PROJECT #16451 RESEARCH FOR COVID-19
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project is studying the NSP10 (Non-structural-protein-10) of SARS-CoV-2!

In this project we are analyzing the role of _every_ single residue in NSP10 using a computational mutagenesis approach. Each RUN in this project is simulating a unique mutant of NSP10, which we will compare to one another to identify critical residues of importance for NSP10 function. 

NSP10 is an "activator" protein for critical viral function. Two other proteins, NSP14, and NSP16 are important enzymes for viral function, but they both require NSP10 to bind them and "activate" them. Without NSP10, these two enzymes would not function which would inhibit the virus from being able to replicate and transmit the infection COVID19. This makes NSP10 an interesting potential biological target, as blocking its role as an activator could provide a therapeutic opportunity.

However, it only participates in protein-protein interactions and does not have any obvious "pockets" or grooves amenable to targeting by drug design methods. We are simulating NSP10 to identify potential druggable sites that have not been previously observed using experimental studies. From a basic research standpoint, it will also be useful to understand how NSP10 actually "activates" its targets, as the mechanism of activation remains unknown.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 29,571

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 18 January 2021 21:44:07

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 18 January 2021 21:44:08

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3970X 32-CORE 64 14,097 902,208 AMD
2 RYZEN THREADRIPPER 3960X 24-CORE 48 13,594 652,512 AMD
3 RYZEN 9 3950X 16-CORE 32 15,630 500,160 AMD
4 RYZEN 9 5950X 16-CORE 32 15,258 488,256 AMD
5 RYZEN 9 5900X 12-CORE 24 15,821 379,704 AMD
6 RYZEN 9 3900XT 12-CORE 24 13,479 323,496 AMD
7 CORE I9-9980XE CPU @ 3.00GHZ 36 8,646 311,256 Intel
8 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,458 309,984 AMD
9 RYZEN 7 5800X 8-CORE 16 18,343 293,488 AMD
10 RYZEN 9 3900X 12-CORE 24 11,611 278,664 AMD
11 RYZEN THREADRIPPER 2950X 16-CORE 32 7,217 230,944 AMD
12 CORE I9-10900K CPU @ 3.70GHZ 20 10,852 217,040 Intel
13 CORE I9-9900K CPU @ 3.60GHZ 16 12,907 206,512 Intel
14 XEON CPU E5-2686 V4 @ 2.30GHZ 36 5,666 203,976 Intel
15 RYZEN 7 3800X 8-CORE 16 11,369 181,904 AMD
16 CORE I7-8700K CPU @ 3.70GHZ 12 13,958 167,496 Intel
17 CORE I7-9700K CPU @ 3.60GHZ 8 19,985 159,880 Intel
18 RYZEN THREADRIPPER 1920X 12-CORE 24 6,615 158,760 AMD
19 XEON W-2245 CPU @ 3.90GHZ 16 9,511 152,176 Intel
20 RYZEN 7 3700X 8-CORE 16 8,836 141,376 AMD
21 RYZEN 5 3600 6-CORE 12 11,128 133,536 AMD
22 RYZEN 5 3600X 6-CORE 12 11,117 133,404 AMD
23 CORE I9-9900 CPU @ 3.10GHZ 16 7,379 118,064 Intel
24 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,136 102,720 Intel
25 XEON CPU E5-2660 0 @ 2.20GHZ 32 3,180 101,760 Intel
26 CORE I7-9700 CPU @ 3.00GHZ 8 12,652 101,216 Intel
27 RYZEN 5 3500 6-CORE 6 14,329 85,974 AMD
28 RYZEN 7 2700X EIGHT-CORE 16 4,794 76,704 AMD
29 CORE I5-8400 CPU @ 2.80GHZ 6 11,320 67,920 Intel
30 CORE I7-10710U CPU @ 1.10GHZ 12 5,641 67,692 Intel
31 RYZEN 5 2600X SIX-CORE 12 5,233 62,796 AMD
32 CORE I7-8550U CPU @ 1.80GHZ 8 7,162 57,296 Intel
33 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,378 57,072 Intel
34 CORE I5-9400 CPU @ 2.90GHZ 6 9,483 56,898 Intel
35 CORE I7-4790K CPU @ 4.00GHZ 8 6,515 52,120 Intel
36 RYZEN 5 2600 SIX-CORE 12 4,047 48,564 AMD
37 CORE I3-6100 CPU @ 3.70GHZ 4 11,823 47,292 Intel
38 RYZEN 5 4600HS 12 3,866 46,392 AMD
39 CORE I5-7600 CPU @ 3.50GHZ 4 10,751 43,004 Intel
40 RYZEN 3 3200G 4 9,934 39,736 AMD
41 CORE I5-6500 CPU @ 3.20GHZ 4 8,885 35,540 Intel
42 CORE I7-3770 CPU @ 3.40GHZ 8 3,396 27,168 Intel
43 CORE I5-4590 CPU @ 3.30GHZ 4 5,745 22,980 Intel
44 CORE I5-2500K CPU @ 3.30GHZ 4 5,633 22,532 Intel
45 FX-8350 EIGHT-CORE 8 2,748 21,984 AMD
46 CORE I5-4460 CPU @ 3.20GHZ 4 4,828 19,312 Intel
47 CORE I3-6006U CPU @ 2.00GHZ 4 1,661 6,644 Intel
 

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