Folding project #16918, CANCER research

Research section Research projects and references

Project #16918 overview

Project Summary AI Beta

This project relates to FOX01, a protein that helps regulate insulin and is linked to certain cancers. Researchers are studying how changes in FOX01 affect its shape and ability to bind to DNA. Understanding this could lead to new treatments for these cancers.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Dylan Novack
Institution: Temple University
Website: Open project site

Work unit

Atoms: 65,536
Core: OPENMM_22
Status: Public

No related projects listed.

Source material

Official Project Description

FOX01 is a human forkhead transcription factor involved in insulin signaling.

Mutations in this protein have been found in Diffuse Large B-Cell Lymphoma (DLBCL) patient’s cell lines, and associated with decreased survival in DLBCL patients. Do these mutations affect the folding of FOX01, or disrupt the binding of FOX01 to DNA? As part of our efforts to answer this question, we are performing all-atom simulations of wild type FOX01 to examine the folding landscape of this system.

Understanding how mutations affect the regulatory function of this transcription factor will help elucidate the role of FOX01 in the development of DLBCL, and may provide insight for the development of new therapeutics.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

FOX01

A human forkhead transcription factor involved in insulin signaling.

Protein: BiotechnologyOncology / Lymphoma

FOX01 is a protein that plays a role in regulating how cells use insulin. It's important for controlling blood sugar levels. Studies have shown that changes or mutations in FOX01 can be found in certain types of cancer, particularly Diffuse Large B-Cell Lymphoma (DLBCL). These mutations may affect how well FOX01 works and could contribute to the development of the disease.

Transcription factor

A protein that binds to specific DNA sequences and regulates gene expression.

Scientific: BiotechnologyMolecular Biology / Genetics

Transcription factors are like switches that turn genes on or off. They bind to sections of DNA called promoters, which control whether a gene is read and used to make proteins. These proteins play essential roles in many cellular processes, including growth, development, and response to the environment.

Diffuse Large B-Cell Lymphoma (DLBCL)

A type of non-Hodgkin lymphoma that affects B lymphocytes.

Medical: HealthcareOncology / Lymphoma

DLBCL is a cancer that starts in the lymphatic system, specifically in a type of white blood cell called B lymphocytes. These cells are important for fighting infections. In DLBCL, these B cells grow uncontrollably and form tumors in lymph nodes, bone marrow, and other tissues.

Mutations

Permanent changes in the DNA sequence.

Scientific: BiotechnologyGenetics / Molecular Biology

Mutations are alterations in the genetic code that makes up our DNA. These changes can happen spontaneously or be caused by environmental factors like radiation. Most mutations are harmless, but some can lead to diseases like cancer.

Protein

A large biomolecule composed of amino acids.

Scientific: BiotechnologyBiology / Biochemistry

Proteins are the workhorses of our cells, carrying out a vast array of functions. They build and repair tissues, transport molecules, catalyze chemical reactions, and much more. Their diverse roles make them essential for life.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	5,131,728	275,791	18.61	1 ^hrs 17 ^mins
2	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,067,016	260,164	15.63	1 ^hrs 32 ^mins
3	Tesla V100 SXM2 16GB GV100GL [Tesla V100 SXM2 16GB] M 14899	Nvidia	GV100GL	4,063,209	260,978	15.57	1 ^hrs 32 ^mins
4	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	4,045,710	257,834	15.69	1 ^hrs 32 ^mins
5	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	3,880,526	256,090	15.15	1 ^hrs 35 ^mins
6	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,007,445	232,937	12.91	1 ^hrs 52 ^mins
7	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	2,937,489	230,762	12.73	1 ^hrs 53 ^mins
8	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,778,478	228,916	12.14	1 ^hrs 59 ^mins
9	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,722,040	227,033	11.99	2 ^hrs 0 ^mins
10	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,439,627	220,165	11.08	2 ^hrs 10 ^mins
11	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,232,111	188,703	11.83	2 ^hrs 2 ^mins
12	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,213,222	210,299	10.52	2 ^hrs 17 ^mins
13	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER]	Nvidia	TU104	2,203,778	212,698	10.36	2 ^hrs 19 ^mins
14	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	2,049,978	207,296	9.89	2 ^hrs 26 ^mins
15	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,975,890	203,146	9.73	2 ^hrs 28 ^mins
16	GeForce RTX 2080 SUPER Mobile / Max-Q TU104BM [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104BM	1,812,494	197,925	9.16	2 ^hrs 37 ^mins
17	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,799,811	198,433	9.07	2 ^hrs 39 ^mins
18	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	1,746,401	195,550	8.93	2 ^hrs 41 ^mins
19	GeForce RTX 2060 KO TU106-200A [GeForce RTX 2060]	Nvidia	TU106-200A	1,733,841	196,341	8.83	2 ^hrs 43 ^mins

