PROJECT #16458 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project studies the R241P mutant of Tem-1 β-Lactmase

β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 33,302

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 17 January 2021 01:19:17

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 17 January 2021 01:19:17

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 13,851 664,848 AMD
2 RYZEN 9 3950X 16-CORE 32 14,821 474,272 AMD
3 RYZEN 9 5900X 12-CORE 24 17,353 416,472 AMD
4 RYZEN 9 5950X 16-CORE 32 12,017 384,544 AMD
5 RYZEN 9 3900XT 12-CORE 24 14,280 342,720 AMD
6 CORE I9-9980XE CPU @ 3.00GHZ 36 9,356 336,816 Intel
7 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,777 325,296 AMD
8 RYZEN 9 3900X 12-CORE 24 11,812 283,488 AMD
9 RYZEN 7 5800X 8-CORE 16 17,382 278,112 AMD
10 CORE I9-9900K CPU @ 3.60GHZ 16 16,973 271,568 Intel
11 RYZEN THREADRIPPER 2950X 16-CORE 32 8,074 258,368 AMD
12 CORE I9-10900K CPU @ 3.70GHZ 20 10,080 201,600 Intel
13 RYZEN THREADRIPPER 1920X 12-CORE 24 7,494 179,856 AMD
14 RYZEN 7 3800X 8-CORE 16 11,181 178,896 AMD
15 XEON W-2245 CPU @ 3.90GHZ 16 9,268 148,288 Intel
16 RYZEN 7 2700X EIGHT-CORE 16 9,191 147,056 AMD
17 RYZEN 7 4800H 16 8,702 139,232 AMD
18 CORE I7-9700K CPU @ 3.60GHZ 8 16,969 135,752 Intel
19 RYZEN 7 3700X 8-CORE 16 7,783 124,528 AMD
20 RYZEN 5 3600 6-CORE 12 10,140 121,680 AMD
21 RYZEN 5 3600XT 6-CORE 12 9,891 118,692 AMD
22 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,801 116,020 Intel
23 XEON CPU E5-2650 V2 @ 2.60GHZ 32 3,557 113,824 Intel
24 CORE I7-9700 CPU @ 3.00GHZ 8 12,168 97,344 Intel
25 RYZEN 5 3500 6-CORE 6 13,727 82,362 AMD
26 CORE2 DUO CPU T7700 @ 2.40GHZ 12 5,272 63,264 Intel
27 CORE I7-6700K CPU @ 4.00GHZ 8 7,396 59,168 Intel
28 RYZEN 7 1700 EIGHT-CORE 16 3,553 56,848 AMD
29 RYZEN 5 2600X SIX-CORE 12 4,404 52,848 AMD
30 CORE I7-4790K CPU @ 4.00GHZ 8 6,001 48,008 Intel
31 CORE I9-8950HK CPU @ 2.90GHZ 12 3,968 47,616 Intel
32 CORE I7-8705G CPU @ 3.10GHZ 8 5,569 44,552 Intel
33 CORE I5-7600 CPU @ 3.50GHZ 4 10,300 41,200 Intel
34 RYZEN 5 2600 SIX-CORE 12 3,230 38,760 AMD
35 CORE I5-6500 CPU @ 3.20GHZ 4 8,290 33,160 Intel
36 CORE I7-3770 CPU @ 3.40GHZ 8 3,589 28,712 Intel
37 RYZEN 5 4600HS 12 2,236 26,832 AMD
38 CORE I7-2600K CPU @ 3.40GHZ 8 3,188 25,504 Intel
39 CORE I5-10210U CPU @ 1.60GHZ 7 1,998 13,986 Intel
40 CORE I3-7100 CPU @ 3.90GHZ 4 3,334 13,336 Intel
41 CORE I3-6006U CPU @ 2.00GHZ 4 2,017 8,068 Intel
42 CORE I5-2540M CPU @ 2.60GHZ 4 1,788 7,152 Intel
43 CELERON(R) CPU G550 @ 2.60GHZ 2 524 1,048 Intel
 

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