PROJECT #16452 RESEARCH FOR COVID-19
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project is studying the NSP10 (Non-structural-protein-10) of SARS-CoV-2!

In this project we are analyzing the role of _every_ single residue in NSP10 using a computational mutagenesis approach. Each RUN in this project is simulating a unique mutant of NSP10, which we will compare to one another to identify critical residues of importance for NSP10 function. 

NSP10 is an "activator" protein for critical viral function. Two other proteins, NSP14, and NSP16 are important enzymes for viral function, but they both require NSP10 to bind them and "activate" them. Without NSP10, these two enzymes would not function which would inhibit the virus from being able to replicate and transmit the infection COVID19. This makes NSP10 an interesting potential biological target, as blocking its role as an activator could provide a therapeutic opportunity.

However, it only participates in protein-protein interactions and does not have any obvious "pockets" or grooves amenable to targeting by drug design methods. We are simulating NSP10 to identify potential druggable sites that have not been previously observed using experimental studies. From a basic research standpoint, it will also be useful to understand how NSP10 actually "activates" its targets, as the mechanism of activation remains unknown.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 29,571

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 18 January 2021 21:01:02

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 18 January 2021 21:01:04

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3950X 16-CORE 32 17,856 571,392 AMD
2 RYZEN 9 5950X 16-CORE 32 13,242 423,744 AMD
3 RYZEN 9 5900X 12-CORE 24 16,527 396,648 AMD
4 RYZEN 9 3900XT 12-CORE 24 14,678 352,272 AMD
5 RYZEN 9 3900X 12-CORE 24 14,350 344,400 AMD
6 CORE I9-9980XE CPU @ 3.00GHZ 36 9,366 337,176 Intel
7 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,633 318,384 AMD
8 CORE I9-9900K CPU @ 3.60GHZ 16 17,424 278,784 Intel
9 RYZEN THREADRIPPER 2950X 16-CORE 32 7,353 235,296 AMD
10 RYZEN 7 5800X 8-CORE 16 13,300 212,800 AMD
11 RYZEN 7 3800X 8-CORE 16 12,675 202,800 AMD
12 RYZEN THREADRIPPER 1920X 12-CORE 24 7,514 180,336 AMD
13 RYZEN 7 3700X 8-CORE 16 9,712 155,392 AMD
14 CORE I7-10700K CPU @ 3.80GHZ 16 8,804 140,864 Intel
15 RYZEN 5 3600 6-CORE 12 10,703 128,436 AMD
16 CORE I7-9700K CPU @ 3.60GHZ 8 15,613 124,904 Intel
17 RYZEN 7 4800H 16 7,285 116,560 AMD
18 RYZEN 5 1600X SIX-CORE 12 9,527 114,324 AMD
19 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,538 110,760 Intel
20 CORE I7-9700 CPU @ 3.00GHZ 8 12,850 102,800 Intel
21 RYZEN 7 2700X EIGHT-CORE 16 6,083 97,328 AMD
22 RYZEN 5 3500 6-CORE 6 14,161 84,966 AMD
23 CORE I5-9400F CPU @ 2.90GHZ 6 11,147 66,882 Intel
24 RYZEN 7 1700 EIGHT-CORE 16 3,577 57,232 AMD
25 RYZEN 5 2600X SIX-CORE 12 4,709 56,508 AMD
26 CORE I7-8550U CPU @ 1.80GHZ 8 7,013 56,104 Intel
27 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,337 56,088 Intel
28 CORE I7-4790K CPU @ 4.00GHZ 8 6,452 51,616 Intel
29 RYZEN 5 2600 SIX-CORE 12 4,154 49,848 AMD
30 CORE I7-8705G CPU @ 3.10GHZ 8 6,094 48,752 Intel
31 RYZEN 3 3200G 4 11,493 45,972 AMD
32 CORE I7-6700K CPU @ 4.00GHZ 8 5,671 45,368 Intel
33 XEON W-2123 CPU @ 3.60GHZ 8 5,658 45,264 Intel
34 CORE I5-7600 CPU @ 3.50GHZ 4 10,447 41,788 Intel
35 CORE I7-4770 CPU @ 3.40GHZ 8 5,017 40,136 Intel
36 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 4,698 37,584 Intel
37 CORE I5-6500 CPU @ 3.20GHZ 4 8,897 35,588 Intel
38 CORE I7-3770 CPU @ 3.40GHZ 8 3,277 26,216 Intel
39 XEON CPU E3-1230 V2 @ 3.30GHZ 8 3,255 26,040 Intel
40 CORE I7-2600K CPU @ 3.40GHZ 8 2,909 23,272 Intel
41 FX-8350 EIGHT-CORE 8 2,813 22,504 AMD
42 CORE I3-6100 CPU @ 3.70GHZ 4 5,123 20,492 Intel
43 PHENOM II X4 965 4 3,471 13,884 AMD
44 CORE I3-7100 CPU @ 3.90GHZ 4 3,373 13,492 Intel
45 FX-8300 EIGHT-CORE 8 1,247 9,976 AMD
46 FX-8320 EIGHT-CORE 8 1,116 8,928 AMD
47 CORE I3-6006U CPU @ 2.00GHZ 4 2,066 8,264 Intel
48 CORE I5-4570 CPU @ 3.20GHZ 4 1,184 4,736 Intel
49 A8-6410 APU 4 467 1,868 AMD
 

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