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Research: COVID-19 Folding Project #16515

Project #16515 overview

Project Summary AI Beta

This project uses computer simulations to study how certain drugs might stop the SARS-CoV-2 virus from replicating. They focus on proteins nsp12 and nsp14, which are important for viral replication. The project tests different drug candidates, including Ribavirin and analogs, to see if they can block these proteins and stop the virus.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Xuhui Huang
Institution
Hong Kong University of Science and Technology

Work unit

Atoms
226,493
Core
GRO_A7
Status
Public
Source material

Official Project Description

This series of CPU projects to simulation the Nonstructural protein 12 (nsp12) and Nonstructural protein 14 (nsp14) complexes.

We will screen existing FDA-approved NTP analog drugs (e.g.

Ribirine).

We aim to repurpose drugs that can inhibit SARS-CoV-2 replication 16500: This project contains simulations of nsp14-ExoN and nsp10 of the SARS-CoV-2 in complex with a short nascent RNA.

Nsp14 is in charge of proofeading of the replication SARS-CoV-2 by removing mis-incoproated nucleotides including drugs, so that it is important that NTP analog drugs (e.g.

Remdesivir) added to the nascent RNA do not get cleaved by nsp14. 16501: This project contains simulations of nsp12, nsp7, and nsp8 of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA, and Ribavirin Triphosphate in the active site.

We aim to examine if the drug Ribirine can inhibite the viral replicaiton of SARS-CoV-2. 16502: This project contains simulations of nsp12, nsp7 and nsp8 of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA with Ribavirin as the 3’ terminal nucleotide. 16503: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA and Cladribine Triphosphate in the active site. 16504: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA and Clofarabine Triphosphate in the active site. 16505: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA and Cordycepin Triphosphate in the active site.

16506: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA(Cladribine at 3'-terminal), and ATP in the active site.

16507: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA(Clofarabine at 3'-terminal), and ATP in the active site. 16508: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA(Cordycepin at 3'-terminal), and ATP in the active site. 16509: Nonstructural protein 14 and 10 (nsp14-ExoN & nsp 10) of the SARS-CoV-2 in complex with a short nascent RNA containing Cordycepin at 3'-terminal. 16510: Nonstructural protein 14 and 10 (nsp14-ExoN & nsp 10) of the SARS-CoV-2 in complex with a short nascent RNA containing Clofarabine at 3'-terminal. 16513: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA, and ATP in the active site. 16514: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA, and GTP in the active site. 16515: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA, and GTP in the active site with nonbonded dummy ion model. 16516: Nonstructural protein 12 (nsp12-RdRp & nsp7 & nsp8) of the SARS-CoV-2 in complex with the RNA template, a short nascent RNA, and ATP in the active site with nonbonded dummy ion model.

Performance data

Hardware Performance for Project 16515

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:02:19

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN THREADRIPPER 3970X 32-CORE 64 17,849 1,142,336 AMD
2 RYZEN 9 3950X 16-CORE 32 18,850 603,200 AMD
3 RYZEN 9 3900X 12-CORE 24 12,845 308,280 AMD
4 XEON CPU E5-2686 V4 @ 2.30GHZ 36 6,762 243,432 Intel
5 CORE I9-10980XE CPU @ 3.00GHZ 36 6,605 237,780 Intel
6 RYZEN 9 3900XT 12-CORE 24 9,849 236,376 AMD
7 CORE I9-7920X CPU @ 2.90GHZ 24 7,194 172,656 Intel
8 RYZEN 7 3700X 8-CORE 16 10,694 171,104 AMD
9 CORE I9-9900K CPU @ 3.60GHZ 16 9,464 151,424 Intel
10 RYZEN THREADRIPPER 1920X 12-CORE 24 4,982 119,568 AMD
11 RYZEN 5 3600 6-CORE 12 9,602 115,224 AMD
12 RYZEN 5 3600X 6-CORE 12 8,555 102,660 AMD
13 XEON CPU E5-2660 0 @ 2.20GHZ 32 3,022 96,704 Intel
14 CORE I7-9700 CPU @ 3.00GHZ 8 11,148 89,184 Intel
15 CORE I5-10400F CPU @ 2.90GHZ 12 6,570 78,840 Intel
16 RYZEN 5 2600X SIX-CORE 12 5,823 69,876 AMD
17 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,285 54,840 Intel
18 CORE I7-7700K CPU @ 4.20GHZ 8 6,603 52,824 Intel
19 CORE I7-8705G CPU @ 3.10GHZ 8 4,562 36,496 Intel
20 CORE I3-8100 CPU @ 3.60GHZ 4 8,862 35,448 Intel
21 CORE I5-6600K CPU @ 3.50GHZ 4 7,314 29,256 Intel
22 CORE I5-8265U CPU @ 1.60GHZ 8 2,894 23,152 Intel
23 RYZEN 5 3500U 8 1,390 11,120 AMD