PROJECT #16453 RESEARCH FOR Î’-LACTMASES
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project studies the R241P mutant of Tem-1 β-Lactmase

β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 33,302

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 04 August 2021 19:04:09

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Folding@Home Identifier
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GPU
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 04 August 2021 19:04:09

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 15,491 743,568 AMD
2 RYZEN 9 3950X 16-CORE 32 15,464 494,848 AMD
3 RYZEN 9 3900XT 12-CORE 24 12,434 298,416 AMD
4 RYZEN 9 3900X 12-CORE 24 12,296 295,104 AMD
5 RYZEN THREADRIPPER 2950X 16-CORE 32 7,842 250,944 AMD
6 RYZEN 7 5800X 8-CORE 16 14,186 226,976 AMD
7 XEON CPU E5-2686 V4 @ 2.30GHZ 36 6,036 217,296 Intel
8 CORE I9-10900X CPU @ 3.70GHZ 20 9,435 188,700 Intel
9 RYZEN 7 3700X 8-CORE 16 10,991 175,856 AMD
10 CORE I9-7920X CPU @ 2.90GHZ 24 6,877 165,048 Intel
11 CORE I9-9900KF CPU @ 3.60GHZ 16 9,992 159,872 Intel
12 RYZEN 7 2700X EIGHT-CORE 16 9,907 158,512 AMD
13 CORE I9-9900K CPU @ 3.60GHZ 16 8,984 143,744 Intel
14 RYZEN THREADRIPPER 1920X 12-CORE 24 5,936 142,464 AMD
15 CORE I7-8700K CPU @ 3.70GHZ 12 11,479 137,748 Intel
16 RYZEN 5 3600 6-CORE 12 9,870 118,440 AMD
17 RYZEN 5 3600X 6-CORE 12 9,353 112,236 AMD
18 XEON CPU E5-2660 0 @ 2.20GHZ 32 3,123 99,936 Intel
19 CORE I7-9700 CPU @ 3.00GHZ 8 12,332 98,656 Intel
20 XEON CPU E5-2690 V2 @ 3.00GHZ 20 3,535 70,700 Intel
21 CORE I5-10400F CPU @ 2.90GHZ 12 5,693 68,316 Intel
22 CORE2 DUO CPU T7700 @ 2.40GHZ 12 5,675 68,100 Intel
23 XEON CPU E5-2630 0 @ 2.30GHZ 24 2,799 67,176 Intel
24 RYZEN 5 2600X SIX-CORE 12 5,549 66,588 AMD
25 XEON CPU X5570 @ 2.93GHZ 16 4,121 65,936 Intel
26 CORE I7-4980HQ CPU @ 2.80GHZ 8 7,590 60,720 Intel
27 CORE I9-9880H CPU @ 2.30GHZ 16 3,464 55,424 Intel
28 CORE I5-3570K CPU @ 3.40GHZ 4 10,704 42,816 Intel
29 CORE I7-8705G CPU @ 3.10GHZ 8 4,287 34,296 Intel
30 CORE I7-6700K CPU @ 4.00GHZ 8 4,155 33,240 Intel
31 XEON SILVER 4116 CPU @ 2.10GHZ 24 1,375 33,000 Intel
32 CORE I5-2500K CPU @ 3.30GHZ 4 5,230 20,920 Intel
33 PHENOM II X6 1090T 6 3,399 20,394 AMD
34 CORE I3-6006U CPU @ 2.00GHZ 4 1,448 5,792 Intel