PROJECT #16462 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project studies the E240A mutant of Tem-1 β-Lactmase

β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 33,227

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 27 January 2021 17:42:09

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 27 January 2021 17:42:09

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make
1	RYZEN THREADRIPPER 3960X 24-CORE	48	12,870	617,760	AMD
2	RYZEN 9 5950X 16-CORE	32	14,424	461,568	AMD
3	RYZEN 9 3950X 16-CORE	32	12,917	413,344	AMD
4	CORE I9-9980XE CPU @ 3.00GHZ	36	9,089	327,204	Intel
5	RYZEN THREADRIPPER 2970WX 24-CORE	48	6,399	307,152	AMD
6	RYZEN 9 3900X 12-CORE	24	12,388	297,312	AMD
7	RYZEN 9 5900X 12-CORE	24	12,199	292,776	AMD
8	CORE I9-9900K CPU @ 3.60GHZ	16	15,920	254,720	Intel
9	RYZEN THREADRIPPER 2950X 16-CORE	32	7,481	239,392	AMD
10	CORE I9-10900K CPU @ 3.70GHZ	20	10,605	212,100	Intel
11	RYZEN 7 3800X 8-CORE	16	11,265	180,240	AMD
12	RYZEN THREADRIPPER 1920X 12-CORE	24	6,891	165,384	AMD
13	RYZEN 7 3700X 8-CORE	16	8,380	134,080	AMD
14	CORE I7-9700K CPU @ 3.60GHZ	8	16,276	130,208	Intel
15	RYZEN 5 3600X 6-CORE	12	10,600	127,200	AMD
16	RYZEN 5 3600 6-CORE	12	9,881	118,572	AMD
17	XEON CPU E5-2690 V2 @ 3.00GHZ	20	5,617	112,340	Intel
18	RYZEN 5 3600XT 6-CORE	12	9,019	108,228	AMD
19	CORE I7-9700 CPU @ 3.00GHZ	8	12,000	96,000	Intel
20	XEON CPU E5-2650 V2 @ 2.60GHZ	32	2,991	95,712	Intel
21	RYZEN 5 2600X SIX-CORE	12	4,956	59,472	AMD
22	CORE I9-9900 CPU @ 3.10GHZ	16	3,408	54,528	Intel
23	RYZEN 7 1700 EIGHT-CORE	16	3,342	53,472	AMD
24	CORE I7-8550U CPU @ 1.80GHZ	8	6,449	51,592	Intel
25	RYZEN 5 2600 SIX-CORE	12	3,851	46,212	AMD
26	CORE I7-8705G CPU @ 3.10GHZ	8	5,732	45,856	Intel
27	CORE I5-7600 CPU @ 3.50GHZ	4	9,843	39,372	Intel
28	CORE I5-7500 CPU @ 3.40GHZ	4	9,421	37,684	Intel
29	RYZEN 5 1400 QUAD-CORE	8	2,786	22,288	AMD
30	CORE I5-4570S CPU @ 2.90GHZ	4	3,916	15,664	Intel
31	CORE I3-7100 CPU @ 3.90GHZ	4	3,370	13,480	Intel
32	CORE I5-4300U CPU @ 1.90GHZ	4	2,332	9,328	Intel
33	CORE2 QUAD CPU Q6600 @ 2.40GHZ	4	1,908	7,632	Intel

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