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PROJECT #16955 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulations the dynamics of the human enzyme lactate dehydrogenase (LDH), the key metabolic enzyme that converts lactate to pyruvate and back.

We are simulating apo and holo-state dynamics to study how this enzyme binds inhibitors, which should lead to a better understanding of allostery and inform new computational drug discovery efforts..

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 151,566

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Saturday, 01 April 2023 12:14:50

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 Iris(R) Iris Xe Graphics
TGL GT2 [Iris(R) Iris Xe Graphics]		 Intel TGL GT2 4,720 6,444 0.73 33 hrs 46 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Saturday, 01 April 2023 12:14:50

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 XEON E-2124G CPU @ 3.40GHZ 4 1,105,019 4,420,076 Intel
2 CORE I7-8700 CPU @ 3.20GHZ 12 332,087 3,985,044 Intel
3 CORE I3-2120 CPU @ 3.30GHZ 4 928,875 3,715,500 Intel
4 CORE I5-6500 CPU @ 3.20GHZ 4 711,011 2,844,044 Intel
5 RYZEN THREADRIPPER 3970X 32-CORE 64 17,099 1,094,336 AMD
6 ATOM(TM) CPU Z3775 @ 1.46GHZ 4 176,785 707,140 Intel
7 CORE I3-3225 CPU @ 3.30GHZ 4 168,367 673,468 Intel
8 RYZEN 9 3950X 16-CORE 32 18,574 594,368 AMD
9 RYZEN 9 5950X 16-CORE 32 18,520 592,640 AMD
10 RYZEN 7 5800X 8-CORE 16 33,460 535,360 AMD
11 RYZEN 9 3900 12-CORE 24 17,790 426,960 AMD
12 12TH GEN CORE I7-12700K 20 20,101 402,020 Intel
13 11TH GEN CORE I9-11900K @ 3.50GHZ 16 24,642 394,272 Intel
14 XEON CPU E5-2620 0 @ 2.00GHZ 12 32,477 389,724 Intel
15 RYZEN 9 5900X 12-CORE 24 15,960 383,040 AMD
16 XEON CPU E5-2670 0 @ 2.60GHZ 32 11,879 380,128 Intel
17 RYZEN THREADRIPPER 2970WX 24-CORE 48 7,702 369,696 AMD
18 RYZEN 7 5700G 16 21,484 343,744 AMD
19 CORE I9-7920X CPU @ 2.90GHZ 24 14,197 340,728 Intel
20 RYZEN 9 3900XT 12-CORE 24 13,884 333,216 AMD
21 RYZEN 9 3900X 12-CORE 24 13,336 320,064 AMD
22 RYZEN THREADRIPPER 3960X 24-CORE 48 6,621 317,808 AMD
23 12TH GEN CORE I7-12700 20 15,670 313,400 Intel
24 CORE I9-10850K CPU @ 3.60GHZ 20 14,770 295,400 Intel
25 RYZEN 7 3800X 8-CORE 16 17,969 287,504 AMD
26 XEON CPU E5-2690 V4 @ 2.60GHZ 28 10,031 280,868 Intel
27 11TH GEN CORE I7-11700K @ 3.60GHZ 16 17,041 272,656 Intel
28 CORE I9-10900X CPU @ 3.70GHZ 20 13,166 263,320 Intel
29 RYZEN THREADRIPPER 2950X 16-CORE 32 8,200 262,400 AMD
30 CORE I9-9900K CPU @ 3.60GHZ 16 15,749 251,984 Intel
31 XEON CPU E5-2667 V2 @ 3.30GHZ 32 7,647 244,704 Intel
32 CORE2 DUO CPU E6550 @ 2.33GHZ 2 122,104 244,208 Intel
33 CORE I7-9700K CPU @ 3.60GHZ 8 29,916 239,328 Intel
34 XEON CPU E5-2650 V2 @ 2.60GHZ 32 6,678 213,696 Intel
35 XEON CPU E5-2680 V3 @ 2.50GHZ 24 8,786 210,864 Intel
36 11TH GEN CORE I7-11850H @ 2.50GHZ 16 12,853 205,648 Intel
37 RYZEN 5 5600X 6-CORE 12 16,956 203,472 AMD
38 CORE I7-5960X CPU @ 3.00GHZ 16 12,694 203,104 Intel
39 CORE I7-10700K CPU @ 3.80GHZ 16 12,518 200,288 Intel
40 RYZEN 9 5900HS 16 12,139 194,224 AMD
41 CORE I9-9900 CPU @ 3.10GHZ 16 11,979 191,664 Intel
42 11TH GEN CORE I5-11600K @ 3.90GHZ 12 15,655 187,860 Intel
43 XEON CPU E5-2660 V3 @ 2.60GHZ 20 9,181 183,620 Intel
44 CORE I7-10700 CPU @ 2.90GHZ 16 11,463 183,408 Intel
45 XEON W-2175 CPU @ 2.50GHZ 28 6,457 180,796 Intel
46 CORE I7-9700 CPU @ 3.00GHZ 8 21,519 172,152 Intel
47 RYZEN 5 2600X SIX-CORE 12 13,656 163,872 AMD
48 RYZEN THREADRIPPER 1920X 12-CORE 24 6,569 157,656 AMD
49 RYZEN 7 PRO 4750G 16 9,682 154,912 AMD
50 RYZEN 7 4800H 16 9,413 150,608 AMD
51 RYZEN 7 3700X 8-CORE 16 9,368 149,888 AMD
52 CORE I5-10400 CPU @ 2.90GHZ 12 12,303 147,636 Intel
53 RYZEN 5 3600 6-CORE 12 11,909 142,908 AMD
54 CORE I7-9700T CPU @ 2.00GHZ 8 17,129 137,032 Intel
55 XEON CPU E5-2673 V3 @ 2.40GHZ 24 5,605 134,520 Intel
56 11TH GEN CORE I9-11900F @ 2.50GHZ 16 8,235 131,760 Intel
57 RYZEN 7 2700X EIGHT-CORE 16 7,582 121,312 AMD
58 CORE I3-10105F CPU @ 3.70GHZ 8 14,691 117,528 Intel
59 CORE I5-9600K CPU @ 3.70GHZ 6 19,565 117,390 Intel
60 CORE I5-10400F CPU @ 2.90GHZ 12 9,755 117,060 Intel
61 CORE I9-9880H CPU @ 2.30GHZ 16 6,965 111,440 Intel
62 CORE I7-10870H CPU @ 2.20GHZ 16 6,941 111,056 Intel
63 CORE I7-8700B CPU @ 3.20GHZ 12 8,447 101,364 Intel
64 CORE I7-7700 CPU @ 3.60GHZ 8 12,140 97,120 Intel
65 RYZEN 3 3100 4-CORE 8 11,981 95,848 AMD
66 CORE I7-10700T CPU @ 2.00GHZ 16 5,926 94,816 Intel
67 CORE I5-4300U CPU @ 1.90GHZ 4 23,301 93,204 Intel
68 CORE I7-5820K CPU @ 3.30GHZ 12 7,758 93,096 Intel
69 11TH GEN CORE I5-11400 @ 2.60GHZ 12 7,711 92,532 Intel
70 CORE I7-4790K CPU @ 4.00GHZ 8 10,821 86,568 Intel
71 CORE I7-8705G CPU @ 3.10GHZ 8 10,675 85,400 Intel
72 CORE I7-6700K CPU @ 4.00GHZ 8 10,255 82,040 Intel
73 CORE I7-10750H CPU @ 2.60GHZ 12 6,665 79,980 Intel
74 RYZEN 5 2600 SIX-CORE 12 6,517 78,204 AMD
75 RYZEN 5 1600 SIX-CORE 12 6,464 77,568 AMD
76 CORE I7-6700 CPU @ 3.40GHZ 8 9,599 76,792 Intel
77 CORE I3-8100 CPU @ 3.60GHZ 4 18,934 75,736 Intel
78 CORE I7-4790 CPU @ 3.60GHZ 8 9,240 73,920 Intel
79 CORE I5-8400 CPU @ 2.80GHZ 6 12,029 72,174 Intel
80 CORE I5-7600 CPU @ 3.50GHZ 4 17,702 70,808 Intel
81 CORE I7-1065G7 CPU @ 1.30GHZ 8 8,804 70,432 Intel
82 RYZEN 5 3600X 6-CORE 12 5,863 70,356 AMD
83 RYZEN 7 5700U 16 4,365 69,840 AMD
84 CORE I3-3220 CPU @ 3.30GHZ 4 17,326 69,304 Intel
