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Research: IL2-RECEPTOR-DYNAMICS Folding Project #18280

Project #18280 overview

Project Summary AI Beta

This project compares computer simulations of human interleukin-2 (IL-2), a molecule that controls immune responses, to real-life lab data. The goal is to find the best simulation methods for understanding how IL-2 works and designing new versions that can be used as medicines.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Justin Miller
Institution
University of Pennsylvania

Work unit

Atoms
32,732
Core
0x27
Status
Public
Source material

Official Project Description

As part of our ongoing effort to benchmark the most popular force field and water combinations, this project series focuses on human interleukin-2 (IL-2).

Our aim is to compare the results of these simulations to experimental nuclear magnetic resonance (NMR) spectroscopy data. Human interleukin-2 (IL-2) is an important signaling molecule, or cytokine, for the regulation of T-cell activity.

IL-2 can act as a promotor or inhibitor in immune cells depending on which of its receptors are bound.

There have been efforts to modify IL-2’s receptor binding sites to bias its activity towards either promoting or inhibiting immune cells.

However, the dynamics underlying IL-2 receptor recognition and binding are still not fully understood.

In addition to quantifying force field accuracy, a better understanding of these dynamics will help design IL-2 variants with more specific activity, thus improving its potential as a therapeutic.
p18278- amber03 with tip3p water 18279 - amber19sb with opc water p18280- amber99sb-disp with aadisp water p18281- charmm36m with tip3p water p18282- amber99sb-star-ILDN with tip4p water p18283- amber99sb-star-ILDN with tip4pd water.

