PROJECT #16457 RESEARCH FOR Î’-LACTMASES
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project studies the E240A mutant of Tem-1 β-Lactmase β-Lactmases are enzymes which break down penicillin-like antibiotics.

This is the most common method by which bacteria become resistant to such antibiotics.

This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases.

We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases.

Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance..

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 33,227

Core: GRO_A7

Status: Public