85 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,245 67,920 Intel
86 XEON W-10855M CPU @ 2.80GHZ 12 5,565 66,780 Intel
87 GENUINE CPU 0000 @ 2.70GHZ 8 8,312 66,496 Intel
88 EPYC 7251 8-CORE 16 4,138 66,208 AMD
89 CORE I7-8550U CPU @ 1.80GHZ 8 7,740 61,920 Intel
90 CORE I9-8950HK CPU @ 2.90GHZ 12 5,150 61,800 Intel
91 CORE I5-5200U CPU @ 2.20GHZ 4 15,250 61,000 Intel
92 CORE I5-7400 CPU @ 3.00GHZ 4 15,195 60,780 Intel
93 CORE I3-8300 CPU @ 3.70GHZ 4 15,046 60,184 Intel
94 CORE I7-4980HQ CPU @ 2.80GHZ 8 7,180 57,440 Intel
95 CORE I7-10510U CPU @ 1.80GHZ 8 7,163 57,304 Intel
96 CORE I5-8300H CPU @ 2.30GHZ 8 6,975 55,800 Intel
97 CORE I7-10610U CPU @ 1.80GHZ 8 6,658 53,264 Intel
98 CORE I5-6500T CPU @ 2.50GHZ 4 13,297 53,188 Intel
99 XEON CPU X5570 @ 2.93GHZ 16 3,286 52,576 Intel
100 CORE I7-4790T CPU @ 2.70GHZ 8 6,443 51,544 Intel
101 CORE I5-6600K CPU @ 3.50GHZ 4 12,788 51,152 Intel
102 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 6,338 50,704 Intel
103 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 6,212 49,696 Intel
104 CORE I7-3720QM CPU @ 2.60GHZ 8 6,146 49,168 Intel
105 CORE I5-4590 CPU @ 3.30GHZ 4 12,121 48,484 Intel
106 CORE I3-8100T CPU @ 3.10GHZ 4 12,015 48,060 Intel
107 CORE I5-4670 CPU @ 3.40GHZ 4 11,905 47,620 Intel
108 RYZEN 5 5500U 12 3,901 46,812 AMD
109 CELERON(R) CPU 847 @ 1.10GHZ 2 23,005 46,010 Intel
110 11TH GEN CORE I7-1185G7 @ 3.00GHZ 8 5,630 45,040 Intel
111 CORE I5-4570 CPU @ 3.20GHZ 4 11,257 45,028 Intel
112 CORE I7-4770HQ CPU @ 2.20GHZ 8 5,575 44,600 Intel
113 CORE I7-6700HQ CPU @ 2.60GHZ 8 5,485 43,880 Intel
114 CORE I7-7700HQ CPU @ 2.80GHZ 8 5,469 43,752 Intel
115 CORE I5-6400 CPU @ 2.70GHZ 4 10,813 43,252 Intel
116 CORE I7-4770 CPU @ 3.40GHZ 8 5,378 43,024 Intel
117 CORE I5-6600 CPU @ 3.30GHZ 4 10,617 42,468 Intel
118 RYZEN 3 3200G 4 10,508 42,032 AMD
119 XEON CPU E5-1620 0 @ 3.60GHZ 8 5,221 41,768 Intel
120 CORE I3-10100 CPU @ 3.60GHZ 8 5,212 41,696 Intel
121 CORE I7-3770 CPU @ 3.40GHZ 8 5,154 41,232 Intel
122 CORE I5-8259U CPU @ 2.30GHZ 8 4,974 39,792 Intel
123 XEON CPU E3-1241 V3 @ 3.50GHZ 8 4,940 39,520 Intel
124 CORE I5-4570S CPU @ 2.90GHZ 4 9,620 38,480 Intel
125 CORE I7-4770K CPU @ 3.50GHZ 8 4,804 38,432 Intel
126 CORE I5-8250U CPU @ 1.60GHZ 8 4,800 38,400 Intel
127 CORE I5-8265U CPU @ 1.60GHZ 8 4,794 38,352 Intel
128 XEON CPU X5670 @ 2.93GHZ 12 3,185 38,220 Intel
129 CORE I5-6300HQ CPU @ 2.30GHZ 4 9,436 37,744 Intel
130 CORE I7-4765T CPU @ 2.00GHZ 8 4,693 37,544 Intel
131 CORE I7-3840QM CPU @ 2.80GHZ 8 4,643 37,144 Intel
132 XEON CPU E3-1240 V2 @ 3.40GHZ 8 4,610 36,880 Intel
133 RYZEN 5 3400G 8 4,607 36,856 AMD
134 CORE I5-4690K CPU @ 3.50GHZ 4 9,010 36,040 Intel
