Folding project #15503, CANCER research

Research section Research projects and references

Project #15503 overview

Project Summary AI Beta

This project studies small molecules that could block HDAC8, a protein linked to some cancers. Researchers are using experiments to see how these molecules move and attach to HDAC8.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Vincent Voelz
Institution: Temple University

Work unit

Atoms: 77,209
Core: 0xa8
Status: Beta

Source material

Official Project Description

This project simulates small macrocyclic inhibitors of HDAC8 (histone deacetylase 8), a therapeutic target for certain types of cancer.

This work, a collaboration with Kathryn Cole's group at Christopher Newport University, aims to understand the conformational flexibility of these ligands in solution and bound to the HDAC8 receptor.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

HDAC8

Histone Deacetylase 8

Technical: MedicineBiotechnology / Pharmacology

HDAC8 is an enzyme that removes acetyl groups from histones, proteins that help package DNA. By inhibiting HDAC8, cancer cell growth can be slowed. It is a therapeutic target for certain types of cancer.

inhibitors

Substances that block or reduce the activity of another substance.

Technical: MedicineBiotechnology / Pharmacology

Inhibitors are molecules that prevent or slow down the action of other molecules. In medicine, they are often used to treat diseases by blocking the function of harmful proteins.

ligands

Molecules that bind to a specific receptor or target.

Technical: MedicineBiotechnology / Pharmacology

Ligands are molecules that attach to other molecules, often proteins, called receptors. This binding can trigger various cellular responses. In drug development, ligands are often designed to bind to specific targets within the body to produce a desired effect.

receptor

A protein that binds to a specific molecule (ligand) and triggers a cellular response.

Technical: MedicineBiotechnology / Pharmacology

Receptors are specialized proteins found on the surface of cells. They act like cellular antennas, receiving signals from outside the cell in the form of ligands. This binding can activate various pathways within the cell, leading to changes in its behavior.

cancer

A group of diseases characterized by abnormal cell growth.

Technical: HealthcareMedicine / Oncology

Cancer is a broad term for a group of diseases where cells grow and divide uncontrollably. This uncontrolled growth can form tumors and spread to other parts of the body.

CPU PPD Averages Beta

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make
1	CORE I7-7700HQ CPU @ 2.80GHZ	8	1,699	13,592	Intel

Research: CANCER Folding Project #15503

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 15503

CPU PPD Averages Beta

Research: CANCER Folding Project #15503

Project Summary AI Beta

Project team

Work unit

Related projects

CPU PPD Averages Beta