PROJECT #16918 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

FOX01 is a human forkhead transcription factor involved in insulin signaling. Mutations in this protein have been found in Diffuse Large B-Cell Lymphoma (DLBCL) patient’s cell lines, and associated with decreased survival in DLBCL patients.

Do these mutations affect the folding of FOX01, or disrupt the binding of FOX01 to DNA?  As part of our efforts to answer this question, we are performing all-atom simulations of wild type FOX01 to examine the folding landscape of this system. Understanding how mutations affect the regulatory function of this transcription factor will help elucidate the role of FOX01 in the development of DLBCL, and may provide insight for the development of new therapeutics.

PROJECT INFO

Manager(s): Dylan Novack

Institution: Temple University

Project URL: http://voelzlab.org

PROJECT WORK UNIT SUMMARY

Atoms: 65,536

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 15 April 2021 18:22:42

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,131,728 275,791 18.61 1 hrs 17 mins
2 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,067,016 260,164 15.63 2 hrs 32 mins
3 Tesla V100 SXM2 16GB
GV100GL [Tesla V100 SXM2 16GB] M 14899
Nvidia GV100GL 4,063,209 260,978 15.57 2 hrs 32 mins
4 GeForce RTX 3080 10GB / 20GB
GA102 [GeForce RTX 3080 10GB / 20GB]
Nvidia GA102 4,045,710 257,834 15.69 2 hrs 32 mins
5 TITAN RTX
TU102 [TITAN RTX] 16310
Nvidia TU102 3,880,526 256,090 15.15 2 hrs 35 mins
6 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,007,445 232,937 12.91 2 hrs 52 mins
7 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,937,489 230,762 12.73 2 hrs 53 mins
8 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,778,478 228,916 12.14 2 hrs 59 mins
9 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,722,040 227,033 11.99 2 hrs 0 mins
10 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,439,627 220,165 11.08 2 hrs 10 mins
11 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,232,111 188,703 11.83 2 hrs 2 mins
12 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,213,222 210,299 10.52 2 hrs 17 mins
13 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER]
Nvidia TU104 2,203,778 212,698 10.36 2 hrs 19 mins
14 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 2,049,978 207,296 9.89 2 hrs 26 mins
15 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,975,890 203,146 9.73 2 hrs 28 mins
16 GeForce RTX 2080 SUPER Mobile / Max-Q
TU104BM [GeForce RTX 2080 SUPER Mobile / Max-Q]
Nvidia TU104BM 1,812,494 197,925 9.16 3 hrs 37 mins
17 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,799,811 198,433 9.07 3 hrs 39 mins
18 GeForce RTX 2080 SUPER Mobile / Max-Q
TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]
Nvidia TU104M 1,746,401 195,550 8.93 3 hrs 41 mins
19 GeForce RTX 2060 KO
TU106-200A [GeForce RTX 2060]
Nvidia TU106-200A 1,733,841 196,341 8.83 3 hrs 43 mins
20 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 1,587,237 188,187 8.43 3 hrs 51 mins
21 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,493,192 185,641 8.04 3 hrs 59 mins
22 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,473,647 184,173 8.00 3 hrs 60 mins
23 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,473,450 185,929 7.92 3 hrs 2 mins
24 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,458,998 180,469 8.08 3 hrs 58 mins
25 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,427,252 184,253 7.75 3 hrs 6 mins
26 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,404,555 179,189 7.84 3 hrs 4 mins
27 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile] 4608
Nvidia TU106M 1,366,108 181,832 7.51 3 hrs 12 mins
28 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,072,137 167,202 6.41 4 hrs 45 mins
29 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,050,383 164,017 6.40 4 hrs 45 mins
30 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,012,664 164,012 6.17 4 hrs 53 mins
31 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 968,681 161,490 6.00 4 hrs 0 mins
32 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 944,915 159,261 5.93 4 hrs 3 mins
33 Radeon RX 5600/5600 XT - 5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]
AMD Navi 10 889,136 154,275 5.76 4 hrs 10 mins
34 GeForce GTX 1070 Mobile
GP104M [GeForce GTX 1070 Mobile]
Nvidia GP104M 865,741 142,575 6.07 4 hrs 57 mins
35 Tesla T4
TU104GL [Tesla T4] 8141
Nvidia TU104GL 864,007 155,833 5.54 4 hrs 20 mins
36 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 804,501 151,226 5.32 5 hrs 31 mins
37 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 792,792 149,592 5.30 5 hrs 32 mins
38 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 684,418 139,046 4.92 5 hrs 53 mins
39 Quadro P4200 Mobile
GP104GLM [Quadro P4200 Mobile]
Nvidia GP104GLM 652,464 134,074 4.87 5 hrs 56 mins
40 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 621,347 139,535 4.45 5 hrs 23 mins
41 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 614,250 138,777 4.43 5 hrs 25 mins
42 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 585,577 133,828 4.38 5 hrs 29 mins
43 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 576,702 131,398 4.39 5 hrs 28 mins
44 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 526,144 131,064 4.01 6 hrs 59 mins
45 GeForce GTX 780 Ti
GK110 [GeForce GTX 780 Ti] 5046
Nvidia GK110 517,725 131,326 3.94 6 hrs 5 mins
46 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 476,755 127,530 3.74 6 hrs 25 mins
47 P104-100
GP104 [P104-100]
Nvidia GP104 449,306 125,347 3.58 7 hrs 42 mins
48 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 437,745 123,934 3.53 7 hrs 48 mins
49 GeForce GTX 1650 Ti Mobile
TU116M [GeForce GTX 1650 Ti Mobile]
Nvidia TU116M 428,428 114,251 3.75 6 hrs 24 mins
50 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 407,693 120,760 3.38 7 hrs 7 mins
51 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 391,926 118,704 3.30 7 hrs 16 mins
52 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 382,920 119,219 3.21 7 hrs 28 mins
53 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 349,066 114,186 3.06 8 hrs 51 mins
54 P106-100
GP106 [P106-100]
Nvidia GP106 341,594 114,331 2.99 8 hrs 2 mins
55 Radeon R9 200/300X Series
Hawaii [Radeon R9 200/300X Series]
AMD Hawaii 339,368 112,707 3.01 8 hrs 58 mins
56 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 337,651 113,898 2.96 8 hrs 6 mins
57 Quadro P5000
GP104GL [Quadro P5000]
Nvidia GP104GL 334,404 108,618 3.08 8 hrs 48 mins
58 P106-090
GP106 [P106-090]
Nvidia GP106 283,926 107,512 2.64 9 hrs 5 mins
59 Radeon R9 200/300 Series
Hawaii [Radeon R9 200/300 Series]
AMD Hawaii 282,063 106,153 2.66 9 hrs 2 mins
60 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 273,677 105,944 2.58 9 hrs 17 mins
61 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]
Nvidia TU117GLM 265,312 104,417 2.54 9 hrs 27 mins
62 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 258,560 104,231 2.48 10 hrs 40 mins
63 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 216,174 98,226 2.20 11 hrs 54 mins
64 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 182,441 93,477 1.95 12 hrs 18 mins
65 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 182,179 91,649 1.99 12 hrs 4 mins
66 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 175,252 84,399 2.08 12 hrs 33 mins
67 Quadro M2200
GM206 [Quadro M2200]
Nvidia GM206 138,575 63,271 2.19 11 hrs 57 mins
68 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 137,790 84,314 1.63 15 hrs 41 mins
69 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 132,398 82,066 1.61 15 hrs 53 mins
70 Radeon RX 460
Baffin XT [Radeon RX 460]
AMD Baffin XT 130,109 80,317 1.62 15 hrs 49 mins
71 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 128,634 78,911 1.63 15 hrs 43 mins
72 Radeon R9 280/HD 7900/8950
Tahiti PRO [Radeon R9 280/HD 7900/8950]
AMD Tahiti PRO 125,010 78,275 1.60 15 hrs 2 mins
73 Polaris11
Baffin [Polaris11]
AMD Baffin 124,111 79,820 1.55 15 hrs 26 mins
74 Radeon HD 7800
Pitcairn [Radeon HD 7800]
AMD Pitcairn 122,615 81,273 1.51 16 hrs 54 mins
75 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 118,805 79,998 1.49 16 hrs 10 mins
76 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 115,867 77,169 1.50 16 hrs 59 mins
77 GeForce GTX 670MX
GK106 [GeForce GTX 670MX]
Nvidia GK106 102,787 75,909 1.35 18 hrs 43 mins
78 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 96,107 73,454 1.31 18 hrs 21 mins
79 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 90,959 73,711 1.23 19 hrs 27 mins
80 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 69,256 56,612 1.22 20 hrs 37 mins
81 Ryzen vega 8 mobile
Raven [Ryzen vega 8 mobile]
AMD Raven 52,954 60,313 0.88 27 hrs 20 mins
82 Radeon R7 250X/HD 7700/8760
R575A [Radeon R7 250X/HD 7700/8760]
AMD R575A 50,150 60,378 0.83 29 hrs 54 mins
83 Quadro P400
GP107GL [Quadro P400] 641
Nvidia GP107GL 44,187 57,280 0.77 31 hrs 7 mins
84 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 36,809 50,531 0.73 33 hrs 57 mins
85 GeForce GTX 560 Ti
GF114 [GeForce GTX 560 Ti]
Nvidia GF114 31,244 51,598 0.61 40 hrs 38 mins
86 Radeon R7 250/HD 7700
R575A [Radeon R7 250/HD 7700]
AMD R575A 28,062 49,758 0.56 43 hrs 33 mins
87 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 27,202 39,349 0.69 35 hrs 43 mins
88 GeForce GT 640
GK107 [GeForce GT 640] 693
Nvidia GK107 24,139 47,346 0.51 47 hrs 4 mins
89 GeForce GTX 460 v2
GF114 [GeForce GTX 460 v2] 1045.6
Nvidia GF114 23,897 47,213 0.51 47 hrs 25 mins
90 GeForce GTX 550 Ti
GF116 [GeForce GTX 550 Ti] 691
Nvidia GF116 17,782 42,702 0.42 58 hrs 38 mins
91 GeForce GTS 450
GF106 [GeForce GTS 450]
Nvidia GF106 12,630 38,114 0.33 72 hrs 26 mins
92 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 7,042 29,864 0.24 102 hrs 47 mins
93 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 2,519 29,000 0.09 276 hrs 18 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 15 April 2021 18:22:42

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make