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Research: Β-LACTMASES Folding Project #16462

Project #16462 overview

Project Summary AI Beta

This project looks at an ancient version of a bacterial enzyme called beta-lactamase, which breaks down penicillin. By comparing this old enzyme to modern ones, scientists hope to find weak spots that could be targeted by new drugs to fight antibiotic resistance.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Sukrit Singh
Institution
Washington University in St. Louis

Work unit

Atoms
33,227
Core
GRO_A7
Status
Public

No related projects listed.

Source material

Official Project Description

This project studies the E240A mutant of Tem-1 β-Lactmase β-Lactmases are enzymes which break down penicillin-like antibiotics.

This is the most common method by which bacteria become resistant to such antibiotics.

This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases.

We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases.

Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

Performance data

Hardware Performance for Project 16462

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:02:58

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 12,870 617,760 AMD
2 RYZEN 9 5950X 16-CORE 32 14,424 461,568 AMD
3 RYZEN 9 3950X 16-CORE 32 12,917 413,344 AMD
4 CORE I9-9980XE CPU @ 3.00GHZ 36 9,089 327,204 Intel
5 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,399 307,152 AMD
6 RYZEN 9 3900X 12-CORE 24 12,388 297,312 AMD
7 RYZEN 9 5900X 12-CORE 24 12,199 292,776 AMD
8 CORE I9-9900K CPU @ 3.60GHZ 16 15,920 254,720 Intel
9 RYZEN THREADRIPPER 2950X 16-CORE 32 7,481 239,392 AMD
10 CORE I9-10900K CPU @ 3.70GHZ 20 10,605 212,100 Intel
11 RYZEN 7 3800X 8-CORE 16 11,265 180,240 AMD
12 RYZEN THREADRIPPER 1920X 12-CORE 24 6,891 165,384 AMD
13 RYZEN 7 3700X 8-CORE 16 8,380 134,080 AMD
14 CORE I7-9700K CPU @ 3.60GHZ 8 16,276 130,208 Intel
15 RYZEN 5 3600X 6-CORE 12 10,600 127,200 AMD
16 RYZEN 5 3600 6-CORE 12 9,881 118,572 AMD
17 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,617 112,340 Intel
18 RYZEN 5 3600XT 6-CORE 12 9,019 108,228 AMD
19 CORE I7-9700 CPU @ 3.00GHZ 8 12,000 96,000 Intel
20 XEON CPU E5-2650 V2 @ 2.60GHZ 32 2,991 95,712 Intel
21 RYZEN 5 2600X SIX-CORE 12 4,956 59,472 AMD
22 CORE I9-9900 CPU @ 3.10GHZ 16 3,408 54,528 Intel
23 RYZEN 7 1700 EIGHT-CORE 16 3,342 53,472 AMD
24 CORE I7-8550U CPU @ 1.80GHZ 8 6,449 51,592 Intel
25 RYZEN 5 2600 SIX-CORE 12 3,851 46,212 AMD
26 CORE I7-8705G CPU @ 3.10GHZ 8 5,732 45,856 Intel
27 CORE I5-7600 CPU @ 3.50GHZ 4 9,843 39,372 Intel
28 CORE I5-7500 CPU @ 3.40GHZ 4 9,421 37,684 Intel
29 RYZEN 5 1400 QUAD-CORE 8 2,786 22,288 AMD
30 CORE I5-4570S CPU @ 2.90GHZ 4 3,916 15,664 Intel
31 CORE I3-7100 CPU @ 3.90GHZ 4 3,370 13,480 Intel
32 CORE I5-4300U CPU @ 1.90GHZ 4 2,332 9,328 Intel
33 CORE2 QUAD CPU Q6600 @ 2.40GHZ 4 1,908 7,632 Intel