Folding project #16465, CANCER research

Research section Research projects and references

Project #16465 overview

Project Summary AI Beta

The project relates to Aurora A Kinase (AURKA), a protein crucial for cell growth. When AURKA is faulty, it can cause cancer. Blocking AURKA could help fight cancer by stopping tumor growth and making chemotherapy more effective.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Sukrit Singh
Institution: Memorial Sloan-Kettering Cancer-Center
Website: Open project site

Work unit

Atoms: 50,572
Core: OPENMM_22
Status: Public

No related projects listed.

Source material

Official Project Description

This project studies a cancer target named Aurora A Kinase (AURKA) - It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation (AKA Mitosis).

AURKA misbehaving (via mutation) has been associated with high occurrence of cancers like Prostate Cancer.

In the clinic, when other cancer targets like EGFR are treated with Chemotherapy AURKA reactivate tumors and prevent chemotherapy efficacy.

Therefore, studying AURKA and ways to block AURKA function will provide new ways to target tumors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Aurora A Kinase

A protein kinase involved in cell division.

Scientific: BiotechnologyOncology / Cancer Biology

Aurora A Kinase (AURKA) is a protein crucial for cell division. It helps regulate processes like mitosis and meiosis, which are essential for healthy cell growth. When AURKA malfunctions due to mutations, it can contribute to the development of various cancers, including prostate cancer. Understanding how to inhibit AURKA activity could lead to new cancer treatment strategies.

Mitosis

The process of cell division that produces two identical daughter cells.

Scientific: BiotechnologyOncology / Cell Biology

Mitosis is a fundamental process where a single cell divides into two identical daughter cells. It's essential for growth, repair, and asexual reproduction in organisms. During mitosis, chromosomes are replicated and evenly distributed to the new cells, ensuring each daughter cell receives a complete set of genetic information.

Meiosis

A type of cell division that produces gametes (sperm and egg cells).

Scientific: BiotechnologyOncology / Genetics

Meiosis is a specialized type of cell division that occurs in sexually reproducing organisms. It involves two rounds of cell division, resulting in four daughter cells with half the number of chromosomes as the parent cell. These daughter cells are called gametes (sperm and egg) and are essential for sexual reproduction.

Prostate Cancer

Cancer that originates in the prostate gland.

Medical: HealthcareOncology / Urology

Prostate cancer is a type of cancer that develops in the prostate gland, a small walnut-shaped gland found in men. It's one of the most common cancers among men and can spread to other parts of the body if left untreated. Treatment options for prostate cancer include surgery, radiation therapy, hormone therapy, and chemotherapy.

Chemotherapy

The use of drugs to treat cancer.

Medical: PharmaceuticalsOncology / Cancer Treatment

Chemotherapy is a powerful treatment method used to kill cancer cells. It involves using various drugs that target and destroy rapidly dividing cells, including cancer cells. Chemotherapy can be administered intravenously, orally, or topically, depending on the type and stage of cancer.

EGFR

Epidermal Growth Factor Receptor

Acronym: BiotechnologyOncology / Targeted Therapy

EGFR (Epidermal Growth Factor Receptor) is a protein found on the surface of many cells. Certain types of cancer can have too much EGFR, which promotes uncontrolled cell growth. Targeted therapies that inhibit EGFR are used to treat these cancers.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	5,222,463	121,351	43.04	0 ^hrs 33 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	4,431,699	117,462	37.73	0 ^hrs 38 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,013,726	113,036	35.51	0 ^hrs 41 ^mins
4	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,166,140	97,166	32.58	0 ^hrs 44 ^mins
5	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,028,601	102,723	29.48	0 ^hrs 49 ^mins
6	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	2,787,497	100,591	27.71	0 ^hrs 52 ^mins
7	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,750,697	100,043	27.50	0 ^hrs 52 ^mins
8	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,719,694	99,585	27.31	0 ^hrs 53 ^mins
9	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,627,906	98,153	26.77	0 ^hrs 54 ^mins
10	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,561,291	96,286	26.60	0 ^hrs 54 ^mins
11	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,515,157	96,786	25.99	0 ^hrs 55 ^mins
12	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,403,260	95,745	25.10	0 ^hrs 57 ^mins
13	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,356,987	95,005	24.81	0 ^hrs 58 ^mins
14	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	2,080,801	91,192	22.82	1 ^hrs 3 ^mins
15	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,026,156	90,499	22.39	1 ^hrs 4 ^mins
16	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,941,007	89,097	21.79	1 ^hrs 6 ^mins
17	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	1,765,864	86,066	20.52	1 ^hrs 10 ^mins
18	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,541,209	82,573	18.66	1 ^hrs 17 ^mins
19	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,531,819	82,217	18.63	1 ^hrs 17 ^mins

20	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	1,516,030	80,817	18.76	1 ^hrs 17 ^mins
21	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,494,787	81,739	18.29	1 ^hrs 19 ^mins
22	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,494,463	79,347	18.83	1 ^hrs 16 ^mins
23	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,227,507	76,568	16.03	1 ^hrs 30 ^mins
24	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,220,102	76,458	15.96	1 ^hrs 30 ^mins
25	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,147,655	74,821	15.34	1 ^hrs 34 ^mins
26	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	1,007,118	70,218	14.34	1 ^hrs 40 ^mins
27	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,005,956	70,493	14.27	1 ^hrs 41 ^mins
28	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	980,042	70,989	13.81	1 ^hrs 44 ^mins
29	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	768,906	65,470	11.74	2 ^hrs 3 ^mins
30	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	691,308	62,173	11.12	2 ^hrs 10 ^mins
31	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	655,574	62,341	10.52	2 ^hrs 17 ^mins
32	GeForce GTX 1650 TU117 [GeForce GTX 1650] 3091	Nvidia	TU117	600,964	60,622	9.91	2 ^hrs 25 ^mins
33	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	505,849	56,908	8.89	2 ^hrs 42 ^mins
34	P104-100 GP104 [P104-100]	Nvidia	GP104	483,973	56,319	8.59	2 ^hrs 48 ^mins
35	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	471,649	46,119	10.23	2 ^hrs 21 ^mins
36	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	456,693	54,000	8.46	2 ^hrs 50 ^mins
37	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	446,515	53,765	8.30	2 ^hrs 53 ^mins
38	P106-100 GP106 [P106-100]	Nvidia	GP106	386,715	52,252	7.40	3 ^hrs 15 ^mins
39	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	386,493	52,159	7.41	3 ^hrs 14 ^mins

40	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	347,244	42,932	8.09	2 ^hrs 58 ^mins
41	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	287,843	47,331	6.08	3 ^hrs 57 ^mins
42	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	286,682	47,159	6.08	3 ^hrs 57 ^mins
43	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	255,249	45,222	5.64	4 ^hrs 15 ^mins
44	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	241,221	44,703	5.40	4 ^hrs 27 ^mins
45	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	213,434	42,951	4.97	4 ^hrs 50 ^mins
46	GeForce GTX 660 GK106 [GeForce GTX 660]	Nvidia	GK106	139,160	37,080	3.75	6 ^hrs 24 ^mins
47	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	138,111	37,154	3.72	6 ^hrs 27 ^mins
48	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	132,229	36,331	3.64	6 ^hrs 36 ^mins
49	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	129,770	36,342	3.57	6 ^hrs 43 ^mins
50	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	129,198	35,815	3.61	6 ^hrs 39 ^mins
51	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	119,594	35,384	3.38	7 ^hrs 6 ^mins
52	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	119,053	35,298	3.37	7 ^hrs 7 ^mins
53	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	93,905	32,629	2.88	8 ^hrs 20 ^mins
54	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	82,727	18,730	4.42	5 ^hrs 26 ^mins
55	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	33,159	23,159	1.43	16 ^hrs 46 ^mins
56	GeForce GTX 670M GF114 [GeForce GTX 670M]	Nvidia	GF114	16,419	17,366	0.95	25 ^hrs 23 ^mins

Research: CANCER Folding Project #16465

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 16465

GPU PPD Averages

Research: CANCER Folding Project #16465

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages