / Cellular Physiology

Secondary active transporters are essential proteins found in all living organisms. They work by using the energy from an existing ion gradient to move other molecules across cell membranes. This process is crucial for various cellular functions, including nutrient uptake, waste removal, and signal transduction. Many secondary active transporters are targeted by drugs to treat diseases like cancer, diabetes, and neurological disorders.

Ion

An atom or molecule with a net electrical charge.

Scientific: Pharmaceutical ResearchBiochemistry / Electrochemistry

Ions are atoms or molecules that have gained or lost electrons, giving them a net positive or negative charge. They play crucial roles in biological systems, such as nerve impulse transmission, muscle contraction, and maintaining fluid balance.

Membrane

A thin barrier that separates the inside of a cell from its external environment.

Scientific: BiotechnologyCell Biology / Cellular Structure

Membranes are essential structures in cells, separating internal compartments and controlling the passage of molecules in and out. They consist primarily of lipids and proteins, with various functions such as transport, signaling, and providing structural support.

Proteins

Large biomolecules essential for various cellular functions.

Scientific: PharmaceuticalsMolecular Biology / Biochemistry

Proteins are complex molecules made up of amino acids, performing diverse roles in living organisms. They act as enzymes, structural components, hormones, antibodies, and transporters, among others.

Simulations

Computer models used to mimic real-world processes.

Technical: BiotechnologyBioinformatics / Computational Biology

Simulations are powerful tools used in various fields, including biology and medicine. They involve creating computer models that represent real-world systems, allowing researchers to study complex phenomena and predict outcomes.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,538,164	126,906	59.40	0 ^hrs 24 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,557,647	115,864	47.97	0 ^hrs 30 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,134,545	112,973	45.45	0 ^hrs 32 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,564,626	108,228	42.18	0 ^hrs 34 ^mins
5	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	3,801,339	105,593	36.00	0 ^hrs 40 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,076,840	95,418	32.25	0 ^hrs 45 ^mins
7	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,037,101	95,324	31.86	0 ^hrs 45 ^mins
8	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,854,624	93,420	30.56	0 ^hrs 47 ^mins
9	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,831,626	91,525	30.94	0 ^hrs 47 ^mins
10	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,828,209	91,808	30.81	0 ^hrs 47 ^mins
11	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,629,367	90,430	29.08	0 ^hrs 50 ^mins
12	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,371,003	87,929	26.96	0 ^hrs 53 ^mins
13	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,220,239	85,889	25.85	0 ^hrs 56 ^mins
14	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,129,095	84,789	25.11	0 ^hrs 57 ^mins
15	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,020,001	83,071	24.32	0 ^hrs 59 ^mins
16	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,804,694	79,849	22.60	1 ^hrs 4 ^mins
17	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,761,353	78,413	22.46	1 ^hrs 4 ^mins
18	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	1,655,174	77,012	21.49	1 ^hrs 7 ^mins
19	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,499,252	75,362	19.89	1 ^hrs 12 ^mins

20	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,354,976	72,917	18.58	1 ^hrs 17 ^mins
21	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,338,700	72,983	18.34	1 ^hrs 19 ^mins
22	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,303,066	71,881	18.13	1 ^hrs 19 ^mins
23	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] 4608	Nvidia	TU106M	1,177,652	68,151	17.28	1 ^hrs 23 ^mins
24	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,087,290	68,030	15.98	1 ^hrs 30 ^mins
25	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,014,293	66,044	15.36	1 ^hrs 34 ^mins
26	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,008,491	64,828	15.56	1 ^hrs 33 ^mins
27	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	943,459	64,785	14.56	1 ^hrs 39 ^mins
28	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	814,521	56,768	14.35	1 ^hrs 40 ^mins
29	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	680,031	56,098	12.12	1 ^hrs 59 ^mins
30	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	579,860	51,312	11.30	2 ^hrs 7 ^mins
31	P106-100 GP106 [P106-100]	Nvidia	GP106	504,970	52,597	9.60	2 ^hrs 30 ^mins
32	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	496,177	52,613	9.43	2 ^hrs 33 ^mins
33	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	485,919	52,068	9.33	2 ^hrs 34 ^mins
34	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	478,649	49,931	9.59	2 ^hrs 30 ^mins
35	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	464,789	51,313	9.06	2 ^hrs 39 ^mins
36	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	426,149	42,619	10.00	2 ^hrs 24 ^mins
37	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	407,046	44,607	9.13	2 ^hrs 38 ^mins
38	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	394,588	48,374	8.16	2 ^hrs 57 ^mins
39	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	360,087	46,255	7.78	3 ^hrs 5 ^mins

40	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	351,216	46,704	7.52	3 ^hrs 11 ^mins
41	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	306,237	44,767	6.84	3 ^hrs 31 ^mins
42	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	234,002	38,859	6.02	3 ^hrs 59 ^mins
43	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	219,936	39,916	5.51	4 ^hrs 21 ^mins
44	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	212,054	39,561	5.36	4 ^hrs 29 ^mins
45	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	165,724	35,833	4.62	5 ^hrs 11 ^mins
46	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	120,462	32,611	3.69	6 ^hrs 30 ^mins
47	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	114,677	32,198	3.56	6 ^hrs 44 ^mins
48	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	112,645	32,086	3.51	6 ^hrs 50 ^mins
49	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	108,976	31,660	3.44	6 ^hrs 58 ^mins
50	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	108,222	31,697	3.41	7 ^hrs 2 ^mins
51	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	104,115	30,451	3.42	7 ^hrs 1 ^mins
52	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	89,310	29,657	3.01	7 ^hrs 58 ^mins
53	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	76,515	28,326	2.70	8 ^hrs 53 ^mins
54	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	73,662	27,886	2.64	9 ^hrs 5 ^mins
55	Radeon R7/R6 360 Series Bonaire [Radeon R7/R6 360 Series]	AMD	Bonaire	47,678	23,817	2.00	11 ^hrs 59 ^mins
56	Radeon RX 550 Series AMD/ATI [Radeon RX 550 Series]	AMD	AMD/ATI	41,326	20,976	1.97	12 ^hrs 11 ^mins
57	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	26,244	18,265	1.44	16 ^hrs 42 ^mins

Research: CANCER Folding Project #17741

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17741

GPU PPD Averages

Research: CANCER Folding Project #17741

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages