PROJECT #16461 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project studies the E240D mutant of Tem-1 β-Lactmase

β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 33,222

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 18 January 2021 22:03:35

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 18 January 2021 22:03:35

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 13,962 670,176 AMD
2 RYZEN 9 5900X 12-CORE 24 18,504 444,096 AMD
3 RYZEN 9 5950X 16-CORE 32 13,597 435,104 AMD
4 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,761 324,528 AMD
5 CORE I9-9980XE CPU @ 3.00GHZ 36 8,878 319,608 Intel
6 RYZEN 9 3900X 12-CORE 24 11,795 283,080 AMD
7 RYZEN 7 5800X 8-CORE 16 16,557 264,912 AMD
8 CORE I9-9900K CPU @ 3.60GHZ 16 15,705 251,280 Intel
9 CORE I9-10900K CPU @ 3.70GHZ 20 10,644 212,880 Intel
10 RYZEN 7 3800X 8-CORE 16 11,078 177,248 AMD
11 CORE I7-8700 CPU @ 3.20GHZ 12 13,247 158,964 Intel
12 CORE I7-9700K CPU @ 3.60GHZ 8 15,966 127,728 Intel
13 RYZEN 5 3600 6-CORE 12 10,643 127,716 AMD
14 RYZEN 7 3700X 8-CORE 16 7,443 119,088 AMD
15 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,523 110,460 Intel
16 RYZEN 5 3600XT 6-CORE 12 8,585 103,020 AMD
17 CORE I9-7920X CPU @ 2.90GHZ 24 4,211 101,064 Intel
18 RYZEN 7 2700X EIGHT-CORE 16 6,238 99,808 AMD
19 CORE I7-9700 CPU @ 3.00GHZ 8 11,978 95,824 Intel
20 RYZEN 5 3500 6-CORE 6 13,438 80,628 AMD
21 CORE I7-10710U CPU @ 1.10GHZ 12 5,519 66,228 Intel
22 RYZEN 7 1700 EIGHT-CORE 16 3,432 54,912 AMD
23 RYZEN 5 2600 SIX-CORE 12 4,260 51,120 AMD
24 CORE I7-8705G CPU @ 3.10GHZ 8 5,789 46,312 Intel
25 CORE I7-4790K CPU @ 4.00GHZ 8 5,643 45,144 Intel
26 CORE I5-7600 CPU @ 3.50GHZ 4 9,849 39,396 Intel
27 CORE I7-9700F CPU @ 3.00GHZ 8 4,886 39,088 Intel
28 CORE I7-6700T CPU @ 2.80GHZ 8 4,326 34,608 Intel
29 CORE I7-3770 CPU @ 3.40GHZ 8 3,093 24,744 Intel
30 XEON CPU E3-1230 V2 @ 3.30GHZ 8 3,045 24,360 Intel
31 CORE I7-8565U CPU @ 1.80GHZ 8 2,880 23,040 Intel
32 CORE I5-2520M CPU @ 2.50GHZ 4 4,336 17,344 Intel
33 CORE I3-7100 CPU @ 3.90GHZ 4 3,468 13,872 Intel
34 FX-8320 EIGHT-CORE 8 1,313 10,504 AMD
35 CORE I5-2415M CPU @ 2.30GHZ 4 2,346 9,384 Intel
36 CORE2 QUAD CPU Q6600 @ 2.40GHZ 4 1,785 7,140 Intel
37 CORE I3-6006U CPU @ 2.00GHZ 4 1,429 5,716 Intel
 

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