PROJECT #16462 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project studies the E240A mutant of Tem-1 β-Lactmase

β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 33,227

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 15 April 2021 06:43:41

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Project
Model Name
Folding@Home Identifier
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GPU
Model
PPD
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 15 April 2021 06:43:41

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 12,870 617,760 AMD
2 RYZEN 9 5950X 16-CORE 32 14,424 461,568 AMD
3 RYZEN 9 3950X 16-CORE 32 12,917 413,344 AMD
4 CORE I9-9980XE CPU @ 3.00GHZ 36 9,089 327,204 Intel
5 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,399 307,152 AMD
6 RYZEN 9 3900X 12-CORE 24 12,388 297,312 AMD
7 RYZEN 9 5900X 12-CORE 24 12,199 292,776 AMD
8 CORE I9-9900K CPU @ 3.60GHZ 16 15,920 254,720 Intel
9 RYZEN THREADRIPPER 2950X 16-CORE 32 7,481 239,392 AMD
10 CORE I9-10900K CPU @ 3.70GHZ 20 10,605 212,100 Intel
11 RYZEN 7 3800X 8-CORE 16 11,265 180,240 AMD
12 RYZEN THREADRIPPER 1920X 12-CORE 24 6,891 165,384 AMD
13 RYZEN 7 3700X 8-CORE 16 8,380 134,080 AMD
14 CORE I7-9700K CPU @ 3.60GHZ 8 16,276 130,208 Intel
15 RYZEN 5 3600X 6-CORE 12 10,600 127,200 AMD
16 RYZEN 5 3600 6-CORE 12 9,881 118,572 AMD
17 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,617 112,340 Intel
18 RYZEN 5 3600XT 6-CORE 12 9,019 108,228 AMD
19 CORE I7-9700 CPU @ 3.00GHZ 8 12,000 96,000 Intel
20 XEON CPU E5-2650 V2 @ 2.60GHZ 32 2,991 95,712 Intel
21 RYZEN 5 2600X SIX-CORE 12 4,956 59,472 AMD
22 CORE I9-9900 CPU @ 3.10GHZ 16 3,408 54,528 Intel
23 RYZEN 7 1700 EIGHT-CORE 16 3,342 53,472 AMD
24 CORE I7-8550U CPU @ 1.80GHZ 8 6,449 51,592 Intel
25 RYZEN 5 2600 SIX-CORE 12 3,851 46,212 AMD
26 CORE I7-8705G CPU @ 3.10GHZ 8 5,732 45,856 Intel
27 CORE I5-7600 CPU @ 3.50GHZ 4 9,843 39,372 Intel
28 CORE I5-7500 CPU @ 3.40GHZ 4 9,421 37,684 Intel
29 RYZEN 5 1400 QUAD-CORE 8 2,786 22,288 AMD
30 CORE I5-4570S CPU @ 2.90GHZ 4 3,916 15,664 Intel
31 CORE I3-7100 CPU @ 3.90GHZ 4 3,370 13,480 Intel
32 CORE I5-4300U CPU @ 1.90GHZ 4 2,332 9,328 Intel
33 CORE2 QUAD CPU Q6600 @ 2.40GHZ 4 1,908 7,632 Intel