20	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	1,587,237	188,187	8.43	2 ^hrs 51 ^mins
21	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,493,192	185,641	8.04	2 ^hrs 59 ^mins
22	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,473,647	184,173	8.00	2 ^hrs 60 ^mins
23	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,473,450	185,929	7.92	3 ^hrs 2 ^mins
24	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,458,998	180,469	8.08	2 ^hrs 58 ^mins
25	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,427,252	184,253	7.75	3 ^hrs 6 ^mins
26	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,404,555	179,189	7.84	3 ^hrs 4 ^mins
27	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] 4608	Nvidia	TU106M	1,366,108	181,832	7.51	3 ^hrs 12 ^mins
28	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,072,137	167,202	6.41	3 ^hrs 45 ^mins
29	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,050,383	164,017	6.40	3 ^hrs 45 ^mins
30	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,012,664	164,012	6.17	3 ^hrs 53 ^mins
31	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	968,681	161,490	6.00	4 ^hrs 0 ^mins
32	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	944,915	159,261	5.93	4 ^hrs 3 ^mins
33	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	889,136	154,275	5.76	4 ^hrs 10 ^mins
34	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	865,741	142,575	6.07	3 ^hrs 57 ^mins
35	Tesla T4 TU104GL [Tesla T4] 8141	Nvidia	TU104GL	864,007	155,833	5.54	4 ^hrs 20 ^mins
36	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	804,501	151,226	5.32	4 ^hrs 31 ^mins
37	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	792,792	149,592	5.30	4 ^hrs 32 ^mins
38	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	684,418	139,046	4.92	4 ^hrs 53 ^mins
39	Quadro P4200 Mobile GP104GLM [Quadro P4200 Mobile]	Nvidia	GP104GLM	652,464	134,074	4.87	4 ^hrs 56 ^mins

40	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	621,347	139,535	4.45	5 ^hrs 23 ^mins
41	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	614,250	138,777	4.43	5 ^hrs 25 ^mins
42	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	585,577	133,828	4.38	5 ^hrs 29 ^mins
43	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	576,702	131,398	4.39	5 ^hrs 28 ^mins
44	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	526,144	131,064	4.01	5 ^hrs 59 ^mins
45	GeForce GTX 780 Ti GK110 [GeForce GTX 780 Ti] 5046	Nvidia	GK110	517,725	131,326	3.94	6 ^hrs 5 ^mins
46	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	476,755	127,530	3.74	6 ^hrs 25 ^mins
47	P104-100 GP104 [P104-100]	Nvidia	GP104	449,306	125,347	3.58	6 ^hrs 42 ^mins
48	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	437,745	123,934	3.53	6 ^hrs 48 ^mins
49	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	428,428	114,251	3.75	6 ^hrs 24 ^mins
50	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	407,693	120,760	3.38	7 ^hrs 7 ^mins
51	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	391,926	118,704	3.30	7 ^hrs 16 ^mins
52	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	382,920	119,219	3.21	7 ^hrs 28 ^mins
53	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	349,066	114,186	3.06	7 ^hrs 51 ^mins
54	P106-100 GP106 [P106-100]	Nvidia	GP106	341,594	114,331	2.99	8 ^hrs 2 ^mins
55	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	339,368	112,707	3.01	7 ^hrs 58 ^mins
56	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	337,651	113,898	2.96	8 ^hrs 6 ^mins
57	Quadro P5000 GP104GL [Quadro P5000]	Nvidia	GP104GL	334,404	108,618	3.08	7 ^hrs 48 ^mins
58	P106-090 GP106 [P106-090]	Nvidia	GP106	283,926	107,512	2.64	9 ^hrs 5 ^mins
59	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	282,063	106,153	2.66	9 ^hrs 2 ^mins

60	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	273,677	105,944	2.58	9 ^hrs 17 ^mins
61	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	265,312	104,417	2.54	9 ^hrs 27 ^mins
62	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	258,560	104,231	2.48	9 ^hrs 40 ^mins
63	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	216,174	98,226	2.20	10 ^hrs 54 ^mins
64	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	182,441	93,477	1.95	12 ^hrs 18 ^mins
65	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	182,179	91,649	1.99	12 ^hrs 4 ^mins
66	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	175,252	84,399	2.08	11 ^hrs 33 ^mins
67	Quadro M2200 GM206 [Quadro M2200]	Nvidia	GM206	138,575	63,271	2.19	10 ^hrs 57 ^mins
68	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	137,790	84,314	1.63	14 ^hrs 41 ^mins
69	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	132,398	82,066	1.61	14 ^hrs 53 ^mins
70	Radeon RX 460 Baffin XT [Radeon RX 460]	AMD	Baffin XT	130,109	80,317	1.62	14 ^hrs 49 ^mins
71	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	128,634	78,911	1.63	14 ^hrs 43 ^mins
72	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	125,010	78,275	1.60	15 ^hrs 2 ^mins
73	Polaris11 Baffin [Polaris11]	AMD	Baffin	124,111	79,820	1.55	15 ^hrs 26 ^mins
74	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	122,615	81,273	1.51	15 ^hrs 54 ^mins
75	Radeon R9 200 Series Hawaii [Radeon R9 200 Series]	AMD	Hawaii	118,805	79,998	1.49	16 ^hrs 10 ^mins
76	Radeon RX Vega M XL [Radeon RX Vega M XL]	AMD	Vega	115,867	77,169	1.50	15 ^hrs 59 ^mins
77	GeForce GTX 670MX GK106 [GeForce GTX 670MX]	Nvidia	GK106	102,787	75,909	1.35	17 ^hrs 43 ^mins
78	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	96,107	73,454	1.31	18 ^hrs 21 ^mins
79	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	90,959	73,711	1.23	19 ^hrs 27 ^mins

80	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	69,256	56,612	1.22	19 ^hrs 37 ^mins
81	Ryzen vega 8 mobile Raven [Ryzen vega 8 mobile]	AMD	Raven	52,954	60,313	0.88	27 ^hrs 20 ^mins
82	Radeon R7 250X/HD 7700/8760 R575A [Radeon R7 250X/HD 7700/8760]	AMD	R575A	50,150	60,378	0.83	28 ^hrs 54 ^mins
83	Quadro P400 GP107GL [Quadro P400] 641	Nvidia	GP107GL	44,187	57,280	0.77	31 ^hrs 7 ^mins
84	Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902]	AMD	raven	36,809	50,531	0.73	32 ^hrs 57 ^mins
85	GeForce GTX 560 Ti GF114 [GeForce GTX 560 Ti]	Nvidia	GF114	31,244	51,598	0.61	39 ^hrs 38 ^mins
86	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	28,062	49,758	0.56	42 ^hrs 33 ^mins
87	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	27,202	39,349	0.69	34 ^hrs 43 ^mins
88	GeForce GT 640 GK107 [GeForce GT 640] 693	Nvidia	GK107	24,139	47,346	0.51	47 ^hrs 4 ^mins
89	GeForce GTX 460 v2 GF114 [GeForce GTX 460 v2] 1045.6	Nvidia	GF114	23,897	47,213	0.51	47 ^hrs 25 ^mins
90	GeForce GTX 550 Ti GF116 [GeForce GTX 550 Ti] 691	Nvidia	GF116	17,782	42,702	0.42	57 ^hrs 38 ^mins
91	GeForce GTS 450 GF106 [GeForce GTS 450]	Nvidia	GF106	12,630	38,114	0.33	72 ^hrs 26 ^mins
92	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	7,042	29,864	0.24	101 ^hrs 47 ^mins
93	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	2,519	29,000	0.09	276 ^hrs 18 ^mins

Research: CANCER Folding Project #16918

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 16918

GPU PPD Averages

Research: CANCER Folding Project #16918

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages