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Research: Β-LACTMASES Folding Project #16458

Project #16458 overview

Project Summary AI Beta

This project looks at old versions of beta-lactamases (enzymes that break down penicillin). By comparing them to modern ones, scientists hope to find hidden parts that could be targeted by new drugs to fight antibiotic resistance.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Sukrit Singh
Institution
Washington University in St. Louis

Work unit

Atoms
33,302
Core
GRO_A7
Status
Public

No related projects listed.

Source material

Official Project Description

This project studies the R241P mutant of Tem-1 β-Lactmase β-Lactmases are enzymes which break down penicillin-like antibiotics.

This is the most common method by which bacteria become resistant to such antibiotics.

This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases.

We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases.

Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

Performance data

Hardware Performance for Project 16458

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:03:02

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 13,851 664,848 AMD
2 RYZEN 9 3950X 16-CORE 32 14,821 474,272 AMD
3 RYZEN 9 5900X 12-CORE 24 17,353 416,472 AMD
4 RYZEN 9 5950X 16-CORE 32 12,017 384,544 AMD
5 RYZEN 9 3900XT 12-CORE 24 14,280 342,720 AMD
6 CORE I9-9980XE CPU @ 3.00GHZ 36 9,356 336,816 Intel
7 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,777 325,296 AMD
8 RYZEN 9 3900X 12-CORE 24 11,812 283,488 AMD
9 RYZEN 7 5800X 8-CORE 16 17,382 278,112 AMD
10 CORE I9-9900K CPU @ 3.60GHZ 16 16,973 271,568 Intel
11 RYZEN THREADRIPPER 2950X 16-CORE 32 8,074 258,368 AMD
12 CORE I9-10900K CPU @ 3.70GHZ 20 10,080 201,600 Intel
13 RYZEN THREADRIPPER 1920X 12-CORE 24 7,494 179,856 AMD
14 RYZEN 7 3800X 8-CORE 16 11,181 178,896 AMD
15 XEON W-2245 CPU @ 3.90GHZ 16 9,268 148,288 Intel
16 RYZEN 7 2700X EIGHT-CORE 16 9,191 147,056 AMD
17 RYZEN 7 4800H 16 8,702 139,232 AMD
18 CORE I7-9700K CPU @ 3.60GHZ 8 16,969 135,752 Intel
19 RYZEN 7 3700X 8-CORE 16 7,783 124,528 AMD
20 RYZEN 5 3600 6-CORE 12 10,140 121,680 AMD
21 RYZEN 5 3600XT 6-CORE 12 9,891 118,692 AMD
22 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,801 116,020 Intel
23 XEON CPU E5-2650 V2 @ 2.60GHZ 32 3,557 113,824 Intel
24 CORE I7-9700 CPU @ 3.00GHZ 8 12,168 97,344 Intel
25 RYZEN 5 3500 6-CORE 6 13,727 82,362 AMD
26 CORE2 DUO CPU T7700 @ 2.40GHZ 12 5,272 63,264 Intel
27 CORE I7-6700K CPU @ 4.00GHZ 8 7,396 59,168 Intel
28 RYZEN 7 1700 EIGHT-CORE 16 3,553 56,848 AMD
29 RYZEN 5 2600X SIX-CORE 12 4,404 52,848 AMD
30 CORE I7-4790K CPU @ 4.00GHZ 8 6,001 48,008 Intel
31 CORE I9-8950HK CPU @ 2.90GHZ 12 3,968 47,616 Intel
32 CORE I7-8705G CPU @ 3.10GHZ 8 5,569 44,552 Intel
33 CORE I5-7600 CPU @ 3.50GHZ 4 10,300 41,200 Intel
34 RYZEN 5 2600 SIX-CORE 12 3,230 38,760 AMD
35 CORE I5-6500 CPU @ 3.20GHZ 4 8,290 33,160 Intel
36 CORE I7-3770 CPU @ 3.40GHZ 8 3,589 28,712 Intel
37 RYZEN 5 4600HS 12 2,236 26,832 AMD
38 CORE I7-2600K CPU @ 3.40GHZ 8 3,188 25,504 Intel
39 CORE I5-10210U CPU @ 1.60GHZ 7 1,998 13,986 Intel
40 CORE I3-7100 CPU @ 3.90GHZ 4 3,334 13,336 Intel
41 CORE I3-6006U CPU @ 2.00GHZ 4 2,017 8,068 Intel
42 CORE I5-2540M CPU @ 2.60GHZ 4 1,788 7,152 Intel
43 CELERON(R) CPU G550 @ 2.60GHZ 2 524 1,048 Intel