135 CORE I3-6100 CPU @ 3.70GHZ 4 8,995 35,980 Intel
136 CORE I7-4850HQ CPU @ 2.30GHZ 8 4,312 34,496 Intel
137 RYZEN 7 4700U 8 4,266 34,128 AMD
138 CORE I5-3330 CPU @ 3.00GHZ 4 8,474 33,896 Intel
139 CORE I5-10210U CPU @ 1.60GHZ 7 4,701 32,907 Intel
140 RYZEN 5 3500X 6-CORE 6 5,468 32,808 AMD
141 XEON CPU E3-1245 V2 @ 3.40GHZ 8 4,071 32,568 Intel
142 XEON CPU E5-2678 V3 @ 2.50GHZ 6 5,421 32,526 Intel
143 CORE I5-3570 CPU @ 3.40GHZ 4 7,537 30,148 Intel
144 CORE I7-6500U CPU @ 2.50GHZ 4 7,491 29,964 Intel
145 XEON CPU E5-2450 0 @ 2.10GHZ 10 2,957 29,570 Intel
146 CORE I5-2500K CPU @ 3.30GHZ 4 7,293 29,172 Intel
147 CORE I3-7100 CPU @ 3.90GHZ 4 7,234 28,936 Intel
148 XEON CPU E31245 @ 3.30GHZ 8 3,381 27,048 Intel
149 CORE I7 CPU 975 @ 3.33GHZ 8 3,300 26,400 Intel
150 CORE I7-2600 CPU @ 3.40GHZ 8 3,255 26,040 Intel
151 CORE I7-3610QM CPU @ 2.30GHZ 8 3,034 24,272 Intel
152 XEON CPU W3550 @ 3.07GHZ 8 2,962 23,696 Intel
153 CORE I5-4278U CPU @ 2.60GHZ 4 5,780 23,120 Intel
154 CORE I7-8565U CPU @ 1.80GHZ 8 2,630 21,040 Intel
155 CORE I5-3470 CPU @ 3.20GHZ 4 5,200 20,800 Intel
156 ATHLON 220GE 4 5,163 20,652 AMD
157 CORE I7-7500U CPU @ 2.70GHZ 4 5,010 20,040 Intel
158 CORE I7-7Y75 CPU @ 1.30GHZ 4 4,935 19,740 Intel
159 CORE I3-4130 CPU @ 3.40GHZ 4 4,896 19,584 Intel
160 CORE I5-4690 CPU @ 3.50GHZ 4 4,798 19,192 Intel
161 RYZEN 3 2200G 4 4,473 17,892 AMD
162 CORE I5-6300U CPU @ 2.40GHZ 4 4,319 17,276 Intel
163 CORE I5-7200U CPU @ 2.50GHZ 4 4,136 16,544 Intel
164 CORE I7-8750H CPU @ 2.20GHZ 12 1,249 14,988 Intel
165 CORE M3-7Y30 CPU @ 1.00GHZ 4 3,726 14,904 Intel
166 CORE2 QUAD CPU Q9550 @ 2.83GHZ 4 2,976 11,904 Intel
167 CORE I3-3240 CPU @ 3.40GHZ 4 2,871 11,484 Intel
168 PENTIUM(R) GOLD G5400 CPU @ 3.70GHZ 4 2,748 10,992 Intel
169 CORE I3-6006U CPU @ 2.00GHZ 4 2,700 10,800 Intel
170 CORE I3-3110M CPU @ 2.40GHZ 4 2,430 9,720 Intel
171 RYZEN 3 3200U 4 2,331 9,324 AMD
172 RYZEN 5 3500U 8 1,066 8,528 AMD
173 CELERON(R) J4125 CPU @ 2.00GHZ 4 1,957 7,828 Intel
174 A10-6700 APU RADEON(TM) HD GRAPHICS 4 1,893 7,572 AMD
175 FX-8800P RADEON R7, 12 COMPUTE CORES 4C+8G 4 1,879 7,516 AMD
176 CORE I5-3337U CPU @ 1.80GHZ 4 1,860 7,440 Intel
177 FX-4300 QUAD-CORE 4 1,218 4,872 AMD
178 FX-4350 QUAD-CORE 4 1,213 4,852 AMD
179 CORE I5-9300H CPU @ 2.40GHZ 8 596 4,768 Intel
180 CORE2 DUO CPU E8400 @ 3.00GHZ 2 2,355 4,710 Intel
181 RYZEN 3 3250U 4 1,129 4,516 AMD
182 A12-9800 RADEON R7, 12 COMPUTE CORES 4C+8G 4 839 3,356 AMD
183 PENTIUM(R) CPU N3700 @ 1.60GHZ 4 525 2,100 Intel
184 ATOM(TM) X5-Z8350 CPU @ 1.44GHZ 4 255 1,020 Intel
185 A8-6410 APU 4 254 1,016 AMD
186 PENTIUM(R) CPU G2020T @ 2.50GHZ 2 369 738 Intel