Performance data

Hardware Performance for Project 18280

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:52:31

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]		 Nvidia GA106 8,967,480 23,500 381.59 0 hrs 4 mins
2 TITAN V
GV100 [TITAN V] M 12288		 Nvidia GV100 3,841,295 23,500 163.46 0 hrs 9 mins
3 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 Super]		 Nvidia TU106 2,325,466 75,064 30.98 0 hrs 46 mins
4 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380		 Nvidia GP102 2,290,157 23,500 97.45 0 hrs 15 mins
5 TITAN Xp
GP102 [TITAN Xp] 12150		 Nvidia GP102 2,198,077 23,500 93.54 0 hrs 15 mins
6 Intel Arc B580 Graphics
Battlemage G21 [Intel Arc B580 Graphics]		 Intel Battlemage G21 2,171,967 30,932 70.22 0 hrs 21 mins
7 GeForce RTX 2060
TU104 [GeForce RTX 2060]		 Nvidia TU104 2,106,118 23,500 89.62 0 hrs 16 mins
8 Quadro RTX 4000
TU104GL [Quadro RTX 4000]		 Nvidia TU104GL 2,039,958 29,635 68.84 0 hrs 21 mins
9 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]		 Nvidia GA106M 2,029,169 27,241 74.49 0 hrs 19 mins
10 GeForce RTX 2060
TU106 [Geforce RTX 2060]		 Nvidia TU106 1,821,952 155,585 11.71 2 hrs 3 mins
11 GeForce RTX 2060
TU106 [Geforce RTX 2ᠰ60]		 Nvidia TU106 1,821,952 155,585 11.71 2 hrs 3 mins
12 P102-100
GP102 [P102-100]		 Nvidia GP102 1,751,354 23,500 74.53 0 hrs 19 mins
13 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]		 Nvidia TU116 1,741,756 23,500 74.12 0 hrs 19 mins
14 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873		 Nvidia GP104 1,710,789 125,456 13.64 1 hrs 46 mins
15 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]		 Nvidia TU106M 1,425,476 23,500 60.66 0 hrs 24 mins
16 GeForce GTX 1660
TU116 [GeForce GTX 1660]		 Nvidia TU116 1,353,837 31,463 43.03 0 hrs 33 mins
17 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463		 Nvidia GP104 1,255,774 114,492 10.97 2 hrs 11 mins
18 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632		 Nvidia GM200 1,216,105 23,500 51.75 0 hrs 28 mins
19 P104-100
GP104 [P104-100]		 Nvidia GP104 1,125,704 23,500 47.90 0 hrs 30 mins
20 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]		 Nvidia TU116 1,023,016 28,813 35.51 0 hrs 41 mins
21 P106-100
GP106 [P106-100]		 Nvidia GP106 907,326 23,500 38.61 0 hrs 37 mins
22 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372		 Nvidia GP106 859,248 29,555 29.07 0 hrs 50 mins
23 Tesla P4
GP104GL [Tesla P4] 5704		 Nvidia GP104GL 839,072 119,482 7.02 3 hrs 25 mins
24 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935		 Nvidia GP106 820,830 23,500 34.93 0 hrs 41 mins
25 CMP 30HX
TU116 [CMP 30HX]		 Nvidia TU116 811,954 23,500 34.55 0 hrs 42 mins
26 RX 5600 OEM/5600XT/5700(XT)
Navi 10 [RX 5600 OEM/5600XT/5700(XT)]		 AMD Navi 10 793,760 23,500 33.78 0 hrs 43 mins
27 GeForce GTX 1650
TU116 [GeForce GTX 1650] 3091		 Nvidia TU116 753,282 23,500 32.05 0 hrs 45 mins
28 GeForce RTX 3050 6GB Laptop GPU
GN20-P0-R-K2 [GeForce RTX 3050 6GB Laptop GPU]		 Nvidia GN20-P0-R-K2 686,459 23,500 29.21 0 hrs 49 mins
29 GeForce GTX 970
GM204 [GeForce GTX 970] 3494		 Nvidia GM204 591,971 23,500 25.19 0 hrs 57 mins
30 GeForce GTX 1650
TU106 [GeForce GTX 1650]		 Nvidia TU106 459,296 23,500 19.54 1 hrs 14 mins
31 GeForce GTX 1650
TU117 [GeForce GTX 1650]		 Nvidia TU117 458,000 23,500 19.49 1 hrs 14 mins
32 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144		 Nvidia GM200 445,074 97,557 4.56 5 hrs 16 mins
33 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]		 Nvidia TU117GLM 389,872 92,261 4.23 5 hrs 41 mins
34 Quadro M5000
GM204GL [Quadro M5000]		 Nvidia GM204GL 365,555 23,500 15.56 1 hrs 33 mins
35 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862		 Nvidia GP107 331,129 23,500 14.09 1 hrs 42 mins
36 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138		 Nvidia GP107 285,729 59,953 4.77 5 hrs 2 mins
37 Quadro K5200
GK110 [Quadro K5200]		 Nvidia GK110 277,881 23,500 11.82 2 hrs 2 mins
38 Radeon PRO W6400
Navi 24 [Radeon PRO W6400]		 AMD Navi 24 251,610 23,500 10.71 2 hrs 14 mins
39 Quadro P1000
GP107GL [Quadro P1000]		 Nvidia GP107GL 222,662 76,979 2.89 8 hrs 18 mins
40 Quadro T400 Mobile
TU117GLM [Quadro T400 Mobile]		 Nvidia TU117GLM 195,970 23,500 8.34 2 hrs 53 mins
41 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389		 Nvidia GM107 167,211 23,500 7.12 3 hrs 22 mins
42 RX 5500(M)/Pro 5500M
Navi 14 [RX 5500(M)/Pro 5500M]		 AMD Navi 14 88,227 23,500 3.75 6 hrs 24 mins
43 GeForce GT 1030
GP108 [GeForce GT 1030]		 Nvidia GP108 54,435 34,022 1.60 15 hrs 0 mins
44 GeForce GT 710
GK208B [GeForce GT 710] 366		 Nvidia GK208B 5,764 23,500 0.25 97 hrs 51 mins