PROJECT #16457 RESEARCH FOR Î’-LACTMASES
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
This project studies the E240A mutant of Tem-1 β-Lactmase
β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.
PROJECT INFO
Manager(s): Sukrit Singh
Institution: Washington University in St. Louis
PROJECT WORK UNIT SUMMARY
Atoms: 33,227
Core: GRO_A7
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Friday, 30 July 2021 00:39:51
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Rank Project |
Model Name Folding@Home Identifier |
Make Brand |
GPU Model |
PPD Average |
Points WU Average |
WUs Day Average |
WU Time Average |
|---|
PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Friday, 30 July 2021 00:39:51
|
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
|---|---|---|---|---|---|
| 1 | RYZEN 9 3950X 16-CORE | 32 | 13,130 | 420,160 | AMD |
| 2 | RYZEN 9 3900X 12-CORE | 24 | 14,063 | 337,512 | AMD |
| 3 | RYZEN THREADRIPPER 1920X 12-CORE | 24 | 7,604 | 182,496 | AMD |
| 4 | RYZEN 7 2700X EIGHT-CORE | 16 | 9,449 | 151,184 | AMD |
| 5 | RYZEN 7 3700X 8-CORE | 16 | 7,505 | 120,080 | AMD |
| 6 | RYZEN 5 3600 6-CORE | 12 | 9,039 | 108,468 | AMD |
| 7 | RYZEN 5 3500 6-CORE | 6 | 13,269 | 79,614 | AMD |
| 8 | XEON CPU E5-2690 V2 @ 3.00GHZ | 20 | 3,334 | 66,680 | Intel |
| 9 | XEON CPU E5-2630 0 @ 2.30GHZ | 24 | 2,684 | 64,416 | Intel |
| 10 | RYZEN 5 2600 SIX-CORE | 12 | 3,790 | 45,480 | AMD |
| 11 | RYZEN 5 4600HS | 12 | 2,176 | 26,112 | AMD |
| 12 | CORE I5-7300HQ CPU @ 2.50GHZ | 4 | 2,587 | 10,348 | Intel |
| 13 | CORE I7-6700HQ CPU @ 2.60GHZ | 8 | 1,225 | 9,800 | Intel |
| 14 | XEON CPU L5420 @ 2.50GHZ | 4 | 2,169 | 8,676 | Intel |
| 15 | CORE I3-6006U CPU @ 2.00GHZ | 4 | 1,384 | 5,536 | Intel |
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