PROJECT #16452 RESEARCH FOR COVID-19
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project is studying the NSP10 (Non-structural-protein-10) of SARS-CoV-2!

In this project we are analyzing the role of _every_ single residue in NSP10 using a computational mutagenesis approach. Each RUN in this project is simulating a unique mutant of NSP10, which we will compare to one another to identify critical residues of importance for NSP10 function. 

NSP10 is an "activator" protein for critical viral function. Two other proteins, NSP14, and NSP16 are important enzymes for viral function, but they both require NSP10 to bind them and "activate" them. Without NSP10, these two enzymes would not function which would inhibit the virus from being able to replicate and transmit the infection COVID19. This makes NSP10 an interesting potential biological target, as blocking its role as an activator could provide a therapeutic opportunity.

However, it only participates in protein-protein interactions and does not have any obvious "pockets" or grooves amenable to targeting by drug design methods. We are simulating NSP10 to identify potential druggable sites that have not been previously observed using experimental studies. From a basic research standpoint, it will also be useful to understand how NSP10 actually "activates" its targets, as the mechanism of activation remains unknown.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 29,571

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Saturday, 17 April 2021 19:06:03

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Project
Model Name
Folding@Home Identifier
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Brand
GPU
Model
PPD
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Saturday, 17 April 2021 19:06:03

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3950X 16-CORE 32 17,993 575,776 AMD
2 RYZEN 9 5900X 12-CORE 24 17,379 417,096 AMD
3 RYZEN 9 5950X 16-CORE 32 12,827 410,464 AMD
4 RYZEN 9 3900XT 12-CORE 24 14,682 352,368 AMD
5 RYZEN 9 3900X 12-CORE 24 14,330 343,920 AMD
6 CORE I9-9980XE CPU @ 3.00GHZ 36 9,366 337,176 Intel
7 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,543 314,064 AMD
8 CORE I9-9900K CPU @ 3.60GHZ 16 17,383 278,128 Intel
9 XEON PLATINUM 8124M CPU @ 3.00GHZ 36 7,131 256,716 Intel
10 RYZEN THREADRIPPER 2950X 16-CORE 32 7,290 233,280 AMD
11 RYZEN 7 5800X 8-CORE 16 13,095 209,520 AMD
12 RYZEN 7 3800X 8-CORE 16 12,675 202,800 AMD
13 RYZEN THREADRIPPER 1920X 12-CORE 24 7,514 180,336 AMD
14 RYZEN 7 3700X 8-CORE 16 10,335 165,360 AMD
15 CORE I7-10700K CPU @ 3.80GHZ 16 8,804 140,864 Intel
16 RYZEN 5 3600 6-CORE 12 10,784 129,408 AMD
17 CORE I7-9700K CPU @ 3.60GHZ 8 15,122 120,976 Intel
18 RYZEN 7 4800H 16 7,285 116,560 AMD
19 RYZEN 5 1600X SIX-CORE 12 9,527 114,324 AMD
20 CORE I7-9700 CPU @ 3.00GHZ 8 13,757 110,056 Intel
21 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,471 109,420 Intel
22 RYZEN 7 2700X EIGHT-CORE 16 6,011 96,176 AMD
23 RYZEN 5 3500 6-CORE 6 14,101 84,606 AMD
24 CORE I5-9600K CPU @ 3.70GHZ 6 13,196 79,176 Intel
25 CORE I5-9400F CPU @ 2.90GHZ 6 11,147 66,882 Intel
26 RYZEN 5 2600X SIX-CORE 12 4,790 57,480 AMD
27 RYZEN 5 1600 SIX-CORE 12 4,730 56,760 AMD
28 RYZEN 7 1700 EIGHT-CORE 16 3,540 56,640 AMD
29 CORE I7-8550U CPU @ 1.80GHZ 8 7,027 56,216 Intel
30 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,337 56,088 Intel
31 CORE I7-4790K CPU @ 4.00GHZ 8 6,452 51,616 Intel
32 CORE I7-6700K CPU @ 4.00GHZ 8 6,106 48,848 Intel
33 CORE I7-8705G CPU @ 3.10GHZ 8 6,083 48,664 Intel
34 RYZEN 5 2600 SIX-CORE 12 4,043 48,516 AMD
35 RYZEN 3 3200G 4 11,493 45,972 AMD
36 XEON W-2123 CPU @ 3.60GHZ 8 5,658 45,264 Intel
37 CORE I7-4770 CPU @ 3.40GHZ 8 5,017 40,136 Intel
38 CORE I5-7600 CPU @ 3.50GHZ 4 9,944 39,776 Intel
39 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 4,698 37,584 Intel
40 CORE I7-6700 CPU @ 3.40GHZ 8 4,628 37,024 Intel
41 CORE I5-6500 CPU @ 3.20GHZ 4 9,182 36,728 Intel
42 CORE I3-6100 CPU @ 3.70GHZ 4 7,645 30,580 Intel
43 CORE I7-2600K CPU @ 3.40GHZ 8 3,496 27,968 Intel
44 CORE I7-8565U CPU @ 1.80GHZ 8 3,471 27,768 Intel
45 CORE I5-6600K CPU @ 3.50GHZ 4 6,646 26,584 Intel
46 CORE I7-3770 CPU @ 3.40GHZ 8 3,271 26,168 Intel
47 XEON CPU E3-1230 V2 @ 3.30GHZ 8 3,255 26,040 Intel
48 FX-8350 EIGHT-CORE 8 2,813 22,504 AMD
49 CORE I3-7100 CPU @ 3.90GHZ 4 3,723 14,892 Intel
50 PHENOM II X4 965 4 3,471 13,884 AMD
51 PENTIUM(R) SILVER N5000 CPU @ 1.10GHZ 4 2,686 10,744 Intel
52 PHENOM II X6 1055T 6 1,702 10,212 AMD
53 FX-8320 EIGHT-CORE 8 1,251 10,008 AMD
54 FX-8300 EIGHT-CORE 8 1,247 9,976 AMD
55 CORE I3-6006U CPU @ 2.00GHZ 4 2,058 8,232 Intel
56 CORE I5-4570 CPU @ 3.20GHZ 4 1,184 4,736 Intel
57 A8-6410 APU 4 467 1,868 AMD