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Research: Β-LACTMASES Folding Project #16459

Project #16459 overview

Project Summary AI Beta

This project studies an ancient type of enzyme called beta-lactamase which breaks down penicillin-like antibiotics. By comparing it to modern versions, scientists hope to find 'pockets' in the enzyme that could be targeted by new drugs to fight antibiotic resistance.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Sukrit Singh
Institution
Washington University in St. Louis

Work unit

Atoms
33,296
Core
GRO_A7
Status
Public

No related projects listed.

Source material

Official Project Description

This project studies the R241F mutant of Tem-1 β-Lactmase β-Lactmases are enzymes which break down penicillin-like antibiotics.

This is the most common method by which bacteria become resistant to such antibiotics.

This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases.

We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases.

Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

Performance data

Hardware Performance for Project 16459

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:03:01

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 13,591 652,368 AMD
2 RYZEN 9 3950X 16-CORE 32 15,263 488,416 AMD
3 RYZEN 9 5950X 16-CORE 32 13,877 444,064 AMD
4 RYZEN 9 5900X 12-CORE 24 18,079 433,896 AMD
5 RYZEN 9 3900XT 12-CORE 24 14,426 346,224 AMD
6 CORE I9-9980XE CPU @ 3.00GHZ 36 8,693 312,948 Intel
7 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,517 312,816 AMD
8 RYZEN 9 3900X 12-CORE 24 12,391 297,384 AMD
9 CORE I9-9900K CPU @ 3.60GHZ 16 16,464 263,424 Intel
10 CORE I9-10900K CPU @ 3.70GHZ 20 10,846 216,920 Intel
11 RYZEN 7 4800H 16 9,048 144,768 AMD
12 RYZEN 7 3800X 8-CORE 16 8,579 137,264 AMD
13 RYZEN 7 3700X 8-CORE 16 8,270 132,320 AMD
14 RYZEN 5 3600X 6-CORE 12 10,613 127,356 AMD
15 RYZEN THREADRIPPER 1920X 12-CORE 24 5,218 125,232 AMD
16 RYZEN 5 3600 6-CORE 12 10,180 122,160 AMD
17 RYZEN 5 3600XT 6-CORE 12 9,699 116,388 AMD
18 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,814 116,280 Intel
19 CORE I7-9700K CPU @ 3.60GHZ 8 13,994 111,952 Intel
20 RYZEN 7 2700X EIGHT-CORE 16 6,275 100,400 AMD
21 XEON CPU E5-2660 0 @ 2.20GHZ 32 3,053 97,696 Intel
22 CORE I7-9700 CPU @ 3.00GHZ 8 11,937 95,496 Intel
23 RYZEN 5 3500 6-CORE 6 13,572 81,432 AMD
24 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,486 59,664 Intel
25 RYZEN 5 2600X SIX-CORE 12 4,950 59,400 AMD
26 RYZEN 7 1700 EIGHT-CORE 16 3,336 53,376 AMD
27 CORE I7-4790K CPU @ 4.00GHZ 8 5,934 47,472 Intel
28 CORE I7-8705G CPU @ 3.10GHZ 8 5,528 44,224 Intel
29 CORE I5-7600 CPU @ 3.50GHZ 4 10,726 42,904 Intel
30 RYZEN 5 2600 SIX-CORE 12 3,014 36,168 AMD
31 CORE I7-6700T CPU @ 2.80GHZ 8 3,859 30,872 Intel
32 CORE I5-6500 CPU @ 3.20GHZ 4 7,542 30,168 Intel
33 CORE I7-8550U CPU @ 1.80GHZ 8 3,172 25,376 Intel
34 CORE I7-3770 CPU @ 3.40GHZ 8 3,101 24,808 Intel
35 XEON E-2124G CPU @ 3.40GHZ 4 5,104 20,416 Intel
36 RYZEN 3 2200G 4 3,865 15,460 AMD
37 PHENOM II X4 965 4 3,013 12,052 AMD
38 CORE I5-4300U CPU @ 1.90GHZ 4 2,451 9,804 Intel
39 XEON CPU L5420 @ 2.50GHZ 4 2,289 9,156 Intel
40 FX-9590 EIGHT-CORE 8 906 7,248 AMD
41 FX-8320 EIGHT-CORE 8 469 3,752 AMD