PROJECT #16451 RESEARCH FOR COVID-19
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project is studying the NSP10 (Non-structural-protein-10) of SARS-CoV-2!

In this project we are analyzing the role of _every_ single residue in NSP10 using a computational mutagenesis approach. Each RUN in this project is simulating a unique mutant of NSP10, which we will compare to one another to identify critical residues of importance for NSP10 function. 

NSP10 is an "activator" protein for critical viral function. Two other proteins, NSP14, and NSP16 are important enzymes for viral function, but they both require NSP10 to bind them and "activate" them. Without NSP10, these two enzymes would not function which would inhibit the virus from being able to replicate and transmit the infection COVID19. This makes NSP10 an interesting potential biological target, as blocking its role as an activator could provide a therapeutic opportunity.

However, it only participates in protein-protein interactions and does not have any obvious "pockets" or grooves amenable to targeting by drug design methods. We are simulating NSP10 to identify potential druggable sites that have not been previously observed using experimental studies. From a basic research standpoint, it will also be useful to understand how NSP10 actually "activates" its targets, as the mechanism of activation remains unknown.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 29,571

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 28 July 2021 15:34:04

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Folding@Home Identifier
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GPU
Model
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 28 July 2021 15:34:04

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3970X 32-CORE 64 14,097 902,208 AMD
2 RYZEN THREADRIPPER 3960X 24-CORE 48 13,594 652,512 AMD
3 RYZEN 9 3950X 16-CORE 32 18,746 599,872 AMD
4 RYZEN 9 5950X 16-CORE 32 14,499 463,968 AMD
5 RYZEN 9 5900X 12-CORE 24 17,218 413,232 AMD
6 RYZEN 9 3900XT 12-CORE 24 13,479 323,496 AMD
7 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,505 312,240 AMD
8 CORE I9-9980XE CPU @ 3.00GHZ 36 8,646 311,256 Intel
9 RYZEN 9 3900X 12-CORE 24 10,984 263,616 AMD
10 RYZEN 7 5800X 8-CORE 16 16,380 262,080 AMD
11 EPYC 7302P 16-CORE 32 8,019 256,608 AMD
12 RYZEN THREADRIPPER 2950X 16-CORE 32 7,217 230,944 AMD
13 CORE I9-10900K CPU @ 3.70GHZ 20 10,852 217,040 Intel
14 CORE I9-9900K CPU @ 3.60GHZ 16 12,780 204,480 Intel
15 XEON CPU E5-2686 V4 @ 2.30GHZ 36 5,666 203,976 Intel
16 RYZEN 7 3800X 8-CORE 16 10,657 170,512 AMD
17 CORE I9-7920X CPU @ 2.90GHZ 24 7,062 169,488 Intel
18 CORE I7-8700K CPU @ 3.70GHZ 12 13,958 167,496 Intel
19 XEON CPU E5-2667 V2 @ 3.30GHZ 32 5,027 160,864 Intel
20 RYZEN 7 3700X 8-CORE 16 9,990 159,840 AMD
21 RYZEN THREADRIPPER 1920X 12-CORE 24 6,615 158,760 AMD
22 CORE I7-9700K CPU @ 3.60GHZ 8 19,154 153,232 Intel
23 XEON W-2245 CPU @ 3.90GHZ 16 9,511 152,176 Intel
24 RYZEN 5 3600X 6-CORE 12 11,117 133,404 AMD
25 RYZEN 5 3600 6-CORE 12 10,984 131,808 AMD
26 RYZEN 5 PRO 4650G 12 10,153 121,836 AMD
27 CORE I9-9900 CPU @ 3.10GHZ 16 7,379 118,064 Intel
28 XEON CPU E5-2660 0 @ 2.20GHZ 32 3,341 106,912 Intel
29 RYZEN 7 4800H 16 6,589 105,424 AMD
30 CORE I7-9700 CPU @ 3.00GHZ 8 12,664 101,312 Intel
31 XEON CPU E5-2690 V2 @ 3.00GHZ 20 4,925 98,500 Intel
32 RYZEN 3 3100 4-CORE 8 11,115 88,920 AMD
33 RYZEN 5 3500 6-CORE 6 14,318 85,908 AMD
34 RYZEN 7 2700X EIGHT-CORE 16 5,225 83,600 AMD
35 RYZEN 5 2600X SIX-CORE 12 6,126 73,512 AMD
36 CORE I5-8400 CPU @ 2.80GHZ 6 11,320 67,920 Intel
37 CORE I7-10710U CPU @ 1.10GHZ 12 5,641 67,692 Intel
38 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,539 60,936 Intel
39 CORE I7-3840QM CPU @ 2.80GHZ 8 7,453 59,624 Intel
40 CORE I5-9400 CPU @ 2.90GHZ 6 9,483 56,898 Intel
41 CORE I7-4790K CPU @ 4.00GHZ 8 6,627 53,016 Intel
42 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,934 47,472 Intel
43 CORE I3-6100 CPU @ 3.70GHZ 4 11,823 47,292 Intel
44 RYZEN 5 2600 SIX-CORE 12 3,874 46,488 AMD
45 RYZEN 5 4600HS 12 3,866 46,392 AMD
46 CORE I7-8550U CPU @ 1.80GHZ 8 5,525 44,200 Intel
47 CORE I5-7600 CPU @ 3.50GHZ 4 10,224 40,896 Intel
48 RYZEN 3 3200G 4 9,934 39,736 AMD
49 CORE I5-4690K CPU @ 3.50GHZ 4 9,882 39,528 Intel
50 CORE I7-4770 CPU @ 3.40GHZ 8 4,910 39,280 Intel
51 CORE I7-8705G CPU @ 3.10GHZ 8 4,525 36,200 Intel
52 CORE I5-6500 CPU @ 3.20GHZ 4 8,818 35,272 Intel
53 CORE I7-4770K CPU @ 3.50GHZ 8 4,009 32,072 Intel
54 CORE I5-7400 CPU @ 3.00GHZ 4 7,277 29,108 Intel
55 PHENOM II X6 1090T 6 4,735 28,410 AMD
56 CORE I7-3770 CPU @ 3.40GHZ 8 3,396 27,168 Intel
57 CORE I5-4590 CPU @ 3.30GHZ 4 5,745 22,980 Intel
58 CORE I5-2500K CPU @ 3.30GHZ 4 5,633 22,532 Intel
59 FX-8350 EIGHT-CORE 8 2,748 21,984 AMD
60 CORE I5-4460 CPU @ 3.20GHZ 4 4,828 19,312 Intel
61 RYZEN 5 3500U 8 1,922 15,376 AMD
62 CORE I7-4790T CPU @ 2.70GHZ 8 1,834 14,672 Intel
63 CORE I7-8565U CPU @ 1.80GHZ 8 1,515 12,120 Intel
64 PENTIUM(R) SILVER N5000 CPU @ 1.10GHZ 4 2,670 10,680 Intel
65 CORE I3-6006U CPU @ 2.00GHZ 4 1,661 6,644 Intel
66 A8-6410 APU 4 356 1,424 AMD