Folding project #17746, CANCER research

Research section Research projects and references

Project #17746 overview

Project Summary AI Beta

This project looks at how proteins move stuff across cell membranes using ions like tiny power sources. These proteins are important for many things and some can even be used to treat diseases! By studying them, we can learn more about how cells work.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Matthew Chan
Institution: University of Illinois at Urbana-Champaign

Work unit

Atoms: 89,869
Core: OPENMM_22
Status: Beta

Source material

Official Project Description

Projects 17745-17750 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Transporters

Proteins that move molecules across cell membranes.

Scientific: BiotechnologyBiochemistry / Membrane Transport

Transporters are essential proteins found in all living organisms. They help move different substances, like nutrients and waste products, across cell membranes. This is crucial for many biological processes, including absorbing nutrients from food and getting rid of cellular waste.

Secondary Active Transporters

Proteins that use an ion gradient to transport molecules across cell membranes.

Scientific: BiotechnologyBiochemistry / Membrane Transport

Secondary active transporters are a type of protein that rely on the movement of ions (charged particles) to power the transport of other molecules across cell membranes. This process is called co-transport and is essential for many cellular functions, such as nutrient uptake and waste removal.

Ion Gradient

A difference in ion concentration across a cell membrane.

Scientific: BiotechnologyBiochemistry / Membrane Transport

An ion gradient is a difference in the concentration of charged particles (ions) between two areas. This concentration difference creates a force that can drive the movement of ions across a membrane. In cells, ion gradients are crucial for many processes, including nerve impulse transmission and muscle contraction.

Drug Targets

Molecules that are targeted by drugs to treat diseases.

Technical: PharmaceuticalsPharmacology / Disease Treatment

Drug targets are specific molecules in the body that are involved in disease processes. By targeting these molecules with drugs, scientists aim to block or modify their activity and alleviate symptoms.

Simulations

Computer models used to study biological systems.

Technical: BiotechnologyBioinformatics / Computational Biology

Simulations are computer programs that mimic real-world processes. In bioinformatics, simulations are used to study complex biological systems, such as protein interactions and drug effects, without the need for expensive and time-consuming experiments.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,950,783	92,278	75.32	0 ^hrs 19 ^mins
2	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,745,198	67,967	40.39	0 ^hrs 36 ^mins
3	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	866,523	46,629	18.58	1 ^hrs 17 ^mins

Research: CANCER Folding Project #17746

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17746

GPU PPD Averages

Research: CANCER Folding Project #17746

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages